{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T13:28:23Z","timestamp":1775050103159,"version":"3.50.1"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD12\/0043\/0030"],"award-info":[{"award-number":["RD12\/0043\/0030"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD12\/0043\/0017"],"award-info":[{"award-number":["RD12\/0043\/0017"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI13\/02741"],"award-info":[{"award-number":["PI13\/02741"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FI14\/00405"],"award-info":[{"award-number":["FI14\/00405"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/02009"],"award-info":[{"award-number":["PI17\/02009"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011941","name":"Gobierno del Principado de Asturias","doi-asserted-by":"publisher","award":["GRUPIN14-071"],"award-info":[{"award-number":["GRUPIN14-071"]}],"id":[{"id":"10.13039\/100011941","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000785","name":"Education, Audiovisual and Culture Executive Agency","doi-asserted-by":"publisher","award":["2013-2586\/001-001-EMA2"],"award-info":[{"award-number":["2013-2586\/001-001-EMA2"]}],"id":[{"id":"10.13039\/501100000785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s12035-018-0967-2","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T14:05:29Z","timestamp":1519826729000},"page":"7973-7986","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["High-Fructose Consumption Impairs the Redox System and Protein Quality Control in the Brain of Syrian Hamsters: Therapeutic Effects of Melatonin"],"prefix":"10.1007","volume":"55","author":[{"given":"Juan Carlos","family":"Bermejo-Millo","sequence":"first","affiliation":[]},{"given":"Marcela Rodrigues Moreira","family":"Guimar\u00e3es","sequence":"additional","affiliation":[]},{"given":"Beatriz","family":"de Lux\u00e1n-Delgado","sequence":"additional","affiliation":[]},{"given":"Yaiza","family":"Potes","sequence":"additional","affiliation":[]},{"given":"Zulema","family":"P\u00e9rez-Mart\u00ednez","sequence":"additional","affiliation":[]},{"given":"Andrea","family":"D\u00edaz-Luis","sequence":"additional","affiliation":[]},{"given":"Beatriz","family":"Caballero","sequence":"additional","affiliation":[]},{"given":"Juan Jos\u00e9","family":"Solano","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1993-6725","authenticated-orcid":false,"given":"Ignacio","family":"Vega-Naredo","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Coto-Montes","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,2,28]]},"reference":[{"key":"967_CR1","doi-asserted-by":"publisher","unstructured":"Pereira RM, Botezelli JD, da Cruz Rodrigues KC, Mekary RA, Cintra DE, Pauli JR, da Silva ASR, Ropelle ER et al (2017) Fructose consumption in the development of obesity and the effects of different protocols of physical exercise on the hepatic metabolism. Nutrients 9(4). https:\/\/doi.org\/10.3390\/nu9040405","DOI":"10.3390\/nu9040405"},{"key":"967_CR2","unstructured":"WHO (2003) Diet, nutrition and the prevention of chronic diseases. World Health Organ Tech Rep Ser 916:1\u2013149. http:\/\/whqlibdoc.who.int\/trs\/WHO_TRS_916.pdf . Accessed 23 Feb 2018"},{"key":"967_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2015.00005","volume":"2","author":"K Lowette","year":"2015","unstructured":"Lowette K, Roosen L, Tack J, Vanden Berghe P (2015) Effects of high-fructose diets on central appetite signaling and cognitive function. Front Nutr 2:5. https:\/\/doi.org\/10.3389\/fnut.2015.00005","journal-title":"Front Nutr"},{"key":"967_CR4","doi-asserted-by":"publisher","unstructured":"Aragno M, Mastrocola R (2017) Dietary sugars and endogenous formation of advanced glycation Endproducts: emerging mechanisms of disease. Nutrients 9(4). https:\/\/doi.org\/10.3390\/nu9040385","DOI":"10.3390\/nu9040385"},{"key":"967_CR5","first-page":"66","volume":"55","author":"A Jagua Gualdr\u00f3n","year":"2007","unstructured":"Jagua Gualdr\u00f3n A, \u00c1vila \u00c1vila V (2007) Insulin and Alzheimer disease: type 3 diabetes? Rev Fac Med Univ Nac Colomb 55:66\u201370","journal-title":"Rev Fac Med Univ Nac Colomb"},{"issue":"7","key":"967_CR6","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.bcp.2013.07.030","volume":"86","author":"IA Clark","year":"2013","unstructured":"Clark IA, Vissel B (2013) Treatment implications of the altered cytokine-insulin axis in neurodegenerative disease. Biochem Pharmacol 86(7):862\u2013871. https:\/\/doi.org\/10.1016\/j.bcp.2013.07.030","journal-title":"Biochem Pharmacol"},{"issue":"1 Suppl","key":"967_CR7","doi-asserted-by":"publisher","first-page":"S26","DOI":"10.1016\/j.jalz.2013.12.004","volume":"10","author":"FG Felice De","year":"2014","unstructured":"De Felice FG, Lourenco MV, Ferreira ST (2014) How does brain insulin resistance develop in Alzheimer's disease? Alzheimers Dement 10(1 Suppl):S26\u2013S32. https:\/\/doi.org\/10.1016\/j.jalz.2013.12.004","journal-title":"Alzheimers Dement"},{"issue":"4","key":"967_CR8","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.bcp.2013.12.012","volume":"88","author":"SM Monte de la","year":"2014","unstructured":"de la Monte SM, Tong M (2014) Brain metabolic dysfunction at the core of Alzheimer\u2019s disease. Biochem Pharmacol 88(4):548\u2013559. https:\/\/doi.org\/10.1016\/j.bcp.2013.12.012","journal-title":"Biochem Pharmacol"},{"issue":"1 Suppl","key":"967_CR9","doi-asserted-by":"publisher","first-page":"S76","DOI":"10.1016\/j.jalz.2013.12.010","volume":"10","author":"ST Ferreira","year":"2014","unstructured":"Ferreira ST, Clarke JR, Bomfim TR, De Felice FG (2014) Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer\u2019s disease. Alzheimers Dement 10(1 Suppl):S76\u2013S83. https:\/\/doi.org\/10.1016\/j.jalz.2013.12.010","journal-title":"Alzheimers Dement"},{"issue":"10","key":"967_CR10","doi-asserted-by":"publisher","first-page":"2485","DOI":"10.1113\/jphysiol.2012.230078","volume":"590","author":"R Agrawal","year":"2012","unstructured":"Agrawal R, Gomez-Pinilla F (2012) \u2018Metabolic syndrome\u2019 in the brain: deficiency in omega-3 fatty acid exacerbates dysfunctions in insulin receptor signalling and cognition. J Physiol 590(10):2485\u20132499. https:\/\/doi.org\/10.1113\/jphysiol.2012.230078","journal-title":"J Physiol"},{"issue":"3","key":"967_CR11","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1007\/s12035-014-8676-y","volume":"50","author":"A Lopes","year":"2014","unstructured":"Lopes A, Vilela TC, Taschetto L, Vuolo F, Petronilho F, Dal-Pizzol F, Streck EL, Ferreira GC et al (2014) Evaluation of the effects of fructose on oxidative stress and inflammatory parameters in rat brain. Mol Neurobiol 50(3):1124\u20131130. https:\/\/doi.org\/10.1007\/s12035-014-8676-y","journal-title":"Mol Neurobiol"},{"issue":"7","key":"967_CR12","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1111\/j.1460-9568.2004.03246.x","volume":"19","author":"A Wu","year":"2004","unstructured":"Wu A, Ying Z, Gomez-Pinilla F (2004) The interplay between oxidative stress and brain-derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition. Eur J Neurosci 19(7):1699\u20131707. https:\/\/doi.org\/10.1111\/j.1460-9568.2004.03246.x","journal-title":"Eur J Neurosci"},{"key":"967_CR13","first-page":"283","volume-title":"Monograf\u00eda XXIX: Acci\u00f3n de las hormonas a nivel cerebral","author":"CC Mic\u00f3","year":"2010","unstructured":"Mic\u00f3 CC, Oliva SB, Tormo GS (2010) Estr\u00e9s oxidativo en las enfermedades neurodegenerativas. In: Pascual-Leone AM, Medina JM (eds) Monograf\u00eda XXIX: Acci\u00f3n de las hormonas a nivel cerebral. RANF, Madrid, pp. 283\u2013302"},{"issue":"Suppl","key":"967_CR14","doi-asserted-by":"publisher","first-page":"S18","DOI":"10.1038\/nrn1434","volume":"10","author":"JK Andersen","year":"2004","unstructured":"Andersen JK (2004) Oxidative stress in neurodegeneration: cause or consequence? Nat Med 10(Suppl):S18\u2013S25. https:\/\/doi.org\/10.1038\/nrn1434","journal-title":"Nat Med"},{"issue":"3","key":"967_CR15","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/jpi.12010","volume":"54","author":"A Galano","year":"2013","unstructured":"Galano A, Tan DX, Reiter RJ (2013) On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK. J Pineal Res 54(3):245\u2013257. https:\/\/doi.org\/10.1111\/jpi.12010","journal-title":"J Pineal Res"},{"issue":"7","key":"967_CR16","doi-asserted-by":"publisher","first-page":"14575","DOI":"10.3390\/ijms140714575","volume":"14","author":"L Lin","year":"2013","unstructured":"Lin L, Huang QX, Yang SS, Chu J, Wang JZ, Tian Q (2013) Melatonin in Alzheimer\u2019s disease. Int J Mol Sci 14(7):14575\u201314593. https:\/\/doi.org\/10.3390\/ijms140714575","journal-title":"Int J Mol Sci"},{"issue":"9","key":"967_CR17","doi-asserted-by":"publisher","first-page":"G1043","DOI":"10.1152\/ajpgi.00250.2011","volume":"302","author":"M Naples","year":"2012","unstructured":"Naples M, Baker C, Lino M, Iqbal J, Hussain MM, Adeli K (2012) Ezetimibe ameliorates intestinal chylomicron overproduction and improves glucose tolerance in a diet-induced hamster model of insulin resistance. Am J Physiol Gastrointest Liver Physiol 302(9):G1043\u2013G1052. https:\/\/doi.org\/10.1152\/ajpgi.00250.2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"967_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/srep28014","volume":"6","author":"Y Wang","year":"2016","unstructured":"Wang Y, Kayoumu A, Lu G, Xu P, Qiu X, Chen L, Qi R, Huang S et al (2016) Experimental models in Syrian golden hamster replicate human acute pancreatitis. Sci Rep 6:28014. https:\/\/doi.org\/10.1038\/srep28014","journal-title":"Sci Rep"},{"issue":"12","key":"967_CR19","doi-asserted-by":"publisher","first-page":"8416","DOI":"10.1074\/jbc.275.12.8416","volume":"275","author":"C Taghibiglou","year":"2000","unstructured":"Taghibiglou C, Carpentier A, Van Iderstine SC, Chen B, Rudy D, Aiton A, Lewis GF, Adeli K (2000) Mechanisms of hepatic very low density lipoprotein overproduction in insulin resistance. Evidence for enhanced lipoprotein assembly, reduced intracellular ApoB degradation, and increased microsomal triglyceride transfer protein in a fructose-fed hamster model. J Biol Chem 275(12):8416\u20138425","journal-title":"J Biol Chem"},{"issue":"2","key":"967_CR20","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/S0022-2143(96)90013-X","volume":"128","author":"SE Kasim-Karakas","year":"1996","unstructured":"Kasim-Karakas SE, Vriend H, Almario R, Chow LC, Goodman MN (1996) Effects of dietary carbohydrates on glucose and lipid metabolism in golden Syrian hamsters. J Lab Clin Med 128(2):208\u2013213","journal-title":"J Lab Clin Med"},{"key":"967_CR21","doi-asserted-by":"publisher","first-page":"195","DOI":"10.2147\/DMSO.S18435","volume":"4","author":"J Bhathena","year":"2011","unstructured":"Bhathena J, Kulamarva A, Martoni C, Urbanska AM, Malhotra M, Paul A, Prakash S (2011) Diet-induced metabolic hamster model of nonalcoholic fatty liver disease. Diabetes Metab Obes 4:195\u2013203. https:\/\/doi.org\/10.2147\/DMSO.S18435","journal-title":"Diabetes Metab Obes"},{"issue":"6","key":"967_CR22","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.carpath.2006.09.001","volume":"15","author":"JC Russell","year":"2006","unstructured":"Russell JC, Proctor SD (2006) Small animal models of cardiovascular disease: tools for the study of the roles of metabolic syndrome, dyslipidemia, and atherosclerosis. Cardiovasc Pathol 15(6):318\u2013330. https:\/\/doi.org\/10.1016\/j.carpath.2006.09.001","journal-title":"Cardiovasc Pathol"},{"issue":"1\u20132","key":"967_CR23","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/0300-9629(91)90263-C","volume":"99","author":"GL Liu","year":"1991","unstructured":"Liu GL, Fan LM, Redinger RN (1991) The association of hepatic apoprotein and lipid metabolism in hamsters and rats. Comp Biochem Physiol A Comp Physiol 99(1\u20132):223\u2013228","journal-title":"Comp Biochem Physiol A Comp Physiol"},{"issue":"2","key":"967_CR24","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/0305-0491(94)90058-2","volume":"107","author":"E Bravo","year":"1994","unstructured":"Bravo E, Cantafora A, Calcabrini A, Ortu G (1994) Why prefer the golden Syrian hamster (Mesocricetus auratus) to the Wistar rat in experimental studies on plasma lipoprotein metabolism? Comp Biochem Physiol B Comp Biochem 107(2):347\u2013355. https:\/\/doi.org\/10.1016\/0305-0491(94)90058-2","journal-title":"Comp Biochem Physiol B Comp Biochem"},{"key":"967_CR25","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/1743-7075-7-89","volume":"7","author":"A Dillard","year":"2010","unstructured":"Dillard A, Matthan NR, Lichtenstein AH (2010) Use of hamster as a model to study diet-induced atherosclerosis. Nutr Metab (Lond) 7:89. https:\/\/doi.org\/10.1186\/1743-7075-7-89","journal-title":"Nutr Metab (Lond)"},{"key":"967_CR26","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"key":"967_CR27","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/0076-6879(90)86134-H","volume":"186","author":"H Esterbauer","year":"1990","unstructured":"Esterbauer H, Cheeseman KH (1990) Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol 186:407\u2013421","journal-title":"Methods Enzymol"},{"issue":"10","key":"967_CR28","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1021\/tx9701790","volume":"11","author":"D Gerard-Monnier","year":"1998","unstructured":"Gerard-Monnier D, Erdelmeier I, Regnard K, Moze-Henry N, Yadan JC, Chaudiere J (1998) Reactions of 1-methyl-2-phenylindole with malondialdehyde and 4-hydroxyalkenals. Analytical applications to a colorimetric assay of lipid peroxidation. Chem Res Toxicol 11(10):1176\u20131183. https:\/\/doi.org\/10.1021\/tx9701790","journal-title":"Chem Res Toxicol"},{"issue":"2","key":"967_CR29","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/0003-9861(87)90400-0","volume":"255","author":"JP Martin Jr","year":"1987","unstructured":"Martin JP Jr, Dailey M, Sugarman E (1987) Negative and positive assays of superoxide dismutase based on hematoxylin autoxidation. Arch Biochem Biophys 255(2):329\u2013336","journal-title":"Arch Biochem Biophys"},{"issue":"4","key":"967_CR30","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/genetics\/91.4.723","volume":"91","author":"S Lubinsky","year":"1979","unstructured":"Lubinsky S, Bewley GC (1979) Genetics of catalase in DROSOPHILA MELANOGASTER: rates of synthesis and degradation of the enzyme in flies Aneuploid and Euploid for the structural gene. Genetics 91(4):723\u2013742","journal-title":"Genetics"},{"issue":"5","key":"967_CR31","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.freeradbiomed.2010.05.019","volume":"49","author":"D Gonzalo-Calvo de","year":"2010","unstructured":"de Gonzalo-Calvo D, Neitzert K, Fernandez M, Vega-Naredo I, Caballero B, Garcia-Macia M, Suarez FM, Rodriguez-Colunga MJ et al (2010) Differential inflammatory responses in aging and disease: TNF-alpha and IL-6 as possible biomarkers. Free Radic Biol Med 49(5):733\u2013737. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2010.05.019","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"967_CR32","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0308-8146(00)00324-1","volume":"73","author":"MB Arnao","year":"2001","unstructured":"Arnao MB, Cano AC, Acosta A (2001) The hydrophilic and lipophilic contribution to total antioxidant activity. Food Chem 73(2):239\u2013244. https:\/\/doi.org\/10.1016\/S0308-8146(00)00324-1","journal-title":"Food Chem"},{"key":"967_CR33","doi-asserted-by":"publisher","unstructured":"Bidwell AJ (2017) Chronic fructose ingestion as a major health concern: is a sedentary lifestyle making it worse? A review. Nutrients 9(6). https:\/\/doi.org\/10.3390\/nu9060549","DOI":"10.3390\/nu9060549"},{"key":"967_CR34","doi-asserted-by":"publisher","unstructured":"Cigliano L, Spagnuolo MS, Crescenzo R, Cancelliere R, Iannotta L, Mazzoli A, Liverini G, Iossa S (2017) Short-term fructose feeding induces inflammation and oxidative stress in the hippocampus of young and adult rats. Mol Neurobiol. https:\/\/doi.org\/10.1007\/s12035-017-0518-2","DOI":"10.1007\/s12035-017-0518-2"},{"issue":"4","key":"967_CR35","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1111\/j.1600-079X.2011.00955.x","volume":"52","author":"A Kitagawa","year":"2012","unstructured":"Kitagawa A, Ohta Y, Ohashi K (2012) Melatonin improves metabolic syndrome induced by high fructose intake in rats. J Pineal Res 52(4):403\u2013413. https:\/\/doi.org\/10.1111\/j.1600-079X.2011.00955.x","journal-title":"J Pineal Res"},{"issue":"10","key":"967_CR36","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1080\/10408398.2010.512990","volume":"50","author":"LC Dolan","year":"2010","unstructured":"Dolan LC, Potter SM, Burdock GA (2010) Evidence-based review on the effect of normal dietary consumption of fructose on blood lipids and body weight of overweight and obese individuals. Crit Rev Food Sci Nutr 50(10):889\u2013918. https:\/\/doi.org\/10.1080\/10408398.2010.512990","journal-title":"Crit Rev Food Sci Nutr"},{"key":"967_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/385976","volume":"2015","author":"JH Park","year":"2015","unstructured":"Park JH, Kho MC, Kim HY, Ahn YM, Lee YJ, Kang DG, Lee HS (2015) Blackcurrant suppresses metabolic syndrome induced by high-fructose diet in rats. Evid Based Complement Alternat Med 2015:1\u201311. https:\/\/doi.org\/10.1155\/2015\/385976","journal-title":"Evid Based Complement Alternat Med"},{"issue":"3","key":"967_CR38","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.cmet.2009.01.011","volume":"9","author":"Y Nagai","year":"2009","unstructured":"Nagai Y, Yonemitsu S, Erion DM, Iwasaki T, Stark R, Weismann D, Dong J, Zhang D et al (2009) The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance. Cell Metab 9(3):252\u2013264. https:\/\/doi.org\/10.1016\/j.cmet.2009.01.011","journal-title":"Cell Metab"},{"issue":"5","key":"967_CR39","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1248\/bpb.b15-00060","volume":"38","author":"YK Kaneko","year":"2015","unstructured":"Kaneko YK, Ishikawa T (2015) Diacylglycerol signaling pathway in pancreatic beta-cells: an essential role of diacylglycerol kinase in the regulation of insulin secretion. Biol Pharm Bull 38(5):669\u2013673. https:\/\/doi.org\/10.1248\/bpb.b15-00060","journal-title":"Biol Pharm Bull"},{"issue":"5","key":"967_CR40","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1093\/ajcn\/49.5.832","volume":"49","author":"S Reiser","year":"1989","unstructured":"Reiser S, Powell AS, Scholfield DJ, Panda P, Ellwood KC, Canary JJ (1989) Blood lipids, lipoproteins, apoproteins, and uric acid in men fed diets containing fructose or high-amylose cornstarch. Am J Clin Nutr 49(5):832\u2013839","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"967_CR41","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1210\/er.2008-0033","volume":"30","author":"RJ Johnson","year":"2009","unstructured":"Johnson RJ, Perez-Pozo SE, Sautin YY, Manitius J, Sanchez-Lozada LG, Feig DI, Shafiu M, Segal M et al (2009) Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes? Endocr Rev 30(1):96\u2013116. https:\/\/doi.org\/10.1210\/er.2008-0033","journal-title":"Endocr Rev"},{"key":"967_CR42","first-page":"163","volume-title":"Pineal gland: Research advances and clinical challenges","author":"R Hardeland","year":"2017","unstructured":"Hardeland R (2017) Melatonin and neuroinflammation: encouraging findings vs. fundamental problems. In: Catala A (ed) Pineal gland: Research advances and clinical challenges. Nova Science, Hauppauge, pp. 163\u2013204"},{"issue":"2","key":"967_CR43","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.ejim.2010.12.017","volume":"22","author":"S Seneff","year":"2011","unstructured":"Seneff S, Wainwright G, Mascitelli L (2011) Nutrition and Alzheimer\u2019s disease: the detrimental role of a high carbohydrate diet. Eur J Intern Med 22(2):134\u2013140. https:\/\/doi.org\/10.1016\/j.ejim.2010.12.017","journal-title":"Eur J Intern Med"},{"key":"967_CR44","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1007\/s12010-017-2461-0","volume":"183","author":"M Putakala","year":"2017","unstructured":"Putakala M, Gujjala S, Nukala S, Desireddy S (2017) Beneficial effects of Phyllanthus amarus against high fructose diet induced insulin resistance and hepatic oxidative stress in male Wistar rats. Appl Biochem Biotechnol 183:744\u2013764. https:\/\/doi.org\/10.1007\/s12010-017-2461-0","journal-title":"Appl Biochem Biotechnol"},{"key":"967_CR45","doi-asserted-by":"publisher","first-page":"312943","DOI":"10.1155\/2012\/312943","volume":"2012","author":"BS Zha","year":"2012","unstructured":"Zha BS, Zhou H (2012) ER stress and lipid metabolism in adipocytes. Biochem Res Int 2012:312943\u2013312949. https:\/\/doi.org\/10.1155\/2012\/312943","journal-title":"Biochem Res Int"},{"key":"967_CR46","doi-asserted-by":"publisher","unstructured":"Ariyasu D, Yoshida H, Hasegawa Y (2017) Endoplasmic reticulum (ER) stress and endocrine disorders. Int J Mol Sci 18(2). https:\/\/doi.org\/10.3390\/ijms18020382","DOI":"10.3390\/ijms18020382"},{"issue":"2","key":"967_CR47","doi-asserted-by":"publisher","first-page":"e30816","DOI":"10.1371\/journal.pone.0030816","volume":"7","author":"LP Ren","year":"2012","unstructured":"Ren LP, Chan SM, Zeng XY, Laybutt DR, Iseli TJ, Sun RQ, Kraegen EW, Cooney GJ et al (2012) Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance. PLoS One 7(2):e30816. https:\/\/doi.org\/10.1371\/journal.pone.0030816","journal-title":"PLoS One"},{"issue":"10","key":"967_CR48","doi-asserted-by":"publisher","first-page":"7947","DOI":"10.1074\/jbc.M110.156430","volume":"286","author":"N Egawa","year":"2011","unstructured":"Egawa N, Yamamoto K, Inoue H, Hikawa R, Nishi K, Mori K, Takahashi R (2011) The endoplasmic reticulum stress sensor, ATF6alpha, protects against neurotoxin-induced dopaminergic neuronal death. J Biol Chem 286(10):7947\u20137957. https:\/\/doi.org\/10.1074\/jbc.M110.156430","journal-title":"J Biol Chem"},{"issue":"10","key":"967_CR49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047950","volume":"7","author":"K Hashida","year":"2012","unstructured":"Hashida K, Kitao Y, Sudo H, Awa Y, Maeda S, Mori K, Takahashi R, Iinuma M et al (2012) ATF6alpha promotes astroglial activation and neuronal survival in a chronic mouse model of Parkinson\u2019s disease. PLoS One 7(10):e47950. https:\/\/doi.org\/10.1371\/journal.pone.0047950","journal-title":"PLoS One"},{"issue":"1","key":"967_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3164\/jcbn.15-3","volume":"57","author":"MS Ottum","year":"2015","unstructured":"Ottum MS, Mistry AM (2015) Advanced glycation end-products: modifiable environmental factors profoundly mediate insulin resistance. J Clin Biochem Nutr 57(1):1\u201312. https:\/\/doi.org\/10.3164\/jcbn.15-3","journal-title":"J Clin Biochem Nutr"},{"issue":"12","key":"967_CR51","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1016\/j.bbamcr.2012.08.021","volume":"1823","author":"Z Rasheed","year":"2012","unstructured":"Rasheed Z, Haqqi TM (2012) Endoplasmic reticulum stress induces the expression of COX-2 through activation of eIF2alpha, p38-MAPK and NF-kappaB in advanced glycation end products stimulated human chondrocytes. Biochim Biophys Acta 1823(12):2179\u20132189. https:\/\/doi.org\/10.1016\/j.bbamcr.2012.08.021","journal-title":"Biochim Biophys Acta"},{"key":"967_CR52","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.mam.2015.08.005","volume":"46","author":"EA Whitcomb","year":"2015","unstructured":"Whitcomb EA, Chiu CJ, Taylor A (2015) Dietary glycemia as a determinant of health and longevity. Mol Asp Med 46:14\u201320. https:\/\/doi.org\/10.1016\/j.mam.2015.08.005","journal-title":"Mol Asp Med"},{"issue":"3","key":"967_CR53","doi-asserted-by":"publisher","first-page":"811","DOI":"10.2337\/db11-1652","volume":"62","author":"T Otoda","year":"2013","unstructured":"Otoda T, Takamura T, Misu H, Ota T, Murata S, Hayashi H, Takayama H, Kikuchi A et al (2013) Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver. Diabetes 62(3):811\u2013824. https:\/\/doi.org\/10.2337\/db11-1652","journal-title":"Diabetes"},{"key":"967_CR54","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/j.freeradbiomed.2013.08.186","volume":"65","author":"EN Tsakiri","year":"2013","unstructured":"Tsakiri EN, Iliaki KK, Hohn A, Grimm S, Papassideri IS, Grune T, Trougakos IP (2013) Diet-derived advanced glycation end products or lipofuscin disrupts proteostasis and reduces life span in Drosophila melanogaster. Free Radic Biol Med 65:1155\u20131163. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2013.08.186","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"967_CR55","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1007\/s12263-013-0357-3","volume":"8","author":"M Aijala","year":"2013","unstructured":"Aijala M, Malo E, Ukkola O, Bloigu R, Lehenkari P, Autio-Harmainen H, Santaniemi M, Kesaniemi YA (2013) Long-term fructose feeding changes the expression of leptin receptors and autophagy genes in the adipose tissue and liver of male rats: a possible link to elevated triglycerides. Genes Nutr 8(6):623\u2013635. https:\/\/doi.org\/10.1007\/s12263-013-0357-3","journal-title":"Genes Nutr"},{"issue":"2","key":"967_CR56","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.bbalip.2014.11.003","volume":"1851","author":"M Baena","year":"2015","unstructured":"Baena M, Sanguesa G, Hutter N, Sanchez RM, Roglans N, Laguna JC, Alegret M (2015) Fructose supplementation impairs rat liver autophagy through mTORC activation without inducing endoplasmic reticulum stress. Biochim Biophys Acta 1851(2):107\u2013116. https:\/\/doi.org\/10.1016\/j.bbalip.2014.11.003","journal-title":"Biochim Biophys Acta"},{"issue":"8","key":"967_CR57","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1093\/gerona\/glq079","volume":"65","author":"BC Stephan","year":"2010","unstructured":"Stephan BC, Wells JC, Brayne C, Albanese E, Siervo M (2010) Increased fructose intake as a risk factor for dementia. J Gerontol A Biol Sci Med Sci 65(8):809\u2013814. https:\/\/doi.org\/10.1093\/gerona\/glq079","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"3","key":"967_CR58","first-page":"229","volume":"142","author":"N Manzano-Leon","year":"2006","unstructured":"Manzano-Leon N, Mas-Oliva J (2006) Oxidative stress, beta-amyloide peptide and Alzheimer\u2019s disease. Gac Med Mex 142(3):229\u2013238","journal-title":"Gac Med Mex"},{"key":"967_CR59","first-page":"329","volume":"140","author":"T Garc\u00eda","year":"2004","unstructured":"Garc\u00eda T, Jay D (2004) Phosphorylation of tau and Alzheimer\u2019s disease. Gac Med Mex 140:329\u2013333","journal-title":"Gac Med Mex"},{"issue":"32","key":"967_CR60","doi-asserted-by":"publisher","first-page":"24977","DOI":"10.1074\/jbc.M000808200","volume":"275","author":"DB Evans","year":"2000","unstructured":"Evans DB, Rank KB, Bhattacharya K, Thomsen DR, Gurney ME, Sharma SK (2000) Tau phosphorylation at serine 396 and serine 404 by human recombinant tau protein kinase II inhibits tau's ability to promote microtubule assembly. J Biol Chem 275(32):24977\u201324983. https:\/\/doi.org\/10.1074\/jbc.M000808200","journal-title":"J Biol Chem"},{"issue":"3","key":"967_CR61","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.nbd.2008.05.011","volume":"31","author":"CA Rankin","year":"2008","unstructured":"Rankin CA, Sun Q, Gamblin TC (2008) Pre-assembled tau filaments phosphorylated by GSK-3b form large tangle-like structures. Neurobiol Dis 31(3):368\u2013377. https:\/\/doi.org\/10.1016\/j.nbd.2008.05.011","journal-title":"Neurobiol Dis"},{"issue":"2","key":"967_CR62","doi-asserted-by":"publisher","first-page":"2502","DOI":"10.3390\/ijms14022502","volume":"14","author":"DP Cardinali","year":"2013","unstructured":"Cardinali DP, Bernasconi PA, Reynoso R, Toso CF, Scacchi P (2013) Melatonin may curtail the metabolic syndrome: studies on initial and fully established fructose-induced metabolic syndrome in rats. Int J Mol Sci 14(2):2502\u20132514. https:\/\/doi.org\/10.3390\/ijms14022502","journal-title":"Int J Mol Sci"},{"issue":"22","key":"967_CR63","doi-asserted-by":"publisher","first-page":"3004","DOI":"10.1016\/j.cub.2015.10.011","volume":"25","author":"RH Eckel","year":"2015","unstructured":"Eckel RH, Depner CM, Perreault L, Markwald RR, Smith MR, McHill AW, Higgins J, Melanson EL et al (2015) Morning circadian misalignment during short sleep duration impacts insulin sensitivity. Curr Biol 25(22):3004\u20133010. https:\/\/doi.org\/10.1016\/j.cub.2015.10.011","journal-title":"Curr Biol"},{"issue":"2","key":"967_CR64","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1093\/aje\/kws470","volume":"178","author":"CJ McMullan","year":"2013","unstructured":"McMullan CJ, Curhan GC, Schernhammer ES, Forman JP (2013) Association of nocturnal melatonin secretion with insulin resistance in nondiabetic young women. Am J Epidemiol 178(2):231\u2013238. https:\/\/doi.org\/10.1093\/aje\/kws470","journal-title":"Am J Epidemiol"},{"issue":"10","key":"967_CR65","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.5665\/sleep.4088","volume":"37","author":"P Rubio-Sastre","year":"2014","unstructured":"Rubio-Sastre P, Scheer FA, Gomez-Abellan P, Madrid JA, Garaulet M (2014) Acute melatonin administration in humans impairs glucose tolerance in both the morning and evening. Sleep 37(10):1715\u20131719. https:\/\/doi.org\/10.5665\/sleep.4088","journal-title":"Sleep"},{"issue":"1","key":"967_CR66","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/ng.288","volume":"41","author":"V Lyssenko","year":"2009","unstructured":"Lyssenko V, Nagorny CL, Erdos MR, Wierup N, Jonsson A, Spegel P, Bugliani M, Saxena R et al (2009) Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet 41(1):82\u201388. https:\/\/doi.org\/10.1038\/ng.288","journal-title":"Nat Genet"},{"issue":"6","key":"967_CR67","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/j.cmet.2016.04.009","volume":"23","author":"T Tuomi","year":"2016","unstructured":"Tuomi T, Nagorny CLF, Singh P, Bennet H, Yu Q, Alenkvist I, Isomaa B, Ostman B et al (2016) Increased melatonin signaling is a risk factor for type 2 diabetes. Cell Metab 23(6):1067\u20131077. https:\/\/doi.org\/10.1016\/j.cmet.2016.04.009","journal-title":"Cell Metab"},{"issue":"2","key":"967_CR68","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0304-3940(98)00170-0","volume":"245","author":"BK Jin","year":"1998","unstructured":"Jin BK, Shin DY, Jeong MY, Gwag MR, Baik HW, Yoon KS, Cho YH, Joo WS et al (1998) Melatonin protects nigral dopaminergic neurons from 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity in rats. Neurosci Lett 245(2):61\u201364","journal-title":"Neurosci Lett"},{"issue":"3","key":"967_CR69","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/jpi.12360","volume":"61","author":"RJ Reiter","year":"2016","unstructured":"Reiter RJ, Mayo JC, Tan DX, Sainz RM, Alatorre-Jimenez M, Qin L (2016) Melatonin as an antioxidant: under promises but over delivers. J Pineal Res 61(3):253\u2013278. https:\/\/doi.org\/10.1111\/jpi.12360","journal-title":"J Pineal Res"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-018-0967-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-0967-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-0967-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:57:13Z","timestamp":1660525033000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-018-0967-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,28]]},"references-count":69,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["967"],"URL":"https:\/\/doi.org\/10.1007\/s12035-018-0967-2","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,28]]},"assertion":[{"value":"13 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Oviedo University Local Animal Care and Use Committee approved the experimental protocol. All experiments were carried out according to the Spanish Government Guide and the European Community Guide for Animal Care.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}