{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:57:39Z","timestamp":1776473859492,"version":"3.51.2"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,5,10]],"date-time":"2012-05-10T00:00:00Z","timestamp":1336608000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathol. Oncol. Res."],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1007\/s12253-012-9530-z","type":"journal-article","created":{"date-parts":[[2012,5,9]],"date-time":"2012-05-09T12:57:49Z","timestamp":1336568269000},"page":"111-117","source":"Crossref","is-referenced-by-count":50,"title":["Analysis of Clinicopathologic Characteristics and Prognosis of Gastric Cancer in Young and Older Patients"],"prefix":"10.1007","volume":"19","author":[{"given":"Amelia","family":"Tavares","sequence":"first","affiliation":[]},{"given":"Antonio","family":"Gandra","sequence":"additional","affiliation":[]},{"given":"Fernando","family":"Viveiros","sequence":"additional","affiliation":[]},{"given":"Cassilda","family":"Cidade","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Maciel","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2012,5,10]]},"reference":[{"key":"9530_CR1","doi-asserted-by":"crossref","first-page":"6329","DOI":"10.1038\/sj.onc.1207726","volume":"23","author":"DM Parkin","year":"2004","unstructured":"Parkin DM (2004) International variation. Oncogene 23:6329\u20136340","journal-title":"Oncogene"},{"key":"9530_CR2","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/S0959-8049(01)00267-2","volume":"37","author":"DM Parkin","year":"2001","unstructured":"Parkin DM, Bray FI, Devesa SS (2001) Cancer burden in the year 2000, the global picture. Eur J Cancer 37:S4\u2013S66","journal-title":"Eur J Cancer"},{"key":"9530_CR3","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1136\/bmj.302.6788.1302","volume":"302","author":"D Forman","year":"1991","unstructured":"Forman D, Newell DG, Fullerton F, Yarnell JW, Stacey AR, Wald N, Sitas F (1991) Association between infection with Helicobacter Pylori and risk of gastric cancer: evidence from a prospective investigation. BMJ 302:1302\u20131305","journal-title":"BMJ"},{"key":"9530_CR4","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1056\/NEJM199110173251603","volume":"325","author":"J Parsonnet","year":"1991","unstructured":"Parsonnet J, Friedman GD, Vandersteen DP, Chang Y, Vogelman JH, Orentreich N, Sibley RK (1991) Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 325:1127\u20131131","journal-title":"N Engl J Med"},{"key":"9530_CR5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2174\/156652407779940503","volume":"7","author":"AN Milne","year":"2007","unstructured":"Milne AN, Sitarz R, Carvalho R, Carneiro F, Offerhaus GJ (2007) Early onset gastric cancer: on the road to unraveling gastric carcinogenesis. Curr Mol Med 7:15\u201328","journal-title":"Curr Mol Med"},{"key":"9530_CR6","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/35006081","volume":"404","author":"EM El-Omar","year":"2000","unstructured":"El-Omar EM, Carrington M, Chow WH, McColl KE, Bream JH, Young HA, Herrera J, Lissowska J, Yuan CC, Rothman N, Lanyon G, Martin M, Fraumeni JF Jr, Rabkin CS (2000) Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 404:398\u2013402","journal-title":"Nature"},{"issue":"2","key":"9530_CR7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4251\/wjgo.v2.i2.59","volume":"2","author":"AN Milne","year":"2010","unstructured":"Milne AN, Offerhaus GJA (2010) Early-onset gastric cancer: Learning lessons from the young. World J Gastrointest Oncol 2(2):59\u201364","journal-title":"World J Gastrointest Oncol"},{"key":"9530_CR8","first-page":"1941s","volume":"54","author":"P Correa","year":"1994","unstructured":"Correa P, Shiao YH (1994) Phenotypic and genotypic events in gastric carcinogenesis. Cancer Res 54:1941s\u20131943s","journal-title":"Cancer Res"},{"key":"9530_CR9","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1002\/(SICI)1097-0142(19960501)77:9<1774::AID-CNCR3>3.0.CO;2-C","volume":"77","author":"Y Maehara","year":"1996","unstructured":"Maehara Y, Emi Y, Tomisaki S, Oshiro T, Kakeji Y, Ichiyoshi Y, Sugimachi K (1996) Age-related characteristics of gastric carcinoma in young and elderly patients. Cancer 77:1774\u20131780","journal-title":"Cancer"},{"key":"9530_CR10","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0002-9610(96)00223-1","volume":"172","author":"CP Theuer","year":"1996","unstructured":"Theuer CP, de Virgilio C, Keese G, French S, Arnell T, Tolmos J, Klein S, Powers W, Oh T, Stabile BE (1996) Gastric adenocarcinoma in patients 40\u00a0years of age or younger. Am J Surg 172:473\u2013476","journal-title":"Am J Surg"},{"key":"9530_CR11","unstructured":"Hamilton SR, Aaltonen LA. World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of the Digestive System. Lyon, France: IARC Press, 2000: 204"},{"key":"9530_CR12","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.gassur.2003.12.009","volume":"8","author":"A Ramos De la Medina","year":"2004","unstructured":"Ramos De la Medina A, Salgado-Nesme N, Torres-Villalobos G, Medina-Franco H (2004) Clinicopathologic characteristics of gastric cancer in a young patient population. J Gastrointest Surg 8:240\u2013244","journal-title":"J Gastrointest Surg"},{"key":"9530_CR13","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s10434-000-0515-x","volume":"7","author":"H Medina-Franco","year":"2000","unstructured":"Medina-Franco H, Heslin MJ, Cortes-Gonzalez R (2000) Clinicopathological characteristics of gastric carcinoma in young and elderly patients: a comparative study. Ann Surg Oncol 7:515\u2013519","journal-title":"Ann Surg Oncol"},{"key":"9530_CR14","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/00000658-198811000-00008","volume":"208","author":"PJ Matley","year":"1988","unstructured":"Matley PJ, Dent DM, Madden MV, Price SK (1988) Gastric carcinoma in young adults. Ann Surg 208:593\u2013596","journal-title":"Ann Surg"},{"key":"9530_CR15","first-page":"1552","volume":"48","author":"A Kokkola","year":"2001","unstructured":"Kokkola A, Sipponen P (2001) Gastric carcinoma in young adults. Hepatogastroenterology 48:1552\u20131555","journal-title":"Hepatogastroenterology"},{"key":"9530_CR16","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1046\/j.1365-2559.2003.01546.x","volume":"42","author":"S Lim","year":"2003","unstructured":"Lim S, Lee HS, Kim HS, Kim YI, Kim WH (2003) Alteration of E-cadherin-mediated adhesion protein is common, but microsatellite instability is uncommon in young age gastric cancers. Histopathology 42:128\u2013136","journal-title":"Histopathology"},{"key":"9530_CR17","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/jso.2930580310","volume":"58","author":"M Maeta","year":"1995","unstructured":"Maeta M, Yamashiro H, Oka A, Tsujitani S, Ikeguchi M, Kaibara N (1995) Gastric cancer in the young, with special reference to 14 pregnancy-associated cases: analysis based on 2,325 consecutive cases of gastric cancer. J Surg Oncol 58:191\u2013195","journal-title":"J Surg Oncol"},{"key":"9530_CR18","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/gut.2008.161331","volume":"58","author":"MH Derakhshan","year":"2009","unstructured":"Derakhshan MH, Liptrot S, Paul J, Brown IL, Morrison D, McColl KE (2009) Oesophageal and gastric intestinal-type adenocarcinomas show the same male predominance due to a 17\u00a0year delayed development in females. Gut 58:16\u201323","journal-title":"Gut"},{"key":"9530_CR19","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1159\/000129044","volume":"21","author":"H Furukawa","year":"1989","unstructured":"Furukawa H, Iwanaga T, Imaoka S, Hiratsuka M, Fukuda I, Kabuto T, Ishikawa O, Sasaki Y (1989) Multifocal gastric cancer in patients younger than 50\u00a0years of age. Eur Surg Res 21:313\u2013318","journal-title":"Eur Surg Res"},{"key":"9530_CR20","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/hmg\/ddg048","volume":"12","author":"G Suriano","year":"2003","unstructured":"Suriano G, Oliveira C, Ferreira P, Machado JC, Bordin MC, De Wever O, Bruyneel EA, Moguilevsky N, Grehan N, Porter TR, Richards FM, Hruban RH, Roviello F, Huntsman D, Mareel M, Carneiro F, Caldas C, Seruca R (2003) Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands. Hum Mol Genet 12:575\u2013582","journal-title":"Hum Mol Genet"},{"key":"9530_CR21","doi-asserted-by":"crossref","first-page":"5401","DOI":"10.1158\/1078-0432.CCR-05-0247","volume":"11","author":"G Suriano","year":"2005","unstructured":"Suriano G, Yew S, Ferreira P, Senz J, Kaurah P, Ford JM, Longacre TA, Norton JA, Chun N, Young S, Oliveira MJ, Macgillivray B, Rao A, Sears D, Jackson CE, Boyd J, Yee C, Deters C, Pai GS, Hammond LS, McGivern BJ, Medgyesy D, Sartz D, Arun B, Oelschlager BK, Upton MP, Neufeld-Kaiser W, Silva OE, Donenberg TR, Kooby DA, Sharma S, Jonsson BA, Gronberg H, Gallinger S, Seruca R, Lynch H, Huntsman DG (2005) Characterization of a recurrent germ line mutation of the E-cadherin gene: implications for genetic testing and clinical management. Clin Cancer Res 11:5401\u20135409","journal-title":"Clin Cancer Res"},{"key":"9530_CR22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1136\/jcp.2006.043679","volume":"61","author":"F Carneiro","year":"2008","unstructured":"Carneiro F, Oliveira C, Suriano G, Seruca R (2008) Molecular pathology of familial gastric cancer, with an emphasis on hereditary diffuse gastric cancer. J Clin Pathol 61:25\u201330","journal-title":"J Clin Pathol"},{"issue":"4","key":"9530_CR23","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s10147-011-0185-7","volume":"16","author":"R Nakamura","year":"2011","unstructured":"Nakamura R, Saikawa Y, Takahashi T, Takeuchi H, Asanuma H, Yamada Y, Kitagawa Y (2011) Retrospective analysis of prognostic outcome of gastric cancer in young patients. Int J Clin Oncol 16(4):328\u2013334","journal-title":"Int J Clin Oncol"},{"issue":"3","key":"9530_CR24","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.gassur.2003.12.009","volume":"8","author":"A Ramos-De la Medina","year":"2004","unstructured":"Ramos-De la Medina A, Salgado-Nesme N et al (2004) Clinicopathologic characteristics of gastric cancer in a young patient population. J Gastrointest Surg 8(3):240\u2013244","journal-title":"J Gastrointest Surg"},{"issue":"5","key":"9530_CR25","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/s10434-000-0346-9","volume":"7","author":"JB Koea","year":"2000","unstructured":"Koea JB, Karpeh MS, Brennan MF (2000) Gastric cancer in young patients: demographic, clinicopathological, and prognostic factors in 92 patients. Ann Surg Oncol 7(5):346\u2013351","journal-title":"Ann Surg Oncol"},{"key":"9530_CR26","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1111\/j.1440-1746.2004.03369.x","volume":"19","author":"T Hiyama","year":"2004","unstructured":"Hiyama T, Tanaka S, Yoshihara M, Sasao S, Kose K, Shima H, Tuncel H, Ueno Y, Ito M, Kitadai Y, Yasui W, Haruma K, Chayama K (2004) Chromosomal and microsatellite instability in sporadic gastric cancer. J Gastroenterol Hepatol 19:756\u2013760","journal-title":"J Gastroenterol Hepatol"},{"key":"9530_CR27","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s10120-004-0300-9","volume":"7","author":"M Wu","year":"2004","unstructured":"Wu M, Semba S, Oue N, Ikehara N, Yasui W, Yokozaki H (2004) BRAF\/K-ras mutation, microsatellite instability, and promoter hypermethylation of hMLH1\/MGMT in human gastric carcinomas. Gastric Cancer 7:246\u2013253","journal-title":"Gastric Cancer"},{"issue":"1","key":"9530_CR28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/modpathol.3800714","volume":"20","author":"M Hirahashi","year":"2007","unstructured":"Hirahashi M, Yao T, Matsumoto T, Nishiyama K, Oya M, Iida M, Tsuneyoshi M (2007) Intramucosal gastric adenocarcinoma of poorly differentiated type in the young is characterized by Helicobacter pylori infection and antral lymphoid hyperplasia. Mod Pathol 20(1):29\u201334","journal-title":"Mod Pathol"},{"issue":"2","key":"9530_CR29","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3748\/wjg.v16.i2.256","volume":"16","author":"HW Chung","year":"2010","unstructured":"Chung HW, Noh SH, Lim JB (2010) Analysis of demographic characteristics in 3242 young age gastric cancer patients in Korea. World J Gastroenterol 16(2):256\u2013263","journal-title":"World J Gastroenterol"},{"issue":"6","key":"9530_CR30","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1001\/archsurg.2009.77","volume":"144","author":"BR Smith","year":"2009","unstructured":"Smith BR, Stabile BE (2009) Extreme aggressiveness and lethality of gastric adenocarcinoma in the very young. Arch Surg 144(6):506\u2013510","journal-title":"Arch Surg"},{"issue":"6","key":"9530_CR31","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/bjs.5600","volume":"94","author":"R Santoro","year":"2007","unstructured":"Santoro R, Carboni F, Lepiane P, Ettorre GM, Santoro E (2007) Clinicopathological features and prognosis of gastric cancer in young European adults. Br J Surg 94(6):737\u2013742","journal-title":"Br J Surg"},{"issue":"5","key":"9530_CR32","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1245\/s10434-008-9809-1","volume":"15","author":"JF Lai","year":"2008","unstructured":"Lai JF, Kim S, Li C, Oh SJ, Hyung WJ, Choi WH, Choi SH, Wang LB, Noh SH (2008) Clinicopathologic characteristics and prognosis for young gastric adenocarcinoma patients after curative resection. Ann Surg Oncol 15(5):1464\u20131469","journal-title":"Ann Surg Oncol"}],"container-title":["Pathology &amp; Oncology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-012-9530-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12253-012-9530-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-012-9530-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T08:49:47Z","timestamp":1561711787000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12253-012-9530-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,10]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["9530"],"URL":"https:\/\/doi.org\/10.1007\/s12253-012-9530-z","relation":{},"ISSN":["1219-4956","1532-2807"],"issn-type":[{"value":"1219-4956","type":"print"},{"value":"1532-2807","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,10]]}}}