{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:08:44Z","timestamp":1760299724438,"version":"3.37.3"},"reference-count":100,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FISS-13-RD12\/0043\/0030","FISS-13-RD12\/0043\/0017","FISS-14-PI13\/02741","FI14\/00405"],"award-info":[{"award-number":["FISS-13-RD12\/0043\/0030","FISS-13-RD12\/0043\/0017","FISS-14-PI13\/02741","FI14\/00405"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FICYT, PCTI","award":["FC-15-GRUPIN14-071","FC-15-GRUPIN14-071","FC-15-GRUPIN14-071"],"award-info":[{"award-number":["FC-15-GRUPIN14-071","FC-15-GRUPIN14-071","FC-15-GRUPIN14-071"]}]},{"DOI":"10.13039\/501100008530","name":"FEDER","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1007\/s12035-017-0796-8","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T07:12:02Z","timestamp":1509347522000},"page":"5830-5846","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Melatonin Prevents the Harmful Effects of Obesity on the Brain, Including at the Behavioral Level"],"prefix":"10.1007","volume":"55","author":[{"name":"Members of Research Team cROS (cellular Response to Oxidative Stress)","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1458-2115","authenticated-orcid":false,"given":"Adrian","family":"Rubio-Gonz\u00e1lez","sequence":"first","affiliation":[]},{"given":"Juan Carlos","family":"Bermejo-Millo","sequence":"additional","affiliation":[]},{"given":"Beatriz","family":"de Lux\u00e1n-Delgado","sequence":"additional","affiliation":[]},{"given":"Yaiza","family":"Potes","sequence":"additional","affiliation":[]},{"given":"Zulema","family":"P\u00e9rez-Mart\u00ednez","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 Antonio","family":"Boga","sequence":"additional","affiliation":[]},{"given":"Ignacio","family":"Vega-Naredo","sequence":"additional","affiliation":[]},{"given":"Beatriz","family":"Caballero","sequence":"additional","affiliation":[]},{"given":"Juan Jos\u00e9","family":"Solano","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Coto-Montes","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2017,10,30]]},"reference":[{"key":"796_CR1","unstructured":"WHO (2015) Obesity and Overweight. World Health Organization (WHO) http:\/\/www.who.int\/mediacentre\/factsheets\/fs311\/es\/ . Accessed 6 March 2017"},{"key":"796_CR2","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/S0140-6736(05)67483-1","volume":"366","author":"DW Haslam","year":"2005","unstructured":"Haslam DW, James WP (2005) Obesity. Lancet 366:1197\u20131209. https:\/\/doi.org\/10.1016\/S0140-6736(05)67483-1","journal-title":"Lancet"},{"key":"796_CR3","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/j.1467-789X.2008.00473.x","volume":"9","author":"MA Beydoun","year":"2008","unstructured":"Beydoun MA, Beydoun HA, Wang Y (2008) Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis. Obes Rev 9:204\u2013218. https:\/\/doi.org\/10.1111\/j.1467-789X.2008.00473.x","journal-title":"Obes Rev"},{"key":"796_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00401-013-1190-x","volume":"127","author":"EB Lee","year":"2014","unstructured":"Lee EB, Mattson MP (2014) The neuropathology of obesity: insights from human disease. Acta Neuropathol 127:3\u201328. https:\/\/doi.org\/10.1007\/s00401-013-1190-x","journal-title":"Acta Neuropathol"},{"key":"796_CR5","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.3233\/JAD-2010-1298","volume":"19","author":"G Marwarha","year":"2010","unstructured":"Marwarha G, Dasari B, Prasanthi JR, Schommer J, Ghribi O (2010) Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. J Alzheimer\u2019s Dis: JAD 19:1007\u20131019. https:\/\/doi.org\/10.3233\/JAD-2010-1298","journal-title":"J Alzheimer\u2019s Dis: JAD"},{"key":"796_CR6","doi-asserted-by":"publisher","first-page":"10237","DOI":"10.1073\/pnas.172399499","volume":"99","author":"ME Raichle","year":"2002","unstructured":"Raichle ME, Gusnard DA (2002) Appraising the brain\u2019s energy budget. Proc Natl Acad Sci U S A 99:10237\u201310239. https:\/\/doi.org\/10.1073\/pnas.172399499","journal-title":"Proc Natl Acad Sci U S A"},{"key":"796_CR7","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1096\/fasebj.9.7.7737461","volume":"9","author":"RJ Reiter","year":"1995","unstructured":"Reiter RJ (1995) Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J 9:526\u2013533","journal-title":"FASEB J"},{"key":"796_CR8","doi-asserted-by":"publisher","first-page":"6926","DOI":"10.1523\/JNEUROSCI.0800-08.2008","volume":"28","author":"B Boland","year":"2008","unstructured":"Boland B, Kumar A, Lee S, Platt FM, Wegiel J, WH Y, Nixon RA (2008) Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer\u2019s disease. J Neurosci 28:6926\u20136937. https:\/\/doi.org\/10.1523\/JNEUROSCI.0800-08.2008","journal-title":"J Neurosci"},{"key":"796_CR9","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1038\/sj.cdd.4402200","volume":"14","author":"M Hoyer-Hansen","year":"2007","unstructured":"Hoyer-Hansen M, Jaattela M (2007) Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium. Cell Death Differ 14:1576\u20131582. https:\/\/doi.org\/10.1038\/sj.cdd.4402200","journal-title":"Cell Death Differ"},{"key":"796_CR10","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s13105-015-0384-1","volume":"71","author":"N Zhang","year":"2015","unstructured":"Zhang N, Cao MM, Liu H, Xie GY, Li YB (2015) Autophagy regulates insulin resistance following endoplasmic reticulum stress in diabetes. J Physiol Biochem 71:319\u2013327. https:\/\/doi.org\/10.1007\/s13105-015-0384-1","journal-title":"J Physiol Biochem"},{"key":"796_CR11","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1126\/science.292.5521.1552","volume":"292","author":"NF Bence","year":"2001","unstructured":"Bence NF, Sampat RM, Kopito RR (2001) Impairment of the ubiquitin-proteasome system by protein aggregation. Science 292:1552\u20131555. https:\/\/doi.org\/10.1126\/science.292.5521.1552","journal-title":"Science"},{"key":"796_CR12","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.mce.2012.04.009","volume":"361","author":"A Coto-Montes","year":"2012","unstructured":"Coto-Montes A, Boga JA, Rosales-Corral S, Fuentes-Broto L, Tan DX, Reiter RJ (2012) Role of melatonin in the regulation of autophagy and mitophagy: a review. Mol Cell Endocrinol 361:12\u201323. https:\/\/doi.org\/10.1016\/j.mce.2012.04.009","journal-title":"Mol Cell Endocrinol"},{"key":"796_CR13","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1111\/jpi.12333","volume":"61","author":"B Luxan-Delgado de","year":"2016","unstructured":"de Luxan-Delgado B, Potes Y, Rubio-Gonzalez A, Caballero B, Solano JJ, Fernandez-Fernandez M, Bermudez M, Rodrigues Moreira Guimaraes M et al (2016) Melatonin reduces endoplasmic reticulum stress and autophagy in liver of leptin-deficient mice. J Pineal Res 61:108\u2013123. https:\/\/doi.org\/10.1111\/jpi.12333","journal-title":"J Pineal Res"},{"key":"796_CR14","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1111\/jnc.12380","volume":"128","author":"DJ Bonda","year":"2014","unstructured":"Bonda DJ, Stone JG, Torres SL, Siedlak SL, Perry G, Kryscio R, Jicha G, Casadesus G et al (2014) Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance. J Neurochem 128:162\u2013172. https:\/\/doi.org\/10.1111\/jnc.12380","journal-title":"J Neurochem"},{"key":"796_CR15","doi-asserted-by":"publisher","first-page":"M1","DOI":"10.1530\/JOE-14-0224","volume":"223","author":"RT Turner","year":"2014","unstructured":"Turner RT, Philbrick KA, Wong CP, Olson DA, Branscum AJ, Iwaniec UT (2014) Morbid obesity attenuates the skeletal abnormalities associated with leptin deficiency in mice. J Endocrinol 223:M1\u201315. https:\/\/doi.org\/10.1530\/JOE-14-0224","journal-title":"J Endocrinol"},{"key":"796_CR16","doi-asserted-by":"publisher","first-page":"564","DOI":"10.3109\/07853890.2011.586365","volume":"44","author":"RJ Reiter","year":"2012","unstructured":"Reiter RJ, Tan DX, Korkmaz A, Ma S (2012) Obesity and metabolic syndrome: association with chronodisruption, sleep deprivation, and melatonin suppression. Ann Med 44:564\u2013577. https:\/\/doi.org\/10.3109\/07853890.2011.586365","journal-title":"Ann Med"},{"issue":"1","key":"796_CR17","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1111\/j.1600-079X.2011.00922.x","volume":"52","author":"I Vega-Naredo","year":"2012","unstructured":"Vega-Naredo I, Caballero B, Sierra V, Garcia-Macia M, de Gonzalo-Calvo D, Oliveira PJ, Rodriguez-Colunga MJ, Coto-Montes A (2012) Melatonin modulates autophagy through a redox-mediated action in female Syrian hamster Harderian gland controlling cell types and gland activity. J Pineal Res 52(1):80\u201392. https:\/\/doi.org\/10.1111\/j.1600-079X.2011.00922.x","journal-title":"J Pineal Res"},{"key":"796_CR18","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1046\/j.1525-1373.2000.22414.x","volume":"224","author":"CA Mastronardi","year":"2000","unstructured":"Mastronardi CA, Walczewska A, WH Y, Karanth S, Parlow AF, McCann SM (2000) The possible role of prolactin in the circadian rhythm of leptin secretion in male rats. Proc Soc Exp Biol Med 224:152\u2013158","journal-title":"Proc Soc Exp Biol Med"},{"key":"796_CR19","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/j.1600-079X.2011.00928.x","volume":"52","author":"A Agil","year":"2012","unstructured":"Agil A, Rosado I, Ruiz R, Figueroa A, Zen N, Fernandez-Vazquez G (2012) Melatonin improves glucose homeostasis in young Zucker diabetic fatty rats. J Pineal Res 52:203\u2013210. https:\/\/doi.org\/10.1111\/j.1600-079X.2011.00928.x","journal-title":"J Pineal Res"},{"key":"796_CR20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0014-2999(01)01230-4","volume":"428","author":"S Canpolat","year":"2001","unstructured":"Canpolat S, Sandal S, Yilmaz B, Yasar A, Kutlu S, Baydas G, Kelestimur H (2001) Effects of pinealectomy and exogenous melatonin on serum leptin levels in male rat. Eur J Pharmacol 428:145\u2013148","journal-title":"Eur J Pharmacol"},{"key":"796_CR21","first-page":"449","volume":"22","author":"G Baydas","year":"2001","unstructured":"Baydas G, Gursu F, Canpolat S, Konar V, Yasar A, Canatan H, Kelestimur H (2001) Effects of pinealectomy on the circadian release pattern of leptin in male rat. Neuro Endocrinol Lett 22:449\u2013452","journal-title":"Neuro Endocrinol Lett"},{"key":"796_CR22","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1111\/jpi.12267","volume":"59","author":"LC Manchester","year":"2015","unstructured":"Manchester LC, Coto-Montes A, Boga JA, Andersen LP, Zhou Z, Galano A, Vriend J, Tan DX et al (2015) Melatonin: an ancient molecule that makes oxygen metabolically tolerable. J Pineal Res 59:403\u2013419. https:\/\/doi.org\/10.1111\/jpi.12267","journal-title":"J Pineal Res"},{"key":"796_CR23","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/jpi.12360","volume":"61","author":"RJ Reiter","year":"2016","unstructured":"Reiter RJ, Mayo JC, Tan DX, Sainz RM, Alatorre-Jimenez M, Qin L (2016) Melatonin as an antioxidant: under promises but over delivers. J Pineal Res 61:253\u2013278. https:\/\/doi.org\/10.1111\/jpi.12360","journal-title":"J Pineal Res"},{"key":"796_CR24","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/j.1467-789X.2010.00756.x","volume":"12","author":"DX Tan","year":"2011","unstructured":"Tan DX, Manchester LC, Fuentes-Broto L, Paredes SD, Reiter RJ (2011) Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity. Obes Rev 12:167\u2013188. https:\/\/doi.org\/10.1111\/j.1467-789X.2010.00756.x","journal-title":"Obes Rev"},{"key":"796_CR25","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1111\/jpi.12089","volume":"55","author":"A Jimenez-Aranda","year":"2013","unstructured":"Jimenez-Aranda A, Fernandez-Vazquez G, Campos D, Tassi M, Velasco-Perez L, Tan DX, Reiter RJ, Agil A (2013) Melatonin induces browning of inguinal white adipose tissue in Zucker diabetic fatty rats. J Pineal Res 55:416\u2013423. https:\/\/doi.org\/10.1111\/jpi.12089","journal-title":"J Pineal Res"},{"key":"796_CR26","first-page":"E934","volume":"275","author":"FB Lima","year":"1998","unstructured":"Lima FB, Machado UF, Bartol I, Seraphim PM, Sumida DH, Moraes SM, Hell NS, Okamoto MM et al (1998) Pinealectomy causes glucose intolerance and decreases adipose cell responsiveness to insulin in rats. Am J Phys 275:E934\u2013E941","journal-title":"Am J Phys"},{"key":"796_CR27","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/j.1600-079X.2010.00835.x","volume":"50","author":"M Kozirog","year":"2011","unstructured":"Kozirog M, Poliwczak AR, Duchnowicz P, Koter-Michalak M, Sikora J, Broncel M (2011) Melatonin treatment improves blood pressure, lipid profile, and parameters of oxidative stress in patients with metabolic syndrome. J Pineal Res 50:261\u2013266. https:\/\/doi.org\/10.1111\/j.1600-079X.2010.00835.x","journal-title":"J Pineal Res"},{"key":"796_CR28","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/jpi.12344","volume":"61","author":"H Wu","year":"2016","unstructured":"Wu H, Shao A, Zhao M, Chen S, Yu J, Zhou J, Liang F, Shi L et al (2016) Melatonin attenuates neuronal apoptosis through up-regulation of K(+)-Cl(\u2212) cotransporter KCC2 expression following traumatic brain injury in rats. J Pineal Res 61:241\u2013250. https:\/\/doi.org\/10.1111\/jpi.12344","journal-title":"J Pineal Res"},{"key":"796_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-0-387-31416-7_1","volume-title":"Leptin. Endocrine updates","author":"VD Castracane","year":"2007","unstructured":"Castracane VD, Henson MC (2007) The obese (ob\/ob) mouse and the discovery of leptin. In: Castracane VD, Henson MC (eds) Leptin. Endocrine updates, vol 25. New York City, Springer US, pp. 1\u20139. https:\/\/doi.org\/10.1007\/978-0-387-31416-7_1"},{"key":"796_CR30","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"key":"796_CR31","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0076-6879(90)86141-H","volume":"186","author":"RL Levine","year":"1990","unstructured":"Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz AG, Ahn BW, Shaltiel S et al (1990) Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 186:464\u2013478","journal-title":"Methods Enzymol"},{"key":"796_CR32","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1600-079X.1999.tb00610.x","volume":"27","author":"A Coto-Montes","year":"1999","unstructured":"Coto-Montes A, Hardeland R (1999) Antioxidative effects of melatonin in Drosophila melanogaster: antagonization of damage induced by the inhibition of catalase. J Pineal Res 27:154\u2013158","journal-title":"J Pineal Res"},{"key":"796_CR33","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0308-8146(00)00324-1","volume":"73","author":"MB Arnao","year":"2001","unstructured":"Arnao MB, Cano A, Acosta M (2001) The hydrophilic and lipophilic contribution to total antioxidant activity. Food Chem 73:239\u2013244","journal-title":"Food Chem"},{"key":"796_CR34","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.freeradbiomed.2010.05.019","volume":"49","author":"D Gonzalo-Calvo de","year":"2010","unstructured":"de Gonzalo-Calvo D, Neitzert K, Fernandez M, Vega-Naredo I, Caballero B, Garcia-Macia M, Suarez FM, Rodriguez-Colunga MJ et al (2010) Differential inflammatory responses in aging and disease: TNF-alpha and IL-6 as possible biomarkers. Free Radic Biol Med 49:733\u2013737. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2010.05.019","journal-title":"Free Radic Biol Med"},{"key":"796_CR35","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0003-9861(87)90400-0","volume":"255","author":"JP Martin Jr","year":"1987","unstructured":"Martin JP Jr, Dailey M, Sugarman E (1987) Negative and positive assays of superoxide dismutase based on hematoxylin autoxidation. Arch Biochem Biophys 255:329\u2013336","journal-title":"Arch Biochem Biophys"},{"key":"796_CR36","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/genetics\/91.4.723","volume":"91","author":"S Lubinsky","year":"1979","unstructured":"Lubinsky S, Bewley GC (1979) Genetics of catalase in Drosophila melanogaster: rates of synthesis and degradation of the enzyme in flies aneuploid and euploid for the structural gene. Genetics 91:723\u2013742","journal-title":"Genetics"},{"key":"796_CR37","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0009-8981(75)80002-7","volume":"58","author":"L Kum-Tatt","year":"1975","unstructured":"Kum-Tatt L, Tan IK, Seet AM (1975) A new colorimetric method for the determination of NADH\/NADPH dependent glutathione reductase in erythrocytes and in plasma. Clin Chim Acta 58:101\u2013108","journal-title":"Clin Chim Acta"},{"key":"796_CR38","first-page":"258","volume-title":"Methods of enzymatic analysis","author":"DM Goldberg","year":"1983","unstructured":"Goldberg DM, Spooner RJ (1983) Glutathione reductase. In: Bergmeyer HU (ed) Methods of enzymatic analysis, 3rd edn. Verlag Chemie, Deerfield Beach, pp. 258\u2013265","edition":"3"},{"issue":"5","key":"796_CR39","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1038\/nn.3988","volume":"18","author":"BM Nugent","year":"2015","unstructured":"Nugent BM, Wright CL, Shetty AC, Hodes GE, Lenz KM, Mahurkar A, Russo SJ, Devine SE et al (2015) Brain feminization requires active repression of masculinization via DNA methylation. Nat Neurosci 18(5):690\u2013697. https:\/\/doi.org\/10.1038\/nn.3988","journal-title":"Nat Neurosci"},{"key":"796_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.9734\/BBJ\/2016\/22402","volume":"11","author":"M Oliv\u00e1n","year":"2016","unstructured":"Oliv\u00e1n M, Fern\u00e1ndez-Su\u00e1rez V, D\u00edaz-Mart\u00ednez F, Sierra V, Coto-Montes A, de Lux\u00e1n-Delgado B, Pe\u00f1a R, Bassols A et al (2016) Identification of biomarkers of stress in meat of pigs managed under different mixing treatments. Br Biotechnol J 11:1\u201313. https:\/\/doi.org\/10.9734\/BBJ\/2016\/22402","journal-title":"Br Biotechnol J"},{"key":"796_CR41","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1021\/ac026136s","volume":"75","author":"J Havlis","year":"2003","unstructured":"Havlis J, Thomas H, Sebela M, Shevchenko A (2003) Fast-response proteomics by accelerated in-gel digestion of proteins. Anal Chem 75:1300\u20131306","journal-title":"Anal Chem"},{"key":"796_CR42","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1074\/mcp.M900327-MCP200","volume":"9","author":"MS Jami","year":"2010","unstructured":"Jami MS, Barreiro C, Garcia-Estrada C, Martin JF (2010) Proteome analysis of the penicillin producer Penicillium chrysogenum: characterization of protein changes during the industrial strain improvement. Mol Cell Proteomics: MCP 9:1182\u20131198. https:\/\/doi.org\/10.1074\/mcp.M900327-MCP200","journal-title":"Mol Cell Proteomics: MCP"},{"key":"796_CR43","first-page":"327","volume":"229","author":"RD Porsolt","year":"1977","unstructured":"Porsolt RD, Bertin A, Jalfre M (1977) Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther 229:327\u2013336","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"796_CR44","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.jneumeth.2004.09.017","volume":"143","author":"R Gersner","year":"2005","unstructured":"Gersner R, Dar DE, Shabat-Simon M, Zangen A (2005) Behavioral analysis during the forced swimming test using a joystick device. J Neurosci Methods 143:117\u2013121. https:\/\/doi.org\/10.1016\/j.jneumeth.2004.09.017","journal-title":"J Neurosci Methods"},{"key":"796_CR45","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/978-1-4939-2522-3_15","volume":"1292","author":"A Dandekar","year":"2015","unstructured":"Dandekar A, Mendez R, Zhang K (2015) Cross talk between ER stress, oxidative stress, and inflammation in health and disease. Methods Mol Biol 1292:205\u2013214. https:\/\/doi.org\/10.1007\/978-1-4939-2522-3_15","journal-title":"Methods Mol Biol"},{"key":"796_CR46","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1111\/jpi.12064","volume":"55","author":"YM Yoo","year":"2013","unstructured":"Yoo YM (2013) Melatonin-mediated insulin synthesis during endoplasmic reticulum stress involves HuD expression in rat insulinoma INS-1E cells. J Pineal Res 55:207\u2013220. https:\/\/doi.org\/10.1111\/jpi.12064","journal-title":"J Pineal Res"},{"key":"796_CR47","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1534-5807(03)00022-4","volume":"4","author":"H Yoshida","year":"2003","unstructured":"Yoshida H, Matsui T, Hosokawa N, Kaufman RJ, Nagata K, Mori K (2003) A time-dependent phase shift in the mammalian unfolded protein response. Dev Cell 4:265\u2013271","journal-title":"Dev Cell"},{"key":"796_CR48","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/nature20137","volume":"539","author":"A Mashaghi","year":"2016","unstructured":"Mashaghi A, Bezrukavnikov S, Minde DP, Wentink AS, Kityk R, Zachmann-Brand B, Mayer MP, Kramer G et al (2016) Alternative modes of client binding enable functional plasticity of Hsp70. Nature 539:448\u2013451. https:\/\/doi.org\/10.1038\/nature20137","journal-title":"Nature"},{"key":"796_CR49","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.devcel.2007.07.005","volume":"13","author":"J Wu","year":"2007","unstructured":"Wu J, Rutkowski DT, Dubois M, Swathirajan J, Saunders T, Wang J, Song B, Yau GD et al (2007) ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress. Dev Cell 13:351\u2013364. https:\/\/doi.org\/10.1016\/j.devcel.2007.07.005","journal-title":"Dev Cell"},{"key":"796_CR50","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.4161\/auto.5.7.9610","volume":"5","author":"I Vega-Naredo","year":"2009","unstructured":"Vega-Naredo I, Caballero B, Sierra V, Huidobro-Fernandez C, de Gonzalo-Calvo D, Garcia-Macia M, Tolivia D, Rodriguez-Colunga MJ et al (2009) Sexual dimorphism of autophagy in Syrian hamster Harderian gland culminates in a holocrine secretion in female glands. Autophagy 5:1004\u20131017","journal-title":"Autophagy"},{"key":"796_CR51","doi-asserted-by":"publisher","first-page":"340520","DOI":"10.1155\/2015\/340520","volume":"2015","author":"M Reinisalo","year":"2015","unstructured":"Reinisalo M, Karlund A, Koskela A, Kaarniranta K, Karjalainen RO (2015) Polyphenol stilbenes: molecular mechanisms of defence against oxidative stress and aging-related diseases. Oxidative Med Cell Longev 2015:340520. https:\/\/doi.org\/10.1155\/2015\/340520","journal-title":"Oxidative Med Cell Longev"},{"key":"796_CR52","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/ncb0310-207","volume":"12","author":"TE Rusten","year":"2010","unstructured":"Rusten TE, Stenmark H (2010) p62, an autophagy hero or culprit? Nat Cell Biol 12:207\u2013209. https:\/\/doi.org\/10.1038\/ncb0310-207","journal-title":"Nat Cell Biol"},{"key":"796_CR53","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S0962-8924(00)01852-3","volume":"10","author":"RR Kopito","year":"2000","unstructured":"Kopito RR (2000) Aggresomes, inclusion bodies and protein aggregation. Trends Cell Biol 10:524\u2013530","journal-title":"Trends Cell Biol"},{"key":"796_CR54","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1242\/jcs.017665","volume":"121","author":"F Lazaro-Dieguez","year":"2008","unstructured":"Lazaro-Dieguez F, Aguado C, Mato E, Sanchez-Ruiz Y, Esteban I, Alberch J, Knecht E, Egea G (2008) Dynamics of an F-actin aggresome generated by the actin-stabilizing toxin jasplakinolide. J Cell Sci 121:1415\u20131425. https:\/\/doi.org\/10.1242\/jcs.017665","journal-title":"J Cell Sci"},{"key":"796_CR55","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1083\/jcb.143.7.1883","volume":"143","author":"JA Johnston","year":"1998","unstructured":"Johnston JA, Ward CL, Kopito RR (1998) Aggresomes: a cellular response to misfolded proteins. J Cell Biol 143:1883\u20131898","journal-title":"J Cell Biol"},{"key":"796_CR56","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1002\/path.1650","volume":"204","author":"NJ Cairns","year":"2004","unstructured":"Cairns NJ, Lee VM, Trojanowski JQ (2004) The cytoskeleton in neurodegenerative diseases. J Pathol 204:438\u2013449. https:\/\/doi.org\/10.1002\/path.1650","journal-title":"J Pathol"},{"key":"796_CR57","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/1749-799X-6-30","volume":"6","author":"JJ Cao","year":"2011","unstructured":"Cao JJ (2011) Effects of obesity on bone metabolism. J Orthop Surg Res 6:30. https:\/\/doi.org\/10.1186\/1749-799X-6-30","journal-title":"J Orthop Surg Res"},{"key":"796_CR58","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1016\/j.biochi.2012.05.010","volume":"94","author":"B Dubern","year":"2012","unstructured":"Dubern B, Clement K (2012) Leptin and leptin receptor-related monogenic obesity. Biochimie 94:2111\u20132115. https:\/\/doi.org\/10.1016\/j.biochi.2012.05.010","journal-title":"Biochimie"},{"key":"796_CR59","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1002\/hbm.21334","volume":"33","author":"AM Hedman","year":"2012","unstructured":"Hedman AM, van Haren NE, Schnack HG, Kahn RS, Hulshoff Pol HE (2012) Human brain changes across the life span: a review of 56 longitudinal magnetic resonance imaging studies. Hum Brain Mapp 33:1987\u20132002. https:\/\/doi.org\/10.1002\/hbm.21334","journal-title":"Hum Brain Mapp"},{"key":"796_CR60","doi-asserted-by":"publisher","first-page":"263","DOI":"10.14670\/HH-27.263","volume":"27","author":"B Caballero","year":"2012","unstructured":"Caballero B, Coto-Montes A (2012) An insight into the role of autophagy in cell responses in the aging and neurodegenerative brain. Histol Histopathol 27:263\u2013275. 10.14670\/HH-27.263","journal-title":"Histol Histopathol"},{"key":"796_CR61","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s10522-005-6041-2","volume":"7","author":"O Alvarez-Garcia","year":"2006","unstructured":"Alvarez-Garcia O, Vega-Naredo I, Sierra V, Caballero B, Tomas-Zapico C, Camins A, Garcia JJ, Pallas M et al (2006) Elevated oxidative stress in the brain of senescence-accelerated mice at 5\u00a0months of age. Biogerontology 7:43\u201352. https:\/\/doi.org\/10.1007\/s10522-005-6041-2","journal-title":"Biogerontology"},{"key":"796_CR62","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1089\/met.2015.0095","volume":"13","author":"P Manna","year":"2015","unstructured":"Manna P, Jain SK (2015) Obesity, oxidative stress, adipose tissue dysfunction, and the associated health risks: causes and therapeutic strategies. Metab Syndr Relat Disord 13:423\u2013444. https:\/\/doi.org\/10.1089\/met.2015.0095","journal-title":"Metab Syndr Relat Disord"},{"key":"796_CR63","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1111\/j.1600-079X.2008.00591.x","volume":"45","author":"B Caballero","year":"2008","unstructured":"Caballero B, Vega-Naredo I, Sierra V, Huidobro-Fernandez C, Soria-Valles C, De Gonzalo-Calvo D, Tolivia D, Gutierrez-Cuesta J et al (2008) Favorable effects of a prolonged treatment with melatonin on the level of oxidative damage and neurodegeneration in senescence-accelerated mice. J Pineal Res 45:302\u2013311. https:\/\/doi.org\/10.1111\/j.1600-079X.2008.00591.x","journal-title":"J Pineal Res"},{"key":"796_CR64","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1111\/j.1600-079X.2008.00637.x","volume":"46","author":"B Caballero","year":"2009","unstructured":"Caballero B, Vega-Naredo I, Sierra V, Huidobro-Fernandez C, Soria-Valles C, De Gonzalo-Calvo D, Tolivia D, Pallas M et al (2009) Melatonin alters cell death processes in response to age-related oxidative stress in the brain of senescence-accelerated mice. J Pineal Res 46:106\u2013114. https:\/\/doi.org\/10.1111\/j.1600-079X.2008.00637.x","journal-title":"J Pineal Res"},{"key":"796_CR65","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1189\/jlb.68.4.437","volume":"68","author":"G Fantuzzi","year":"2000","unstructured":"Fantuzzi G, Faggioni R (2000) Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol 68:437\u2013446","journal-title":"J Leukoc Biol"},{"key":"796_CR66","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.7150\/ijbs.4679","volume":"8","author":"M Erta","year":"2012","unstructured":"Erta M, Quintana A, Hidalgo J (2012) Interleukin-6, a major cytokine in the central nervous system. Int J Biol Sci 8:1254\u20131266. https:\/\/doi.org\/10.7150\/ijbs.4679","journal-title":"Int J Biol Sci"},{"key":"796_CR67","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1749-6632.1998.tb09587.x","volume":"840","author":"W Pierpaoli","year":"1998","unstructured":"Pierpaoli W (1998) Neuroimmunomodulation of aging. A program in the pineal gland. Ann N Y Acad Sci 840:491\u2013497","journal-title":"Ann N Y Acad Sci"},{"issue":"Suppl 6","key":"796_CR68","first-page":"115","volume":"58","author":"M Szczepanik","year":"2007","unstructured":"Szczepanik M (2007) Melatonin and its influence on immune system. J Physiol Pharmacol 58(Suppl 6):115\u2013124","journal-title":"J Physiol Pharmacol"},{"key":"796_CR69","doi-asserted-by":"publisher","first-page":"8638","DOI":"10.3390\/ijms14048638","volume":"14","author":"A Carrillo-Vico","year":"2013","unstructured":"Carrillo-Vico A, Lardone PJ, Alvarez-Sanchez N, Rodriguez-Rodriguez A, Guerrero JM (2013) Melatonin: buffering the immune system. Int J Mol Sci 14:8638\u20138683. https:\/\/doi.org\/10.3390\/ijms14048638","journal-title":"Int J Mol Sci"},{"key":"796_CR70","doi-asserted-by":"publisher","first-page":"3027","DOI":"10.1210\/endo.142.7.8225","volume":"142","author":"NM Rizk","year":"2001","unstructured":"Rizk NM, Stammsen D, Preibisch G, Eckel JR (2001) Leptin and tumor necrosis factor-alpha induce the tyrosine phosphorylation of signal transducer and activator of transcription proteins in the hypothalamus of normal rats in vivo. Endocrinology 142:3027\u20133032. https:\/\/doi.org\/10.1210\/endo.142.7.8225","journal-title":"Endocrinology"},{"key":"796_CR71","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1093\/hmg\/ddr445","volume":"21","author":"H Lee","year":"2012","unstructured":"Lee H, Noh JY, Oh Y, Kim Y, Chang JW, Chung CW, Lee ST, Kim M et al (2012) IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux. Hum Mol Genet 21:101\u2013114. https:\/\/doi.org\/10.1093\/hmg\/ddr445","journal-title":"Hum Mol Genet"},{"key":"796_CR72","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.virusres.2014.12.018","volume":"207","author":"M Torres","year":"2015","unstructured":"Torres M, Matamala JM, Duran-Aniotz C, Cornejo VH, Foley A, Hetz C (2015) ER stress signaling and neurodegeneration: at the intersection between Alzheimer\u2019s disease and Prion-related disorders. Virus Res 207:69\u201375. https:\/\/doi.org\/10.1016\/j.virusres.2014.12.018","journal-title":"Virus Res"},{"key":"796_CR73","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1089\/ars.2007.1782","volume":"9","author":"JD Malhotra","year":"2007","unstructured":"Malhotra JD, Kaufman RJ (2007) Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid Redox Signal 9:2277\u20132293. https:\/\/doi.org\/10.1089\/ars.2007.1782","journal-title":"Antioxid Redox Signal"},{"key":"796_CR74","doi-asserted-by":"publisher","first-page":"22067","DOI":"10.3390\/ijms141122067","volume":"14","author":"D Mizuno","year":"2013","unstructured":"Mizuno D, Kawahara M (2013) The molecular mechanisms of zinc neurotoxicity and the pathogenesis of vascular type senile dementia. Int J Mol Sci 14:22067\u201322081. https:\/\/doi.org\/10.3390\/ijms141122067","journal-title":"Int J Mol Sci"},{"key":"796_CR75","doi-asserted-by":"publisher","first-page":"7358","DOI":"10.1523\/JNEUROSCI.5358-09.2010","volume":"30","author":"E Nosyreva","year":"2010","unstructured":"Nosyreva E, Kavalali ET (2010) Activity-dependent augmentation of spontaneous neurotransmission during endoplasmic reticulum stress. J Neurosci 30:7358\u20137368. https:\/\/doi.org\/10.1523\/JNEUROSCI.5358-09.2010","journal-title":"J Neurosci"},{"key":"796_CR76","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.ceb.2014.12.002","volume":"33","author":"R Volmer","year":"2015","unstructured":"Volmer R, Ron D (2015) Lipid-dependent regulation of the unfolded protein response. Curr Opin Cell Biol 33:67\u201373. https:\/\/doi.org\/10.1016\/j.ceb.2014.12.002","journal-title":"Curr Opin Cell Biol"},{"key":"796_CR77","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.brainres.2016.04.017","volume":"1648","author":"RC Taylor","year":"2016","unstructured":"Taylor RC (2016) Aging and the UPR(ER). Brain Res 1648:588\u2013593. https:\/\/doi.org\/10.1016\/j.brainres.2016.04.017","journal-title":"Brain Res"},{"key":"796_CR78","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1002\/oby.21081","volume":"23","author":"LM Bollinger","year":"2015","unstructured":"Bollinger LM, Powell JJ, Houmard JA, Witczak CA, Brault JJ (2015) Skeletal muscle myotubes in severe obesity exhibit altered ubiquitin-proteasome and autophagic\/lysosomal proteolytic flux. Obesity 23:1185\u20131193. https:\/\/doi.org\/10.1002\/oby.21081","journal-title":"Obesity"},{"key":"796_CR79","doi-asserted-by":"publisher","first-page":"2831","DOI":"10.1210\/en.2014-1090","volume":"155","author":"LM Ignacio-Souza","year":"2014","unstructured":"Ignacio-Souza LM, Bombassaro B, Pascoal LB, Portovedo MA, Razolli DS, Coope A, Victorio SC, de Moura RF et al (2014) Defective regulation of the ubiquitin\/proteasome system in the hypothalamus of obese male mice. Endocrinology 155:2831\u20132844. https:\/\/doi.org\/10.1210\/en.2014-1090","journal-title":"Endocrinology"},{"key":"796_CR80","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.freeradbiomed.2017.05.018","volume":"110","author":"Y Potes","year":"2017","unstructured":"Potes Y, de Luxan-Delgado B, Rodriguez-Gonzalez S, Guimaraes MRM, Solano JJ, Fernandez-Fernandez M, Bermudez M, Boga JA et al (2017) Overweight in elderly people induces impaired autophagy in skeletal muscle. Free Radic Biol Med 110:31\u201341. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2017.05.018","journal-title":"Free Radic Biol Med"},{"key":"796_CR81","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1016\/j.bbamcr.2014.03.016","volume":"1843","author":"L Wang","year":"2014","unstructured":"Wang L, Cano M, Handa JT (2014) p62 provides dual cytoprotection against oxidative stress in the retinal pigment epithelium. Biochim Biophys Acta 1843:1248\u20131258. https:\/\/doi.org\/10.1016\/j.bbamcr.2014.03.016","journal-title":"Biochim Biophys Acta"},{"key":"796_CR82","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.neulet.2007.09.068","volume":"429","author":"I Santa-Maria","year":"2007","unstructured":"Santa-Maria I, Hernandez F, Moreno FJ, Avila J (2007) Taurine, an inducer for tau polymerization and a weak inhibitor for amyloid-beta-peptide aggregation. Neurosci Lett 429:91\u201394. https:\/\/doi.org\/10.1016\/j.neulet.2007.09.068","journal-title":"Neurosci Lett"},{"key":"796_CR83","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/s00401-013-1158-x","volume":"126","author":"C Richter-Landsberg","year":"2013","unstructured":"Richter-Landsberg C, Leyk J (2013) Inclusion body formation, macroautophagy, and the role of HDAC6 in neurodegeneration. Acta Neuropathol 126:793\u2013807. https:\/\/doi.org\/10.1007\/s00401-013-1158-x","journal-title":"Acta Neuropathol"},{"key":"796_CR84","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1385\/JMN:29:2:153","volume":"29","author":"NG Bauer","year":"2006","unstructured":"Bauer NG, Richter-Landsberg C (2006) The dynamic instability of microtubules is required for aggresome formation in oligodendroglial cells after proteolytic stress. J Mol Neurosci: MN 29:153\u2013168. https:\/\/doi.org\/10.1385\/JMN:29:2:153","journal-title":"J Mol Neurosci: MN"},{"key":"796_CR85","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1750-1326-4-13","volume":"4","author":"TF Gendron","year":"2009","unstructured":"Gendron TF, Petrucelli L (2009) The role of tau in neurodegeneration. Mol Neurodegener 4:13. https:\/\/doi.org\/10.1186\/1750-1326-4-13","journal-title":"Mol Neurodegener"},{"key":"796_CR86","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.nurt.2008.05.006","volume":"5","author":"A Schneider","year":"2008","unstructured":"Schneider A, Mandelkow E (2008) Tau-based treatment strategies in neurodegenerative diseases. Neurotherapeutics 5:443\u2013457. https:\/\/doi.org\/10.1016\/j.nurt.2008.05.006","journal-title":"Neurotherapeutics"},{"key":"796_CR87","doi-asserted-by":"publisher","first-page":"14575","DOI":"10.3390\/ijms140714575","volume":"14","author":"L Lin","year":"2013","unstructured":"Lin L, Huang QX, Yang SS, Chu J, Wang JZ, Tian Q (2013) Melatonin in Alzheimer\u2019s disease. Int J Mol Sci 14:14575\u201314593. https:\/\/doi.org\/10.3390\/ijms140714575","journal-title":"Int J Mol Sci"},{"key":"796_CR88","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1007\/s00401-011-0833-z","volume":"121","author":"L Fellner","year":"2011","unstructured":"Fellner L, Jellinger KA, Wenning GK, Stefanova N (2011) Glial dysfunction in the pathogenesis of alpha-synucleinopathies: emerging concepts. Acta Neuropathol 121:675\u2013693. https:\/\/doi.org\/10.1007\/s00401-011-0833-z","journal-title":"Acta Neuropathol"},{"key":"796_CR89","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1097\/NEN.0b013e31825018f7","volume":"71","author":"PT Nelson","year":"2012","unstructured":"Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ et al (2012) Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol 71:362\u2013381. https:\/\/doi.org\/10.1097\/NEN.0b013e31825018f7","journal-title":"J Neuropathol Exp Neurol"},{"key":"796_CR90","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1111\/pcn.12091","volume":"67","author":"H Xiao","year":"2013","unstructured":"Xiao H, Run X, Cao X, Su Y, Sun Z, Tian C, Sun S, Liang Z (2013) Temperature control can abolish anesthesia-induced tau hyperphosphorylation and partly reverse anesthesia-induced cognitive impairment in old mice. Psychiatry Clin Neurosci 67:493\u2013500. https:\/\/doi.org\/10.1111\/pcn.12091","journal-title":"Psychiatry Clin Neurosci"},{"key":"796_CR91","doi-asserted-by":"publisher","first-page":"2683","DOI":"10.3892\/mmr.2015.3763","volume":"12","author":"X Zhao","year":"2015","unstructured":"Zhao X, Sun X, Cai S, Ran D, Yan Y, Pei Z (2015) Role of alpha-synuclein in cognitive dysfunction: studies in Drosophila melanogaster. Mol Med Rep 12:2683\u20132688. https:\/\/doi.org\/10.3892\/mmr.2015.3763","journal-title":"Mol Med Rep"},{"key":"796_CR92","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1176\/jnp.15.2.180","volume":"15","author":"VR Porter","year":"2003","unstructured":"Porter VR, Buxton WG, Fairbanks LA, Strickland T, O\u2019Connor SM, Rosenberg-Thompson S, Cummings JL (2003) Frequency and characteristics of anxiety among patients with Alzheimer\u2019s disease and related dementias. J Neuropsychiatry Clin Neurosci 15:180\u2013186. https:\/\/doi.org\/10.1176\/jnp.15.2.180","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"796_CR93","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.bbi.2015.11.011","volume":"55","author":"LE Santos","year":"2016","unstructured":"Santos LE, Beckman D, Ferreira ST (2016) Microglial dysfunction connects depression and Alzheimer\u2019s disease. Brain Behav Immun 55:151\u2013165. https:\/\/doi.org\/10.1016\/j.bbi.2015.11.011","journal-title":"Brain Behav Immun"},{"key":"796_CR94","doi-asserted-by":"crossref","first-page":"M348","DOI":"10.1093\/gerona\/54.7.M348","volume":"54","author":"L Teri","year":"1999","unstructured":"Teri L, Ferretti LE, Gibbons LE, Logsdon RG, McCurry SM, Kukull WA, McCormick WC, Bowen JD et al (1999) Anxiety of Alzheimer\u2019s disease: prevalence, and comorbidity. J Gerontol Ser A Biol Sci Med Sci 54:M348\u2013M352","journal-title":"J Gerontol Ser A Biol Sci Med Sci"},{"key":"796_CR95","doi-asserted-by":"publisher","first-page":"3472032","DOI":"10.1155\/2016\/3472032","volume":"2016","author":"JM Mack","year":"2016","unstructured":"Mack JM, Schamne MG, Sampaio TB, Pertile RA, Fernandes PA, Markus RP, Prediger RD (2016) Melatoninergic system in Parkinson\u2019s disease: from neuroprotection to the management of motor and nonmotor symptoms. Oxidative Med Cell Longev 2016:3472032. https:\/\/doi.org\/10.1155\/2016\/3472032","journal-title":"Oxidative Med Cell Longev"},{"key":"796_CR96","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.jad.2003.07.002","volume":"81","author":"S Westling","year":"2004","unstructured":"Westling S, Ahren B, Traskman-Bendz L, Westrin A (2004) Low CSF leptin in female suicide attempters with major depression. J Affect Disord 81:41\u201348. https:\/\/doi.org\/10.1016\/j.jad.2003.07.002","journal-title":"J Affect Disord"},{"key":"796_CR97","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1055\/s-2002-36390","volume":"35","author":"T Kraus","year":"2002","unstructured":"Kraus T, Haack M, Schuld A, Hinze-Selch D, Koethe D, Pollmacher T (2002) Body weight, the tumor necrosis factor system, and leptin production during treatment with mirtazapine or venlafaxine. Pharmacopsychiatry 35:220\u2013225. https:\/\/doi.org\/10.1055\/s-2002-36390","journal-title":"Pharmacopsychiatry"},{"key":"796_CR98","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s13024-016-0136-x","volume":"11","author":"RC Ng","year":"2016","unstructured":"Ng RC, Cheng OY, Jian M, Kwan JS, Ho PW, Cheng KK, Yeung PK, Zhou LL et al (2016) Chronic adiponectin deficiency leads to Alzheimer\u2019s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice. Mol Neurodegener 11:71. https:\/\/doi.org\/10.1186\/s13024-016-0136-x","journal-title":"Mol Neurodegener"},{"key":"796_CR99","doi-asserted-by":"publisher","first-page":"34128","DOI":"10.18632\/oncotarget.6021","volume":"6","author":"B Wu","year":"2015","unstructured":"Wu B, Wei Y, Wang Y, Su T, Zhou L, Liu Y, He R (2015) Gavage of D-ribose induces Abeta-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice. Oncotarget 6:34128\u201334142. 10.18632\/oncotarget.6021","journal-title":"Oncotarget"},{"key":"796_CR100","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0091-3057(92)90118-Y","volume":"41","author":"B Guardiola-Lemaitre","year":"1992","unstructured":"Guardiola-Lemaitre B, Lenegre A, Porsolt RD (1992) Combined effects of diazepam and melatonin in two tests for anxiolytic activity in the mouse. Pharmacol Biochem Behav 41:405\u2013408","journal-title":"Pharmacol Biochem Behav"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-017-0796-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-017-0796-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-017-0796-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T18:56:53Z","timestamp":1693162613000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-017-0796-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,30]]},"references-count":100,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["796"],"URL":"https:\/\/doi.org\/10.1007\/s12035-017-0796-8","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"type":"print","value":"0893-7648"},{"type":"electronic","value":"1559-1182"}],"subject":[],"published":{"date-parts":[[2017,10,30]]}}}