{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:51:39Z","timestamp":1760161899910},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Pharm Innov"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s12247-020-09478-6","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T02:02:59Z","timestamp":1600912979000},"page":"60-70","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Influence of the Glidant on Diluent Flow Characterization Using Shear Cell Method"],"prefix":"10.1007","volume":"17","author":[{"given":"Paulo Jos\u00e9","family":"Sal\u00fastio","sequence":"first","affiliation":[]},{"given":"Mafalda","family":"Machado","sequence":"additional","affiliation":[]},{"given":"Telmo","family":"Nunes","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 Paulo","family":"Sousa e Silva","sequence":"additional","affiliation":[]},{"given":"Paulo Cardoso","family":"Costa","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"key":"9478_CR1","unstructured":"Von Behren DA. Physical characterization of excipients in practice. Pharm Technol. 1996;06:87\u20139."},{"key":"9478_CR2","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1002\/jps.20172","volume":"93","author":"S Jonat","year":"2004","unstructured":"Jonat S, Hasenzahl S, Gray A, Schmidt PC. Mechanism of glidants: investigation of the effect of different colloidal silicon dioxide types on powder flow by atomic force and scanning electron microscopy. J Pharm Sci. 2004;93:2635\u201344.","journal-title":"J Pharm Sci"},{"key":"9478_CR3","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3390\/lubricants2010021","volume":"2","author":"J Li","year":"2014","unstructured":"Li J, Wu Y. Lubricants in pharmaceutical solid dosage forms. Lubricants. 2014;2:21\u201343.","journal-title":"Lubricants."},{"key":"9478_CR4","volume-title":"Handbook of pharmaceutical excipients","author":"RC Rowe","year":"2009","unstructured":"Rowe RC, Sheskey PJ, Weller PJ. Handbook of pharmaceutical excipients. 6th ed. London: Pharmaceutical Press; 2009.","edition":"6"},{"key":"9478_CR5","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1111\/j.2042-7158.1966.tb07903.x","volume":"18","author":"TM Jones","year":"1966","unstructured":"Jones TM, Pilpel N. The flow of granular magnesia. J Pharm Pharmacol. 1966;18:429\u201342.","journal-title":"J Pharm Pharmacol"},{"key":"9478_CR6","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1002\/jps.2600570429","volume":"57","author":"G Gold","year":"1968","unstructured":"Gold G, Duvall RN, Palermo BT, Slater JG. Powder flow studies. 3. Factors affecting the flow of lactose granules. J Pharm Sci. 1968;57:667\u201371.","journal-title":"J Pharm Sci"},{"key":"9478_CR7","doi-asserted-by":"crossref","unstructured":"Salustio PJ, Machado M, Nunes T. Sousa e Silva JP, Costa PC. Lactose monohydrate flow characterization using shear cell method. Pharm Dev Technol. 2020;25(6):686\u201393.","DOI":"10.1080\/10837450.2020.1731531"},{"key":"9478_CR8","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1080\/10837450.2019.1688348","volume":"25","author":"PJ Salustio","year":"2020","unstructured":"Salustio PJ, Inacio C, Nunes T, Sousa e Silva JP, Costa PC. Flow characterization of a pharmaceutical excipient using the shear cell method. Pharm Dev Technol. 2020;25:237\u201344.","journal-title":"Pharm Dev Technol"},{"key":"9478_CR9","unstructured":"Schulze D. Flow properties of bulk solids. In: Schulze D, editor. Powders and bulk solids: Behavior, characterization, storage and flow. Berlin, Heidelberg, New York, Tokyo: Springer; 2008. p. 35\u201374."},{"key":"9478_CR10","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1208\/s12249-010-9397-9","volume":"11","author":"K Seppala","year":"2010","unstructured":"Seppala K, Heinamaki J, Hatara J, Seppala L, Yliruusi J. Development of a new method to get a reliable powder flow characteristics using only 1 to 2 g of powder. AAPS PharmSciTech. 2010;11:402\u20138.","journal-title":"AAPS PharmSciTech"},{"key":"9478_CR11","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.ijpharm.2014.07.040","volume":"473","author":"T Horio","year":"2014","unstructured":"Horio T, Yasuda M, Matsusaka S. Effect of particle shape on powder flowability of microcrystalline cellulose as determined using the vibration shear tube method. Int J Pharm. 2014;473:572\u20138.","journal-title":"Int J Pharm"},{"key":"9478_CR12","doi-asserted-by":"publisher","first-page":"3804","DOI":"10.1002\/jps.24600","volume":"104","author":"PD Jager","year":"2015","unstructured":"Jager PD, Bramante T, Luner PE. Assessment of pharmaceutical powder flowability using shear cell-based methods and application of Jenike\u2019s methodology. J Pharm Sci. 2015;104:3804\u201313.","journal-title":"J Pharm Sci"},{"key":"9478_CR13","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1208\/s12249-008-9046-8","volume":"9","author":"RB Shah","year":"2008","unstructured":"Shah RB, Tawakkul MA, Khan MA. Comparative evaluation of flow for pharmaceutical powders and granules. AAPS PharmSciTech. 2008;9:250\u20138.","journal-title":"AAPS PharmSciTech"},{"key":"9478_CR14","unstructured":"2.9.16. Flowability. In: European Pharmacopoeia 9, EDQM Council of Europe (Ed.); 2017."},{"key":"9478_CR15","unstructured":"2.9.34 Bulk density and tapped density of powders. In: European Pharmacopoeia 9, EDQM Council of Europe (Ed.); 2017."},{"key":"9478_CR16","unstructured":"2.9.36. Powder flow. In: European Pharmacopoeia 9, EDQM Council of Europe (Ed.); 2017."},{"key":"9478_CR17","unstructured":"2.9.49. Powder flow properties by shear cell methods. In: European Pharmacopoeia 10, EDQM Council of Europe (Ed.); 2020"},{"key":"9478_CR18","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.powtec.2011.05.024","volume":"212","author":"LA Shi","year":"2011","unstructured":"Shi LA, Chattoraj S, Sun CC. Reproducibility of flow properties of microcrystalline cellulose - Avicel PH102. Powder Technol. 2011;212:253\u20137.","journal-title":"Powder Technol"},{"key":"9478_CR19","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.3109\/03639045.2012.728228","volume":"39","author":"M Kuentz","year":"2013","unstructured":"Kuentz M, Schirg P. Powder flow in an automated uniaxial tester and an annular shear cell: a study of pharmaceutical excipients and analytical data comparison. Drug Dev Ind Pharm. 2013;39:1476\u201383.","journal-title":"Drug Dev Ind Pharm"},{"key":"9478_CR20","unstructured":"2.9.35. Powder fineness. In: European Pharmacopoeia 9, EDQM Council of Europe (Ed.); 2017"},{"key":"9478_CR21","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1002\/jps.21885","volume":"99","author":"Q Zhou","year":"2010","unstructured":"Zhou Q, Armstrong B, Larson L, Stewart PJ, Morton DA. Improving powder flow properties of a cohesive lactose monohydrate powder by intensive mechanical dry coating. J Pharm Sci. 2010;99:969\u201381.","journal-title":"J Pharm Sci"},{"key":"9478_CR22","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.ijpharm.2006.12.024","volume":"336","author":"AM Faqih","year":"2007","unstructured":"Faqih AM, Mehrotra A, Hammond SV, Muzzio FJ. Effect of moisture and magnesium stearate concentration on flow properties of cohesive granular materials. Int J Pharm. 2007;336:338\u201345.","journal-title":"Int J Pharm"},{"key":"9478_CR23","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.proeng.2015.01.112","volume":"102","author":"C Modugno","year":"2015","unstructured":"Modugno C, Paterson AHJ, McLeod J. Lactose caking: influence of the particle size distribution and the water content. Procedia Eng. 2015;102:114\u201322.","journal-title":"Procedia Eng"},{"key":"9478_CR24","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1208\/s12249-013-0036-0","volume":"15","author":"A Crouter","year":"2014","unstructured":"Crouter A, Briens L. The effect of moisture on the flowability of pharmaceutical excipients. AAPS PharmSciTech. 2014;15:65\u201374.","journal-title":"AAPS PharmSciTech"},{"key":"9478_CR25","doi-asserted-by":"publisher","first-page":"4030","DOI":"10.1002\/jps.21288","volume":"97","author":"H Hou","year":"2008","unstructured":"Hou H, Sun CC. Quantifying effects of particulate properties on powder flow properties using a ring shear tester. J Pharm Sci. 2008;97:4030\u20139.","journal-title":"J Pharm Sci"},{"key":"9478_CR26","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0378-5173(99)00243-4","volume":"189","author":"E Guerin","year":"1999","unstructured":"Guerin E, Tchoreloff P, Leclerc B, Tanguy D, Deleuil M, Couarraze G. Rheological characterization of pharmaceutical powders using tap testing, shear cell and mercury porosimeter. Int J Pharm. 1999;189:91\u2013103.","journal-title":"Int J Pharm"},{"key":"9478_CR27","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.proeng.2015.01.132","volume":"102","author":"HY Saw","year":"2015","unstructured":"Saw HY, Davies CE, Paterson AHJ, Jones JR. Correlation between powder flow properties measured by shear testing and Hausner ratio. Procedia Eng. 2015;102:218\u201325.","journal-title":"Procedia Eng"},{"key":"9478_CR28","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.powtec.2016.02.027","volume":"294","author":"YF Wang","year":"2016","unstructured":"Wang YF, Koynov S, Glasser BJ, Muzzio FJ. A method to analyze shear cell data of powders measured under different initial consolidation stresses. Powder Technol. 2016;294:105\u201312.","journal-title":"Powder Technol"},{"key":"9478_CR29","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1016\/j.xphs.2017.04.012","volume":"106","author":"LY Leung","year":"2017","unstructured":"Leung LY, Mao C, Srivastava I, Du P, Yang CY. Flow function of pharmaceutical powders is predominantly governed by cohesion, not by friction coefficients. J Pharm Sci. 2017;106:1865\u201373.","journal-title":"J Pharm Sci"},{"key":"9478_CR30","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.powtec.2012.02.015","volume":"224","author":"G Lumay","year":"2012","unstructured":"Lumay G, Boschini F, Traina K, Bontempi S, Remy JC, Cloots R, et al. Measuring the flowing properties of powders and grains. Powder Technol. 2012;224:19\u201327.","journal-title":"Powder Technol"}],"container-title":["Journal of Pharmaceutical Innovation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12247-020-09478-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12247-020-09478-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12247-020-09478-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T08:24:42Z","timestamp":1648023882000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12247-020-09478-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,24]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["9478"],"URL":"https:\/\/doi.org\/10.1007\/s12247-020-09478-6","relation":{},"ISSN":["1872-5120","1939-8042"],"issn-type":[{"value":"1872-5120","type":"print"},{"value":"1939-8042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,24]]},"assertion":[{"value":"24 September 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest"}}]}}