{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T14:46:54Z","timestamp":1776005214378,"version":"3.50.1"},"reference-count":138,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/00709\/2020+UIDP\/00709\/2020"],"award-info":[{"award-number":["UIDB\/00709\/2020+UIDP\/00709\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["2020.06616.BD"],"award-info":[{"award-number":["2020.06616.BD"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1007\/s12035-022-03178-7","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T01:02:20Z","timestamp":1672794140000},"page":"1964-1985","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Non-genomic Effect of Estradiol on the Neurovascular Unit and Possible Involvement in the Cerebral Vascular Accident"],"prefix":"10.1007","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0835-1708","authenticated-orcid":false,"given":"Francisca Jorge","family":"Gon\u00e7alves","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6319-7873","authenticated-orcid":false,"given":"Fatima","family":"Abrantes-Soares","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9816-6284","authenticated-orcid":false,"given":"Manuel R.","family":"Pouso","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4752-6398","authenticated-orcid":false,"given":"Margarida","family":"Lorigo","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4823-5701","authenticated-orcid":false,"given":"Elisa","family":"Cairrao","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"3178_CR1","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1146\/annurev-neuro-070918-050443","volume":"42","author":"BS Khakh","year":"2019","unstructured":"Khakh BS, Deneen B (2019) The emerging nature of astrocyte diversity. Annu Rev Neurosci 42:187\u2013207. https:\/\/doi.org\/10.1146\/annurev-neuro-070918-050443","journal-title":"Annu Rev Neurosci"},{"issue":"4","key":"3178_CR2","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1111\/apha.12250","volume":"210","author":"V Muoio","year":"2014","unstructured":"Muoio V, Persson PB, Sendeski MM (2014) The neurovascular unit - concept review. Acta Physiol (Oxf) 210(4):790\u2013798. https:\/\/doi.org\/10.1111\/apha.12250","journal-title":"Acta Physiol (Oxf)"},{"key":"3178_CR3","doi-asserted-by":"publisher","first-page":"5819514","DOI":"10.1155\/2017\/5819514","volume":"2017","author":"M Xiao","year":"2017","unstructured":"Xiao M, Li Q, Feng H, Zhang L, Chen Y (2017) Neural vascular mechanism for the cerebral blood flow autoregulation after hemorrhagic stroke. Neural Plast 2017:5819514. https:\/\/doi.org\/10.1155\/2017\/5819514","journal-title":"Neural Plast"},{"key":"3178_CR4","doi-asserted-by":"publisher","first-page":"282","DOI":"10.3389\/fncel.2019.00282","volume":"13","author":"LS Brown","year":"2019","unstructured":"Brown LS, Foster CG, Courtney JM, King NE, Howells DW, Sutherland BA (2019) Pericytes and neurovascular function in the healthy and diseased brain. Front Cell Neurosci 13:282. https:\/\/doi.org\/10.3389\/fncel.2019.00282","journal-title":"Front Cell Neurosci"},{"issue":"6","key":"3178_CR5","doi-asserted-by":"publisher","first-page":"892","DOI":"10.2174\/1570159x15666170112170226","volume":"15","author":"S Yang","year":"2017","unstructured":"Yang S, Jin H, Zhu Y, Wan Y, Opoku EN, Zhu L, Hu B (2017) Diverse functions and mechanisms of pericytes in ischemic stroke. Curr Neuropharmacol 15(6):892\u2013905. https:\/\/doi.org\/10.2174\/1570159x15666170112170226","journal-title":"Curr Neuropharmacol"},{"issue":"5","key":"3178_CR6","doi-asserted-by":"publisher","first-page":"502","DOI":"10.2174\/1567202616666191026122642","volume":"16","author":"P Quelhas","year":"2019","unstructured":"Quelhas P, Baltazar G, Cairrao E (2019) The neurovascular unit: focus on the regulation of arterial smooth muscle cells. Curr Neurovasc Res 16(5):502\u2013515. https:\/\/doi.org\/10.2174\/1567202616666191026122642","journal-title":"Curr Neurovasc Res"},{"key":"3178_CR7","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/978-1-60761-938-3_2","volume":"686","author":"P Dore-Duffy","year":"2011","unstructured":"Dore-Duffy P, Cleary K (2011) Morphology and properties of pericytes. Methods Mol Biol 686:49\u201368. https:\/\/doi.org\/10.1007\/978-1-60761-938-3_2","journal-title":"Methods Mol Biol"},{"issue":"2","key":"3178_CR8","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/j.1365-2796.2009.02199.x","volume":"267","author":"GJ del Zoppo","year":"2010","unstructured":"del Zoppo GJ (2010) The neurovascular unit in the setting of stroke. J Intern Med 267(2):156\u2013171. https:\/\/doi.org\/10.1111\/j.1365-2796.2009.02199.x","journal-title":"J Intern Med"},{"key":"3178_CR9","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.brainresbull.2022.03.011","volume":"184","author":"MR Pouso","year":"2022","unstructured":"Pouso MR, Cairrao E (2022) Effect of retinoic acid on the neurovascular unit: a review. Brain Res Bull 184:34\u201345. https:\/\/doi.org\/10.1016\/j.brainresbull.2022.03.011","journal-title":"Brain Res Bull"},{"key":"3178_CR10","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1146\/annurev.physiol.70.113006.100518","volume":"70","author":"ER Prossnitz","year":"2008","unstructured":"Prossnitz ER, Arterburn JB, Smith HO, Oprea TI, Sklar LA, Hathaway HJ (2008) Estrogen signaling through the transmembrane G protein-coupled receptor GPR30. Annu Rev Physiol 70:165\u2013190. https:\/\/doi.org\/10.1146\/annurev.physiol.70.113006.100518","journal-title":"Annu Rev Physiol"},{"issue":"12","key":"3178_CR11","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/nrendo.2011.122","volume":"7","author":"ER Prossnitz","year":"2011","unstructured":"Prossnitz ER, Barton M (2011) The G-protein-coupled estrogen receptor GPER in health and disease. Nat Rev Endocrinol 7(12):715\u2013726. https:\/\/doi.org\/10.1038\/nrendo.2011.122","journal-title":"Nat Rev Endocrinol"},{"issue":"1\u20132","key":"3178_CR12","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.mce.2014.02.002","volume":"389","author":"ER Prossnitz","year":"2014","unstructured":"Prossnitz ER, Barton M (2014) Estrogen biology: new insights into GPER function and clinical opportunities. Mol Cell Endocrinol 389(1\u20132):71\u201383. https:\/\/doi.org\/10.1016\/j.mce.2014.02.002","journal-title":"Mol Cell Endocrinol"},{"issue":"12","key":"3178_CR13","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1002\/hipo.22475","volume":"25","author":"A Kumar","year":"2015","unstructured":"Kumar A, Bean LA, Rani A, Jackson T, Foster TC (2015) Contribution of estrogen receptor subtypes, ER\u03b1, ER\u03b2, and GPER1 in rapid estradiol-mediated enhancement of hippocampal synaptic transmission in mice. Hippocampus 25(12):1556\u20131566. https:\/\/doi.org\/10.1002\/hipo.22475","journal-title":"Hippocampus"},{"issue":"3","key":"3178_CR14","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1124\/pr.114.009712","volume":"67","author":"ER Prossnitz","year":"2015","unstructured":"Prossnitz ER, Arterburn JB (2015) International Union of Basic and Clinical Pharmacology. XCVII. G protein-coupled estrogen receptor and its pharmacologic modulators. Pharmacol Rev 67(3):505\u2013540. https:\/\/doi.org\/10.1124\/pr.114.009712","journal-title":"Pharmacol Rev"},{"key":"3178_CR15","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/bs.apha.2016.05.003","volume":"77","author":"MR Meyer","year":"2016","unstructured":"Meyer MR, Barton M (2016) Estrogens and coronary artery disease: new clinical perspectives. Adv Pharmacol 77:307\u2013360. https:\/\/doi.org\/10.1016\/bs.apha.2016.05.003","journal-title":"Adv Pharmacol"},{"issue":"5","key":"3178_CR16","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1055\/s-0044-100920","volume":"50","author":"A Kumar","year":"2018","unstructured":"Kumar A, Banerjee A, Singh D, Thakur G, Kasarpalkar N, Gavali S, Gadkar S, Madan T et al (2018) Estradiol: a steroid with multiple facets. Horm Metab Res 50(5):359\u2013374. https:\/\/doi.org\/10.1055\/s-0044-100920","journal-title":"Horm Metab Res"},{"key":"3178_CR17","doi-asserted-by":"publisher","first-page":"733","DOI":"10.3389\/fendo.2019.00733","volume":"10","author":"R Puglisi","year":"2019","unstructured":"Puglisi R, Mattia G, Car\u00e8 A, Marano G, Malorni W, Matarrese P (2019) Non-genomic effects of estrogen on cell homeostasis and remodeling with special focus on cardiac ischemia\/reperfusion injury. Front Endocrinol (Lausanne) 10:733. https:\/\/doi.org\/10.3389\/fendo.2019.00733","journal-title":"Front Endocrinol (Lausanne)"},{"key":"3178_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.568203","volume":"11","author":"QK Tran","year":"2020","unstructured":"Tran QK (2020) Reciprocality between estrogen biology and calcium signaling in the cardiovascular system. Front Endocrinol (Lausanne) 11:568203. https:\/\/doi.org\/10.3389\/fendo.2020.568203","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"3178_CR19","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1002\/glia.23697","volume":"68","author":"XS Wang","year":"2019","unstructured":"Wang XS, Yue J, Hu LN, Tian Z, Zhang K, Yang L, Zhang HN, Guo YY et al (2019) Activation of G protein-coupled receptor 30 protects neurons by regulating autophagy in astrocytes. Glia 68(1):27\u201343. https:\/\/doi.org\/10.1002\/glia.23697","journal-title":"Glia"},{"issue":"4\u20135","key":"3178_CR20","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/s0960-0760(02)00119-x","volume":"81","author":"C Beyer","year":"2002","unstructured":"Beyer C, Ivanova T, Karolczak M, K\u00fcppers E (2002) Cell type-specificity of nonclassical estrogen signaling in the developing midbrain. J Steroid Biochem Mol Biol 81(4\u20135):319\u2013325. https:\/\/doi.org\/10.1016\/s0960-0760(02)00119-x","journal-title":"J Steroid Biochem Mol Biol"},{"key":"3178_CR21","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.steroids.2016.02.016","volume":"111","author":"M Barton","year":"2016","unstructured":"Barton M (2016) Not lost in translation: emerging clinical importance of the G protein-coupled estrogen receptor GPER. Steroids 111:37\u201345. https:\/\/doi.org\/10.1016\/j.steroids.2016.02.016","journal-title":"Steroids"},{"key":"3178_CR22","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3389\/fendo.2020.00148","volume":"11","author":"J Luo","year":"2020","unstructured":"Luo J, Liu D (2020) Does GPER really function as a G protein-coupled estrogen receptor in vivo? Front Endocrinol (Lausanne) 11:148. https:\/\/doi.org\/10.3389\/fendo.2020.00148","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"3178_CR23","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/s0301-0082(00)00025-3","volume":"63","author":"LM Garcia-Segura","year":"2001","unstructured":"Garcia-Segura LM, Azcoitia I, DonCarlos LL (2001) Neuroprotection by estradiol. Prog Neurobiol 63(1):29\u201360. https:\/\/doi.org\/10.1016\/s0301-0082(00)00025-3","journal-title":"Prog Neurobiol"},{"issue":"1\u20132","key":"3178_CR24","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.mce.2014.01.024","volume":"387","author":"H Tang","year":"2014","unstructured":"Tang H, Zhang Q, Yang L, Dong Y, Khan M, Yang F, Brann DW, Wang R (2014) GPR30 mediates estrogen rapid signaling and neuroprotection. Mol Cell Endocrinol 387(1\u20132):52\u201358. https:\/\/doi.org\/10.1016\/j.mce.2014.01.024","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"3178_CR25","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s13293-017-0152-8","volume":"8","author":"A Iorga","year":"2017","unstructured":"Iorga A, Cunningham CM, Moazeni S, Ruffenach G, Umar S, Eghbali M (2017) The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy. Biol Sex Differ 8(1):33. https:\/\/doi.org\/10.1186\/s13293-017-0152-8","journal-title":"Biol Sex Differ"},{"key":"3178_CR26","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/978-1-4939-7571-6_31","volume":"1727","author":"R Crupi","year":"2018","unstructured":"Crupi R, Di Paola R, Esposito E, Cuzzocrea S (2018) Middle cerebral artery occlusion by an intraluminal suture method. Methods Mol Biol 1727:393\u2013401. https:\/\/doi.org\/10.1007\/978-1-4939-7571-6_31","journal-title":"Methods Mol Biol"},{"issue":"10","key":"3178_CR27","doi-asserted-by":"publisher","first-page":"4218","DOI":"10.1007\/s12035-020-02021-1","volume":"57","author":"Y Xing","year":"2020","unstructured":"Xing Y, Bai Y (2020) A review of exercise-induced neuroplasticity in ischemic stroke: pathology and mechanisms. Mol Neurobiol 57(10):4218\u20134231. https:\/\/doi.org\/10.1007\/s12035-020-02021-1","journal-title":"Mol Neurobiol"},{"issue":"12","key":"3178_CR28","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1016\/j.amjmed.2021.07.027","volume":"134","author":"SK Feske","year":"2021","unstructured":"Feske SK (2021) Ischemic stroke. Am J Med 134(12):1457\u20131464. https:\/\/doi.org\/10.1016\/j.amjmed.2021.07.027","journal-title":"Am J Med"},{"key":"3178_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113518","volume":"335","author":"S Paul","year":"2021","unstructured":"Paul S, Candelario-Jalil E (2021) Emerging neuroprotective strategies for the treatment of ischemic stroke: an overview of clinical and preclinical studies. Exp Neurol 335:113518. https:\/\/doi.org\/10.1016\/j.expneurol.2020.113518","journal-title":"Exp Neurol"},{"key":"3178_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.755955","volume":"15","author":"XY Shen","year":"2021","unstructured":"Shen XY, Gao ZK, Han Y, Yuan M, Guo YS, Bi X (2021) Activation and role of astrocytes in ischemic stroke. Front Cell Neurosci 15:755955. https:\/\/doi.org\/10.3389\/fncel.2021.755955","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"3178_CR31","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/cns.13561","volume":"27","author":"L Wang","year":"2021","unstructured":"Wang L, Xiong X, Zhang L, Shen J (2021) Neurovascular unit: a critical role in ischemic stroke. CNS Neurosci Ther 27(1):7\u201316. https:\/\/doi.org\/10.1111\/cns.13561","journal-title":"CNS Neurosci Ther"},{"issue":"6","key":"3178_CR32","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1159\/000517378","volume":"84","author":"S Zhang","year":"2021","unstructured":"Zhang S, Shang D, Shi H, Teng W, Tian L (2021) Function of astrocytes in neuroprotection and repair after ischemic stroke. Eur Neurol 84(6):426\u2013434. https:\/\/doi.org\/10.1159\/000517378","journal-title":"Eur Neurol"},{"issue":"2","key":"3178_CR33","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s12035-012-8244-2","volume":"45","author":"I S\u00e1-Pereira","year":"2012","unstructured":"S\u00e1-Pereira I, Brites D, Brito MA (2012) Neurovascular unit: a focus on pericytes. Mol Neurobiol 45(2):327\u2013347. https:\/\/doi.org\/10.1007\/s12035-012-8244-2","journal-title":"Mol Neurobiol"},{"issue":"1","key":"3178_CR34","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.neuron.2017.07.030","volume":"96","author":"C Iadecola","year":"2017","unstructured":"Iadecola C (2017) The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease. Neuron 96(1):17\u201342. https:\/\/doi.org\/10.1016\/j.neuron.2017.07.030","journal-title":"Neuron"},{"key":"3178_CR35","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1146\/annurev-neuro-071714-033835","volume":"38","author":"BJ Andreone","year":"2015","unstructured":"Andreone BJ, Lacoste B, Gu C (2015) Neuronal and vascular interactions. Annu Rev Neurosci 38:25\u201346. https:\/\/doi.org\/10.1146\/annurev-neuro-071714-033835","journal-title":"Annu Rev Neurosci"},{"issue":"4","key":"3178_CR36","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.beem.2015.04.008","volume":"29","author":"M Jia","year":"2015","unstructured":"Jia M, Dahlman-Wright K, Gustafsson J (2015) Estrogen receptor alpha and beta in health and disease. Best Pract Res Clin Endocrinol Metab 29(4):557\u2013568. https:\/\/doi.org\/10.1016\/j.beem.2015.04.008","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"8","key":"3178_CR37","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1080\/14728222.2017.1350264","volume":"21","author":"L Molina","year":"2017","unstructured":"Molina L, Figueroa CD, Bhoola KD, Ehrenfeld P (2017) GPER-1\/GPR30 a novel estrogen receptor sited in the cell membrane: therapeutic coupling to breast cancer. Expert Opin Ther Targets 21(8):755\u2013766. https:\/\/doi.org\/10.1080\/14728222.2017.1350264","journal-title":"Expert Opin Ther Targets"},{"issue":"1","key":"3178_CR38","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/rmb2.12006","volume":"16","author":"P Ya\u015far","year":"2017","unstructured":"Ya\u015far P, Ayaz G, User SD, G\u00fcp\u00fcr G, Muyan M (2017) Molecular mechanism of estrogen-estrogen receptor signaling. Reprod Med Biol 16(1):4\u201320. https:\/\/doi.org\/10.1002\/rmb2.12006","journal-title":"Reprod Med Biol"},{"issue":"1\u20132","key":"3178_CR39","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.mce.2009.03.009","volume":"308","author":"MR Meyer","year":"2009","unstructured":"Meyer MR, Haas E, Prossnitz ER, Barton M (2009) Non-genomic regulation of vascular cell function and growth by estrogen. Mol Cell Endocrinol 308(1\u20132):9\u201316. https:\/\/doi.org\/10.1016\/j.mce.2009.03.009","journal-title":"Mol Cell Endocrinol"},{"issue":"3\u20134","key":"3178_CR40","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.prostaglandins.2009.05.001","volume":"89","author":"ER Prossnitz","year":"2009","unstructured":"Prossnitz ER, Barton M (2009) Signaling, physiological functions and clinical relevance of the G protein-coupled estrogen receptor GPER. Prostaglandins Other Lipid Mediat 89(3\u20134):89\u201397. https:\/\/doi.org\/10.1016\/j.prostaglandins.2009.05.001","journal-title":"Prostaglandins Other Lipid Mediat"},{"issue":"1\u20133","key":"3178_CR41","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.vph.2011.06.003","volume":"55","author":"MR Meyer","year":"2011","unstructured":"Meyer MR, Prossnitz ER, Barton M (2011) The G protein-coupled estrogen receptor GPER\/GPR30 as a regulator of cardiovascular function. Vascul Pharmacol 55(1\u20133):17\u201325. https:\/\/doi.org\/10.1016\/j.vph.2011.06.003","journal-title":"Vascul Pharmacol"},{"key":"3178_CR42","doi-asserted-by":"publisher","first-page":"7564","DOI":"10.1038\/srep07564","volume":"4","author":"MR Meyer","year":"2014","unstructured":"Meyer MR, Fredette NC, Howard TA, Hu C, Ramesh C, Daniel C, Amann K, Arterburn JB et al (2014) G protein-coupled estrogen receptor protects from atherosclerosis. Sci Rep 4:7564. https:\/\/doi.org\/10.1038\/srep07564","journal-title":"Sci Rep"},{"issue":"1","key":"3178_CR43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008642","volume":"5","author":"D Lebesgue","year":"2010","unstructured":"Lebesgue D, Traub M, De Butte-Smith M, Chen C, Zukin RS, Kelly MJ, Etgen AM (2010) Acute administration of non-classical estrogen receptor agonists attenuates ischemia-induced hippocampal neuron loss in middle-aged female rats. PLoS ONE 5(1):e8642. https:\/\/doi.org\/10.1371\/journal.pone.0008642","journal-title":"PLoS ONE"},{"key":"3178_CR44","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.phrs.2013.02.008","volume":"71","author":"G Han","year":"2013","unstructured":"Han G, Li F, Yu X, White RE (2013) GPER: a novel target for non-genomic estrogen action in the cardiovascular system. Pharmacol Res 71:53\u201360. https:\/\/doi.org\/10.1016\/j.phrs.2013.02.008","journal-title":"Pharmacol Res"},{"key":"3178_CR45","doi-asserted-by":"publisher","first-page":"385","DOI":"10.3389\/fendo.2020.00385","volume":"11","author":"A Kumar","year":"2020","unstructured":"Kumar A, Foster TC (2020) G protein-coupled estrogen receptor: rapid effects on hippocampal-dependent spatial memory and synaptic plasticity. Front Endocrinol (Lausanne) 11:385. https:\/\/doi.org\/10.3389\/fendo.2020.00385","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"4","key":"3178_CR46","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nchembio775","volume":"2","author":"CG Bologa","year":"2006","unstructured":"Bologa CG, Revankar CM, Young SM, Edwards BS, Arterburn JB, Kiselyov AS, Parker MA, Tkachenko SE et al (2006) Virtual and biomolecular screening converge on a selective agonist for GPR30. Nat Chem Biol 2(4):207\u2013212. https:\/\/doi.org\/10.1038\/nchembio775","journal-title":"Nat Chem Biol"},{"key":"3178_CR47","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jsbmb.2017.04.012","volume":"176","author":"MM Hadjimarkou","year":"2018","unstructured":"Hadjimarkou MM, Vasudevan N (2018) GPER1\/GPR30 in the brain: crosstalk with classical estrogen receptors and implications for behavior. J Steroid Biochem Mol Biol 176:57\u201364. https:\/\/doi.org\/10.1016\/j.jsbmb.2017.04.012","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"12","key":"3178_CR48","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.tem.2011.08.002","volume":"22","author":"I Azcoitia","year":"2011","unstructured":"Azcoitia I, Arevalo MA, De Nicola AF, Garcia-Segura LM (2011) Neuroprotective actions of estradiol revisited. Trends Endocrinol Metab 22(12):467\u2013473. https:\/\/doi.org\/10.1016\/j.tem.2011.08.002","journal-title":"Trends Endocrinol Metab"},{"issue":"5","key":"3178_CR49","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1002\/jnr.1098","volume":"64","author":"K Honda","year":"2001","unstructured":"Honda K, Shimohama S, Sawada H, Kihara T, Nakamizo T, Shibasaki H, Akaike A (2001) Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons. J Neurosci Res 64(5):466\u2013475. https:\/\/doi.org\/10.1002\/jnr.1098","journal-title":"J Neurosci Res"},{"key":"3178_CR50","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1196\/annals.1286.002","volume":"1007","author":"C Beyer","year":"2003","unstructured":"Beyer C, Pawlak J, Brito V, Karolczak M, Ivanova T, Kuppers E (2003) Regulation of gene expression in the developing midbrain by estrogen: implication of classical and nonclassical steroid signaling. Ann N Y Acad Sci 1007:17\u201328. https:\/\/doi.org\/10.1196\/annals.1286.002","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"3178_CR51","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1046\/j.0007-1331.2001.00742.x","volume":"14","author":"T Ivanova","year":"2002","unstructured":"Ivanova T, Mendez P, Garcia-Segura LM, Beyer C (2002) Rapid stimulation of the PI3-kinase\/Akt signalling pathway in developing midbrain neurones by oestrogen. J Neuroendocrinol 14(1):73\u201379. https:\/\/doi.org\/10.1046\/j.0007-1331.2001.00742.x","journal-title":"J Neuroendocrinol"},{"issue":"6","key":"3178_CR52","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.1210\/en.2005-0014","volume":"146","author":"KM Dhandapani","year":"2005","unstructured":"Dhandapani KM, Wade FM, Mahesh VB, Brann DW (2005) Astrocyte-derived transforming growth factor-{beta} mediates the neuroprotective effects of 17{beta}-estradiol: involvement of nonclassical genomic signaling pathways. Endocrinology 146(6):2749\u20132759. https:\/\/doi.org\/10.1210\/en.2005-0014","journal-title":"Endocrinology"},{"issue":"3","key":"3178_CR53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152138","volume":"11","author":"NJ Evans","year":"2016","unstructured":"Evans NJ, Bayliss AL, Reale V, Evans PD (2016) Characterisation of signalling by the endogenous GPER1 (GPR30) receptor in an embryonic mouse hippocampal cell line (mHippoE-18). PLoS ONE 11(3):e0152138. https:\/\/doi.org\/10.1371\/journal.pone.0152138","journal-title":"PLoS ONE"},{"key":"3178_CR54","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.neuroscience.2016.04.026","volume":"328","author":"TZ Zhao","year":"2016","unstructured":"Zhao TZ, Shi F, Hu J, He SM, Ding Q, Ma LT (2016) GPER1 mediates estrogen-induced neuroprotection against oxygen-glucose deprivation in the primary hippocampal neurons. Neuroscience 328:117\u2013126. https:\/\/doi.org\/10.1016\/j.neuroscience.2016.04.026","journal-title":"Neuroscience"},{"issue":"4","key":"3178_CR55","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1007\/s12975-012-0211-8","volume":"3","author":"Y Kosaka","year":"2012","unstructured":"Kosaka Y, Quillinan N, Bond C, Traystman R, Hurn P, Herson P (2012) GPER1\/GPR30 activation improves neuronal survival following global cerebral ischemia induced by cardiac arrest in mice. Transl Stroke Res 3(4):500\u2013507. https:\/\/doi.org\/10.1007\/s12975-012-0211-8","journal-title":"Transl Stroke Res"},{"issue":"1\u20132","key":"3178_CR56","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/s0039-128x(98)00095-6","volume":"64","author":"MJ Kelly","year":"1999","unstructured":"Kelly MJ, Lagrange AH, Wagner EJ, R\u00f8nnekleiv OK (1999) Rapid effects of estrogen to modulate G protein-coupled receptors via activation of protein kinase A and protein kinase C pathways. Steroids 64(1\u20132):64\u201375. https:\/\/doi.org\/10.1016\/s0039-128x(98)00095-6","journal-title":"Steroids"},{"issue":"1","key":"3178_CR57","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1046\/j.1460-9568.1998.00045.x","volume":"10","author":"C Beyer","year":"1998","unstructured":"Beyer C, Raab H (1998) Nongenomic effects of oestrogen: embryonic mouse midbrain neurones respond with a rapid release of calcium from intracellular stores. Eur J Neurosci 10(1):255\u2013262. https:\/\/doi.org\/10.1046\/j.1460-9568.1998.00045.x","journal-title":"Eur J Neurosci"},{"issue":"3","key":"3178_CR58","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/j.bbrc.2006.05.191","volume":"346","author":"T Funakoshi","year":"2006","unstructured":"Funakoshi T, Yanai A, Shinoda K, Kawano MM, Mizukami Y (2006) G protein-coupled receptor 30 is an estrogen receptor in the plasma membrane. Biochem Biophys Res Commun 346(3):904\u2013910. https:\/\/doi.org\/10.1016\/j.bbrc.2006.05.191","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"3178_CR59","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1677\/joe-07-0017","volume":"193","author":"E Brailoiu","year":"2007","unstructured":"Brailoiu E, Dun SL, Brailoiu GC, Mizuo K, Sklar LA, Oprea TI, Prossnitz ER, Dun NJ (2007) Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system. J Endocrinol 193(2):311\u2013321. https:\/\/doi.org\/10.1677\/joe-07-0017","journal-title":"J Endocrinol"},{"issue":"14","key":"3178_CR60","doi-asserted-by":"publisher","first-page":"4887","DOI":"10.1523\/jneurosci.5828-11.2012","volume":"32","author":"SB Liu","year":"2012","unstructured":"Liu SB, Zhang N, Guo YY, Zhao R, Shi TY, Feng SF, Wang SQ, Yang Q et al (2012) G-protein-coupled receptor 30 mediates rapid neuroprotective effects of estrogen via depression of NR2B-containing NMDA receptors. J Neurosci 32(14):4887\u20134900. https:\/\/doi.org\/10.1523\/jneurosci.5828-11.2012","journal-title":"J Neurosci"},{"issue":"17","key":"3178_CR61","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1016\/s0024-3205(01)01534-x","volume":"70","author":"DY Lee","year":"2002","unstructured":"Lee DY, Chai YG, Lee EB, Kim KW, Nah SY, Oh TH, Rhim H (2002) 17Beta-estradiol inhibits high-voltage-activated calcium channel currents in rat sensory neurons via a non-genomic mechanism. Life Sci 70(17):2047\u20132059. https:\/\/doi.org\/10.1016\/s0024-3205(01)01534-x","journal-title":"Life Sci"},{"issue":"7","key":"3178_CR62","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1038\/nn.4043","volume":"18","author":"BS Khakh","year":"2015","unstructured":"Khakh BS, Sofroniew MV (2015) Diversity of astrocyte functions and phenotypes in neural circuits. Nat Neurosci 18(7):942\u2013952. https:\/\/doi.org\/10.1038\/nn.4043","journal-title":"Nat Neurosci"},{"issue":"2","key":"3178_CR63","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.nrl.2012.12.007","volume":"30","author":"T Guillam\u00f3n-Vivancos","year":"2015","unstructured":"Guillam\u00f3n-Vivancos T, G\u00f3mez-Pinedo U, Mat\u00edas-Guiu J (2015) Astrocytes in neurodegenerative diseases (I): function and molecular description. Neurologia 30(2):119\u2013129. https:\/\/doi.org\/10.1016\/j.nrl.2012.12.007","journal-title":"Neurologia"},{"issue":"6","key":"3178_CR64","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1111\/cns.13123","volume":"25","author":"B Zhou","year":"2019","unstructured":"Zhou B, Zuo YX, Jiang RT (2019) Astrocyte morphology: diversity, plasticity, and role in neurological diseases. CNS Neurosci Ther 25(6):665\u2013673. https:\/\/doi.org\/10.1111\/cns.13123","journal-title":"CNS Neurosci Ther"},{"issue":"1","key":"3178_CR65","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020412","volume":"7","author":"R Daneman","year":"2015","unstructured":"Daneman R, Prat A (2015) The blood-brain barrier. Cold Spring Harb Perspect Biol 7(1):a020412. https:\/\/doi.org\/10.1101\/cshperspect.a020412","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"3178_CR66","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.pneurobio.2015.09.008","volume":"144","author":"Z Liu","year":"2016","unstructured":"Liu Z, Chopp M (2016) Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke. Prog Neurobiol 144:103\u2013120. https:\/\/doi.org\/10.1016\/j.pneurobio.2015.09.008","journal-title":"Prog Neurobiol"},{"issue":"1","key":"3178_CR67","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1084\/jem.20180200","volume":"216","author":"KA Guttenplan","year":"2019","unstructured":"Guttenplan KA, Liddelow SA (2019) Astrocytes and microglia: Models and tools. J Exp Med 216(1):71\u201383. https:\/\/doi.org\/10.1084\/jem.20180200","journal-title":"J Exp Med"},{"issue":"9","key":"3178_CR68","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.it.2020.07.004","volume":"41","author":"MV Sofroniew","year":"2020","unstructured":"Sofroniew MV (2020) Astrocyte reactivity: subtypes, states, and functions in CNS innate immunity. Trends Immunol 41(9):758\u2013770. https:\/\/doi.org\/10.1016\/j.it.2020.07.004","journal-title":"Trends Immunol"},{"key":"3178_CR69","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2019.104538","volume":"131","author":"F Galland","year":"2019","unstructured":"Galland F, Seady M, Taday J, Smaili SS, Gon\u00e7alves CA, Leite MC (2019) Astrocyte culture models: molecular and function characterization of primary culture, immortalized astrocytes and C6 glioma cells. Neurochem Int 131:104538. https:\/\/doi.org\/10.1016\/j.neuint.2019.104538","journal-title":"Neurochem Int"},{"issue":"38","key":"3178_CR70","doi-asserted-by":"publisher","first-page":"7355","DOI":"10.1523\/jneurosci.0115-20.2020","volume":"40","author":"Y Lu","year":"2020","unstructured":"Lu Y, Sareddy GR, Wang J, Zhang Q, Tang FL, Pratap UP, Tekmal RR, Vadlamudi RK et al (2020) Neuron-derived estrogen is critical for astrocyte activation and neuroprotection of the ischemic brain. J Neurosci 40(38):7355\u20137374. https:\/\/doi.org\/10.1523\/jneurosci.0115-20.2020","journal-title":"J Neurosci"},{"issue":"3","key":"3178_CR71","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1007\/s12035-020-02171-2","volume":"58","author":"J Wang","year":"2021","unstructured":"Wang J, Hou Y, Zhang L, Liu M, Zhao J, Zhang Z, Ma Y, Hou W (2021) Estrogen attenuates traumatic brain injury by inhibiting the activation of microglia and astrocyte-mediated neuroinflammatory responses. Mol Neurobiol 58(3):1052\u20131061. https:\/\/doi.org\/10.1007\/s12035-020-02171-2","journal-title":"Mol Neurobiol"},{"issue":"3","key":"3178_CR72","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1002\/glia.20162","volume":"50","author":"J Pawlak","year":"2005","unstructured":"Pawlak J, Karolczak M, Krust A, Chambon P, Beyer C (2005) Estrogen receptor-alpha is associated with the plasma membrane of astrocytes and coupled to the MAP\/Src-kinase pathway. Glia 50(3):270\u2013275. https:\/\/doi.org\/10.1002\/glia.20162","journal-title":"Glia"},{"issue":"11","key":"3178_CR73","doi-asserted-by":"publisher","first-page":"5080","DOI":"10.1210\/en.2004-0973","volume":"145","author":"MA Sortino","year":"2004","unstructured":"Sortino MA, Chisari M, Merlo S, Vancheri C, Caruso M, Nicoletti F, Canonico PL, Copani A (2004) Glia mediates the neuroprotective action of estradiol on beta-amyloid-induced neuronal death. Endocrinology 145(11):5080\u20135086. https:\/\/doi.org\/10.1210\/en.2004-0973","journal-title":"Endocrinology"},{"issue":"8","key":"3178_CR74","doi-asserted-by":"publisher","first-page":"3788","DOI":"10.1210\/en.2004-0149","volume":"145","author":"VV Chaban","year":"2004","unstructured":"Chaban VV, Lakhter AJ, Micevych P (2004) A membrane estrogen receptor mediates intracellular calcium release in astrocytes. Endocrinology 145(8):3788\u20133795. https:\/\/doi.org\/10.1210\/en.2004-0149","journal-title":"Endocrinology"},{"issue":"11\u201312","key":"3178_CR75","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1016\/j.freeradbiomed.2012.03.005","volume":"52","author":"J Guo","year":"2012","unstructured":"Guo J, Duckles SP, Weiss JH, Li X, Krause DN (2012) 17\u03b2-Estradiol prevents cell death and mitochondrial dysfunction by an estrogen receptor-dependent mechanism in astrocytes after oxygen-glucose deprivation\/reperfusion. Free Radic Biol Med 52(11\u201312):2151\u20132160. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2012.03.005","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"3178_CR76","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1111\/imm.12163","volume":"141","author":"L Peferoen","year":"2014","unstructured":"Peferoen L, Kipp M, van der Valk P, van Noort JM, Amor S (2014) Oligodendrocyte-microglia cross-talk in the central nervous system. Immunology 141(3):302\u2013313. https:\/\/doi.org\/10.1111\/imm.12163","journal-title":"Immunology"},{"issue":"Suppl 1","key":"3178_CR77","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/jnc.13062","volume":"136","author":"Z Chen","year":"2016","unstructured":"Chen Z, Trapp BD (2016) Microglia and neuroprotection. J Neurochem 136(Suppl 1):10\u201317. https:\/\/doi.org\/10.1111\/jnc.13062","journal-title":"J Neurochem"},{"issue":"2","key":"3178_CR78","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.cell.2019.08.053","volume":"179","author":"M Prinz","year":"2019","unstructured":"Prinz M, Jung S, Priller J (2019) Microglia biology: one century of evolving concepts. Cell 179(2):292\u2013311. https:\/\/doi.org\/10.1016\/j.cell.2019.08.053","journal-title":"Cell"},{"key":"3178_CR79","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/978-1-4939-9658-2_2","volume":"2034","author":"JC Savage","year":"2019","unstructured":"Savage JC, Carrier M, Tremblay M (2019) Morphology of microglia across contexts of health and disease. Methods Mol Biol 2034:13\u201326. https:\/\/doi.org\/10.1007\/978-1-4939-9658-2_2","journal-title":"Methods Mol Biol"},{"key":"3178_CR80","doi-asserted-by":"publisher","first-page":"4486","DOI":"10.1038\/ncomms5486","volume":"5","author":"Z Chen","year":"2014","unstructured":"Chen Z, Jalabi W, Hu W, Park HJ, Gale JT, Kidd GJ, Bernatowicz R, Gossman ZC et al (2014) Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain. Nat Commun 5:4486. https:\/\/doi.org\/10.1038\/ncomms5486","journal-title":"Nat Commun"},{"issue":"4","key":"3178_CR81","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.449","volume":"6","author":"TZ Zhao","year":"2016","unstructured":"Zhao TZ, Ding Q, Hu J, He SM, Shi F, Ma LT (2016) GPER expressed on microglia mediates the anti-inflammatory effect of estradiol in ischemic stroke. Brain Behav 6(4):e00449. https:\/\/doi.org\/10.1002\/brb3.449","journal-title":"Brain Behav"},{"issue":"1","key":"3178_CR82","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1159\/000478908","volume":"24","author":"J Guan","year":"2017","unstructured":"Guan J, Yang B, Fan Y, Zhang J (2017) GPER Agonist G1 attenuates neuroinflammation and dopaminergic neurodegeneration in parkinson disease. NeuroImmunoModulation 24(1):60\u201366. https:\/\/doi.org\/10.1159\/000478908","journal-title":"NeuroImmunoModulation"},{"issue":"1\u20132","key":"3178_CR83","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/s0165-5728(00)00386-6","volume":"111","author":"PD Drew","year":"2000","unstructured":"Drew PD, Chavis JA (2000) Female sex steroids: effects upon microglial cell activation. J Neuroimmunol 111(1\u20132):77\u201385. https:\/\/doi.org\/10.1016\/s0165-5728(00)00386-6","journal-title":"J Neuroimmunol"},{"issue":"2","key":"3178_CR84","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s12035-014-9070-5","volume":"53","author":"Y Tang","year":"2016","unstructured":"Tang Y, Le W (2016) Differential roles of M1 and M2 microglia in neurodegenerative diseases. Mol Neurobiol 53(2):1181\u20131194. https:\/\/doi.org\/10.1007\/s12035-014-9070-5","journal-title":"Mol Neurobiol"},{"key":"3178_CR85","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1146\/annurev-immunol-051116-052358","volume":"35","author":"M Colonna","year":"2017","unstructured":"Colonna M, Butovsky O (2017) Microglia function in the central nervous system during health and neurodegeneration. Annu Rev Immunol 35:441\u2013468. https:\/\/doi.org\/10.1146\/annurev-immunol-051116-052358","journal-title":"Annu Rev Immunol"},{"issue":"11","key":"3178_CR86","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.3390\/antiox10111682","volume":"10","author":"K Saeed","year":"2021","unstructured":"Saeed K, Jo MH, Park JS, Alam SI, Khan I, Ahmad R, Khan A, Ullah R, Kim MO (2021) 17\u03b2-estradiol abrogates oxidative stress and neuroinflammation after cortical stab wound injury. Antioxidants (Basel) 10(11):1682. https:\/\/doi.org\/10.3390\/antiox10111682","journal-title":"Antioxidants (Basel)"},{"key":"3178_CR87","doi-asserted-by":"publisher","first-page":"4248526","DOI":"10.1155\/2018\/4248526","volume":"2018","author":"R Thakkar","year":"2018","unstructured":"Thakkar R, Wang R, Wang J, Vadlamudi RK, Brann DW (2018) 17\u03b2-estradiol regulates microglia activation and polarization in the hippocampus following global cerebral ischemia. Oxid Med Cell Longev 2018:4248526. https:\/\/doi.org\/10.1155\/2018\/4248526","journal-title":"Oxid Med Cell Longev"},{"key":"3178_CR88","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2020.105667","volume":"202","author":"M Scheld","year":"2020","unstructured":"Scheld M, Heymann F, Zhao W, Tohidnezhad M, Clarner T, Beyer C, Zendedel A (2020) Modulatory effect of 17\u03b2-estradiol on myeloid cell infiltration into the male rat brain after ischemic stroke. J Steroid Biochem Mol Biol 202:105667. https:\/\/doi.org\/10.1016\/j.jsbmb.2020.105667","journal-title":"J Steroid Biochem Mol Biol"},{"key":"3178_CR89","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.neuroscience.2021.03.025","volume":"463","author":"R Aryanpour","year":"2021","unstructured":"Aryanpour R, Zibara K, Pasbakhsh P, Jame\u2019ei SB, Namjoo Z, Ghanbari A, Mahmoudi R, Amani S et al (2021) 17\u03b2-estradiol reduces demyelination in cuprizone-fed mice by promoting M2 Microglia Polarity and Regulating NLRP3 Inflammasome. Neuroscience 463:116\u2013127. https:\/\/doi.org\/10.1016\/j.neuroscience.2021.03.025","journal-title":"Neuroscience"},{"key":"3178_CR90","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/978-3-319-45096-4_10","volume":"13","author":"AI Amaral","year":"2016","unstructured":"Amaral AI, Tavares JM, Sonnewald U, Kotter MR (2016) Oligodendrocytes: development, physiology and glucose metabolism. Adv Neurobiol 13:275\u2013294. https:\/\/doi.org\/10.1007\/978-3-319-45096-4_10","journal-title":"Adv Neurobiol"},{"issue":"9","key":"3178_CR91","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.3390\/cells9092078","volume":"9","author":"M Kipp","year":"2020","unstructured":"Kipp M (2020) Oligodendrocyte physiology and pathology function. Cells 9(9):2078. https:\/\/doi.org\/10.3390\/cells9092078","journal-title":"Cells"},{"issue":"Pt B","key":"3178_CR92","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.neuropharm.2016.04.026","volume":"110","author":"R Tognatta","year":"2016","unstructured":"Tognatta R, Miller RH (2016) Contribution of the oligodendrocyte lineage to CNS repair and neurodegenerative pathologies. Neuropharmacology 110(Pt B):539\u2013547. https:\/\/doi.org\/10.1016\/j.neuropharm.2016.04.026","journal-title":"Neuropharmacology"},{"key":"3178_CR93","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.conb.2017.09.015","volume":"47","author":"L Dimou","year":"2017","unstructured":"Dimou L, Simons M (2017) Diversity of oligodendrocytes and their progenitors. Curr Opin Neurobiol 47:73\u201379. https:\/\/doi.org\/10.1016\/j.conb.2017.09.015","journal-title":"Curr Opin Neurobiol"},{"key":"3178_CR94","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/978-981-32-9636-7_5","volume":"1190","author":"C Hayashi","year":"2019","unstructured":"Hayashi C, Suzuki N (2019) Heterogeneity of oligodendrocytes and their precursor cells. Adv Exp Med Biol 1190:53\u201362. https:\/\/doi.org\/10.1007\/978-981-32-9636-7_5","journal-title":"Adv Exp Med Biol"},{"issue":"3","key":"3178_CR95","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1002\/glia.440140304","volume":"14","author":"AM Butt","year":"1995","unstructured":"Butt AM, Ibrahim M, Ruge FM, Berry M (1995) Biochemical subtypes of oligodendrocyte in the anterior medullary velum of the rat as revealed by the monoclonal antibody Rip. Glia 14(3):185\u2013197. https:\/\/doi.org\/10.1002\/glia.440140304","journal-title":"Glia"},{"key":"3178_CR96","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.neuroscience.2012.12.070","volume":"235","author":"Y Hirahara","year":"2013","unstructured":"Hirahara Y, Matsuda KI, Liu YF, Yamada H, Kawata M, Boggs JM (2013) 17\u03b2-Estradiol and 17\u03b1-estradiol induce rapid changes in cytoskeletal organization in cultured oligodendrocytes. Neuroscience 235:187\u2013199. https:\/\/doi.org\/10.1016\/j.neuroscience.2012.12.070","journal-title":"Neuroscience"},{"issue":"5","key":"3178_CR97","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1002\/jnr.20017","volume":"75","author":"DN Arvanitis","year":"2004","unstructured":"Arvanitis DN, Wang H, Bagshaw RD, Callahan JW, Boggs JM (2004) Membrane-associated estrogen receptor and caveolin-1 are present in central nervous system myelin and oligodendrocyte plasma membranes. J Neurosci Res 75(5):603\u2013613. https:\/\/doi.org\/10.1002\/jnr.20017","journal-title":"J Neurosci Res"},{"issue":"2","key":"3178_CR98","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1002\/glia.20742","volume":"57","author":"Y Hirahara","year":"2009","unstructured":"Hirahara Y, Matsuda K, Gao W, Arvanitis DN, Kawata M, Boggs JM (2009) The localization and non-genomic function of the membrane-associated estrogen receptor in oligodendrocytes. Glia 57(2):153\u2013165. https:\/\/doi.org\/10.1002\/glia.20742","journal-title":"Glia"},{"issue":"3","key":"3178_CR99","doi-asserted-by":"publisher","first-page":"H613","DOI":"10.1152\/ajpheart.00220.2020","volume":"319","author":"J Shi","year":"2020","unstructured":"Shi J, Yang Y, Cheng A, Xu G, He F (2020) Metabolism of vascular smooth muscle cells in vascular diseases. Am J Physiol Heart Circ Physiol 319(3):H613-h631. https:\/\/doi.org\/10.1152\/ajpheart.00220.2020","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"12","key":"3178_CR100","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1038\/nrneurol.2012.210","volume":"8","author":"JH Zhang","year":"2012","unstructured":"Zhang JH, Badaut J, Tang J, Obenaus A, Hartman R, Pearce WJ (2012) The vascular neural network\u2013a new paradigm in stroke pathophysiology. Nat Rev Neurol 8(12):711\u2013716. https:\/\/doi.org\/10.1038\/nrneurol.2012.210","journal-title":"Nat Rev Neurol"},{"key":"3178_CR101","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-021-01103-5","author":"M Mariana","year":"2021","unstructured":"Mariana M, Roque C, Baltazar G, Cairrao E (2021) In vitro model for ischemic stroke: functional analysis of vascular smooth muscle cells. Cell Mol Neurobiol. https:\/\/doi.org\/10.1007\/s10571-021-01103-5","journal-title":"Cell Mol Neurobiol"},{"issue":"3","key":"3178_CR102","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1007\/s12975-013-0304-z","volume":"5","author":"J Badaut","year":"2014","unstructured":"Badaut J, Bix GJ (2014) Vascular neural network phenotypic transformation after traumatic injury: potential role in long-term sequelae. Transl Stroke Res 5(3):394\u2013406. https:\/\/doi.org\/10.1007\/s12975-013-0304-z","journal-title":"Transl Stroke Res"},{"issue":"14","key":"3178_CR103","doi-asserted-by":"publisher","first-page":"3013","DOI":"10.1113\/jp270033","volume":"593","author":"G Wang","year":"2015","unstructured":"Wang G, Jacquet L, Karamariti E, Xu Q (2015) Origin and differentiation of vascular smooth muscle cells. J Physiol 593(14):3013\u20133030. https:\/\/doi.org\/10.1113\/jp270033","journal-title":"J Physiol"},{"key":"3178_CR104","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2020.101400","volume":"66","author":"P Quelhas","year":"2020","unstructured":"Quelhas P, Baltazar G, Cairrao E (2020) Characterization of culture from smooth muscle cells isolated from rat middle cerebral arteries. Tissue Cell 66:101400. https:\/\/doi.org\/10.1016\/j.tice.2020.101400","journal-title":"Tissue Cell"},{"issue":"2","key":"3178_CR105","doi-asserted-by":"publisher","first-page":"H163","DOI":"10.1152\/ajpheart.00493.2013","volume":"306","author":"JJ Reho","year":"2014","unstructured":"Reho JJ, Zheng X, Fisher SA (2014) Smooth muscle contractile diversity in the control of regional circulations. Am J Physiol Heart Circ Physiol 306(2):H163-172. https:\/\/doi.org\/10.1152\/ajpheart.00493.2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"3178_CR106","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1097\/00004647-200104000-00011","volume":"21","author":"JB Salom","year":"2001","unstructured":"Salom JB, Burguete MC, P\u00e9rez-Asensio FJ, Torregrosa G, Alborch E (2001) Relaxant effects of 17-beta-estradiol in cerebral arteries through Ca(2+) entry inhibition. J Cereb Blood Flow Metab 21(4):422\u2013429. https:\/\/doi.org\/10.1097\/00004647-200104000-00011","journal-title":"J Cereb Blood Flow Metab"},{"issue":"1","key":"3178_CR107","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.neures.2011.05.006","volume":"71","author":"S Patkar","year":"2011","unstructured":"Patkar S, Farr TD, Cooper E, Dowell FJ, Carswell HV (2011) Differential vasoactive effects of oestrogen, oestrogen receptor agonists and selective oestrogen receptor modulators in rat middle cerebral artery. Neurosci Res 71(1):78\u201384. https:\/\/doi.org\/10.1016\/j.neures.2011.05.006","journal-title":"Neurosci Res"},{"key":"3178_CR108","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.steroids.2014.07.010","volume":"89","author":"MB Ram\u00edrez-Rosas","year":"2014","unstructured":"Ram\u00edrez-Rosas MB, Cobos-Puc LE, S\u00e1nchez-L\u00f3pez A, Guti\u00e9rrez-Lara EJ, Centuri\u00f3n D (2014) Pharmacological characterization of the mechanisms involved in the vasorelaxation induced by progesterone and 17\u03b2-estradiol on isolated canine basilar and internal carotid arteries. Steroids 89:33\u201340. https:\/\/doi.org\/10.1016\/j.steroids.2014.07.010","journal-title":"Steroids"},{"issue":"10","key":"3178_CR109","doi-asserted-by":"publisher","first-page":"H1285","DOI":"10.1152\/ajpheart.00645.2015","volume":"310","author":"RR Deer","year":"2016","unstructured":"Deer RR, Stallone JN (2016) Effects of estrogen on cerebrovascular function: age-dependent shifts from beneficial to detrimental in small cerebral arteries of the rat. Am J Physiol Heart Circ Physiol 310(10):H1285-1294. https:\/\/doi.org\/10.1152\/ajpheart.00645.2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"3178_CR110","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.409","volume":"6","author":"KW Evanson","year":"2018","unstructured":"Evanson KW, Goldsmith JA, Ghosh P, Delp MD (2018) The G protein-coupled estrogen receptor agonist, G-1, attenuates BK channel activation in cerebral arterial smooth muscle cells. Pharmacol Res Perspect 6(4):e00409. https:\/\/doi.org\/10.1002\/prp2.409","journal-title":"Pharmacol Res Perspect"},{"issue":"12","key":"3178_CR111","doi-asserted-by":"publisher","first-page":"762","DOI":"10.21037\/atm-20-4567","volume":"8","author":"X Xia","year":"2020","unstructured":"Xia X, Zhou C, He X, Liu C, Wang G, Sun X (2020) The relationship between estrogen-induced phenotypic transformation and proliferation of vascular smooth muscle and hypertensive intracerebral hemorrhage. Ann Transl Med 8(12):762. https:\/\/doi.org\/10.21037\/atm-20-4567","journal-title":"Ann Transl Med"},{"key":"3178_CR112","doi-asserted-by":"publisher","first-page":"519","DOI":"10.3389\/fncel.2019.00519","volume":"13","author":"X Su","year":"2019","unstructured":"Su X, Huang L, Qu Y, Xiao D, Mu D (2019) Pericytes in cerebrovascular diseases: an emerging therapeutic target. Front Cell Neurosci 13:519. https:\/\/doi.org\/10.3389\/fncel.2019.00519","journal-title":"Front Cell Neurosci"},{"issue":"9","key":"3178_CR113","doi-asserted-by":"publisher","first-page":"2314","DOI":"10.3390\/cells10092314","volume":"10","author":"L Kurmann","year":"2021","unstructured":"Kurmann L, Okoniewski M, Dubey RK (2021) Estradiol inhibits human brain vascular pericyte migration activity: a functional and transcriptomic analysis. Cells 10(9):2314. https:\/\/doi.org\/10.3390\/cells10092314","journal-title":"Cells"},{"issue":"10","key":"3178_CR114","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.3390\/cells10102712","volume":"10","author":"JK Hennigs","year":"2021","unstructured":"Hennigs JK, Matuszcak C, Trepel M, K\u00f6rbelin J (2021) Vascular endothelial cells: heterogeneity and targeting approaches. Cells 10(10):2712. https:\/\/doi.org\/10.3390\/cells10102712","journal-title":"Cells"},{"key":"3178_CR115","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/978-3-319-57613-8_4","volume":"1003","author":"C Sturtzel","year":"2017","unstructured":"Sturtzel C (2017) Endothelial cells. Adv Exp Med Biol 1003:71\u201391. https:\/\/doi.org\/10.1007\/978-3-319-57613-8_4","journal-title":"Adv Exp Med Biol"},{"issue":"11","key":"3178_CR116","doi-asserted-by":"publisher","first-page":"5930","DOI":"10.1073\/pnas.97.11.5930","volume":"97","author":"KS Russell","year":"2000","unstructured":"Russell KS, Haynes MP, Sinha D, Clerisme E, Bender JR (2000) Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signaling. Proc Natl Acad Sci U S A 97(11):5930\u20135935. https:\/\/doi.org\/10.1073\/pnas.97.11.5930","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"3178_CR117","doi-asserted-by":"publisher","first-page":"193","DOI":"10.2170\/jjphysiol.53.193","volume":"53","author":"H Momoi","year":"2003","unstructured":"Momoi H, Ikomi F, Ohhashi T (2003) Estrogen-induced augmentation of endothelium-dependent nitric oxide-mediated vasodilation in isolated rat cerebral small arteries. Jpn J Physiol 53(3):193\u2013203. https:\/\/doi.org\/10.2170\/jjphysiol.53.193","journal-title":"Jpn J Physiol"},{"key":"3178_CR118","doi-asserted-by":"publisher","unstructured":"Nevzati E, Shafighi M, Bakhtian KD, Treiber H, Fandino J, Fathi AR (2015) Estrogen induces nitric oxide production via nitric oxide synthase activation in endothelial cells. In: Fandino J, Marbacher S, Fathi A-R, Muroi C, Keller E (eds) Neurovascular events after subarachnoid hemorrhage: towards experimental and clinical standardisation. Springer International Publishing, Cham, pp 141\u2013145. https:\/\/doi.org\/10.1007\/978-3-319-04981-6_24","DOI":"10.1007\/978-3-319-04981-6_24"},{"issue":"1","key":"3178_CR119","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1124\/mol.104.004465","volume":"67","author":"C Stirone","year":"2005","unstructured":"Stirone C, Boroujerdi A, Duckles SP, Krause DN (2005) Estrogen receptor activation of phosphoinositide-3 kinase, akt, and nitric oxide signaling in cerebral blood vessels: rapid and long-term effects. Mol Pharmacol 67(1):105\u2013113. https:\/\/doi.org\/10.1124\/mol.104.004465","journal-title":"Mol Pharmacol"},{"issue":"4","key":"3178_CR120","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1159\/000322578","volume":"48","author":"A Holm","year":"2011","unstructured":"Holm A, Baldetorp B, Olde B, Leeb-Lundberg LM, Nilsson BO (2011) The GPER1 agonist G-1 attenuates endothelial cell proliferation by inhibiting DNA synthesis and accumulating cells in the S and G2 phases of the cell cycle. J Vasc Res 48(4):327\u2013335. https:\/\/doi.org\/10.1159\/000322578","journal-title":"J Vasc Res"},{"key":"3178_CR121","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/524324","volume":"2013","author":"J Tu","year":"2013","unstructured":"Tu J, Jufri NF (2013) Estrogen signaling through estrogen receptor beta and G-protein-coupled estrogen receptor 1 in human cerebral vascular endothelial cells: implications for cerebral aneurysms. Biomed Res Int 2013:524324. https:\/\/doi.org\/10.1155\/2013\/524324","journal-title":"Biomed Res Int"},{"issue":"5","key":"3178_CR122","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1111\/jnc.13066","volume":"133","author":"JB Altmann","year":"2015","unstructured":"Altmann JB, Yan G, Meeks JF, Abood ME, Brailoiu E, Brailoiu GC (2015) G protein-coupled estrogen receptor-mediated effects on cytosolic calcium and nanomechanics in brain microvascular endothelial cells. J Neurochem 133(5):629\u2013639. https:\/\/doi.org\/10.1111\/jnc.13066","journal-title":"J Neurochem"},{"issue":"11","key":"3178_CR123","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1097\/00001756-200208070-00024","volume":"13","author":"E Galea","year":"2002","unstructured":"Galea E, Santizo R, Feinstein DL, Adamsom P, Greenwood J, Koenig HM, Pelligrino DA (2002) Estrogen inhibits NF kappa B-dependent inflammation in brain endothelium without interfering with I kappa B degradation. NeuroReport 13(11):1469\u20131472. https:\/\/doi.org\/10.1097\/00001756-200208070-00024","journal-title":"NeuroReport"},{"issue":"5","key":"3178_CR124","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.lfs.2003.12.023","volume":"75","author":"M Mori","year":"2004","unstructured":"Mori M, Tsukahara F, Yoshioka T, Irie K, Ohta H (2004) Suppression by 17beta-estradiol of monocyte adhesion to vascular endothelial cells is mediated by estrogen receptors. Life Sci 75(5):599\u2013609. https:\/\/doi.org\/10.1016\/j.lfs.2003.12.023","journal-title":"Life Sci"},{"issue":"1","key":"3178_CR125","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2005.04.085","volume":"1049","author":"AR Torres-Hern\u00e1ndez","year":"2005","unstructured":"Torres-Hern\u00e1ndez AR, Gonz\u00e1lez-Vegas JA (2005) Effects of 17beta-estradiol on the spontaneous activity of substantia nigra neurons: evidence for a non-genomic mechanism. Brain Res 1049(1):1\u20137. https:\/\/doi.org\/10.1016\/j.brainres.2005.04.085","journal-title":"Brain Res"},{"issue":"3","key":"3178_CR126","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/jcbfm.2009.226","volume":"30","author":"J Guo","year":"2010","unstructured":"Guo J, Krause DN, Horne J, Weiss JH, Li X, Duckles SP (2010) Estrogen-receptor-mediated protection of cerebral endothelial cell viability and mitochondrial function after ischemic insult in vitro. J Cereb Blood Flow Metab 30(3):545\u2013554. https:\/\/doi.org\/10.1038\/jcbfm.2009.226","journal-title":"J Cereb Blood Flow Metab"},{"issue":"6","key":"3178_CR127","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1007\/s12975-020-00806-z","volume":"11","author":"A Datta","year":"2020","unstructured":"Datta A, Sarmah D, Mounica L, Kaur H, Kesharwani R, Verma G, Veeresh P, Kotian V et al (2020) Cell death pathways in ischemic stroke and targeted pharmacotherapy. Transl Stroke Res 11(6):1185\u20131202. https:\/\/doi.org\/10.1007\/s12975-020-00806-z","journal-title":"Transl Stroke Res"},{"key":"3178_CR128","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113599","volume":"338","author":"A Mizuma","year":"2021","unstructured":"Mizuma A, Yenari MA (2021) Clinical perspectives on ischemic stroke. Exp Neurol 338:113599. https:\/\/doi.org\/10.1016\/j.expneurol.2021.113599","journal-title":"Exp Neurol"},{"key":"3178_CR129","unstructured":"Rosner J, Reddy V, Lui F (2022) Neuroanatomy, circle of Willis. In: StatPearls. StatPearls Publishing Copyright \u00a9 2022, StatPearls Publishing LLC., Treasure Island (FL)"},{"key":"3178_CR130","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1159\/000333604","volume":"30","author":"M Gonz\u00e1lez Delgado","year":"2012","unstructured":"Gonz\u00e1lez Delgado M, Bogousslavsky J (2012) Superficial middle cerebral artery territory infarction. Front Neurol Neurosci 30:111\u2013114. https:\/\/doi.org\/10.1159\/000333604","journal-title":"Front Neurol Neurosci"},{"key":"3178_CR131","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.bbadis.2015.11.014","volume":"3","author":"M Pekny","year":"1862","unstructured":"Pekny M (1862) Pekna M (2016) Reactive gliosis in the pathogenesis of CNS diseases. Biochim Biophys Acta 3:483\u2013491. https:\/\/doi.org\/10.1016\/j.bbadis.2015.11.014","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"3178_CR132","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/jnc.14648","volume":"149","author":"C Roque","year":"2019","unstructured":"Roque C, Mendes-Oliveira J, Baltazar G (2019) G protein-coupled estrogen receptor activates cell type-specific signaling pathways in cortical cultures: relevance to the selective loss of astrocytes. J Neurochem 149(1):27\u201340. https:\/\/doi.org\/10.1111\/jnc.14648","journal-title":"J Neurochem"},{"issue":"3\u20134","key":"3178_CR133","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1159\/000338019","volume":"21","author":"BR Broughton","year":"2013","unstructured":"Broughton BR, Brait VH, Guida E, Lee S, Arumugam TV, Gardiner-Mann CV, Miller AA, Tang SC et al (2013) Stroke increases g protein-coupled estrogen receptor expression in the brain of male but not female mice. Neurosignals 21(3\u20134):229\u2013239. https:\/\/doi.org\/10.1159\/000338019","journal-title":"Neurosignals"},{"issue":"3","key":"3178_CR134","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1161\/strokeaha.112.678177","volume":"44","author":"T Murata","year":"2013","unstructured":"Murata T, Dietrich HH, Xiang C, Dacey RG Jr (2013) G protein-coupled estrogen receptor agonist improves cerebral microvascular function after hypoxia\/reoxygenation injury in male and female rats. Stroke 44(3):779\u2013785. https:\/\/doi.org\/10.1161\/strokeaha.112.678177","journal-title":"Stroke"},{"key":"3178_CR135","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.brainres.2013.02.051","volume":"1514","author":"DA Schreihofer","year":"2013","unstructured":"Schreihofer DA, Ma Y (2013) Estrogen receptors and ischemic neuroprotection: who, what, where, and when? Brain Res 1514:107\u2013122. https:\/\/doi.org\/10.1016\/j.brainres.2013.02.051","journal-title":"Brain Res"},{"issue":"3","key":"3178_CR136","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1161\/strokeaha.113.001499","volume":"45","author":"BR Broughton","year":"2014","unstructured":"Broughton BR, Brait VH, Kim HA, Lee S, Chu HX, Gardiner-Mann CV, Guida E, Evans MA et al (2014) Sex-dependent effects of G protein-coupled estrogen receptor activity on outcome after ischemic stroke. Stroke 45(3):835\u2013841. https:\/\/doi.org\/10.1161\/strokeaha.113.001499","journal-title":"Stroke"},{"issue":"6","key":"3178_CR137","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1002\/cne.21240","volume":"500","author":"S Suzuki","year":"2007","unstructured":"Suzuki S, Gerhold LM, B\u00f6ttner M, Rau SW, Dela Cruz C, Yang E, Zhu H, Yu J et al (2007) Estradiol enhances neurogenesis following ischemic stroke through estrogen receptors alpha and beta. J Comp Neurol 500(6):1064\u20131075. https:\/\/doi.org\/10.1002\/cne.21240","journal-title":"J Comp Neurol"},{"issue":"1","key":"3178_CR138","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12883-021-02116-9","volume":"21","author":"JW Choi","year":"2021","unstructured":"Choi JW, Ryoo IW, Hong JY, Lee KY, Nam HS, Kim WC, Oh SH, Kang J et al (2021) Clinical impact of estradiol\/testosterone ratio in patients with acute ischemic stroke. BMC Neurol 21(1):91. https:\/\/doi.org\/10.1186\/s12883-021-02116-9","journal-title":"BMC Neurol"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-022-03178-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-022-03178-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-022-03178-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T08:19:37Z","timestamp":1677831577000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-022-03178-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,4]]},"references-count":138,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["3178"],"URL":"https:\/\/doi.org\/10.1007\/s12035-022-03178-7","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,4]]},"assertion":[{"value":"2 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This is a review article. There is not ethical approval applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicated.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"This is a review article. There is no consent to publish applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}