{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:02:50Z","timestamp":1777399370536,"version":"3.51.4"},"reference-count":103,"publisher":"Tsinghua University Press","issue":"9","license":[{"start":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T00:00:00Z","timestamp":1524700800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nano Res."],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1007\/s12274-018-2071-3","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T12:37:26Z","timestamp":1524746246000},"page":"4489-4506","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Engineering nanoparticles for targeting rheumatoid arthritis: Past, present, and future trends"],"prefix":"10.26599","volume":"11","author":[{"given":"Isabel Matos","family":"Oliveira","sequence":"first","affiliation":[]},{"given":"Cristiana","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"Rui Lu\u00eds","family":"Reis","sequence":"additional","affiliation":[]},{"given":"Joaquim Miguel","family":"Oliveira","sequence":"additional","affiliation":[]}],"member":"11138","published-online":{"date-parts":[[2018,4,26]]},"reference":[{"key":"2071_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2147\/nano.2007.2.1.3","volume":"2","author":"T. Barnes","year":"2007","unstructured":"Barnes, T.; Moots, R. Targeting nanomedicines in the treatment of rheumatoid arthritis: Focus on certolizumab pegol. Int. J. Nanomedicine\n                           2007, 2, 3\u20137.","journal-title":"Int. J. Nanomedicine"},{"key":"2071_CR2","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/mt.2008.220","volume":"17","author":"K. A. Howard","year":"2009","unstructured":"Howard, K. A.; Paludan, S. R.; Behlke, M. A.; Besenbacher, F.; Deleuran, B.; Kjems, J. Chitosan\/siRNA nanoparticle-mediated TNF-\u03b1 knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model. Mol. Ther.\n                           2009, 17, 162\u2013168.","journal-title":"Mol. Ther."},{"key":"2071_CR3","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/scrt337","volume":"4","author":"H. Markides","year":"2013","unstructured":"Markides, H.; Kehoe, O.; Morris, R. H.; El Haj, A. J. Whole body tracking of superparamagnetic iron oxide nanoparticle-labelled cells\u2014A rheumatoid arthritis mouse model. Stem Cell Res. Ther.\n                           2013, 4, 126.","journal-title":"Stem Cell Res. Ther."},{"key":"2071_CR4","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1124\/jpet.108.150276","volume":"329","author":"T. Ishihara","year":"2009","unstructured":"Ishihara, T.; Kubota, T.; Choi, T.; Higaki, M. Treatment of experimental arthritis with stealth-type polymeric nanoparticles encapsulating betamethasone phosphate. J. Pharmacol. Exp. Ther.\n                           2009, 329, 412\u2013417.","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2071_CR5","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/nri2094","volume":"7","author":"I. B. McInnes","year":"2007","unstructured":"McInnes, I. B.; Schett, G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat. Rev. Immunol.\n                           2007, 7, 429\u2013442.","journal-title":"Nat. Rev. Immunol."},{"key":"2071_CR6","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.autrev.2011.04.020","volume":"10","author":"A. Marrelli","year":"2011","unstructured":"Marrelli, A.; Cipriani, P.; Liakouli, V.; Carubbi, F.; Perricone, C.; Perricone, R.; Giacomelli, R. Angiogenesis in rheumatoid arthritis: A disease specific process or a common response to chronic inflammation? Autoimmun. Rev.\n                           2011, 10, 595\u2013598.","journal-title":"Autoimmun. Rev."},{"key":"2071_CR7","first-page":"607","volume":"3","author":"C. T. N. Pham","year":"2011","unstructured":"Pham, C. T. N. Nanotherapeutic approaches for the treatment of rheumatoid arthritis. Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol. 2011, 3, 607\u2013619.","journal-title":"Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol"},{"key":"2071_CR8","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s40064-015-0798-9","volume":"4","author":"K. Oda","year":"2015","unstructured":"Oda, K.; Minata, M. Drug free remission after steroiddependent disappearance of lymphoproliferative disorder in rheumatoid arthritis patient treated with TNF-alpha blockade: Case study. SpringerPlus\n                           2015, 4, 41.","journal-title":"SpringerPlus"},{"key":"2071_CR9","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/nrd2947","volume":"8","author":"J. G. Stoll","year":"2009","unstructured":"Stoll, J. G.; Yasothan, U. Rheumatoid arthritis market. Nat. Rev. Drug Discov.\n                           2009, 8, 693\u2013694.","journal-title":"Nat. Rev. Drug Discov."},{"key":"2071_CR10","first-page":"359","volume":"3","author":"J. Hwang","year":"2008","unstructured":"Hwang, J.; Rodgers, K.; Oliver, J. C.; Schluep, T. \u03b1-Methylprednisolone conjugated cyclodextrin polymer-based nanoparticles for rheumatoid arthritis therapy. Int. J. Nanomedicine\n                           2008, 3, 359\u2013371.","journal-title":"Int. J. Nanomedicine"},{"key":"2071_CR11","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.maturitas.2011.11.021","volume":"73","author":"I. Rubinstein","year":"2012","unstructured":"Rubinstein, I.; Weinberg, G. L. Nanomedicines for chronic non-infectious arthritis: The clinician\u2019s perspective. Maturitas\n                           2012, 73, 68\u201373.","journal-title":"Maturitas"},{"key":"2071_CR12","doi-asserted-by":"publisher","first-page":"3303","DOI":"10.3390\/ijms12053303","volume":"12","author":"H. Boulaiz","year":"2011","unstructured":"Boulaiz, H.; Alvarez, P. J.; Ramirez, A.; Marchal, J. A.; Prados, J.; Rodr\u00edguez-Serrano, F.; Per\u00e1n, M.; Melguizo, C.; Aranega, A. Nanomedicine: Application areas and development prospects. Int. J. Mol. Sci.\n                           2011, 12, 3303\u20133321.","journal-title":"Int. J. Mol. Sci."},{"key":"2071_CR13","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/sj.clpt.6100400","volume":"83","author":"L. Zhang","year":"2008","unstructured":"Zhang, L.; Gu, F. X.; Chan, J. M.; Wang, A. Z.; Langer, R. S.; Farokhzad, O. C. Nanoparticles in medicine: Therapeutic applications and developments. Clin. Pharmacol. Ther.\n                           2008, 83, 761\u2013769.","journal-title":"Clin. Pharmacol. Ther."},{"key":"2071_CR14","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.2174\/138920101415140804121008","volume":"14","author":"B. Mukherjee","year":"2013","unstructured":"Mukherjee, B. Nanosize drug delivery system. Curr. Pharm. Biotechnol.\n                           2013, 14, 1221.","journal-title":"Curr. Pharm. Biotechnol."},{"key":"2071_CR15","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.nano.2011.05.016","volume":"8","author":"S. Parveen","year":"2012","unstructured":"Parveen, S.; Misra, R.; Sahoo, S. K. Nanoparticles: A boon to drug delivery, therapeutics, diagnostics and imaging. Nanomedicine\n                           2012, 8, 147\u2013166.","journal-title":"Nanomedicine"},{"key":"2071_CR16","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1177\/0192623307310946","volume":"36","author":"E. M. Merisko-Liversidge","year":"2008","unstructured":"Merisko-Liversidge, E. M.; Liversidge, G. G. Drug nanoparticles: Formulating poorly water-soluble compounds. Toxicol. Pathol.\n                           2008, 36, 43\u201348.","journal-title":"Toxicol. Pathol."},{"key":"2071_CR17","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.hcl.2010.09.002","volume":"27","author":"J. M. Kahlenberg","year":"2011","unstructured":"Kahlenberg, J. M.; Fox, D. A. Advances in the medical treatment of rheumatoid arthritis. Hand Clin.\n                           2011, 27, 11\u201320.","journal-title":"Hand Clin."},{"key":"2071_CR18","first-page":"1","volume":"1","author":"M. Abhilash","year":"2010","unstructured":"Abhilash, M. Potential applications of Nanoparticles. Int. J. Pharm. Bio Sci.\n                           2010, 1, 1\u201312.","journal-title":"Int. J. Pharm. Bio Sci."},{"key":"2071_CR19","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.jsps.2011.04.001","volume":"19","author":"S. R. Mudshinge","year":"2011","unstructured":"Mudshinge, S. R.; Deore, A. B.; Patil, S.; Bhalgat, C. M. Nanoparticles: Emerging carriers for drug delivery. Saudi Pharmaceut. J.\n                           2011, 19, 129\u2013141.","journal-title":"Saudi Pharmaceut. J."},{"key":"2071_CR20","first-page":"689","volume":"130","author":"A. Surendiran","year":"2009","unstructured":"Surendiran, A.; Sandhiya, S.; Pradhan, S. C.; Adithan, C. Novel applications of nanotechnology in medicine. Indian J. Med. Res.\n                           2009, 130, 689\u2013701.","journal-title":"Indian J. Med. Res."},{"key":"2071_CR21","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.tips.2009.08.004","volume":"30","author":"Y. Malam","year":"2009","unstructured":"Malam, Y.; Loizidou, M.; Seifalian, A. M. Liposomes and nanoparticles: Nanosized vehicles for drug delivery in cancer. Trends Pharmacol. Sci.\n                           2009, 30, 592\u2013599.","journal-title":"Trends Pharmacol. Sci."},{"key":"2071_CR22","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1111\/j.2042-7158.1988.tb05212.x","volume":"40","author":"W. C. Foong","year":"1988","unstructured":"Foong, W. C.; Green, K. L. Association of liposomeentrapped [3H] methotrexate with thioglycollate-elicited macrophages in-vitro. J. Pharm. Pharmacol.\n                           1988, 40, 171\u2013175.","journal-title":"J. Pharm. Pharmacol."},{"key":"2071_CR23","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1517\/17425247.5.9.1027","volume":"5","author":"I. H. Tarner","year":"2008","unstructured":"Tarner, I. H.; M\u00fcller-Ladner, U. Drug delivery systems for the treatment of rheumatoid arthritis. Exp. Opin. Drug Deliv.\n                           2008, 5, 1027\u20131037.","journal-title":"Exp. Opin. Drug Deliv."},{"key":"2071_CR24","doi-asserted-by":"publisher","first-page":"978351","DOI":"10.1155\/2014\/978351","volume":"2014","author":"B. Kapoor","year":"2014","unstructured":"Kapoor, B.; Singh, S. K.; Gulati, M.; Gupta, R.; Vaidya, Y. Application of liposomes in treatment of rheumatoid arthritis: Quo vadis. Sci. World J.\n                           2014, 2014, 978351.","journal-title":"Sci. World J."},{"key":"2071_CR25","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1136\/ard.48.2.143","volume":"48","author":"W. G. Love","year":"1989","unstructured":"Love, W. G.; Amos, N.; Kellaway, I. W.; Williams, B. D. Specific accumulation of technetium-99m radiolabelled, negative liposomes in the inflamed paws of rats with adjuvant induced arthritis: Effect of liposome size. Ann. Rheum. Dis.\n                           1989, 48, 143\u2013148.","journal-title":"Ann. Rheum. Dis."},{"key":"2071_CR26","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1136\/ard.57.7.408","volume":"57","author":"P. L. E. M. Lent van","year":"1998","unstructured":"van Lent, P. L. E. M.; Holthuysen, A. E. M.; van Rooijen, N.; van De Putte, L. B. A.; van Den Berg, W. B. Local removal of phagocytic synovial lining cells by clodronate-liposomes decreases cartilage destruction during collagen type II arthritis. Ann. Rheum. Dis.\n                           1998, 57, 408\u2013413.","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"2071_CR27","doi-asserted-by":"publisher","first-page":"S55","DOI":"10.1098\/rsif.2009.0285.focus","volume":"7","author":"W. Ulbrich","year":"2010","unstructured":"Ulbrich, W.; Lamprecht, A. Targeted drug-delivery approaches by nanoparticulate carriers in the therapy of inflammatory diseases. J. Roy. Soc. Interface\n                           2010, 7(Suppl 1), S55\u2013S66.","journal-title":"J. Roy. Soc. Interface"},{"key":"2071_CR28","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1021\/mp2000742","volume":"8","author":"J. M. Hoven van den","year":"2011","unstructured":"van den Hoven, J. M.; van Tomme, S. R.; Metselaar, J. M.; Nuijen, B.; Beijnen, J. H.; Storm, G. Liposomal drug formulations in the treatment of rheumatoid arthritis. Mol. Pharmaceutics\n                           2011, 8, 1002\u20131015.","journal-title":"Mol. Pharmaceutics"},{"key":"2071_CR29","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1093\/rheumatology\/33.6.530","volume":"33","author":"A. S. Williams","year":"1994","unstructured":"Williams, A. S.; Camilleri, J. P.; Williams, B. D. Suppression of adjuvant-induced arthritis by liposomally conjugated methotrexate in the rat. Rheumatology\n                           1994, 33, 530\u2013533.","journal-title":"Rheumatology"},{"key":"2071_CR30","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1073\/pnas.95.5.2531","volume":"95","author":"R. A. Watson-Clark","year":"1998","unstructured":"Watson-Clark, R. A.; Banquerigo, M. L.; Shelly, K.; Hawthorne, M. F.; Brahn, E. Model studies directed toward the application of boron neutron capture therapy to rheumatoid arthritis: Boron delivery by liposomes in rat collagen-induced arthritis. Proc. Natl. Acad. Sci. USA\n                           1998, 95, 2531\u20132534.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2071_CR31","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1002\/(SICI)1099-081X(199809)19:6<395::AID-BDD117>3.0.CO;2-9","volume":"19","author":"R. K. Chowdhary","year":"1998","unstructured":"Chowdhary, R. K.; Ratkay, L. G.; Canaan, A. J.; Waterfield, J. D.; Richter, A. M.; Levy, J. G. Uptake of Verteporfin\u00ae by articular tissues following systemic and intra-articular administration. Biopharm. Drug Dispos.\n                           1998, 19, 395\u2013400.","journal-title":"Biopharm. Drug Dispos."},{"key":"2071_CR32","first-page":"43","volume":"17","author":"J. Highton","year":"1999","unstructured":"Highton, J.; Gu\u00e9vremont, D.; Thomson, J.; Carlisle, B.; Tucker, I. A trial of clodronate-liposomes as anti-macrophage treatment in a sheep model of arthritis. Clin. Exp. Rheumatol.\n                           1999, 17, 43\u201348.","journal-title":"Clin. Exp. Rheumatol."},{"key":"2071_CR33","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1023\/A:1007577101964","volume":"17","author":"M. L. Corvo","year":"2000","unstructured":"Corvo, M. L.; Boerman, O. C.; Oyen, W. J. G.; Jorge, J. C. S.; Cruz, M. E. M.; Crommelin, D. J. A.; Storm, G. Subcutaneous administration of superoxide dismutase entrapped in long circulating liposomes: In vivo fate and therapeutic activity in an inflammation model. Pharm. Res.\n                           2000, 17, 600\u2013606.","journal-title":"Pharm. Res."},{"key":"2071_CR34","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/S0031-6865(00)00023-6","volume":"74","author":"P. Srinath","year":"2000","unstructured":"Srinath, P.; Chary, M. G.; Vyas, S. P.; Diwan, P. V. Long-circulating liposomes of indomethacin in arthritic rats\u2014A biodisposition study. Pharm. Acta Helv.\n                           2000, 74, 399\u2013404.","journal-title":"Pharm. Acta Helv."},{"key":"2071_CR35","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1002\/1529-0131(200108)44:8<1908::AID-ART329>3.0.CO;2-4","volume":"44","author":"A. \u010ceponis","year":"2001","unstructured":"\u010ceponis, A.; Waris, E.; M\u00f6nkk\u00f6nen, J.; Laasonen, L.; Hyttinen, M.; Solovieva, S. A.; Hanemaaijer, R.; Bitsch, A.; Konttinen, Y. T. Effects of low-dose, noncytotoxic, intraarticular liposomal clodronate on development of erosions and proteoglycan loss in established antigen-induced arthritis in rabbits. Arthritis Rheum.\n                           2001, 44, 1908\u20131916.","journal-title":"Arthritis Rheum."},{"key":"2071_CR36","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1177\/153537020122600608","volume":"226","author":"M. Trif","year":"2001","unstructured":"Trif, M.; Guillen, C.; Vaughan, D. M.; Telfer, J. M.; Brewer, J. M.; Roseanu, A.; Brock, J. H. Liposomes as possible carriers for lactoferrin in the local treatment of inflammatory diseases. Exp. Biol. Med.\n                           2001, 226, 559\u2013564.","journal-title":"Exp. Biol. Med."},{"key":"2071_CR37","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1080\/08982100701530027","volume":"17","author":"M. Trif","year":"2007","unstructured":"Trif, M.; Roseanu, A.; Brock, J. H.; Brewer, J. M. Designing lipid nanostructures for local delivery of biologically active macromolecules. J. Liposome Res.\n                           2007, 17, 237\u2013248.","journal-title":"J. Liposome Res."},{"key":"2071_CR38","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1023\/A:1022298725165","volume":"20","author":"M. Everts","year":"2003","unstructured":"Everts, M.; Koning, G. A.; Kok, R. J.; \u00c1sgeirsd\u00f3ttir, S. A.; Vestweber, D.; Meijer, D. K. F.; Storm, G.; Molema, G. In vitro cellular handling and in vivo targeting of E-selectindirected immunoconjugates and immunoliposomes used for drug delivery to inflamed endothelium. Pharm. Res.\n                           2003, 20, 64\u201372.","journal-title":"Pharm. Res."},{"key":"2071_CR39","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1007\/s12272-011-1109-9","volume":"34","author":"S. Mitragotri","year":"2011","unstructured":"Mitragotri, S.; Yoo, J.-W. Designing micro- and nanoparticles for treating rheumatoid arthritis. Arch. Pharm. Res.\n                           2011, 34, 1887\u20131897.","journal-title":"Arch. Pharm. Res."},{"key":"2071_CR40","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1002\/art.11140","volume":"48","author":"J. M. Metselaar","year":"2003","unstructured":"Metselaar, J. M.; Wauben, M. H. M.; Wagenaar-Hilbers, J. P. A.; Boerman, O. C.; Storm, G. Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes. Arth. Rheumatol.\n                           2003, 48, 2059\u20132066.","journal-title":"Arth. Rheumatol."},{"key":"2071_CR41","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1136\/ard.2003.009944","volume":"63","author":"J. M. Metselaar","year":"2004","unstructured":"Metselaar, J. M.; Van den Berg, W. B.; Holthuysen, A. E. M.; Wauben, M. H. M.; Storm, G.; Van Lent, P. L. E. M. Liposomal targeting of glucocorticoids to synovial lining cells strongly increases therapeutic benefit in collagen type II arthritis. Ann. Rheum. Dis.\n                           2004, 63, 348\u2013353.","journal-title":"Ann. Rheum. Dis."},{"key":"2071_CR42","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1211\/jpp.59.1.0018","volume":"59","author":"T. Harigai","year":"2007","unstructured":"Harigai, T.; Hagiwara, H.; Ogawa, Y.; Ishizuka, T.; Kaneda, S.; Kimura, J. Prednisolone phosphate-containing TRX-20 liposomes inhibit cytokine and chemokine production in human fibroblast-like synovial cells: A novel approach to rheumatoid arthritis therapy. J. Pharm. Pharmacol.\n                           2007, 59, 137\u2013143.","journal-title":"J. Pharm. Pharmacol."},{"key":"2071_CR43","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1002\/art.21719","volume":"54","author":"G. A. Koning","year":"2006","unstructured":"Koning, G. A.; Schiffelers, R. M.; Wauben, M. H. M.; Kok, R. J.; Mastrobattista, E.; Molema, G.; ten Hagen, T. L. M.; Storm, G. Targeting of angiogenic endothelial cells at sites of inflammation by dexamethasone phosphate-containing RGD peptide liposomes inhibits experimental arthritis. Arth. Rheumatol.\n                           2006, 54, 1198\u20131208.","journal-title":"Arth. Rheumatol."},{"key":"2071_CR44","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1248\/bpb.29.1516","volume":"29","author":"Y. Hattori","year":"2006","unstructured":"Hattori, Y.; Sakaguchi, M.; Maitani, Y. Folate-linked lipidbased nanoparticles deliver a NF\u03baB decoy into activated murine macrophage-like RAW264.7 cells. Biol. Pharm. Bull.\n                           2006, 29, 1516\u20131520.","journal-title":"Biol. Pharm. Bull."},{"key":"2071_CR45","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1136\/ard.2009.108985","volume":"68","author":"U. Rauchhaus","year":"2009","unstructured":"Rauchhaus, U.; Kinne, R. W.; Pohlers, D.; Wiegand, S.; W\u00f6lfert, A.; Gajda, M.; Br\u00e4uer, R.; Panzner, S. Targeted delivery of liposomal dexamethasone phosphate to the spleen provides a persistent therapeutic effect in rat antigen-induced arthritis. Ann. Rheum. Dis.\n                           2009, 68, 1933\u20131934.","journal-title":"Ann. Rheum. Dis."},{"key":"2071_CR46","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1093\/rheumatology\/38.9.818","volume":"38","author":"P. J. Richards","year":"1999","unstructured":"Richards, P. J.; Williams, A. S.; Goodfellow, R. M.; Williams, B. D. Liposomal clodronate eliminates synovial macrophages, reduces inflammation and ameliorates joint destruction in antigen-induced arthritis. Rheumatology\n                           1999, 38, 818\u2013825.","journal-title":"Rheumatology"},{"key":"2071_CR47","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1093\/rheumatology\/40.9.978","volume":"40","author":"P. J. Richards","year":"2001","unstructured":"Richards, P. J.; Williams, B. D.; Williams, A. S. Suppression of chronic streptococcal cell wall-induced arthritis in Lewis rats by liposomal clodronate. Rheumatology\n                           2001, 40, 978\u2013987.","journal-title":"Rheumatology"},{"key":"2071_CR48","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.jconrel.2004.12.008","volume":"103","author":"S. Sim\u00f5es","year":"2005","unstructured":"Sim\u00f5es, S.; Delgado, T. C.; Lopes, R. M.; Jesus, S.; Ferreira, A. A.; Morais, J. A.; Cruz, M. E. M.; Corvo, M. L.; Martins, M. B. F. Developments in the rat adjuvant arthritis model and its use in therapeutic evaluation of novel non-invasive treatment by SOD in Transfersomes. J. Control. Release\n                           2005, 103, 419\u2013434.","journal-title":"J. Control. Release"},{"key":"2071_CR49","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.jconrel.2006.10.018","volume":"117","author":"M. M. Gaspar","year":"2007","unstructured":"Gaspar, M. M.; Boerman, O. C.; Laverman, P.; Corvo, M. L.; Storm, G.; Cruz, M. E. M. Enzymosomes with surface-exposed superoxide dismutase: In vivo behaviour and therapeutic activity in a model of adjuvant arthritis. J. Control. Release\n                           2007, 117, 186\u2013195.","journal-title":"J. Control. Release"},{"key":"2071_CR50","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1002\/art.21876","volume":"54","author":"M. Khoury","year":"2006","unstructured":"Khoury, M.; Louis-Plence, P.; Escriou, V.; Noel, D.; Largeau, C.; Cantos, C.; Scherman, D.; Jorgensen, C.; Apparailly, F. Efficient new cationic liposome formulation for systemic delivery of small interfering RNA silencing tumor necrosis factor \u03b1 in experimental arthritis. Arth. Rheumatol.\n                           2006, 54, 1867\u20131877.","journal-title":"Arth. Rheumatol."},{"key":"2071_CR51","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1186\/ar327","volume":"3","author":"D. M. Gerlag","year":"2001","unstructured":"Gerlag, D. M.; Borges, E.; Tak, P. P.; Ellerby, H. M.; Bredesen, D. E.; Pasqualini, R.; Ruoslahti, E.; Firestein, G. S. Suppression of murine collagen-induced arthritis by targeted apoptosis of synovial neovasculature. Arth. Res. Ther.\n                           2001, 3, 357.","journal-title":"Arth. Res. Ther."},{"key":"2071_CR52","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1002\/art.10198","volume":"46","author":"W. U. Kim","year":"2002","unstructured":"Kim, W. U.; Lee, W. K.; Ryoo, J. W.; Kim, S. H.; Kim, J.; Youn, J.; Min, S. Y.; Bae, E. Y.; Hwang, S. Y.; Park, S. H. et al. Suppression of collagen-induced arthritis by single administration of poly (lactic-co-glycolic acid) nanoparticles entrapping type II collagen: A novel treatment strategy for induction of oral tolerance. Arth. Rheumatol.\n                           2002, 46, 1109\u20131120.","journal-title":"Arth. Rheumatol."},{"key":"2071_CR53","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1023\/A:1014260513728","volume":"19","author":"E. Horisawa","year":"2002","unstructured":"Horisawa, E.; Kubota, K.; Tuboi, I.; Sato, K.; Yamamoto, H.; Takeuchi, H.; Kawashima, Y. Size-dependency of DL-lactide\/ glycolide copolymer particulates for intra-articular delivery system on phagocytosis in rat synovium. Pharm. Res.\n                           2002, 19, 132\u2013139.","journal-title":"Pharm. Res."},{"key":"2071_CR54","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.ejpb.2009.06.009","volume":"73","author":"N. Butoescu","year":"2009","unstructured":"Butoescu, N.; Jordan, O.; Doelker, E. Intra-articular drug delivery systems for the treatment of rheumatic diseases: A review of the factors influencing their performance. Eur. J. Pharm. Biopharm.\n                           2009, 73, 205\u2013218.","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"2071_CR55","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1093\/rheumatology\/keh254","volume":"43","author":"C. Fiehn","year":"2004","unstructured":"Fiehn, C.; M\u00fcller-Ladner, U.; Gay, S.; Krienke, S.; Freudenberg-Konrad, S.; Funk, J.; Ho, A. D.; Sinn, H.; Wunder, A. Albumin-coupled methotrexate (MTX-HSA) is a new anti-arthritic drug which acts synergistically to MTX. Rheumatology\n                           2004, 43, 1097\u20131105.","journal-title":"Rheumatology"},{"key":"2071_CR56","first-page":"176","volume":"4","author":"K. Ren","year":"2013","unstructured":"Ren, K.; Dusad, A.; Dong, R.; Quan, L. D. Albumin as a delivery carrier for rheumatoid arthritis. J. Nanomed. Nanotechol.\n                           2013, 4, 176.","journal-title":"J. Nanomed. Nanotechol."},{"key":"2071_CR57","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1136\/ard.2004.030759","volume":"64","author":"M. Higaki","year":"2005","unstructured":"Higaki, M.; Ishihara, T.; Izumo, N.; Takatsu, M.; Mizushima, Y. Treatment of experimental arthritis with poly (D, L-lactic\/ glycolic acid) nanoparticles encapsulating betamethasone sodium phosphate. Ann. Rheum. Dis.\n                           2005, 64, 1132\u20131136.","journal-title":"Ann. Rheum. Dis."},{"key":"2071_CR58","first-page":"1","volume":"5","author":"J. Patel","year":"2008","unstructured":"Patel, J.; Jigar, B.; Shah, H.; Patel, D. Novel drug delivery technologies for the treatment of rheumatoid arthritis. Internet J. Med. Technol.\n                           2008, 5, 1\u201311.","journal-title":"Internet J. Med. Technol."},{"key":"2071_CR59","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.jep.2004.10.031","volume":"97","author":"M. X. Liu","year":"2005","unstructured":"Liu, M. X.; Dong, J.; Yang, Y. J.; Yang, X. L.; Xu, H. B. Anti-inflammatory effects of triptolide loaded poly (D, L-lactic acid) nanoparticles on adjuvant-induced arthritis in rats. J. Ethnopharmacol.\n                           2005, 97, 219\u2013225.","journal-title":"J. Ethnopharmacol."},{"key":"2071_CR60","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1016\/j.biomaterials.2005.09.020","volume":"27","author":"S. Mansouri","year":"2006","unstructured":"Mansouri, S.; Cuie, Y.; Winnik, F.; Shi, Q.; Lavigne, P.; Benderdour, M.; Beaumont, E.; Fernandes, J. C. Characterization of folate-chitosan-DNA nanoparticles for gene therapy. Biomaterials\n                           2006, 27, 2060\u20132065.","journal-title":"Biomaterials"},{"key":"2071_CR61","doi-asserted-by":"publisher","first-page":"R2","DOI":"10.1186\/ar2106","volume":"9","author":"D. Wang","year":"2007","unstructured":"Wang, D.; Miller, S. C.; Liu, X.-M.; Anderson, B.; Wang, X. S.; Goldring, S. R. Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritis. Arth. Res. Ther.\n                           2007, 9, R2.","journal-title":"Arth. Res. Ther."},{"key":"2071_CR62","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nmat2116","volume":"7","author":"D. A. Rothenfluh","year":"2008","unstructured":"Rothenfluh, D. A.; Bermudez, H.; O\u2019Neil, C. P.; Hubbell, J. A. Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage. Nat. Mater.\n                           2008, 7, 248\u2013254.","journal-title":"Nat. Mater."},{"key":"2071_CR63","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.ijpharm.2009.10.025","volume":"385","author":"T. Ishihara","year":"2010","unstructured":"Ishihara, T.; Takahashi, M.; Higaki, M.; Mizushima, Y.; Mizushima, T. Preparation and characterization of a nanoparticulate formulation composed of PEG-PLA and PLA as anti-inflammatory agents. Int. J. Pharm.\n                           2010, 385, 170\u2013175.","journal-title":"Int. J. Pharm."},{"key":"2071_CR64","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1021\/bm100578c","volume":"11","author":"X.-M. Liu","year":"2010","unstructured":"Liu, X.-M.; Quan, L.-D.; Tian, J.; Laquer, F. C.; Ciborowski, P.; Wang, D. Syntheses of click PEG-dexamethasone conjugates for the treatment of rheumatoid arthritis. Biomacromolecules\n                           2010, 11, 2621\u20132628.","journal-title":"Biomacromolecules"},{"key":"2071_CR65","doi-asserted-by":"publisher","first-page":"9057","DOI":"10.1016\/j.biomaterials.2010.08.015","volume":"31","author":"Y.-J. Kim","year":"2010","unstructured":"Kim, Y.-J.; Chae, S. Y.; Jin, C.-H.; Sivasubramanian, M.; Son, S.; Choi, K. Y.; Jo, D.-G.; Kim, K.; Kwon, I. C.; Lee, K. C. et al. Ionic complex systems based on hyaluronic acid and PEGylated TNF-related apoptosis-inducing ligand for treatment of rheumatoid arthritis. Biomaterials\n                           2010, 31, 9057\u20139064.","journal-title":"Biomaterials"},{"key":"2071_CR66","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.jconrel.2010.02.008","volume":"144","author":"F. Schmitt","year":"2010","unstructured":"Schmitt, F.; Lagopoulos, L.; K\u00e4uper, P.; Rossi, N.; Busso, N.; Barge, J.; Wagni\u00e8res, G.; Laue, C.; Wandrey, C.; Juillerat-Jeanneret, L. Chitosan-based nanogels for selective delivery of photosensitizers to macrophages and improved retention in and therapy of articular joints. J. Control. Release\n                           2010, 144, 242\u2013250.","journal-title":"J. Control. Release"},{"key":"2071_CR67","first-page":"2011","volume-title":"J. Biomed. Biotechnol.","author":"Q. Shi","year":"2011","unstructured":"Shi, Q.; Wang, H. J.; Tran, C.; Qiu, X. P.; Winnik, F. M.; Zhang, X. L.; Dai, K. R.; Benderdour, M.; Fernandes, J. C. Hydrodynamic delivery of chitosan-folate-DNA nanoparticles in rats with adjuvant-induced arthritis. J. Biomed. Biotechnol.\n                           2011, 2011, Article ID 148763."},{"key":"2071_CR68","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.2217\/nnm.11.90","volume":"6","author":"R. I. Scheinman","year":"2011","unstructured":"Scheinman, R. I.; Trivedi, R.; Vermillion, S.; Kompella, U. B. Functionalized STAT1 siRNA nanoparticles regress rheumatoid arthritis in a mouse model. Nanomedicine\n                           2011, 6, 1669\u20131682.","journal-title":"Nanomedicine"},{"key":"2071_CR69","doi-asserted-by":"publisher","first-page":"3824","DOI":"10.1002\/art.30628","volume":"63","author":"J. H. Ryu","year":"2011","unstructured":"Ryu, J. H.; Lee, A.; Chu, J. U.; Koo, H.; Ko, C. Y.; Kim, H. S.; Yoon, S. Y.; Kim, B. S.; Choi, K.; Kwon, I. C. et al. Early diagnosis of arthritis in mice with collagen-induced arthritis, using a fluorogenic matrix metalloproteinase 3-specific polymeric probe. Arth. Rheumatol.\n                           2011, 63, 3824\u20133832.","journal-title":"Arth. Rheumatol."},{"key":"2071_CR70","doi-asserted-by":"publisher","first-page":"389","DOI":"10.2310\/7290.2011.00056","volume":"11","author":"K. S. Park","year":"2012","unstructured":"Park, K. S.; Kang, J. H.; Sa, K. H.; Koo, H. B.; Cho, H. J.; Nam, E. J.; Youn, I. C.; Kim, K. M.; Kim, I. S.; Kwon, I. C. et al. In vivo quantitative measurement of arthritis activity based on hydrophobically modified glycol chitosan in inflammatory arthritis: More active than passive accumulation. Mol. Imaging\n                           2012, 11, 389\u2013400.","journal-title":"Mol. Imaging"},{"key":"2071_CR71","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/j.jconrel.2012.05.004","volume":"161","author":"B. C. M. Te Boekhorst","year":"2012","unstructured":"Te Boekhorst, B. C. M.; Jensen, L. B.; Colombo, S.; Varkouhi, A. K.; Schiffelers, R. M.; Lammers, T.; Storm, G.; Nielsen, H. M.; Strijkers, G. J.; Foged, C. et al. MRI-assessed therapeutic effects of locally administered PLGA nanoparticles loaded with anti-inflammatory siRNA in a murine arthritis model. J. Control. Release\n                           2012, 161, 772\u2013780.","journal-title":"J. Control. Release"},{"key":"2071_CR72","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.ijpharm.2012.02.028","volume":"427","author":"A. Rollett","year":"2012","unstructured":"Rollett, A.; Reiter, T.; Nogueira, P.; Cardinale, M.; Loureiro, A.; Gomes, A.; Cavaco-Paulo, A.; Moreira, A.; Carmo, A. M.; Guebitz, G. M. Folic acid-functionalized human serum albumin nanocapsules for targeted drug delivery to chronically activated macrophages. Int. J. Pharm.\n                           2012, 427, 460\u2013466.","journal-title":"Int. J. Pharm."},{"key":"2071_CR73","doi-asserted-by":"publisher","first-page":"11103","DOI":"10.3390\/molecules200611103","volume":"20","author":"J. Albuquerque","year":"2015","unstructured":"Albuquerque, J.; Moura, C. C.; Sarmento, B.; Reis, S. Solid lipid nanoparticles: A potential multifunctional approach towards rheumatoid arthritis theranostics. Molecules\n                           2015, 20, 11103\u201311118.","journal-title":"Molecules"},{"key":"2071_CR74","doi-asserted-by":"publisher","first-page":"10349","DOI":"10.1039\/c3cc44260h","volume":"49","author":"S.-H. Kim","year":"2013","unstructured":"Kim, S.-H.; Kim, J.-H.; You, D. G.; Saravanakumar, G.; Yoon, H. Y.; Choi, K. Y.; Thambi, T.; Deepagan, V. G.; Jo, D.-G.; Park, J. H. Self-assembled dextran sulphate nanoparticles for targeting rheumatoid arthritis. Chem. Commun.\n                           2013, 49, 10349\u201310351.","journal-title":"Chem. Commun."},{"key":"2071_CR75","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.jconrel.2014.07.057","volume":"192","author":"R. Heo","year":"2014","unstructured":"Heo, R.; Park, J.-S.; Jang, H. J.; Kim, S.-H.; Shin, J. M.; Suh, Y. D.; Jeong, J. H.; Jo, D.-G.; Park, J. H. Hyaluronan nanoparticles bearing \u03b3-secretase inhibitor: In vivo therapeutic effects on rheumatoid arthritis. J. Control. Release\n                           2014, 192, 295\u2013300.","journal-title":"J. Control. Release"},{"key":"2071_CR76","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/mt.2013.245","volume":"22","author":"S. J. Lee","year":"2014","unstructured":"Lee, S. J.; Lee, A.; Hwang, S. R.; Park, J.-S.; Jang, J.; Huh, M. S.; Jo, D.-G.; Yoon, S.-Y.; Byun, Y.; Kim, S. H. et al. TNF-\u03b1 gene silencing using polymerized siRNA\/thiolated glycol chitosan nanoparticles for rheumatoid arthritis. Mol. Ther.\n                           2014, 22, 397\u2013408.","journal-title":"Mol. Ther."},{"key":"2071_CR77","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3109\/03639045.2013.850705","volume":"41","author":"U. Bilthariya","year":"2015","unstructured":"Bilthariya, U.; Jain, N.; Rajoriya, V.; Jain, A. K. Folateconjugated albumin nanoparticles for rheumatoid arthritistargeted delivery of etoricoxib. Drug Dev. Ind. Pharm.\n                           2015, 41, 95\u2013104.","journal-title":"Drug Dev. Ind. Pharm."},{"key":"2071_CR78","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1002\/adfm.200800165","volume":"18","author":"J. M. Oliveira","year":"2008","unstructured":"Oliveira, J. M.; Kotobuki, N.; Marques, A. P.; Pirraco, R. P.; Benesch, J.; Hirose, M.; Costa, S. A.; Mano, J. F.; Ohgushi, H.; Reis, R. L. Surface engineered carboxymethylchitosan\/ poly(amidoamine) dendrimer nanoparticles for intracellular targeting. Adv. Funct. Mater.\n                           2008, 18, 1840\u20131853.","journal-title":"Adv. Funct. Mater."},{"key":"2071_CR79","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.1021\/acs.biomac.5b00979","volume":"16","author":"M. M. Yu","year":"2015","unstructured":"Yu, M. M.; Jie, X.; Xu, L.; Chen, C.; Shen, W. L.; Cao, Y. N.; Lian, G.; Qi, R. Recent advances in dendrimer research for cardiovascular diseases. Biomacromolecules\n                           2015, 16, 2588\u20132598.","journal-title":"Biomacromolecules"},{"key":"2071_CR80","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1021\/acs.bioconjchem.5b00031","volume":"26","author":"L.-P. Wu","year":"2015","unstructured":"Wu, L.-P.; Ficker, M.; Christensen, J. B.; Trohopoulos, P. N.; Moghimi, S. M. Dendrimers in medicine: Therapeutic concepts and pharmaceutical challenges. Bioconjugate Chem.\n                           2015, 26, 1198\u20131211.","journal-title":"Bioconjugate Chem."},{"key":"2071_CR81","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1002\/jbm.a.31122","volume":"82","author":"D. Chandrasekar","year":"2007","unstructured":"Chandrasekar, D.; Sistla, R.; Ahmad, F. J.; Khar, R. K.; Diwan, P. V. Folate coupled poly(ethyleneglycol) conjugates of anionic poly(amidoamine) dendrimer for inflammatory tissue specific drug delivery. J. Biomed. Mater. Res. A\n                           2007, 82, 92\u2013103.","journal-title":"J. Biomed. Mater. Res. A"},{"key":"2071_CR82","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.1002\/art.30459","volume":"63","author":"T. P. Thomas","year":"2011","unstructured":"Thomas, T. P.; Goonewardena, S. N.; Majoros, I. J.; Kotlyar, A.; Cao, Z. Y.; Leroueil, P. R.; Baker, J. R. Folate-targeted nanoparticles show efficacy in the treatment of inflammatory arthritis. Arth. Rheumatol.\n                           2011, 63, 2671\u20132680.","journal-title":"Arth. Rheumatol."},{"key":"2071_CR83","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1126\/scitranslmed.3002212","volume":"3","author":"M. Hayder","year":"2011","unstructured":"Hayder, M.; Poupot, M.; Baron, M.; Nigon, D.; Turrin, C.-O.; Caminade, A.-M.; Majoral, J.-P.; Eisenberg, R. A.; Fourni\u00e9, J.-J.; Cantagrel, A. et al. A phosphorus-based dendrimer targets inflammation and osteoclastogenesis in experimental arthritis. Sci. Trans. Med.\n                           2011, 3, 81ra35.","journal-title":"Sci. Trans. Med."},{"key":"2071_CR84","doi-asserted-by":"publisher","first-page":"6779","DOI":"10.1021\/nn203190x","volume":"5","author":"X. Bosch","year":"2011","unstructured":"Bosch, X. Dendrimers to treat rheumatoid arthritis. ACS Nano\n                           2011, 5, 6779\u20136785.","journal-title":"ACS Nano"},{"key":"2071_CR85","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.nbt.2014.03.004","volume":"31","author":"M. C. Edmundson","year":"2014","unstructured":"Edmundson, M. C.; Capeness, M.; Horsfall, L. Exploring the potential of metallic nanoparticles within synthetic biology. New Biotechnol.\n                           2014, 31, 572\u2013578.","journal-title":"New Biotechnol."},{"key":"2071_CR86","doi-asserted-by":"publisher","first-page":"282","DOI":"10.4103\/0975-7406.72127","volume":"2","author":"V. V. Mody","year":"2010","unstructured":"Mody, V. V.; Siwale, R.; Singh, A.; Mody, H. R. Introduction to metallic nanoparticles. J. Pharm. Bioallied Sci.\n                           2010, 2, 282\u2013289.","journal-title":"J. Pharm. Bioallied Sci."},{"key":"2071_CR87","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1002\/art.22401","volume":"56","author":"C. Y. Tsai","year":"2007","unstructured":"Tsai, C. Y.; Shiau, A. L.; Chen, S. Y.; Chen, Y. H.; Cheng, P. C.; Chang, M. Y.; Chen, D. H.; Chou, C. H.; Wang, C. R.; Wu, C. L. Amelioration of collagen-induced arthritis in rats by nanogold. Arth. Rheumatol.\n                           2007, 56, 544\u2013554.","journal-title":"Arth. Rheumatol."},{"key":"2071_CR88","doi-asserted-by":"publisher","first-page":"095101","DOI":"10.1088\/0957-4484\/19\/9\/095101","volume":"19","author":"D. L. Chamberland","year":"2008","unstructured":"Chamberland, D. L.; Agarwal, A.; Kotov, N.; Fowlkes, J. B.; Carson, P. L.; Wang, X. D. Photoacoustic tomography of joints aided by an Etanercept-conjugated gold nanoparticle contrast agent\u2014An ex vivo preliminary rat study. Nanotechnology\n                           2008, 19, 095101.","journal-title":"Nanotechnology"},{"key":"2071_CR89","doi-asserted-by":"publisher","first-page":"4709","DOI":"10.1016\/j.biomaterials.2008.08.038","volume":"29","author":"H. Lee","year":"2008","unstructured":"Lee, H.; Lee, K.; Kim, I. K.; Park, T. G. Synthesis, characterization, and in vivo diagnostic applications of hyaluronic acid immobilized gold nanoprobes. Biomaterials\n                           2008, 29, 4709\u20134718.","journal-title":"Biomaterials"},{"key":"2071_CR90","doi-asserted-by":"publisher","first-page":"170","DOI":"10.22203\/eCM.v023a13","volume":"23","author":"Y.-J. Huang","year":"2012","unstructured":"Huang, Y.-J.; Shiau, A.-L.; Chen, S.-Y.; Chen, Y.-L.; Wang, C.-R.; Tsai, C.-Y.; Chang, M.-Y.; Li, Y.-T.; Leu, C.-H.; Wu, C.-L. Multivalent structure of galectin-1-nanogold complex serves as potential therapeutics for rheumatoid arthritis by enhancing receptor clustering. Eur. Cell. Mater.\n                           2012, 23, 170\u2013181.","journal-title":"Eur. Cell. Mater."},{"key":"2071_CR91","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1021\/nn301215q","volume":"7","author":"S.-M. Lee","year":"2013","unstructured":"Lee, S.-M.; Kim, H. J.; Ha, Y.-J.; Park, Y. N.; Lee, S.-K.; Park, Y.-B.; Yoo, K.-H. Targeted chemo-photothermal treatments of rheumatoid arthritis using gold half-shell multifunctional nanoparticles. ACS Nano\n                           2013, 7, 50\u201357.","journal-title":"ACS Nano"},{"key":"2071_CR92","doi-asserted-by":"publisher","first-page":"4790","DOI":"10.1021\/nn500685h","volume":"8","author":"H. Lee","year":"2014","unstructured":"Lee, H.; Lee, M.-Y.; Bhang, S. H.; Kim, B.-S.; Kim, Y. S.; Ju, J. H.; Kim, K. S.; Hahn, S. K. Hyaluronate\u2013gold nanoparticle\/tocilizumab complex for the treatment of rheumatoid arthritis. ACS Nano\n                           2014, 8, 4790\u20134798.","journal-title":"ACS Nano"},{"key":"2071_CR93","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.jmmm.2005.02.075","volume":"293","author":"K. Schulze","year":"2005","unstructured":"Schulze, K.; Koch, A.; Sch\u00f6pf, B.; Petri, A.; Steitz, B.; Chastellain, M.; Hofmann, M.; Hofmann, H.; von Rechenberg, B. Intraarticular application of superparamagnetic nanoparticles and their uptake by synovial membrane\u2014An experimental study in sheep. J. Magn. Magn. Mater.\n                           2005, 293, 419\u2013432.","journal-title":"J. Magn. Magn. Mater."},{"key":"2071_CR94","first-page":"580","volume":"27","author":"J. Kim","year":"2009","unstructured":"Kim, J.; An, H. Y.; Rieter, W. J.; Esserman, D.; Taylor-Pashow, K. M. L.; Sartor, R. B.; Lin, W.; Tarrant, T. K. Multimodal optical and Gd-based nanoparticles for imaging in inflammatory arthritis. Clin. Exp. Rheumatol.\n                           2009, 27, 580\u2013586.","journal-title":"Clin. Exp. Rheumatol."},{"key":"2071_CR95","first-page":"28","volume":"3","author":"S. R. Prasad","year":"2013","unstructured":"Prasad, S. R.; Elango, K.; Damayanthi, D.; Saranya, J. S. Formulation and evaluation of azathioprine loaded silver nanopartilces for the treatment of rheumatoid arthritis. Asian J. Biomed. Pharm. Sci.\n                           2013, 3, 28\u201332.","journal-title":"Asian J. Biomed. Pharm. Sci."},{"key":"2071_CR96","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.ijpharm.2007.10.014","volume":"352","author":"J. S. Ye","year":"2008","unstructured":"Ye, J. S.; Wang, Q.; Zhou, X. F.; Zhang, N. Injectable actarit-loaded solid lipid nanoparticles as passive targeting therapeutic agents for rheumatoid arthritis. Int. J. Pharm.\n                           2008, 352, 273\u2013279.","journal-title":"Int. J. Pharm."},{"key":"2071_CR97","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.phymed.2012.06.006","volume":"19","author":"M. Xue","year":"2012","unstructured":"Xue, M.; Jiang, Z.-Z.; Wu, T.; Li, J.; Zhang, L.; Zhao, Y.; Li, X.-J.; Zhang, L.-Y.; Yang, S.-Y. Anti-inflammatory effects and hepatotoxicity of Tripterygium-loaded solid lipid nanoparticles on adjuvant-induced arthritis in rats. Phytomedicine\n                           2012, 19, 998\u20131006.","journal-title":"Phytomedicine"},{"key":"2071_CR98","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1248\/bpb.b13-00917","volume":"37","author":"N. Nagai","year":"2014","unstructured":"Nagai, N.; Ito, Y. Effect of solid nanoparticle of indomethacin on therapy for rheumatoid arthritis in adjuvant-induced arthritis rat. Biolog. Pharm. Bull.\n                           2014, 37, 1109\u20131118.","journal-title":"Biolog. Pharm. Bull."},{"key":"2071_CR99","doi-asserted-by":"publisher","first-page":"2978","DOI":"10.1096\/fj.09-129874","volume":"23","author":"H.-F. Zhou","year":"2009","unstructured":"Zhou, H.-F.; Chan, H. W.; Wickline, S. A.; Lanza, G. M.; Pham, C. T. N. \u03b1v\u03b23-Targeted nanotherapy suppresses inflammatory arthritis in mice. FASEB J.\n                           2009, 23, 2978\u20132985.","journal-title":"FASEB J."},{"key":"2071_CR100","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1007\/s11095-010-0330-4","volume":"28","author":"O. M. Y. Koo","year":"2011","unstructured":"Koo, O. M. Y.; Rubinstein, I.; \u00d6ny\u00fcksel, H. Actively targeted low-dose camptothecin as a safe, long-acting, disease-modifying nanomedicine for rheumatoid arthritis. Pharm. Res.\n                           2011, 28, 776\u2013787.","journal-title":"Pharm. Res."},{"key":"2071_CR101","doi-asserted-by":"publisher","first-page":"D668","DOI":"10.1093\/nar\/gkj067","volume":"34","author":"D. S. Wishart","year":"2006","unstructured":"Wishart, D. S.; Knox, C.; Guo, A. C.; Shrivastava, S.; Hassanali, M.; Stothard, P.; Chang, Z.; Woolsey, J. DrugBank: A comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res.\n                           2006, 34, D668\u2013D672.","journal-title":"Nucleic Acids Res."},{"key":"2071_CR102","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/0003-9861(78)90204-7","volume":"185","author":"F. C. Bernstein","year":"1978","unstructured":"Bernstein, F. C.; Koetzle, T. F.; Williams, G. J. B.; Meyer, E. F., Jr.; Brice, M. D.; Rodgers, J. R.; Kennard, O.; Shimanouchi, T.; Tasumi, M. The Protein Data Bank: A computer-based archival file for macromolecular structures. Arch. Biochem. Biophys.\n                           1978, 185, 584\u2013591.","journal-title":"Arch. Biochem. Biophys."},{"key":"2071_CR103","first-page":"3976","volume-title":"Long-circulating liposomal prednisolone versus pulse intramuscular methylprednisolone in patients with active rheumatoid arthritis","author":"P. Barrera","year":"2008","unstructured":"Barrera, P.; Mulder, S.; Smetsers, A. I.; Storm, G.; Beijnen, J. H.; Metselaar, J. M.; van Riel, P. L. Long-circulating liposomal prednisolone versus pulse intramuscular methylprednisolone in patients with active rheumatoid arthritis. In Arthritis and Rheumatism; Wiley-Liss Div John Wiley & Sons Inc: USA, 2008; pp 3976\u20133977."}],"container-title":["Nano Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12274-018-2071-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12274-018-2071-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12274-018-2071-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T23:12:07Z","timestamp":1734045127000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12274-018-2071-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,26]]},"references-count":103,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["2071"],"URL":"https:\/\/doi.org\/10.1007\/s12274-018-2071-3","relation":{},"ISSN":["1998-0124","1998-0000"],"issn-type":[{"value":"1998-0124","type":"print"},{"value":"1998-0000","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,26]]},"assertion":[{"value":"26 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}