{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:26:45Z","timestamp":1767706005308},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Adv Therapy"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1007\/s12325-012-0069-x","type":"journal-article","created":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T14:23:25Z","timestamp":1354890205000},"page":"1026-1036","source":"Crossref","is-referenced-by-count":14,"title":["Variability in the Management of Nonvariceal Upper Gastrointestinal Bleeding in Europe: An Observational Study"],"prefix":"10.1007","volume":"29","author":[{"given":"Angel","family":"Lanas","sequence":"first","affiliation":[]},{"given":"Lars","family":"Aabakken","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Fonseca","sequence":"additional","affiliation":[]},{"given":"Zeynel","family":"Mungan","sequence":"additional","affiliation":[]},{"given":"George","family":"Papatheodoridis","sequence":"additional","affiliation":[]},{"given":"Hubert","family":"Piessevaux","sequence":"additional","affiliation":[]},{"given":"Gianluca","family":"Rotondano","sequence":"additional","affiliation":[]},{"given":"Javier","family":"Nuevo","sequence":"additional","affiliation":[]},{"given":"Monica","family":"Tafalla","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2012,12,6]]},"reference":[{"key":"69_CR1","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1111\/j.1572-0241.2002.06037.x","volume":"97","author":"J.D. Lewis","year":"2002","unstructured":"Lewis JD, Bilker WB, Brensinger C, et al. Hospitalization and mortality rates from peptic ulcer disease and GI bleeding in the 1990s: relationship to sales of nonsteroidal anti-inflammatory drugs and acid suppression medications. Am J Gastroenterol. 2002;97:2540\u20132549.","journal-title":"Am J Gastroenterol"},{"key":"69_CR2","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1111\/j.1572-0241.2006.00518.x","volume":"101","author":"A. Lassen","year":"2006","unstructured":"Lassen A, Hallas J, Schaffalitzky de Muckadell OB. Complicated and uncomplicated peptic ulcers in a Danish county 1993\u20132002: a population-based cohort study. Am J Gastroenterol. 2006;101:945\u2013953.","journal-title":"Am J Gastroenterol"},{"key":"69_CR3","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1111\/j.1572-0241.2003.07517.x","volume":"98","author":"M.E. Leerdam van","year":"2003","unstructured":"van Leerdam ME, Vreeburg EM, Rauws EA, et al. Acute upper GI bleeding: did anything change? Time trend analysis of incidence and outcome of acute upper GI bleeding between 1993\/1994 and 2000. Am J Gastroenterol. 2003;98:1494\u20131499.","journal-title":"Am J Gastroenterol"},{"key":"69_CR4","unstructured":"Zhao Y, Encinosa W. Hospitalizations for Gastrointestinal Bleeding in 1998 and 2006. HCUP Statistical Brief #65, 2008. Available at: http:\/\/www.hcup-us.ahrq.gov\/reports\/statbriefs\/sb65.pdf . Accessed Aug 24 2012."},{"key":"69_CR5","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.cgh.2006.08.018","volume":"4","author":"L.E. Targownik","year":"2006","unstructured":"Targownik LE, Nabalamba A. Trends in management and outcomes of acute nonvariceal upper gastrointestinal bleeding: 1993\u20132003. Clin Gastroenterol Hepatol. 2006;4:1459\u20131466.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"69_CR6","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1111\/j.1572-0241.2004.30272.x","volume":"99","author":"A. Barkun","year":"2004","unstructured":"Barkun A, Sabbah S, Enns R, et al. The Canadian Registry on Nonvariceal Upper Gastrointestinal Bleeding and Endoscopy (RUGBE): endoscopic hemostasis and proton pump inhibition are associated with improved outcomes in a real-life setting. Am J Gastroenterol. 2004;99:1238\u20131246.","journal-title":"Am J Gastroenterol"},{"key":"69_CR7","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.gie.2008.10.051","volume":"70","author":"S. Loperfido","year":"2009","unstructured":"Loperfido S, Baldo V, Piovesana E, et al. Changing trends in acute upper-GI bleeding: a populationbased study. Gastrointest Endosc. 2009;70:212\u2013224.","journal-title":"Gastrointest Endosc"},{"key":"69_CR8","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ajg.2008.62","volume":"104","author":"T. Muller","year":"2009","unstructured":"Muller T, Barkun AN, Martel M. Non-variceal upper GI bleeding in patients already hospitalized for another condition. Am J Gastroenterol. 2009;104:330\u2013339.","journal-title":"Am J Gastroenterol"},{"key":"69_CR9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1067\/mge.2002.119219","volume":"55","author":"L. Cipolletta","year":"2002","unstructured":"Cipolletta L, Bianco MA, Rotondano G, et al. Outpatient management for low-risk nonvariceal upper GI bleeding: a randomized controlled trial. Gastrointest Endosc. 2002;55:1\u20135.","journal-title":"Gastrointest Endosc"},{"key":"69_CR10","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1111\/j.1572-0241.2008.01865.x","volume":"103","author":"R. Marmo","year":"2008","unstructured":"Marmo R, Koch M, Cipolletta L, et al. Predictive factors of mortality from nonvariceal upper gastrointestinal hemorrhage: a multicenter study. Am J Gastroenterol. 2008;103:1639\u20131647.","journal-title":"Am J Gastroenterol"},{"key":"69_CR11","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1111\/j.1572-0241.2000.02230.x","volume":"95","author":"M.H. Sandel","year":"2000","unstructured":"Sandel MH, Kolkman JJ, Kuipers EJ, et al. Nonvariceal upper gastrointestinal bleeding: differences in outcome for patients admitted to internal medicine and gastroenterological services. Am J Gastroenterol. 2000;95:2357\u20132362.","journal-title":"Am J Gastroenterol"},{"key":"69_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1524-4733.2007.00208.x","volume":"11","author":"A. Viviane","year":"2008","unstructured":"Viviane A, Alan BN. Estimates of costs of hospital stay for variceal and nonvariceal upper gastrointestinal bleeding in the United States. Value Health. 2008;11:1\u20133.","journal-title":"Value Health"},{"key":"69_CR13","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/ajg.2009.507","volume":"105","author":"J.J. Sung","year":"2010","unstructured":"Sung JJ, Tsoi KK, Ma TK, et al. Causes of mortality in patients with peptic ulcer bleeding: a prospective cohort study of 10,428 cases. Am J Gastroenterol. 2010;105:84\u201389.","journal-title":"Am J Gastroenterol"},{"key":"69_CR14","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000323958","volume":"84","author":"J.Y. Lau","year":"2011","unstructured":"Lau JY, Sung J, Hill C, et al. Systematic review of the epidemiology of complicated peptic ulcer disease: incidence, recurrence, risk factors and mortality. Digestion. 2011;84:102\u2013113.","journal-title":"Digestion"},{"key":"69_CR15","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1111\/j.1365-2036.2011.04651.x","volume":"33","author":"A. Lanas","year":"2011","unstructured":"Lanas A, Aabakken L, Fonseca J, et al. Clinical predictors of poor outcomes among patients with nonvariceal upper gastrointestinal bleeding in Europe. Aliment Pharmacol Ther. 2011;33:1225\u20131233.","journal-title":"Aliment Pharmacol Ther"},{"key":"69_CR16","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1136\/gut.38.3.316","volume":"38","author":"T.A. Rockall","year":"1996","unstructured":"Rockall TA, Logan RF, Devlin HB, et al. Risk assessment after acute upper gastrointestinal haemorrhage. Gut. 1996;38:316\u2013321.","journal-title":"Gut"},{"key":"69_CR17","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/S0140-6736(00)02816-6","volume":"356","author":"O. Blatchford","year":"2000","unstructured":"Blatchford O, Murray WR, Blatchford M. A risk score to predict need for treatment for upper-gastrointestinal haemorrhage. Lancet. 2000;356:1318\u20131321.","journal-title":"Lancet"},{"key":"69_CR18","doi-asserted-by":"crossref","first-page":"101","DOI":"10.7326\/0003-4819-152-2-201001190-00009","volume":"152","author":"A.N. Barkun","year":"2010","unstructured":"Barkun AN, Bardou M, Kuipers EJ, et al. International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med. 2010;152:101\u2013113.","journal-title":"Ann Intern Med"},{"key":"69_CR19","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.cgh.2007.12.037","volume":"6","author":"S. Al-Sabah","year":"2008","unstructured":"Al-Sabah S, Barkun AN, Herba K, et al. Costeffectiveness of proton-pump inhibition before endoscopy in upper gastrointestinal bleeding. Clin Gastroenterol Hepatol. 2008;6:418\u2013425.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"69_CR20","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.gie.2007.11.056","volume":"67","author":"K.K. Tsoi","year":"2008","unstructured":"Tsoi KK, Lau JY, Sung JJ. Cost-effectiveness analysis of high-dose omeprazole infusion before endoscopy for patients with upper-GI bleeding. Gastrointest Endosc. 2008;67:1056\u20131063.","journal-title":"Gastrointest Endosc"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-012-0069-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12325-012-0069-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-012-0069-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T19:41:23Z","timestamp":1643830883000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12325-012-0069-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["69"],"URL":"https:\/\/doi.org\/10.1007\/s12325-012-0069-x","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}