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Synaptic plasticity within this network is critical for the formation of proper fear memories. Known for their role in the promotion of synaptic plasticity, neurotrophins position as obvious candidates in the regulation of fear processes. Indeed, recent evidence from our laboratory and others associates dysregulated signalling through neurotrophin-3 and its receptor TrkC with the pathophysiology of anxiety and fear-related disorders. Here, we put wild-type C57Bl\/6J mice through a contextual fear conditioning paradigm in order to characterize TrkC activation and expression in the main brain regions involved in (learned) fear \u2013 amygdala, hippocampus, and prefrontal cortex \u2013 during the formation of a fear memory. We report an overall decreased activation of TrkC in the fear network during fear consolidation and reconsolidation. During reconsolidation, hippocampal TrkC downregulation was accompanied by a decrease in the expression and activation of Erk, a critical signalling pathway in fear conditioning. Moreover, we did not find evidence that the observed decrease of TrkC activation was caused by altered expression of dominant negative form of TrkC, neurotrophin-3, or the PTP1B\u00a0phosphatase. Our results indicate hippocampal TrkC inactivation through Erk signalling as a potential mechanism in the regulation of contextual fear memory formation.<\/jats:p>","DOI":"10.1007\/s12035-023-03292-0","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T18:02:28Z","timestamp":1679508148000},"page":"3507-3521","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["TrkC Intracellular Signalling in the Brain Fear Network During the Formation of a Contextual Fear Memory"],"prefix":"10.1007","volume":"60","author":[{"given":"Francisca","family":"Silva","sequence":"first","affiliation":[]},{"given":"Gianluca","family":"Masella","sequence":"additional","affiliation":[]},{"given":"Maria Francisca","family":"Madeira","sequence":"additional","affiliation":[]},{"given":"Carlos B.","family":"Duarte","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3229-8270","authenticated-orcid":false,"given":"M\u00f3nica","family":"Santos","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,3,8]]},"reference":[{"key":"3292_CR1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013) American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders Fifth Edition","DOI":"10.1176\/appi.books.9780890425596"},{"key":"3292_CR2","doi-asserted-by":"publisher","first-page":"327","DOI":"10.31887\/dcns.2015.17.3\/bbandelow","volume":"17","author":"B Bandelow","year":"2015","unstructured":"Bandelow B, Michaelis S (2015) Epidemiology of anxiety disorders in the 21st century. 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