{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T10:54:27Z","timestamp":1768733667927,"version":"3.49.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Food Anal. Methods"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1007\/s12161-020-01916-y","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T19:11:50Z","timestamp":1606158710000},"page":"430-440","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Development and Validation of a Multi-detection Confirmatory Method for Antibiotics Determination in Piglet Kidneys by UHPLC-TOF-MS According Commission Decision 2002\/657\/EC"],"prefix":"10.1007","volume":"14","author":[{"given":"Andreia","family":"Freitas","sequence":"first","affiliation":[]},{"given":"Ana Sofia","family":"Vila Pouca","sequence":"additional","affiliation":[]},{"given":"Daniela","family":"Magalh\u00e3es","sequence":"additional","affiliation":[]},{"given":"Carlota","family":"Gamboa-Cruz","sequence":"additional","affiliation":[]},{"given":"S\u00edlvia","family":"Barros","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Barbosa","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6043-819X","authenticated-orcid":false,"given":"Fernando","family":"Ramos","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,11,23]]},"reference":[{"issue":"7","key":"1916_CR1","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.2527\/2002.8071917x","volume":"80","author":"CL Case","year":"2002","unstructured":"Case CL, Carlson MS (2002) Effect of feeding organic and inorganic sources of additional zinc on growth performance and zinc balance in nursery pigs. J Anim Sci 80(7):1917\u20131924","journal-title":"J Anim Sci"},{"key":"1916_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.envint.2016.04.018","volume":"94","author":"TJ Centner","year":"2016","unstructured":"Centner TJ (2016) Recent government regulations in the United States seek to ensure the effectiveness of antibiotics by limiting their agricultural use. Environ Int 94:1\u20137. https:\/\/doi.org\/10.1016\/j.envint.2016.04.018","journal-title":"Environ Int"},{"key":"1916_CR3","doi-asserted-by":"publisher","unstructured":"Daeseleire E, Van Pamel E, Van Poucke C, Croubels S (2017) Veterinary drug residues in foods. In: Chemical Contaminants and Residues in Food, Second edn, pp 117\u201353. https:\/\/doi.org\/10.1016\/B978-0-08-100674-0.00006-0","DOI":"10.1016\/B978-0-08-100674-0.00006-0"},{"key":"1916_CR4","doi-asserted-by":"publisher","first-page":"e05598","DOI":"10.2903\/j.efsa.2019.5598","volume":"17","author":"European Food Safety, and European Centre for Disease Prevention and Control","year":"2019","unstructured":"European Food Safety, and European Centre for Disease Prevention and Control (2019) The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2017. EFSA J 17:e05598. https:\/\/doi.org\/10.2903\/j.efsa.2019.5598","journal-title":"EFSA J"},{"key":"1916_CR5","unstructured":"European Parliament and the Council of the European Union (2002) Commission Decision 2002\/657\/EC. Off J Eur Communities L221:8\u201336 https:\/\/eur-lex.europa.eu\/legal-content\/EN\/ALL\/?uri=CELEX%3A32002D0657. Accessed 31 July 2020"},{"key":"#cr-split#-1916_CR6.1","unstructured":"European Parliament and the Council of the European Union (2003) Regulation"},{"key":"#cr-split#-1916_CR6.2","unstructured":"(EC) No 1831\/2003. Official Journal of the European Union, no. L 268\/29-42. http:\/\/data.europa.eu\/eli\/reg\/2003\/1831\/oj. Accessed 31 July 2020"},{"key":"1916_CR7","unstructured":"European Parliament and the Council of the European Union (2009) Regulation (EC) No 470\/2009. Official Journal of the European Union, no. L 152\/1. https:\/\/eur-lex.europa.eu\/eli\/reg\/2009\/470\/oj. Accessed 31 July 2020"},{"key":"1916_CR8","unstructured":"European Parliament and the Council of the European Union (2010) Commission Regulation (EU) No 37\/2010\u2019. Official Journal of the European Union, no. L 15\/1. http:\/\/data.europa.eu\/eli\/reg\/2010\/37(1)\/oj. Accessed 31 July 2020"},{"key":"1916_CR9","doi-asserted-by":"publisher","unstructured":"Fallows S (2000) White paper on food safety. Nutr Food Sci 30. https:\/\/doi.org\/10.1108\/nfs.2000.01730fag.002","DOI":"10.1108\/nfs.2000.01730fag.002"},{"key":"1916_CR10","doi-asserted-by":"publisher","unstructured":"FAO (2015) Food Outlook- Biannual Report on Global Food Markets. Global information and early warning system on food and agriculture. https:\/\/doi.org\/10.1044\/leader.PPL.19102014.18","DOI":"10.1044\/leader.PPL.19102014.18"},{"key":"1916_CR11","unstructured":"FAO, and WHO (2019) Joint FAO\/WHO expert meeting in collaboration with OIE on foodborne antimicrobial resistance: role of the environment, crops and biocides"},{"key":"1916_CR12","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jchromb.2014.11.008","volume":"976\u2013977","author":"A Freitas","year":"2015","unstructured":"Freitas A, Barbosa J, Ramos F (2015) Multidetection of antibiotics in liver tissue by ultra-high-pressure-liquid-chromatography-tandem mass spectrometry. J Chromatogr B Anal Technol Biomed Life Sci 976\u2013977:49\u201354. https:\/\/doi.org\/10.1016\/j.jchromb.2014.11.008","journal-title":"J Chromatogr B Anal Technol Biomed Life Sci"},{"issue":"1","key":"1916_CR13","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s12161-015-0174-y","volume":"9","author":"A Freitas","year":"2016","unstructured":"Freitas A, Barbosa J, Ramos F (2016) Matrix effects in ultra-high-performance liquid chromatography\u2013tandem mass spectrometry antibiotic multi-detection methods in food products with animal origins. Food Anal Methods 9(1):23\u201329. https:\/\/doi.org\/10.1007\/s12161-015-0174-y","journal-title":"Food Anal Methods"},{"key":"1916_CR14","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.jchromb.2019.04.038","volume":"1118\u20131119","author":"AF Gaspar","year":"2019","unstructured":"Gaspar AF, Santos L, Rosa J, Leston S, Barbosa J, Vila Pouca AS, Freitas A, Ramos F (2019) Development and validation of a multi-residue and multi-class screening method of 44 antibiotics in salmon (Salmo salar) using ultra-high-performance liquid chromatography\/time-of-flight mass spectrometry: application to farmed salmon. J Chromatogr B 1118\u20131119:78\u201384. https:\/\/doi.org\/10.1016\/j.jchromb.2019.04.038","journal-title":"J Chromatogr B"},{"key":"1916_CR15","unstructured":"General Assembly of United Nations (2019) Follow-up to the political declaration of the high-level meeting of the general assembly on antimicrobial resistance. Vol. A\/73\/869"},{"key":"1916_CR16","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/S0731-7085(01)00350-8","volume":"25","author":"N Haskins","year":"2001","unstructured":"Haskins N (2001) Faster compound analysis by mass spectrometry-the TOF revolution. J Pharm Biomed Anal 25:767\u2013773. https:\/\/doi.org\/10.1016\/S0731-7085(01)00350-8","journal-title":"J Pharm Biomed Anal"},{"key":"1916_CR17","unstructured":"INE (2017) Balan\u00e7a Alimentar Portuguesa 2012-2016. www.ine.pt. Accessed 31 July 2020"},{"key":"1916_CR18","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1007\/s12161-019-01512-9","volume":"12","author":"M Manimekalai","year":"2019","unstructured":"Manimekalai M, Rawson A, Sengar AS, Suresh Kumar K (2019) Development, optimization, and validation of methods for quantification of veterinary drug residues in complex food matrices using liquid-chromatography\u2014a review. Food Anal Methods. Springer New York LLC 12:1823\u20131837. https:\/\/doi.org\/10.1007\/s12161-019-01512-9","journal-title":"Food Anal Methods"},{"issue":"5","key":"1916_CR19","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1136\/inp.d2873","volume":"33","author":"A Mateus","year":"2011","unstructured":"Mateus A, Brodbelt D, St\u00e4rk K (2011) Evidence-based use of antimicrobials in veterinary practice. In Pract 33(5):194\u2013202. https:\/\/doi.org\/10.1136\/inp.d2873","journal-title":"In Pract"},{"key":"1916_CR20","doi-asserted-by":"publisher","unstructured":"Moyo, B, Tavengwa, NT (2019) Modern extraction and cleanup methods of veterinary drug residues in food samples of animal origin. In: Ince, M (ed)\u00a0Recent Advances in Analytical Chemistry, IntechOpen. https:\/\/doi.org\/10.5772\/intechopen.82656","DOI":"10.5772\/intechopen.82656"},{"key":"1916_CR21","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1016\/j.talanta.2005.06.035","volume":"68","author":"L Nov\u00e1kov\u00e1","year":"2006","unstructured":"Nov\u00e1kov\u00e1 L, Matysov\u00e1 L, Solich P (2006) 'Advantages of application of UPLC in pharmaceutical analysis. Talanta 68:908\u2013918. https:\/\/doi.org\/10.1016\/j.talanta.2005.06.035","journal-title":"Talanta"},{"key":"1916_CR22","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/j.talanta.2015.07.048","volume":"144","author":"M Pego de Almeida","year":"2015","unstructured":"Pego de Almeida M, Perdig\u00e3o Rezende C, Domingues Ferreira F, de Souza LF, de Assis DCS, Chaves de Figueiredo T, de Oliveira Leite M, de Vasconcelos Can\u00e7ado S (2015) Optimization and Validation Method to Evaluate the Residues of \u03b2-Lactams and Tetracyclines in Kidney Tissue by UPLC\u2013MS\/MS. Talanta 144:922\u2013932. https:\/\/doi.org\/10.1016\/j.talanta.2015.07.048","journal-title":"Talanta"},{"issue":"4","key":"1916_CR23","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1007\/s12161-016-0649-5","volume":"10","author":"TM Rizzetti","year":"2017","unstructured":"Rizzetti TM, de Souza MP, Prestes OD, Adaime MB, Zanella R (2017) A simple and fast method for the determination of 20 veterinary drug residues in bovine kidney and liver by ultra-high-performance liquid chromatography tandem mass spectrometry. Food Anal Methods 10(4):854\u2013864. https:\/\/doi.org\/10.1007\/s12161-016-0649-5","journal-title":"Food Anal Methods"},{"key":"1916_CR24","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.foodchem.2017.11.049","volume":"246","author":"TM Rizzetti","year":"2018","unstructured":"Rizzetti TM, de Souza MP, Prestes OD, Adaime MB, Zanella R (2018) Optimization of sample preparation by central composite design for multi-class determination of veterinary drugs in bovine muscle, kidney and liver by ultra-high-performance liquid chromatographic-tandem mass spectrometry. Food Chem 246:404\u2013413. https:\/\/doi.org\/10.1016\/j.foodchem.2017.11.049","journal-title":"Food Chem"},{"key":"1916_CR25","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.chroma.2014.12.058","volume":"1379","author":"DG Rocha","year":"2015","unstructured":"Rocha DG, Santos FA, da Silva JCC, Augusti R, Faria AF (2015) Multiresidue determination of fluoroquinolones in poultry muscle and kidney according to the regulation 2002\/657\/EC. A systematic comparison of two different approaches: liquid chromatography coupled to high-resolution mass spectrometry or tandem mass spe. J Chromatogr A 1379:83\u201391. https:\/\/doi.org\/10.1016\/j.chroma.2014.12.058","journal-title":"J Chromatogr A"},{"key":"1916_CR26","doi-asserted-by":"publisher","unstructured":"Saad MMED, Ahmed MBM (2018) Necessary usage of antibiotics in animals. In: Antibiotic Use in Animals. InTech. https:\/\/doi.org\/10.5772\/intechopen.71257","DOI":"10.5772\/intechopen.71257"},{"issue":"2","key":"1916_CR27","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.ijantimicag.2018.03.010","volume":"52","author":"L Santos","year":"2018","unstructured":"Santos L, Ramos F (2018) Antimicrobial resistance in aquaculture: current knowledge and alternatives to tackle the problem. Int J Antimicrob Agents 52(2):135\u2013143. https:\/\/doi.org\/10.1016\/j.ijantimicag.2018.03.010","journal-title":"Int J Antimicrob Agents"},{"key":"1916_CR28","doi-asserted-by":"publisher","unstructured":"Wang J, Macneil JD, Kay JF (2011) Chemical analysis of antibiotic residues in food. Wiley. https:\/\/doi.org\/10.1002\/9781118067208","DOI":"10.1002\/9781118067208"},{"key":"1916_CR29","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.jchromb.2019.06.003","volume":"1124","author":"L Wang","year":"2019","unstructured":"Wang L, Li X, Wang Y, Wang C, Ye D, Zhou L, Hu X, Ke Y, Xia X (2019) Determination of cephalexin residual level using ultra-high-performance liquid chromatography-tandem mass spectrometry: residue depletion study in swine. J Chromatogr B Anal Technol Biomed Life Sci 1124:233\u2013238. https:\/\/doi.org\/10.1016\/j.jchromb.2019.06.003","journal-title":"J Chromatogr B Anal Technol Biomed Life Sci"},{"issue":"1670","key":"1916_CR30","doi-asserted-by":"publisher","first-page":"20140083","DOI":"10.1098\/rstb.2014.0083","volume":"370","author":"M Woolhouse","year":"2015","unstructured":"Woolhouse M, Ward M, van Bunnik B, Farrar J (2015) Antimicrobial resistance in humans, livestock and the wider environment. Philosophical Transactions of the Royal Society B: Biological Sciences 370(1670):20140083. https:\/\/doi.org\/10.1098\/rstb.2014.0083","journal-title":"Philosophical Transactions of the Royal Society B: Biological Sciences"},{"key":"1916_CR31","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.foodchem.2016.02.142","volume":"204","author":"Z Zhang","year":"2016","unstructured":"Zhang Z, Li X, Ding S, Jiang H, Shen J, Xia X (2016) Multiresidue analysis of sulfonamides, quinolones, and tetracyclines in animal tissues by ultra-high performance liquid chromatography\u2013tandem mass spectrometry. Food Chem 204:252\u2013262. https:\/\/doi.org\/10.1016\/j.foodchem.2016.02.142","journal-title":"Food Chem"},{"key":"1916_CR32","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.chroma.2018.03.033","volume":"1549","author":"L Zhao","year":"2018","unstructured":"Zhao L, Lucas D, Long D, Richter B, Stevens J (2018) Multi-class multi-residue analysis of veterinary drugs in meat using enhanced matrix removal lipid cleanup and liquid chromatography-tandem mass spectrometry. J Chromatogr A 1549:14\u201324. https:\/\/doi.org\/10.1016\/j.chroma.2018.03.033","journal-title":"J Chromatogr A"}],"container-title":["Food Analytical Methods"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12161-020-01916-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12161-020-01916-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12161-020-01916-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T14:30:22Z","timestamp":1613053822000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12161-020-01916-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,23]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["1916"],"URL":"https:\/\/doi.org\/10.1007\/s12161-020-01916-y","relation":{},"ISSN":["1936-9751","1936-976X"],"issn-type":[{"value":"1936-9751","type":"print"},{"value":"1936-976X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,23]]},"assertion":[{"value":"10 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Andreia Freitas declares that she has no conflict of interest. Ana Sofia Vila Pouca declares that she has no conflict of interest. Daniela Magalh\u00e3es declares that she has no conflict of interest. Carlota Gamboa-Cruz declares that she has no conflict of interest. S\u00edlvia Barros declares that she has no conflict of interest. Jorge Barbosa declares that he has no conflict of interest. Fernando Ramos declares that he has no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}