{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:31:15Z","timestamp":1740126675469,"version":"3.37.3"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:00:00Z","timestamp":1520985600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT), PortugaL","award":["UID\/BIM\/00009\/2013"],"award-info":[{"award-number":["UID\/BIM\/00009\/2013"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pathol. Oncol. Res."],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1007\/s12253-018-0411-y","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T12:35:16Z","timestamp":1521030916000},"page":"961-969","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Role of Caspase Genes Polymorphisms in Genetic Susceptibility to Philadelphia-Negative Myeloproliferative Neoplasms in a Portuguese Population"],"prefix":"10.1007","volume":"25","author":[{"given":"Ana P.","family":"Azevedo","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9122-0732","authenticated-orcid":false,"given":"Susana N.","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Alice","family":"Reichert","sequence":"additional","affiliation":[]},{"given":"Fernando","family":"Lima","sequence":"additional","affiliation":[]},{"given":"Esmeraldina","family":"J\u00fanior","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Rueff","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,3,14]]},"reference":[{"key":"411_CR1","volume-title":"WHO classification of Tumours of Haematopoieticand lymphoid tissues., 4 edition (October 27, 2008) ed.","author":"CESH Swerdlow","year":"2008","unstructured":"Swerdlow CESH, Harris NL et al (2008) WHO classification of Tumours of Haematopoieticand lymphoid tissues., 4 edition (October 27, 2008) ed. World Health Organization, Lyon"},{"key":"411_CR2","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1182\/blood-2016-03-643544","volume":"127","author":"DA Arber","year":"2016","unstructured":"Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, Bloomfield CD, Cazzola M, Vardiman JW (2016) The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 127:2391\u20132405","journal-title":"Blood"},{"key":"411_CR3","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1038\/nature03546","volume":"434","author":"C James","year":"2005","unstructured":"James C, Ugo V, Le Cou\u00e9dic JP, Staerk J, Delhommeau F, Lacout C, Gar\u00e7on L, Raslova H, Berger R, Bennaceur-Griscelli A, Villeval JL, Constantinescu SN, Casadevall N, Vainchenker W (2005) A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 434:1144\u20131148","journal-title":"Nature"},{"key":"411_CR4","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1056\/NEJMoa051113","volume":"352","author":"R Kralovics","year":"2005","unstructured":"Kralovics R, Passamonti F, Buser AS, Teo SS, Tiedt R, Passweg JR, Tichelli A, Cazzola M, Skoda RC (2005) A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med 352:1779\u20131790","journal-title":"N Engl J Med"},{"key":"411_CR5","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.ccr.2005.03.023","volume":"7","author":"RL Levine","year":"2005","unstructured":"Levine RL, Wadleigh M, Cools J, Ebert BL, Wernig G, Huntly BJ, Boggon TJ, Wlodarska I, Clark JJ, Moore S, Adelsperger J, Koo S, Lee JC, Gabriel S, Mercher T, D'Andrea A, Fr\u00f6hling S, D\u00f6hner K, Marynen P, Vandenberghe P, Mesa RA, Tefferi A, Griffin JD, Eck MJ, Sellers WR, Meyerson M, Golub TR, Lee SJ, Gilliland DG (2005) Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 7:387\u2013397","journal-title":"Cancer Cell"},{"key":"411_CR6","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/S0140-6736(05)71142-9","volume":"365","author":"EJ Baxter","year":"2005","unstructured":"Baxter EJ, Scott LM, Campbell PJ, East C, Fourouclas N, Swanton S, Vassiliou GS, Bench AJ, Boyd EM, Curtin N, Scott MA, Erber WN, Green AR, Project CG (2005) Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 365:1054\u20131061","journal-title":"Lancet"},{"key":"411_CR7","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1056\/NEJMoa065202","volume":"356","author":"LM Scott","year":"2007","unstructured":"Scott LM, Tong W, Levine RL, Scott MA, Beer PA, Stratton MR, Futreal PA, Erber WN, McMullin MF, Harrison CN, Warren AJ, Gilliland DG, Lodish HF, Green AR (2007) JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. N Engl J Med 356:459\u2013468","journal-title":"N Engl J Med"},{"key":"411_CR8","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1590\/S1679-45082013000400025","volume":"11","author":"R Tognon","year":"2013","unstructured":"Tognon R, Nunes NeS, Castro FA (2013) Apoptosis deregulation in myeloproliferative neoplasms. Einstein (Sao Paulo) 11:540\u2013544","journal-title":"Einstein (Sao Paulo)"},{"key":"411_CR9","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1001\/jamaoncol.2015.89","volume":"1","author":"A Tefferi","year":"2015","unstructured":"Tefferi A, Pardanani A (2015) Myeloproliferative neoplasms: a contemporary review. JAMA Oncol 1:97\u2013105","journal-title":"JAMA Oncol"},{"key":"411_CR10","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1056\/NEJMoa1312542","volume":"369","author":"J Nangalia","year":"2013","unstructured":"Nangalia J, Massie CE, Baxter EJ, Nice FL, Gundem G, Wedge DC, Avezov E, Li J, Kollmann K, Kent DG, Aziz A, Godfrey AL, Hinton J, Martincorena I, Van Loo P, Jones AV, Guglielmelli P, Tarpey P, Harding HP, Fitzpatrick JD, Goudie CT, Ortmann CA, Loughran SJ, Raine K, Jones DR, Butler AP, Teague JW, O'Meara S, McLaren S, Bianchi M, Silber Y, Dimitropoulou D, Bloxham D, Mudie L, Maddison M, Robinson B, Keohane C, Maclean C, Hill K, Orchard K, Tauro S, Du MQ, Greaves M, Bowen D, Huntly BJ, Harrison CN, Cross NC, Ron D, Vannucchi AM, Papaemmanuil E, Campbell PJ, Green AR (2013) Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med 369:2391\u20132405","journal-title":"N Engl J Med"},{"key":"411_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4939-3347-1_1","volume":"1395","author":"J Rueff","year":"2016","unstructured":"Rueff J, Rodrigues AS (2016) Cancer drug resistance: a brief overview from a genetic viewpoint. Methods Mol Biol 1395:1\u201318","journal-title":"Methods Mol Biol"},{"key":"411_CR12","doi-asserted-by":"publisher","first-page":"e40","DOI":"10.1038\/bcj.2011.39","volume":"1","author":"KL Rice","year":"2011","unstructured":"Rice KL, Lin X, Wolniak K, Ebert BL, Berkofsky-Fessler W, Buzzai M, Sun Y, Xi C, Elkin P, Levine R, Golub T, Gilliland DG, Crispino JD, Licht JD, Zhang W (2011) Analysis of genomic aberrations and gene expression profiling identifies novel lesions and pathways in myeloproliferative neoplasms. Blood Cancer J 1:e40","journal-title":"Blood Cancer J"},{"key":"411_CR13","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.bcp.2005.12.017","volume":"71","author":"L Valentino","year":"2006","unstructured":"Valentino L, Pierre J (2006) JAK\/STAT signal transduction: regulators and implication in hematological malignancies. Biochem Pharmacol 71:713\u2013721","journal-title":"Biochem Pharmacol"},{"key":"411_CR14","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1016\/j.leukres.2006.01.016","volume":"30","author":"P Bolufer","year":"2006","unstructured":"Bolufer P, Barragan E, Collado M, Cervera J, L\u00f3pez JA, Sanz MA (2006) Influence of genetic polymorphisms on the risk of developing leukemia and on disease progression. Leuk Res 30:1471\u20131491","journal-title":"Leuk Res"},{"key":"411_CR15","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s12185-010-0530-z","volume":"91","author":"F Delhommeau","year":"2010","unstructured":"Delhommeau F, Jeziorowska D, Marzac C, Casadevall N (2010) Molecular aspects of myeloproliferative neoplasms. Int J Hematol 91:165\u2013173","journal-title":"Int J Hematol"},{"key":"411_CR16","doi-asserted-by":"publisher","first-page":"2891","DOI":"10.1182\/blood-2009-08-236596","volume":"115","author":"PA Beer","year":"2010","unstructured":"Beer PA, Delhommeau F, LeCou\u00e9dic JP, Dawson MA, Chen E, Bareford D, Kusec R, McMullin MF, Harrison CN, Vannucchi AM, Vainchenker W, Green AR (2010) Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm. Blood 115:2891\u20132900","journal-title":"Blood"},{"key":"411_CR17","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1038\/leu.2008.229","volume":"22","author":"O Kilpivaara","year":"2008","unstructured":"Kilpivaara O, Levine RL (2008) JAK2 and MPL mutations in myeloproliferative neoplasms: discovery and science. Leukemia 22:1813\u20131817","journal-title":"Leukemia"},{"key":"411_CR18","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.beha.2014.07.003","volume":"27","author":"M Bj\u00f6rkholm","year":"2014","unstructured":"Bj\u00f6rkholm M, Hultcrantz M, Derolf \u00c5 (2014) Leukemic transformation in myeloproliferative neoplasms: therapy-related or unrelated? Best Pract Res Clin Haematol 27:141\u2013153","journal-title":"Best Pract Res Clin Haematol"},{"key":"411_CR19","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.beha.2009.08.006","volume":"22","author":"RL Levine","year":"2009","unstructured":"Levine RL (2009) Mechanisms of mutations in myeloproliferative neoplasms. Best Pract Res Clin Haematol 22:489\u2013494","journal-title":"Best Pract Res Clin Haematol"},{"key":"411_CR20","doi-asserted-by":"publisher","first-page":"150","DOI":"10.5581\/1516-8484.20120035","volume":"34","author":"PV Campregher","year":"2012","unstructured":"Campregher PV, Santos FP, Perini GF, Hamerschlak N (2012) Molecular biology of Philadelphia-negative myeloproliferative neoplasms. Rev Bras Hematol Hemoter 34:150\u2013155","journal-title":"Rev Bras Hematol Hemoter"},{"key":"411_CR21","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.7314\/APJCP.2015.16.6.2129","volume":"16","author":"S Goldar","year":"2015","unstructured":"Goldar S, Khaniani MS, Derakhshan SM, Baradaran B (2015) Molecular mechanisms of apoptosis and roles in cancer development and treatment. Asian Pac J Cancer Prev 16:2129\u20132144","journal-title":"Asian Pac J Cancer Prev"},{"key":"411_CR22","doi-asserted-by":"publisher","first-page":"8471","DOI":"10.1007\/s13277-016-5035-9","volume":"37","author":"Y Kiraz","year":"2016","unstructured":"Kiraz Y, Adan A, Kartal Yandim M, Baran Y (2016) Major apoptotic mechanisms and genes involved in apoptosis. Tumour Biol 37:8471\u20138486","journal-title":"Tumour Biol"},{"key":"411_CR23","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.3109\/10428194.2013.855307","volume":"55","author":"S Zaman","year":"2014","unstructured":"Zaman S, Wang R, Gandhi V (2014) Targeting the apoptosis pathway in hematologic malignancies. Leuk Lymphoma 55:1980\u20131992","journal-title":"Leuk Lymphoma"},{"key":"411_CR24","doi-asserted-by":"crossref","unstructured":"Green DR, Llambi F (2015) Cell death signaling. Cold Spring Harb Perspect Biol 7","DOI":"10.1101\/cshperspect.a006080"},{"key":"411_CR25","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.3109\/10428194.2013.767453","volume":"54","author":"NS Nunes","year":"2013","unstructured":"Nunes NS, Tognon R, Moura LG, Kashima S, Covas DT, Santana M, Souto EX, Zanichelli MA, Sim\u00f5es BP, Souza AM, Castro FA (2013) Differential expression of apoptomiRs in myeloproliferative neoplasms. Leuk Lymphoma 54:2047\u20132051","journal-title":"Leuk Lymphoma"},{"key":"411_CR26","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1136\/jcp.2010.080895","volume":"64","author":"R Tognon","year":"2011","unstructured":"Tognon R, Gasparotto EP, Leroy JM, Oliveira GL, Neves RP, Carrara ReC, Kashima S, Covas DT, Santana M, Souto EX, Zanichelli MA, Velano CE, Sim\u00f5es BP, Alberto FL, Miyashiro K, de Souza AM, Amarante-Mendes GP, de Castro FA (2011) Differential expression of apoptosis-related genes from death receptor pathway in chronic myeloproliferative diseases. J Clin Pathol 64:75\u201382","journal-title":"J Clin Pathol"},{"key":"411_CR27","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1756-8722-5-2","volume":"5","author":"R Tognon","year":"2012","unstructured":"Tognon R, Gasparotto EP, Neves RP, Nunes NS, Ferreira AF, Palma PV, Kashima S, Covas DT, Santana M, Souto EX, Zanichelli MA, Sim\u00f5es BP, de Souza AM, Castro FA (2012) Deregulation of apoptosis-related genes is associated with PRV1 overexpression and JAK2 V617F allele burden in essential thrombocythemia and myelofibrosis. J Hematol Oncol 5:2","journal-title":"J Hematol Oncol"},{"key":"411_CR28","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.3109\/10428194.2015.1071491","volume":"57","author":"R Tognon","year":"2016","unstructured":"Tognon R, Nunes NS, Ambrosio L, Souto EX, Perobelli L, Sim\u00f5es BP, Souza MC, Chauffaille MeL, Atti\u00e9 de Castro F (2016) Apoptosis- and cell cycle-related genes methylation profile in myeloproliferative neoplasms. Leuk Lymphoma 57:1201\u20131204","journal-title":"Leuk Lymphoma"},{"key":"411_CR29","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1038\/cdd.2011.30","volume":"18","author":"M Olsson","year":"2011","unstructured":"Olsson M, Zhivotovsky B (2011) Caspases and cancer. Cell Death Differ 18:1441\u20131449","journal-title":"Cell Death Differ"},{"key":"411_CR30","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1080\/15321819.2016.1152276","volume":"37","author":"C Mambet","year":"2016","unstructured":"Mambet C, Matei L, Necula LG, Diaconu CC (2016) A link between the driver mutations and dysregulated apoptosis in BCR-ABL1 negative myeloproliferative neoplasms. J Immunoassay Immunochem 37:331\u2013345","journal-title":"J Immunoassay Immunochem"},{"key":"411_CR31","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/sj.leu.2404955","volume":"22","author":"A Tefferi","year":"2008","unstructured":"Tefferi A, Vardiman JW (2008) Classification and diagnosis of myeloproliferative neoplasms: the 2008 World Health Organization criteria and point-of-care diagnostic algorithms. Leukemia 22:14\u201322","journal-title":"Leukemia"},{"key":"411_CR32","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/nrm2153","volume":"8","author":"SJ Riedl","year":"2007","unstructured":"Riedl SJ, Salvesen GS (2007) The apoptosome: signalling platform of cell death. Nat Rev Mol Cell Biol 8:405\u2013413","journal-title":"Nat Rev Mol Cell Biol"},{"key":"411_CR33","first-page":"24","volume":"35","author":"SG Cho","year":"2002","unstructured":"Cho SG, Choi EJ (2002) Apoptotic signaling pathways: caspases and stress-activated protein kinases. J Biochem Mol Biol 35:24\u201327","journal-title":"J Biochem Mol Biol"},{"key":"411_CR34","first-page":"82","volume":"26","author":"A Philchenkov","year":"2004","unstructured":"Philchenkov A, Zavelevich M, Kroczak TJ, Los M (2004) Caspases and cancer: mechanisms of inactivation and new treatment modalities. Exp Oncol 26:82\u201397","journal-title":"Exp Oncol"},{"key":"411_CR35","doi-asserted-by":"publisher","first-page":"10301","DOI":"10.1074\/jbc.274.15.10301","volume":"274","author":"PW Ng","year":"1999","unstructured":"Ng PW, Porter AG, J\u00e4nicke RU (1999) Molecular cloning and characterization of two novel pro-apoptotic isoforms of caspase-10. J Biol Chem 274:10301\u201310308","journal-title":"J Biol Chem"},{"key":"411_CR36","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.drup.2005.05.001","volume":"8","author":"L Oliver","year":"2005","unstructured":"Oliver L, Vallette FM (2005) The role of caspases in cell death and differentiation. Drug Resist Updat 8:163\u2013170","journal-title":"Drug Resist Updat"},{"key":"411_CR37","doi-asserted-by":"publisher","first-page":"3563","DOI":"10.2741\/3471","volume":"14","author":"E Petit","year":"2009","unstructured":"Petit E, Oliver L, Vallette FM (2009) The mitochondrial outer membrane protein import machinery: a new player in apoptosis? Front Biosci (Landmark Ed) 14:3563\u20133570","journal-title":"Front Biosci (Landmark Ed)"},{"key":"411_CR38","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1126\/science.1099320","volume":"305","author":"DR Green","year":"2004","unstructured":"Green DR, Kroemer G (2004) The pathophysiology of mitochondrial cell death. Science 305:626\u2013629","journal-title":"Science"},{"key":"411_CR39","first-page":"2922","volume":"15","author":"X Wang","year":"2001","unstructured":"Wang X (2001) The expanding role of mitochondria in apoptosis. Genes Dev 15:2922\u20132933","journal-title":"Genes Dev"},{"key":"411_CR40","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/sj.cdd.4401186","volume":"10","author":"ME Peter","year":"2003","unstructured":"Peter ME, Krammer PH (2003) The CD95(APO-1\/Fas) DISC and beyond. Cell Death Differ 10:26\u201335","journal-title":"Cell Death Differ"},{"key":"411_CR41","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1034\/j.1600-065X.2003.00048.x","volume":"193","author":"EM Creagh","year":"2003","unstructured":"Creagh EM, Conroy H, Martin SJ (2003) Caspase-activation pathways in apoptosis and immunity. Immunol Rev 193:10\u201321","journal-title":"Immunol Rev"},{"key":"411_CR42","doi-asserted-by":"publisher","first-page":"38905","DOI":"10.1074\/jbc.M004714200","volume":"275","author":"HF Ding","year":"2000","unstructured":"Ding HF, Lin YL, McGill G, Juo P, Zhu H, Blenis J, Yuan J, Fisher DE (2000) Essential role for caspase-8 in transcription-independent apoptosis triggered by p53. J Biol Chem 275:38905\u201338911","journal-title":"J Biol Chem"},{"key":"411_CR43","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1038\/sj.leu.2403383","volume":"18","author":"U Testa","year":"2004","unstructured":"Testa U (2004) Apoptotic mechanisms in the control of erythropoiesis. Leukemia 18:1176\u20131199","journal-title":"Leukemia"},{"key":"411_CR44","doi-asserted-by":"crossref","unstructured":"Malherbe JA, Fuller KA, Mirzai B, Kavanagh S, So CC, Ip HW, Guo BB, Forsyth C, Howman R, Erber WN (2016) Dysregulation of the intrinsic apoptotic pathway mediates megakaryocytic hyperplasia in myeloproliferative neoplasms. J Clin Pathol 69(11):1017-1024","DOI":"10.1136\/jclinpath-2016-203625"},{"key":"411_CR45","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1182\/blood-2009-01-198697","volume":"114","author":"Q Lan","year":"2009","unstructured":"Lan Q, Morton LM, Armstrong B, Hartge P, Menashe I, Zheng T, Purdue MP, Cerhan JR, Zhang Y, Grulich A, Cozen W, Yeager M, Holford TR, Vajdic CM, Davis S, Leaderer B, Kricker A, Schenk M, Zahm SH, Chatterjee N, Chanock SJ, Rothman N, Wang SS (2009) Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies. Blood 114:264\u2013267","journal-title":"Blood"},{"key":"411_CR46","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1158\/1055-9965.EPI-10-0581","volume":"19","author":"JL Kelly","year":"2010","unstructured":"Kelly JL, Novak AJ, Fredericksen ZS, Liebow M, Ansell SM, Dogan A, Wang AH, Witzig TE, Call TG, Kay NE, Habermann TM, Slager SL, Cerhan JR (2010) Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. Cancer Epidemiol Biomark Prev 19:2847\u20132858","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"411_CR47","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1093\/hmg\/ddl119","volume":"15","author":"JY Park","year":"2006","unstructured":"Park JY, Park JM, Jang JS, Choi JE, Kim KM, Cha SI, Kim CH, Kang YM, Lee WK, Kam S, Park RW, Kim IS, Lee JT, Jung TH (2006) Caspase 9 promoter polymorphisms and risk of primary lung cancer. Hum Mol Genet 15:1963\u20131971","journal-title":"Hum Mol Genet"},{"key":"411_CR48","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1093\/carcin\/bgs192","volume":"33","author":"J Lin","year":"2012","unstructured":"Lin J, Lu C, Stewart DJ, Gu J, Huang M, Chang DW, Lippman SM, Wu X (2012) Systematic evaluation of apoptotic pathway gene polymorphisms and lung cancer risk. Carcinogenesis 33:1699\u20131706","journal-title":"Carcinogenesis"},{"key":"411_CR49","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.cancergen.2012.08.001","volume":"205","author":"GE Theodoropoulos","year":"2012","unstructured":"Theodoropoulos GE, Michalopoulos NV, Pantou MP, Kontogianni P, Gazouli M, Karantanos T, Lymperi M, Zografos GC (2012) Caspase 9 promoter polymorphisms confer increased susceptibility to breast cancer. Cancer Genet 205:508\u2013512","journal-title":"Cancer Genet"},{"key":"411_CR50","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s10120-011-0045-1","volume":"14","author":"E Liamarkopoulos","year":"2011","unstructured":"Liamarkopoulos E, Gazouli M, Aravantinos G, Tzanakis N, Theodoropoulos G, Rizos S, Nikiteas N (2011) Caspase 8 and caspase 9 gene polymorphisms and susceptibility to gastric cancer. Gastric Cancer 14:317\u2013321","journal-title":"Gastric Cancer"},{"key":"411_CR51","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1136\/jcp.2007.054353","volume":"62","author":"AM Florena","year":"2009","unstructured":"Florena AM, Tripodo C, Di Bernardo A, Iannitto E, Guarnotta C, Porcasi R, Ingrao S, Abbadessa V, Franco V (2009) Different immunophenotypical apoptotic profiles characterise megakaryocytes of essential thrombocythaemia and primary myelofibrosis. J Clin Pathol 62:331\u2013338","journal-title":"J Clin Pathol"},{"key":"411_CR52","unstructured":"Lindholm S\u00f8rensen A, Hasselbalch HC (2015) Smoking and Philadelphia-negative chronic myeloproliferative neoplasms. Eur J Haematol 97(1):63-69"},{"key":"411_CR53","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1016\/j.leukres.2015.09.002","volume":"39","author":"HC Hasselbalch","year":"2015","unstructured":"Hasselbalch HC (2015) Smoking as a contributing factor for development of polycythemia vera and related neoplasms. Leuk Res 39:1137\u20131145","journal-title":"Leuk Res"}],"container-title":["Pathology &amp; Oncology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-018-0411-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12253-018-0411-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-018-0411-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T01:34:40Z","timestamp":1567733680000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12253-018-0411-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,14]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["411"],"URL":"https:\/\/doi.org\/10.1007\/s12253-018-0411-y","relation":{},"ISSN":["1219-4956","1532-2807"],"issn-type":[{"type":"print","value":"1219-4956"},{"type":"electronic","value":"1532-2807"}],"subject":[],"published":{"date-parts":[[2018,3,14]]},"assertion":[{"value":"31 March 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors claim no competing financial or intellectual conflicts of interest in the preparation and submission of this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}