{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T20:04:12Z","timestamp":1770753852030,"version":"3.50.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T00:00:00Z","timestamp":1566000000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T00:00:00Z","timestamp":1566000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Operational Group QUALIMILHO- New sustainable integration strategies that guarantee quality and safety in the national maize)","award":["PDR2020 n\u00ba 101-031295"],"award-info":[{"award-number":["PDR2020 n\u00ba 101-031295"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Food Anal. Methods"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1007\/s12161-019-01625-1","type":"journal-article","created":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T07:02:37Z","timestamp":1566025357000},"page":"2675-2684","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Validation of a Biochip Chemiluminescent Immunoassay for Multi-Mycotoxins Screening in Maize (Zea mays L.)"],"prefix":"10.1007","volume":"12","author":[{"given":"Andreia","family":"Freitas","sequence":"first","affiliation":[]},{"given":"S\u00edlvia","family":"Barros","sequence":"additional","affiliation":[]},{"given":"Carla","family":"Brites","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Barbosa","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0226-921X","authenticated-orcid":false,"given":"Ana Sanches","family":"Silva","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,8,17]]},"reference":[{"key":"1625_CR1","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.foodcont.2012.10.006","volume":"31","author":"WA Abia","year":"2013","unstructured":"Abia WA, Warth B, Sulyok M, Krska R, Tchana AN, Njobeh PB, Dutton MF, Moundipa PF (2013) Determination of multi-mycotoxin occurrence in cereals , nuts and their products in Cameroon by liquid chromatography tandem mass spectrometry (LC-MS\/MS). Food Control 31:438\u2013453. \nhttps:\/\/doi.org\/10.1016\/j.foodcont.2012.10.006","journal-title":"Food Control"},{"issue":"2\u20133","key":"1625_CR2","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/s00216-012-6033-4","volume":"405","author":"L Anfossi","year":"2013","unstructured":"Anfossi L, Baggiani C, Giovannoli C, Arco GD, Giraudi G (2013) Lateral-flow immunoassays for mycotoxins and phycotoxins: a review. Anal Bioanal Chem 405(2\u20133):467\u2013480. \nhttps:\/\/doi.org\/10.1007\/s00216-012-6033-4","journal-title":"Anal Bioanal Chem"},{"key":"1625_CR3","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.copbio.2015.11.005","volume":"37","author":"L Anfossi","year":"2016","unstructured":"Anfossi L, Giovannoli C, Baggiani C (2016) Mycotoxin detection. Curr Opin Biotechnol 37:120\u2013126. \nhttps:\/\/doi.org\/10.1016\/j.copbio.2015.11.005","journal-title":"Curr Opin Biotechnol"},{"key":"1625_CR4","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1002\/mnfr.201100764","volume":"57","author":"F Berthiller","year":"2013","unstructured":"Berthiller F, Crews C, Dall\u2019Asta C, Saeger SD, Haesaert G, Karlovsky P, Oswald IP, Seefelder W, Speijers GSJ (2013) Masked mycotoxins: a review. Mol Nutr Food Res 57:165\u2013186","journal-title":"Mol Nutr Food Res"},{"key":"1625_CR5","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1080\/19440049.2013.809624","volume":"30","author":"M Bryla","year":"2013","unstructured":"Bryla M, Roszko M, Szymczyk K, Jedrzejczak R, Obiedzinsky MW, Sekul J (2013) Fumonisins in plant-origin food and fodder\u2014a review. Food Addit Contam 30:1626\u20131640","journal-title":"Food Addit Contam"},{"issue":"16","key":"1625_CR6","doi-asserted-by":"publisher","first-page":"4639","DOI":"10.1007\/s00216-015-8660-z","volume":"407","author":"MS Castaneto","year":"2015","unstructured":"Castaneto MS, Barnes AJ, Concheiro M, Klette KL, Martin TA, Huestis MA (2015) Biochip array technology immunoassay performance and quantitative confirmation of designer piperazines for urine workplace drug testing. Anal Bioanal Chem 407(16):4639\u20134648","journal-title":"Anal Bioanal Chem"},{"key":"1625_CR7","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/j.bios.2016.03.004","volume":"81","author":"R Chauhan","year":"2016","unstructured":"Chauhan R, Singh J, Sachdev T, Basu T, Malhotra BD (2016) Recent advances in mycotoxins detection. Biosens Bioelectron 81:532\u2013545","journal-title":"Biosens Bioelectron"},{"key":"1625_CR8","unstructured":"Commission decision 2002\/657\/EC of 12 August 2002, Off. J. Eur. Commun. 2002, 221, 836"},{"key":"1625_CR9","unstructured":"CRLs, Community Reference Laboratories Residues. Guidelines for the validation of screening methods for residues of veterinary medicines (initial validation and transfer) 2010. \nhttps:\/\/ec.europa.eu\/food\/sites\/food\/files\/safety\/docs\/cs_vet-med-residues_guideline_validation_screening_en.pdf\n\n. Accessed 2 Apr 2019"},{"key":"1625_CR10","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.trac.2013.11.007","volume":"55","author":"BB Dzantiev","year":"2014","unstructured":"Dzantiev BB, Byzova NA, Urusov AE, Zherdev A (2014) Immunochromatographic methods in food analysis. Trends Anal Chem 55:81\u201393","journal-title":"Trends Anal Chem"},{"key":"1625_CR11","first-page":"12","volume":"L70","author":"EC","year":"2006","unstructured":"EC (2006a) Commission Regulation (EC) no 401\/2006 of 23 February 2006 laying down the methods of sampling and analysis for the official control of the levels of mycotoxins in foodstuffs. Off J Eur Union L70:12\u201334","journal-title":"Off J Eur Union"},{"key":"1625_CR12","unstructured":"EC (2006b) Commission Regulation (EC) no 1881\/2006 of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs. Off J Eur Union:5\u201324"},{"key":"1625_CR13","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.2903\/j.efsa.2011.2197","volume":"9","author":"EFSA","year":"2011","unstructured":"EFSA (2011) Scientific opinion on the risks for public health related to the presence of zearalenone in food. EFSA J 9:2197","journal-title":"EFSA J"},{"key":"1625_CR14","unstructured":"EFSA (2013) Aflatoxins (sum of B1, B2, G1, G2) in cereals and cereal-derived food products. Support Publ 2013:EN\u201340:"},{"key":"1625_CR15","first-page":"3699","volume":"12","author":"EFSA","year":"2014","unstructured":"EFSA (2014) Evaluation of the increase of risk for public health related to a possible temporary derogation from the maximum level of deoxynivalenol, zearalenone and fumonisins for maize and maize products. EFSA J 12:3699","journal-title":"EFSA J"},{"key":"1625_CR16","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s12161-010-9150-8","volume":"4","author":"S Folloni","year":"2011","unstructured":"Folloni S, Bellocchi G, Kagkli DM, Pastor-Benito S, Aguilera M, Mazzeo A, Querci M, van den Eede G, Ermolli M (2011) Development of an ELISA reverse-based assay to assess the presence of mycotoxins in cereal flour. Food Anal Methods 4:221\u2013227. \nhttps:\/\/doi.org\/10.1007\/s12161-010-9150-8","journal-title":"Food Anal Methods"},{"key":"1625_CR17","doi-asserted-by":"publisher","first-page":"2848","DOI":"10.1007\/s12161-017-0850-1","volume":"10","author":"M Guo","year":"2017","unstructured":"Guo M, Zhou B, Huang Z, Zhao C, Zhang J, Huang B (2017) A new method for determination of alfatoxin M1 in milk by ultrasensitive time-resolved fluoroimmunoassay. Food Anal Methods 10:2848\u20132855","journal-title":"Food Anal Methods"},{"key":"1625_CR18","first-page":"245","volume":"56","author":"IARC","year":"1993","unstructured":"IARC (1993a) Some naturally occurring substances: food items and constituents, heterocyclicaromatic amines and mycotoxins. Aflatoxins WHO IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 56:245\u2013395","journal-title":"Aflatoxins WHO IARC Monographs on the Evaluation of Carcinogenic Risks to Humans"},{"key":"1625_CR19","first-page":"489","volume":"56","author":"IARC","year":"1993","unstructured":"IARC (1993b) Some naturally occurring substances: food items and constituents, heterocyclic aromatic amines and mycotoxins. Ochratoxin A WHO IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 56:489\u2013521","journal-title":"Ochratoxin A WHO IARC Monographs on the Evaluation of Carcinogenic Risks to Humans"},{"key":"1625_CR20","unstructured":"IARC (2018). List of classifications. Available at: \nhttps:\/\/monographs.iarc.fr\/list-of-classifications-volumes\/\n\n accessed: 12\/02\/2019"},{"key":"1625_CR21","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1007\/s12161-013-9561-4","volume":"6","author":"X Li","year":"2013","unstructured":"Li X, Li P, Zhang Q, Zhang Z, Li R, Zhang W, Ding X, Chen X, Tang X (2013a) A sensitive Immunoaffinity column-linked indirect competitive ELISA for ochratoxin a in cereal and oil products based on a new monoclonal antibody. Food Anal Methods 6:1433\u20131440","journal-title":"Food Anal Methods"},{"key":"1625_CR22","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.bios.2013.05.039","volume":"49","author":"X Li","year":"2013","unstructured":"Li X, Li P, Zhang Q, Li R, Zhang W, Zhang Z, Ding X, Tang X (2013b) Multicomponent immunochromatographic assay for simultaneous detection of aflatoxin B1, ochratoxin A and zearalenone in agro-food. Biosens Bioelectron 49:426\u2013432","journal-title":"Biosens Bioelectron"},{"key":"1625_CR23","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1021\/jf404818r","volume":"62","author":"Y Li","year":"2014","unstructured":"Li Y, Luo X, Yang S, Cao X, Wang Z, Shi W, Suxia Zhang S (2014) High specific monoclonal antibody production and development of an ELISA method for monitoring T-2 toxin in Rice. J Agric Food Chem 62:1492\u20131497","journal-title":"J Agric Food Chem"},{"key":"1625_CR24","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.jchromb.2014.10.034","volume":"974","author":"M Majdinasaba","year":"2015","unstructured":"Majdinasaba M, Sheikh-Zeinoddin M, Soleimanian-Zad S, Li P, Zhang Q, Li X, Tang X (2015) Ultrasensitive and quantitative gold nanoparticle-based immunochromatographic assay for detection of ochratoxin A in agro-products. J Chromatogr B 974:147\u2013154","journal-title":"J Chromatogr B"},{"key":"1625_CR25","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.talanta.2016.11.032","volume":"164","author":"SE McNamee","year":"2017","unstructured":"McNamee SE, Bravin F, Rosar G, Elliott CT, Campbell K (2017) Development of a nanoarray capable of the rapid and simultaneous detection of zearalenone, T2-toxin and fumonisin. Talanta 164:368\u2013376","journal-title":"Talanta"},{"key":"1625_CR26","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.foodcont.2016.07.040","volume":"72","author":"TC Murashiki","year":"2017","unstructured":"Murashiki TC, Chidewe C, Benhura MA, Maringe DT, Dembedza MP, Manema LR, Mvumi BM, Nyanga LK (2017) Levels and daily intake estimates of aflatoxin B1 and fumonisin B1 in maize consumed by rural households in Shamva and Makoni districts of Zimbabwe. Food Control 72:105\u2013109","journal-title":"Food Control"},{"key":"1625_CR27","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s12550-017-0277-y","volume":"33","author":"E Oldenburg","year":"2017","unstructured":"Oldenburg E, H\u00f6ppner F, Ellner FWJ (2017) Fusarium diseases of maize associated with mycotoxin contamination of agricultural products intended to be used for food and feed. Mycotoxin Res 33:167\u2013182","journal-title":"Mycotoxin Res"},{"key":"1625_CR28","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.foodcont.2014.12.038","volume":"53","author":"MS Oliveira","year":"2015","unstructured":"Oliveira MS, Diel ACL, Rauber RH, Fontoura FP, Mallmann A, Dilkin P, Mallmann CA (2015) Free and hidden fumonisins in Brazilian raw maize samples. Food Control 53:217\u2013221","journal-title":"Food Control"},{"key":"1625_CR29","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.tifs.2014.01.005","volume":"36","author":"VL Pereira","year":"2014","unstructured":"Pereira VL, Fernandes JO, Cunha SC (2014) Mycotoxins in cereals and related foodstuffs : a review on occurrence and recent methods of analysis. Trends Food Sci Technol 36:96\u2013136. \nhttps:\/\/doi.org\/10.1016\/j.tifs.2014.01.005","journal-title":"Trends Food Sci Technol"},{"key":"1625_CR30","doi-asserted-by":"publisher","first-page":"878","DOI":"10.5740\/jaoacint.16-0115","volume":"99","author":"M Plotan","year":"2016","unstructured":"Plotan M, Devlin R, Porter J, Benchikh MEO, Rodr\u00edguez ML, McConnell RI, FitzGerald SP (2016) The use of biochip array technology for rapid multimycotoxin screening. J AOAC Int 99:878\u2013889","journal-title":"J AOAC Int"},{"key":"1625_CR31","first-page":"143","volume":"60","author":"ID Popa","year":"2012","unstructured":"Popa ID, Schiriac EC, Matiut S, Cuciureanu R (2012) Method validation for simultaneous determination of 12 sulfonamides in honey using biochip array technology. Farmacia 60:143\u2013154","journal-title":"Farmacia"},{"key":"1625_CR32","unstructured":"Randox Laboratories Limited (2018). Available at: \nhttps:\/\/www.randox.com\n\n. Accessed on 12-02-2018"},{"key":"1625_CR33","volume-title":"UHPLC-ToF-MS method for determination of multi-mycotoxins in maize: development and validation","author":"A Sanches-Silva","year":"2019","unstructured":"Sanches-Silva, A., Brites, C., Vila Pouca, A.S., Barbosa, J., Freitas, A. (2019) UHPLC-ToF-MS method for determination of multi-mycotoxins in maize: development and validation. Current Research in Food Science"},{"key":"1625_CR34","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1002\/mas.20052","volume":"25","author":"S Sforza","year":"2006","unstructured":"Sforza S, Dall\u2019Asta C, Marchelli R (2006) Recent advances in mycotoxin determination in food and feed by hyphenated chromatographic techniques\/mass spectrometry. Mass Spectrom Rev 25:54\u201376","journal-title":"Mass Spectrom Rev"},{"key":"1625_CR35","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1007\/s12161-017-1126-5","volume":"11","author":"G Singh","year":"2018","unstructured":"Singh G, Velasquez L, Brady B, Koerner T, Huet AC, Delahaut P (2018) Development of an indirect competitive ELISA for analysis of alternariol in bread and bran samples. Food Anal Methods 11:1444\u20131450. \nhttps:\/\/doi.org\/10.1007\/s12161-017-1126-5","journal-title":"Food Anal Methods"},{"key":"1625_CR36","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/j.foodchem.2011.07.131","volume":"130","author":"F Soleimany","year":"2012","unstructured":"Soleimany F, Jinap S, Abas F (2012) Determination of mycotoxins in cereals by liquid chromatography tandem mass spectrometry. Food Chem 130:1055\u20131060. \nhttps:\/\/doi.org\/10.1016\/j.foodchem.2011.07.131","journal-title":"Food Chem"},{"key":"1625_CR37","doi-asserted-by":"publisher","first-page":"4995","DOI":"10.1021\/ac500540z","volume":"86","author":"S Song","year":"2014","unstructured":"Song S, Liu N, Zhao Z, Ediage EN, Wu S, Sun C, De Saeger S, Wu A (2014) Multiplex lateral flow immunoassay for mycotoxin determination. Anal Chem 86:4995\u20135001","journal-title":"Anal Chem"},{"key":"1625_CR38","doi-asserted-by":"publisher","first-page":"11116","DOI":"10.1021\/jf503092j","volume":"62","author":"Y Sun","year":"2014","unstructured":"Sun Y, Hu X, Zhang Y, Yang J, Wang F, Wang Y, Deng R, Zhang G (2014) Development of an Immunochromatographic strip test for the rapid detection of zearalenone in corn. J Agric Food Chem 62:11116\u201311121","journal-title":"J Agric Food Chem"},{"key":"1625_CR39","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.aca.2008.11.010","volume":"632","author":"NW Turner","year":"2009","unstructured":"Turner NW, Subrahmanyam S, Piletsky SA (2009) Analytical methods for determination of mycotoxins: a review. Anal Chim Acta 632:168\u2013180. \nhttps:\/\/doi.org\/10.1016\/j.aca.2008.11.010","journal-title":"Anal Chim Acta"},{"key":"1625_CR40","doi-asserted-by":"publisher","first-page":"4250","DOI":"10.1021\/jf400731j","volume":"61","author":"Y-K Wang","year":"2013","unstructured":"Wang Y-K, Yan Y-X, Ji W-H, Wang H, Zou Q, Sun JH (2013) Novel chemiluminescence immunoassay for the determination of Zearalenone in food samples using gold nanoparticles labeled with streptavidin\u2013horseradish peroxidase. J Agric Food Chem 61:4250\u20134256","journal-title":"J Agric Food Chem"},{"key":"1625_CR41","unstructured":"WHO (2002) World Health Organization. Evaluation of certain mycotoxins in food, Geneva"},{"key":"1625_CR42","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1039\/C4AN01613K","volume":"140","author":"M Zangheri","year":"2015","unstructured":"Zangheri M, Di Nardo F, Anfossi L, Giovannoli C, Baggiani C, Roda A, Mirasoli M (2015) A multiplex chemiluminescent biosensor for type B-fumonisins and aflatoxin B1 quantitative detection in maize flour. Analyst 140:358\u2013365","journal-title":"Analyst"},{"key":"1625_CR43","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1021\/acs.jafc.6b05614","volume":"65","author":"X Zhang","year":"2017","unstructured":"Zhang X, Eremin SA, Wen K, Yu X, Li C, Ke Y, Jiang H, Shen J, Wang Z (2017a) Fluorescence polarization immunoassay based on a new monoclonal antibody for the detection of the Zearalenone class of mycotoxins in maize. J Agric Food Chem 65:2240\u20132247","journal-title":"J Agric Food Chem"},{"key":"1625_CR44","doi-asserted-by":"publisher","first-page":"8063","DOI":"10.1021\/acs.jafc.7b02827","volume":"65","author":"X Zhang","year":"2017","unstructured":"Zhang X, Yu X, Wen K, Li C, Mari GM, Jiang H, Shi W, Shen J, Wang Z (2017b) Multiplex lateral flow immunoassays based on amorphous carbon nanoparticles for detecting three Fusarium mycotoxins in maize. J Agric Food Chem 65:8063\u20138071","journal-title":"J Agric Food Chem"}],"container-title":["Food Analytical Methods"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12161-019-01625-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12161-019-01625-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12161-019-01625-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T00:06:55Z","timestamp":1597536415000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12161-019-01625-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,17]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1625"],"URL":"https:\/\/doi.org\/10.1007\/s12161-019-01625-1","relation":{},"ISSN":["1936-9751","1936-976X"],"issn-type":[{"value":"1936-9751","type":"print"},{"value":"1936-976X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,17]]},"assertion":[{"value":"15 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Andreia Freitas declares that there is no conflict of interest. S\u00edlvia Barros declares that there is no conflict of interest. Carla Brites declares that there is no conflict of interest. Jorge Barbosa declares that there is no conflict of interest. Ana Sanches Silva declares that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research Involving Human Participants and\/or Animals"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}