{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:12:48Z","timestamp":1778285568060,"version":"3.51.4"},"reference-count":110,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s12325-020-01248-7","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T08:04:27Z","timestamp":1582013067000},"page":"1302-1318","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":212,"title":["Burden of Community-Acquired Pneumonia and Unmet Clinical Needs"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5855-8600","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Ferreira-Coimbra","sequence":"first","affiliation":[]},{"given":"Cristina","family":"Sarda","sequence":"additional","affiliation":[]},{"given":"Jordi","family":"Rello","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,2,18]]},"reference":[{"key":"1248_CR1","unstructured":"World Health Organization. Global health estimates 2016: disease burden by cause, age, sex, by country and by region, 2000\u20132016. Geneva; 2018."},{"issue":"5","key":"1248_CR2","doi-asserted-by":"crossref","first-page":"e61","DOI":"10.1093\/cid\/ciw353","volume":"63","author":"AC Kalil","year":"2016","unstructured":"Kalil AC, Metersky ML, Klompas M, et al. Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis. 2016;63(5):e61\u2013111.","journal-title":"Clin Infect Dis"},{"key":"1248_CR3","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/s41591-019-0437-z","volume":"25","author":"RM Dedrick","year":"2019","unstructured":"Dedrick RM, Guerrero-Bustamante CA, Garlena RA, et al. Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus. Nat Med. 2019;25:730\u20133.","journal-title":"Nat Med"},{"issue":"6","key":"1248_CR4","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S1473-3099(18)30805-3","volume":"19","author":"PF Laterre","year":"2019","unstructured":"Laterre PF, Colin G, Dequin PF, et al. CAL02, a novel antitoxin liposomal agent, in severe pneumococcal pneumonia: a first-in-human, double-blind, placebo-controlled, randomised trial. Lancet Infect Dis. 2019;19(6):620\u201330.","journal-title":"Lancet Infect Dis"},{"issue":"2","key":"1248_CR5","doi-asserted-by":"crossref","first-page":"ofy010","DOI":"10.1093\/ofid\/ofy010","volume":"5","author":"A Bjarnason","year":"2018","unstructured":"Bjarnason A, Westin J, Lindh M, et al. Incidence, etiology, and outcomes of community-acquired pneumonia: a population-based study. Open Forum Infect Dis. 2018;5(2):ofy010.","journal-title":"Open Forum Infect Dis"},{"issue":"9","key":"1248_CR6","doi-asserted-by":"crossref","first-page":"e75131","DOI":"10.1371\/journal.pone.0075131","volume":"8","author":"ER Millett","year":"2013","unstructured":"Millett ER, Quint JK, Smeeth L, Daniel RM, Thomas SL. Incidence of community-acquired lower respiratory tract infections and pneumonia among older adults in the United Kingdom: a population-based study. PLoS One. 2013;8(9):e75131.","journal-title":"PLoS One"},{"issue":"6","key":"1248_CR7","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1183\/09031936.00128713","volume":"42","author":"C Sterrantino","year":"2013","unstructured":"Sterrantino C, Trifir\u00f2 G, Lapi F, et al. Burden of community-acquired pneumonia in Italian general practice. Eur Respir J. 2013;42(6):1739\u201342.","journal-title":"Eur Respir J"},{"issue":"6","key":"1248_CR8","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.medmal.2018.02.012","volume":"48","author":"H Partouche","year":"2018","unstructured":"Partouche H, Lepoutre A, Vaure CBD, Poisson T, Toubiana L, Gilberg S. Incidence of all-cause adult community-acquired pneumonia in primary care settings in France. Med Mal Infect. 2018;48(6):389\u201395.","journal-title":"Med Mal Infect"},{"issue":"5","key":"1248_CR9","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1056\/NEJMoa1500245","volume":"373","author":"S Jain","year":"2015","unstructured":"Jain S, Self WH, Wunderink RG, et al. Community-acquired pneumonia requiring hospitalization among U.S. adults. N Engl J Med. 2015;373(5):415\u201327.","journal-title":"N Engl J Med"},{"issue":"8","key":"1248_CR10","first-page":"494","volume":"6","author":"J Broulette","year":"2013","unstructured":"Broulette J, Yu H, Pyenson B, Iwasaki K, Sato R. The incidence rate and economic burden of community-acquired pneumonia in a working-age population. Am Health Drug Benefits. 2013;6(8):494\u2013503.","journal-title":"Am Health Drug Benefits"},{"issue":"4","key":"1248_CR11","doi-asserted-by":"crossref","first-page":"e019439","DOI":"10.1136\/bmjopen-2017-019439","volume":"8","author":"GD Lopardo","year":"2018","unstructured":"Lopardo GD, Fridman D, Raimondo E, et al. Incidence rate of community-acquired pneumonia in adults: a population-based prospective active surveillance study in three cities in South America. BMJ Open. 2018;8(4):e019439.","journal-title":"BMJ Open"},{"issue":"9","key":"1248_CR12","doi-asserted-by":"crossref","first-page":"e673","DOI":"10.1016\/j.ijid.2013.02.006","volume":"17","author":"AR Buzzo","year":"2013","unstructured":"Buzzo AR, Roberts C, Mollinedo LG, Quevedo JM, Casas GL, Soldevilla JM. Morbidity and mortality of pneumonia in adults in six Latin American countries. Int J Infect Dis. 2013;17(9):e673\u20137.","journal-title":"Int J Infect Dis"},{"issue":"44","key":"1248_CR13","doi-asserted-by":"crossref","first-page":"e8429","DOI":"10.1097\/MD.0000000000008429","volume":"96","author":"MJ Choi","year":"2017","unstructured":"Choi MJ, Song JY, Noh JY, et al. Disease burden of hospitalized community-acquired pneumonia in South Korea: analysis based on age and underlying medical conditions. Medicine (Baltimore). 2017;96(44):e8429.","journal-title":"Medicine (Baltimore)"},{"issue":"4","key":"1248_CR14","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3947\/ic.2018.50.4.287","volume":"50","author":"JY Heo","year":"2018","unstructured":"Heo JY, Song JY. Disease burden and etiologic distribution of community-acquired pneumonia in adults: evolving epidemiology in the era of pneumococcal conjugate vaccines. Infect Chemother. 2018;50(4):287\u2013300.","journal-title":"Infect Chemother"},{"key":"1248_CR15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ijid.2016.05.021","volume":"49","author":"S Azmi","year":"2016","unstructured":"Azmi S, Aljunid SM, Maimaiti N, et al. Assessing the burden of pneumonia using administrative data from Malaysia, Indonesia, and the Philippines. Int J Infect Dis. 2016;49:87\u201393.","journal-title":"Int J Infect Dis"},{"issue":"1","key":"1248_CR16","doi-asserted-by":"publisher","first-page":"26","DOI":"10.2478\/jtim-2018-0006","volume":"6","author":"YG Zhu","year":"2018","unstructured":"Zhu YG, Tang XD, Lu YT, Zhang J, Qu JM. Contemporary situation of community-acquired pneumonia in china: a systematic review. J Transl Int Med. 2018;6(1):26\u201331. https:\/\/doi.org\/10.2478\/jtim-2018-0006.","journal-title":"J Transl Int Med"},{"issue":"1","key":"1248_CR17","first-page":"E49","volume":"41","author":"S Sharma","year":"2017","unstructured":"Sharma S, Sneath E, Friedman ND, Cheng AC. Community-acquired syndromes causing morbidity and mortality in Australia. Commun Dis Intell Q Rep. 2017;41(1):E49\u201357.","journal-title":"Commun Dis Intell Q Rep"},{"issue":"5","key":"1248_CR18","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.vaccine.2011.11.103","volume":"30","author":"A Li","year":"2012","unstructured":"Li A, Newall AT, Britt H, Macintyre CR. The cost and disease burden of pneumonia in general practice in Australia. Vaccine. 2012;30(5):830\u20131.","journal-title":"Vaccine"},{"issue":"2","key":"1248_CR19","first-page":"108","volume":"38","author":"JH Song","year":"2011","unstructured":"Song JH, Thamlikitkul V, Hsueh PR. Clinical and economic burden of community-acquired pneumonia amongst adults in the Asia-Pacific region. Int J Antimicrob Agents. 2011;38(2):108\u201317.","journal-title":"Int J Antimicrob Agents"},{"issue":"28","key":"1248_CR20","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1016\/j.vaccine.2015.05.001","volume":"33","author":"MH Rozenbaum","year":"2015","unstructured":"Rozenbaum MH, Mangen MJ, Huijts SM, van der Werf TS, Postma MJ. Incidence, direct costs and duration of hospitalization of patients hospitalized with community acquired pneumonia: a nationwide retrospective claims database analysis. Vaccine. 2015;33(28):3193\u20139.","journal-title":"Vaccine"},{"issue":"4","key":"1248_CR21","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1034\/j.1399-3003.2000.15d21.x","volume":"15","author":"J Almirall","year":"2000","unstructured":"Almirall J, Bol\u00edbar I, Vidal J, et al. Epidemiology of community-acquired pneumonia in adults: a population-based study. Eur Respir J. 2000;15(4):757\u201363.","journal-title":"Eur Respir J"},{"issue":"1","key":"1248_CR22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1136\/thx.2009.129502","volume":"67","author":"T Welte","year":"2012","unstructured":"Welte T, Torres A, Nathwani D. Clinical and economic burden of community-acquired pneumonia among adults in Europe. Thorax. 2012;67(1):71\u20139.","journal-title":"Thorax"},{"issue":"3","key":"1248_CR23","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1155\/2005\/672501","volume":"12","author":"TJ Marrie","year":"2005","unstructured":"Marrie TJ, Huang JQ. Epidemiology of community-acquired pneumonia in Edmonton, Alberta: an emergency department-based study. Can Respir J. 2005;12(3):139\u201342.","journal-title":"Can Respir J"},{"key":"1248_CR24","unstructured":"World Health Organization. Disease burden and mortality estimates. 2000\u20132016, June 2018, Geneva. https:\/\/www.who.int\/healthinfo\/global_burden_disease\/estimates\/en\/index1.html. Accessed 24 June 2019"},{"issue":"9859","key":"1248_CR25","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","volume":"380","author":"R Lozano","year":"2012","unstructured":"Lozano R, Naghavi M, Foreman K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2095\u2013128.","journal-title":"Lancet"},{"issue":"11","key":"1248_CR26","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1093\/cid\/cix647","volume":"65","author":"JA Ramirez","year":"2017","unstructured":"Ramirez JA, Wiemken TL, Peyrani P, et al. Adults hospitalized with pneumonia in the United States: incidence, epidemiology, and mortality. Clin Infect Dis. 2017;65(11):1806\u201312.","journal-title":"Clin Infect Dis"},{"issue":"3","key":"1248_CR27","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1183\/09031936.00105513","volume":"42","author":"GJ Gibson","year":"2013","unstructured":"Gibson GJ, Loddenkemper R, Lundb\u00e4ck B, Sibille Y. Respiratory health and disease in Europe: the new European Lung White Book. Eur Respir J. 2013;42(3):559\u201363.","journal-title":"Eur Respir J"},{"issue":"6","key":"1248_CR28","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/MD.0b013e318190f444","volume":"87","author":"J Johnstone","year":"2008","unstructured":"Johnstone J, Eurich DT, Majumdar SR, Jin Y, Marrie TJ. Long-term morbidity and mortality after hospitalization with community-acquired pneumonia: a population-based cohort study. Medicine (Baltimore). 2008;87(6):329\u201334.","journal-title":"Medicine (Baltimore)"},{"issue":"6","key":"1248_CR29","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1055\/s-0036-1592075","volume":"37","author":"JH Song","year":"2016","unstructured":"Song JH, Huh K, Chung DR. Community-acquired pneumonia in the Asia-Pacific region. Semin Respir Crit Care Med. 2016;37(6):839\u201354.","journal-title":"Semin Respir Crit Care Med"},{"issue":"7","key":"1248_CR30","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1111\/resp.13112","volume":"22","author":"SJ Aston","year":"2017","unstructured":"Aston SJ. Pneumonia in the developing world: characteristic features and approach to management. Respirology. 2017;22(7):1276\u201387.","journal-title":"Respirology"},{"issue":"2","key":"1248_CR31","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.pulmoe.2018.06.004","volume":"25","author":"F Teixeira-Lopes","year":"2019","unstructured":"Teixeira-Lopes F, Cysneiros A, Dias A, et al. Intra-hospital mortality for community-acquired pneumonia in mainland Portugal between 2000 and 2009. Pulmonology. 2019;25(2):66\u201370.","journal-title":"Pulmonology"},{"issue":"3","key":"1248_CR32","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1586\/17476348.2016.1144477","volume":"10","author":"J Rello","year":"2016","unstructured":"Rello J, Perez A. Precision medicine for the treatment of severe pneumonia in intensive care. Expert Rev Respir Med. 2016;10(3):297\u2013316.","journal-title":"Expert Rev Respir Med"},{"issue":"10","key":"1248_CR33","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1164\/rccm.201611-2262OC","volume":"196","author":"OT Ranzani","year":"2017","unstructured":"Ranzani OT, Prina E, Men\u00e9ndez R, et al. New sepsis definition (Sepsis-3) and community-acquired pneumonia mortality. A validation and clinical decision-making study. Am J Respir Crit Care Med. 2017;196(10):1287\u201397.","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"1248_CR34","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.medin.2015.07.005","volume":"40","author":"J Vall\u00e9s","year":"2016","unstructured":"Vall\u00e9s J, Diaz E, Mart\u00edn-Loeches I, et al. Evolution over a 15-year period of the clinical characteristics and outcomes of critically ill patients with severe community-acquired pneumonia. Med Intensiva. 2016;40(4):238\u201345.","journal-title":"Med Intensiva"},{"issue":"Suppl 3","key":"1248_CR35","first-page":"iii3","volume":"66","author":"JA Ramirez","year":"2011","unstructured":"Ramirez JA, Anzueto AR. Changing needs of community-acquired pneumonia. J Antimicrob Chemother. 2011;66(Suppl 3):iii3\u20139.","journal-title":"J Antimicrob Chemother"},{"issue":"11","key":"1248_CR36","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1136\/thoraxjnl-2016-208937","volume":"71","author":"P Daniel","year":"2016","unstructured":"Daniel P, Woodhead M, Welham S, Mckeever TM, Lim WS, British Thoracic Society. Mortality reduction in adult community-acquired pneumonia in the UK (2009\u20132014): results from the British Thoracic Society audit programme. Thorax. 2016;71(11):1061\u20133.","journal-title":"Thorax"},{"issue":"4","key":"1248_CR37","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1183\/09031936.00168811","volume":"40","author":"C Cill\u00f3niz","year":"2012","unstructured":"Cill\u00f3niz C, Ewig S, Polverino E, et al. Community-acquired pneumonia in outpatients: aetiology and outcomes. Eur Respir J. 2012;40(4):931\u20138.","journal-title":"Eur Respir J"},{"issue":"10","key":"1248_CR38","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1093\/cid\/cix549","volume":"65","author":"DM Musher","year":"2017","unstructured":"Musher DM, Abers MS, Bartlett JG. Evolving understanding of the causes of pneumonia in adults, with special attention to the role of Pneumococcus. Clin Infect Dis. 2017;65(10):1736\u201344.","journal-title":"Clin Infect Dis"},{"issue":"2","key":"1248_CR39","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1086\/648678","volume":"50","author":"N Johansson","year":"2010","unstructured":"Johansson N, Kalin M, Tiveljung-Lindell A, Giske CG, Hedlund J. Etiology of community-acquired pneumonia: increased microbiological yield with new diagnostic methods. Clin Infect Dis. 2010;50(2):202\u20139.","journal-title":"Clin Infect Dis"},{"issue":"7","key":"1248_CR40","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/cid\/civ1214","volume":"62","author":"NJ Gadsby","year":"2016","unstructured":"Gadsby NJ, Russell CD, McHugh MP, et al. Comprehensive molecular testing for respiratory pathogens in community-acquired pneumonia. Clin Infect Dis. 2016;62(7):817\u201323.","journal-title":"Clin Infect Dis"},{"issue":"8","key":"1248_CR41","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1111\/j.1440-1843.2009.01637.x","volume":"14","author":"G Lui","year":"2009","unstructured":"Lui G, Ip M, Lee N, et al. Role of \u2018atypical pathogens\u2019 among adult hospitalized patients with community-acquired pneumonia. Respirology. 2009;14(8):1098\u2013105.","journal-title":"Respirology"},{"issue":"8","key":"1248_CR42","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1111\/resp.12851","volume":"21","author":"JM Sahuquillo-Arce","year":"2016","unstructured":"Sahuquillo-Arce JM, Men\u00e9ndez R, M\u00e9ndez R, et al. Age-related risk factors for bacterial aetiology in community-acquired pneumonia. Respirology. 2016;21(8):1472\u20139.","journal-title":"Respirology"},{"issue":"2","key":"1248_CR43","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ijantimicag.2007.09.014","volume":"31","author":"JH Song","year":"2008","unstructured":"Song JH, Oh WS, Kang CI, et al. Epidemiology and clinical outcomes of community-acquired pneumonia in adult patients in Asian countries: a prospective study by the Asian network for surveillance of resistant pathogens. Int J Antimicrob Agents. 2008;31(2):107\u201314.","journal-title":"Int J Antimicrob Agents"},{"issue":"2","key":"1248_CR44","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4103\/lungindia.lungindia_288_17","volume":"35","author":"RA Para","year":"2018","unstructured":"Para RA, Fomda BA, Jan RA, Shah S, Koul PA. Microbial etiology in hospitalized North Indian adults with community-acquired pneumonia. Lung India. 2018;35(2):108\u201315.","journal-title":"Lung India"},{"issue":"1","key":"1248_CR45","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cardfail.2009.08.002","volume":"16","author":"VM van Deursen","year":"2010","unstructured":"van Deursen VM, Damman K, Hillege HL, van Beek AP, van Veldhuisen DJ, Voors AA. Abnormal liver function in relation to hemodynamic profile in heart failure patients. J Card Fail. 2010;16(1):84\u201390.","journal-title":"J Card Fail"},{"key":"1248_CR46","first-page":"A6060","volume":"185","author":"RS Dagaonkar","year":"2012","unstructured":"Dagaonkar RS, Udwadia ZF, Sen T, et al. Severe community acquired pneumonia in Mumbai, India: etiology and predictive value of the modified British Thoracic Society rule. Am J Respir Crit Care Med. 2012;185:A6060.","journal-title":"Am J Respir Crit Care Med"},{"issue":"10","key":"1248_CR47","doi-asserted-by":"crossref","first-page":"e852","DOI":"10.1016\/j.ijid.2010.02.2262","volume":"14","author":"RE Isturiz","year":"2010","unstructured":"Isturiz RE, Luna CM, Ramirez J. Clinical and economic burden of pneumonia among adults in Latin America. Int J Infect Dis. 2010;14(10):e852\u20136.","journal-title":"Int J Infect Dis"},{"issue":"10","key":"1248_CR48","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1164\/rccm.200603-350OC","volume":"175","author":"FW Arnold","year":"2007","unstructured":"Arnold FW, Summersgill JT, Lajoie AS, et al. A worldwide perspective of atypical pathogens in community-acquired pneumonia. Am J Respir Crit Care Med. 2007;175(10):1086\u201393.","journal-title":"Am J Respir Crit Care Med"},{"issue":"8","key":"1248_CR49","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1164\/rccm.201301-0079OC","volume":"188","author":"Y Shindo","year":"2013","unstructured":"Shindo Y, Ito R, Kobayashi D, et al. Risk factors for drug-resistant pathogens in community-acquired and healthcare-associated pneumonia. Am J Respir Crit Care Med. 2013;188(8):985\u201395.","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"1248_CR50","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1007\/s10096-010-1003-2","volume":"29","author":"B Cao","year":"2010","unstructured":"Cao B, Ren LL, Zhao F, et al. Viral and Mycoplasma pneumoniae community-acquired pneumonia and novel clinical outcome evaluation in ambulatory adult patients in China. Eur J Clin Microbiol Infect Dis. 2010;29(11):1443\u20138.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"1248_CR51","doi-asserted-by":"crossref","unstructured":"Tacconelli E, Carrara E, Savoldi A, et al. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Infect Dis. 2018;18(3):318\u201327.","DOI":"10.1016\/S1473-3099(17)30753-3"},{"issue":"3","key":"1248_CR52","first-page":"21","volume":"69","author":"S Patra","year":"2017","unstructured":"Patra S, Shaw T, Eshwara VK, Saravu K, Hande M, Mukhopadhyay C. Pulmonary melioidosis: an experience over years from a tertiary care hospital from southwest India. Indian J Med Sci Vol. 2017;69(3):21\u20136.","journal-title":"Indian J Med Sci Vol"},{"issue":"3","key":"1248_CR53","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/cid\/cir808","volume":"54","author":"EM Meumann","year":"2012","unstructured":"Meumann EM, Cheng AC, Ward L, Currie BJ. Clinical features and epidemiology of melioidosis pneumonia: results from a 21-year study and review of the literature. Clin Infect Dis. 2012;54(3):362\u20139.","journal-title":"Clin Infect Dis"},{"issue":"5","key":"1248_CR54","first-page":"1","volume":"64","author":"TJ Benoit","year":"2015","unstructured":"Benoit TJ, Blaney DD, Gee JE, et al. Melioidosis cases and selected reports of occupational exposures to Burkholderia pseudomallei\u2013United States, 2008\u20132013. MMWR Surveill Summ. 2015;64(5):1\u20139.","journal-title":"MMWR Surveill Summ"},{"issue":"8","key":"1248_CR55","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/s10096-019-03548-5","volume":"38","author":"S Le Tohic","year":"2019","unstructured":"Le Tohic S, Montana M, Koch L, Curti C, Vanelle P. A review of melioidosis cases imported into Europe. Eur J Clin Microbiol Infect Dis. 2019;38(8):1395\u2013408.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"2","key":"1248_CR56","doi-asserted-by":"crossref","first-page":"1701190","DOI":"10.1183\/13993003.01190-2017","volume":"52","author":"MI Restrepo","year":"2018","unstructured":"Restrepo MI, Babu BL, Reyes LF, et al. Burden and risk factors for\u00a0Pseudomonas aeruginosa community-acquired pneumonia: a multinational point prevalence study of hospitalised patients. Eur Respir J. 2018;52(2):1701190.","journal-title":"Eur Respir J"},{"issue":"12","key":"1248_CR57","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/S1473-3099(16)30267-5","volume":"16","author":"S Aliberti","year":"2016","unstructured":"Aliberti S, Reyes LF, Faverio P, et al. Global initiative for meticillin-resistant Staphylococcus aureus pneumonia (GLIMP): an international, observational cohort study. Lancet Infect Dis. 2016;16(12):1364\u201376.","journal-title":"Lancet Infect Dis"},{"issue":"4","key":"1248_CR58","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1159\/000369561","volume":"89","author":"X Wu","year":"2015","unstructured":"Wu X, Wang Q, Wang M, et al. Incidence of respiratory viral infections detected by PCR and real-time PCR in adult patients with community-acquired pneumonia: a meta-analysis. Respiration. 2015;89(4):343\u201352.","journal-title":"Respiration"},{"key":"1248_CR59","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jcv.2017.07.019","volume":"95","author":"Y Alimi","year":"2017","unstructured":"Alimi Y, Lim WS, Lansbury L, Leonardi-Bee J, Nguyen-Van-Tam JS. Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe. J Clin Virol. 2017;95:26\u201335.","journal-title":"J Clin Virol"},{"issue":"140","key":"1248_CR60","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1183\/16000617.0076-2015","volume":"25","author":"M Burk","year":"2016","unstructured":"Burk M, El-Kersh K, Saad M, Wiemken T, Ramirez J, Cavallazzi R. Viral infection in community-acquired pneumonia: a systematic review and meta-analysis. Eur Respir Rev. 2016;25(140):178\u201388.","journal-title":"Eur Respir Rev"},{"issue":"1","key":"1248_CR61","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13613-019-0559-y","volume":"9","author":"L Vidaur","year":"2019","unstructured":"Vidaur L, Totorika I, Montes M, Vicente D, Rello J, Cilla G. Human metapneumovirus as cause of severe community-acquired pneumonia in adults: insights from a ten-year molecular and epidemiological analysis. Ann Intensive Care. 2019;9(1):86.","journal-title":"Ann Intensive Care"},{"key":"1248_CR62","unstructured":"ClinicalTrials.gov. Study to compare delafloxacin to moxifloxacin for the treatment of adults with community-acquired bacterial pneumonia (DEFINE-CABP). https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02679573?term=delafloxacin&cond=pneumonia&rank=1. 2016. Accessed June 21, 2019."},{"issue":"8","key":"1248_CR63","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1093\/cid\/ciw490","volume":"63","author":"TM File Jr","year":"2016","unstructured":"File TM Jr, Rewerska B, Vucinic-Mihailovic V, et al. SOLITAIRE-IV: a randomized, double-blind, multicenter study comparing the efficacy and safety of intravenous-to-oral solithromycin to intravenous-to-oral moxifloxacin for treatment of community-acquired bacterial pneumonia. Clin Infect Dis. 2016;63(8):1007\u201316.","journal-title":"Clin Infect Dis"},{"issue":"4","key":"1248_CR64","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S1473-3099(16)00017-7","volume":"16","author":"CM Barrera","year":"2016","unstructured":"Barrera CM, Mykietiuk A, Metev H, et al. Efficacy and safety of oral solithromycin versus oral moxifloxacin for treatment of community-acquired bacterial pneumonia: a global, double-blind, multicentre, randomised, active-controlled, non-inferiority trial (SOLITAIRE-ORAL). Lancet Infect Dis. 2016;16(4):421\u201330.","journal-title":"Lancet Infect Dis"},{"issue":"Suppl 3","key":"1248_CR65","doi-asserted-by":"crossref","first-page":"iii33","DOI":"10.1093\/jac\/dkr097","volume":"66","author":"DE Low","year":"2011","unstructured":"Low DE, File TM Jr, Eckburg PB, et al. FOCUS 2: a randomized, double-blinded, multicentre, phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia. J Antimicrob Chemother. 2011;66(Suppl 3):iii33\u201344.","journal-title":"J Antimicrob Chemother"},{"issue":"3","key":"1248_CR66","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ijantimicag.2011.11.005","volume":"39","author":"SC Nicholson","year":"2012","unstructured":"Nicholson SC, Welte T, File TM Jr, et al. A randomised, double-blind trial comparing ceftobiprole medocaril with ceftriaxone with or without linezolid for the treatment of patients with community-acquired pneumonia requiring hospitalisation. Int J Antimicrob Agents. 2012;39(3):240\u20136.","journal-title":"Int J Antimicrob Agents"},{"issue":"11","key":"1248_CR67","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1093\/cid\/ciz090","volume":"69","author":"TM File","year":"2019","unstructured":"File TM, Goldberg L, Das A, et al. Efficacy and safety of intravenous-to-oral lefamulin, a pleuromutilin antibiotic, for the treatment of community-acquired bacterial pneumonia: the phase III lefamulin evaluation against pneumonia (LEAP 1) trial. Clin Infect Dis. 2019;69(11):1856\u201367.","journal-title":"Clin Infect Dis"},{"issue":"6","key":"1248_CR68","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1056\/NEJMoa1800201","volume":"380","author":"R Stets","year":"2019","unstructured":"Stets R, Popescu M, Gonong JR, et al. Omadacycline for community-acquired bacterial pneumonia. N Engl J Med. 2019;380(6):517\u201327.","journal-title":"N Engl J Med"},{"issue":"9","key":"1248_CR69","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1164\/rccm.200905-0808OC","volume":"181","author":"D Snijders","year":"2010","unstructured":"Snijders D, Daniels JM, de Graaff CS, van der Werf TS, Boersma WG. Efficacy of corticosteroids in community-acquired pneumonia: a randomized double-blinded clinical trial. Am J Respir Crit Care Med. 2010;181(9):975\u201382.","journal-title":"Am J Respir Crit Care Med"},{"issue":"9782","key":"1248_CR70","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(11)60607-7","volume":"377","author":"SC Meijvis","year":"2011","unstructured":"Meijvis SC, Hardeman H, Remmelts HH, et al. Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial. Lancet. 2011;377(9782):2023\u201330.","journal-title":"Lancet"},{"issue":"3","key":"1248_CR71","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1164\/rccm.200406-808OC","volume":"171","author":"M Confalonieri","year":"2005","unstructured":"Confalonieri M, Urbino R, Potena A, et al. Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized study. Am J Respir Crit Care Med. 2005;171(3):242\u20138.","journal-title":"Am J Respir Crit Care Med"},{"issue":"9977","key":"1248_CR72","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/S0140-6736(14)62447-8","volume":"385","author":"CA Blum","year":"2015","unstructured":"Blum CA, Nigro N, Briel M, et al. Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial. Lancet. 2015;385(9977):1511\u20138.","journal-title":"Lancet"},{"issue":"2","key":"1248_CR73","doi-asserted-by":"crossref","first-page":"R96","DOI":"10.1186\/cc10103","volume":"15","author":"S Fern\u00e1ndez-Serrano","year":"2011","unstructured":"Fern\u00e1ndez-Serrano S, Dorca J, Garcia-Vidal C, et al. Effect of corticosteroids on the clinical course of community-acquired pneumonia: a randomized controlled trial. Crit Care. 2011;15(2):R96.","journal-title":"Crit Care"},{"issue":"7","key":"1248_CR74","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1001\/jama.2015.88","volume":"313","author":"A Torres","year":"2015","unstructured":"Torres A, Sibila O, Ferrer M, et al. Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial. JAMA. 2015;313(7):677\u201386.","journal-title":"JAMA"},{"key":"1248_CR75","unstructured":"ClinicalTrials.gov. Evaluate the safety and efficacy of methylprednisolone in hospitalized veterans with severe community-acquired pneumonia. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01283009. 2011. Accessed June 21, 2019."},{"issue":"12","key":"1248_CR76","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1128\/AAC.42.12.3309","volume":"42","author":"M Duong","year":"1998","unstructured":"Duong M, Simard M, Bergeron Y, Ouellet N, C\u00f4t\u00e9-Richer M, Bergeron MG. Immunomodulating effects of HMR 3004 on pulmonary inflammation caused by heat-killed Streptococcus pneumoniae in mice. Antimicrob Agents Chemother. 1998;42(12):3309\u201312.","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"1248_CR77","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1128\/AAC.01459-06","volume":"51","author":"Y Yasuda","year":"2007","unstructured":"Yasuda Y, Kasahara K, Mizuno F, Nishi K, Mikasa K, Kita E. Roxithromycin favorably modifies the initial phase of resistance against infection with macrolide-resistant Streptococcus pneumoniae in a murine pneumonia model. Antimicrob Agents Chemother. 2007;51(5):1741\u201352.","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"1248_CR78","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1128\/AAC.45.1.252-262.2001","volume":"45","author":"M Duong","year":"2001","unstructured":"Duong M, Simard M, Bergeron Y, Bergeron MG. Kinetic study of the inflammatory response in Streptococcus pneumoniae experimental pneumonia treated with the ketolide HMR 3004. Antimicrob Agents Chemother. 2001;45(1):252\u201362.","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"1248_CR79","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1378\/chest.07-3056","volume":"134","author":"M Leiva","year":"2008","unstructured":"Leiva M, Ruiz-Bravo A, Jimenez-Valera M. Effects of telithromycin in in vitro and in vivo models of lipopolysaccharide-induced airway inflammation. Chest. 2008;134(1):20\u20139.","journal-title":"Chest"},{"issue":"1","key":"1248_CR80","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1179\/joc.2004.16.1.82","volume":"16","author":"G Demartini","year":"2004","unstructured":"Demartini G, Esposti D, Marthyn P, Lapidari A, Fraschini F, Scaglione F. Effect of multiple doses of clarithromycin and amoxicillin on IL-6, IFNgamma and IL-10 plasma levels in patients with community acquired pneumonia. J Chemother. 2004;16(1):82\u20135.","journal-title":"J Chemother"},{"issue":"12","key":"1248_CR81","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1001\/jamainternmed.2014.4887","volume":"174","author":"N Garin","year":"2014","unstructured":"Garin N, Genn\u00e9 D, Carballo S, et al. \u03b2-Lactam monotherapy vs \u03b2-lactam-macrolide combination treatment in moderately severe community-acquired pneumonia: a randomized noninferiority trial. JAMA Intern Med. 2014;174(12):1894\u2013901.","journal-title":"JAMA Intern Med"},{"issue":"8","key":"1248_CR82","first-page":"337","volume":"70","author":"DF Postma","year":"2012","unstructured":"Postma DF, van Werkhoven CH, Huijts SM, Bolkenbaas M, Oosterheert JJ, Bonten MJ. New trends in the prevention and management of community-acquired pneumonia. Neth J Med. 2012;70(8):337\u201348.","journal-title":"Neth J Med"},{"issue":"4","key":"1248_CR83","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1164\/rccm.200311-1578OC","volume":"170","author":"LM Baddour","year":"2004","unstructured":"Baddour LM, Yu VL, Klugman KP, et al. Combination antibiotic therapy lowers mortality among severely ill patients with pneumococcal bacteremia. Am J Respir Crit Care Med. 2004;170(4):440\u20134.","journal-title":"Am J Respir Crit Care Med"},{"issue":"21","key":"1248_CR84","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1001\/jama.2014.4304","volume":"311","author":"EM Mortensen","year":"2014","unstructured":"Mortensen EM, Halm EA, Pugh MJ, et al. Association of azithromycin with mortality and cardiovascular events among older patients hospitalized with pneumonia. JAMA. 2014;311(21):2199\u2013208.","journal-title":"JAMA"},{"issue":"1","key":"1248_CR85","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1183\/09031936.00054108","volume":"33","author":"MI Restrepo","year":"2009","unstructured":"Restrepo MI, Mortensen EM, Waterer GW, Wunderink RG, Coalson JJ, Anzueto A. Impact of macrolide therapy on mortality for patients with severe sepsis due to pneumonia. Eur Respir J. 2009;33(1):153\u20139.","journal-title":"Eur Respir J"},{"issue":"4","key":"1248_CR86","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1007\/s00134-009-1730-y","volume":"36","author":"I Martin-Loeches","year":"2010","unstructured":"Martin-Loeches I, Lisboa T, Rodriguez A, et al. Combination antibiotic therapy with macrolides improves survival in intubated patients with community-acquired pneumonia. Intensive Care Med. 2010;36(4):612\u201320.","journal-title":"Intensive Care Med"},{"issue":"Suppl 2","key":"1248_CR87","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1086\/511159","volume":"44","author":"LA Mandell","year":"2007","unstructured":"Mandell LA, Wunderink RG, Anzueto A, et al. Infectious Diseases Society of America\/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 2007;44(Suppl 2):S27\u201372.","journal-title":"Clin Infect Dis"},{"issue":"Suppl 6","key":"1248_CR88","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1111\/j.1469-0691.2011.03672.x","volume":"17","author":"M Woodhead","year":"2011","unstructured":"Woodhead M, Blasi F, Ewig S, et al. Guidelines for the management of adult lower respiratory tract infections\u2013full version. Clin Microbiol Infect. 2011;17(Suppl 6):E1\u201359.","journal-title":"Clin Microbiol Infect"},{"issue":"5","key":"1248_CR89","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1590\/s1806-37562018000000130","volume":"44","author":"RA Corr\u00eaa","year":"2018","unstructured":"Corr\u00eaa RA, Costa AN, Lundgren F, et al. 2018 recommendations for the management of community acquired pneumonia . J Bras Pneumol. 2018;44(5):405\u201323. (Published correction appears in J Bras Pneumol. 2018 Nov\u2013Dec;44(6):532).","journal-title":"J Bras Pneumol"},{"issue":"10","key":"1248_CR90","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.arbres.2010.06.014","volume":"46","author":"R Men\u00e9ndez","year":"2010","unstructured":"Men\u00e9ndez R, Torres A, Aspa J, et al. Community acquired pneumonia. New guidelines of the Spanish Society of Chest Diseases and Thoracic Surgery (SEPAR). Arch Bronconeumol. 2010;46(10):543\u201358.","journal-title":"Arch Bronconeumol"},{"issue":"14","key":"1248_CR91","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1056\/NEJMoa1406330","volume":"372","author":"DF Postma","year":"2015","unstructured":"Postma DF, van Werkhoven CH, van Elden LJ, et al. Antibiotic treatment strategies for community-acquired pneumonia in adults. N Engl J Med. 2015;372(14):1312\u201323.","journal-title":"N Engl J Med"},{"issue":"1","key":"1248_CR92","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1086\/648593","volume":"201","author":"T Pilishvili","year":"2010","unstructured":"Pilishvili T, Lexau C, Farley MM, et al. Sustained reductions in invasive pneumococcal disease in the era of conjugate vaccine. J Infect Dis. 2010;201(1):32\u201341.","journal-title":"J Infect Dis"},{"issue":"1","key":"1248_CR93","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1016\/S2214-109X(16)30306-0","volume":"5","author":"T Shiri","year":"2017","unstructured":"Shiri T, Datta S, Madan J, et al. Indirect effects of childhood pneumococcal conjugate vaccination on invasive pneumococcal disease: a systematic review and meta-analysis. Lancet Glob Health. 2017;5(1):e51\u20139.","journal-title":"Lancet Glob Health"},{"issue":"39","key":"1248_CR94","doi-asserted-by":"crossref","first-page":"5264","DOI":"10.1016\/j.vaccine.2017.08.007","volume":"35","author":"R Men\u00e9ndez","year":"2017","unstructured":"Men\u00e9ndez R, Espa\u00f1a PP, P\u00e9rez-Trallero E, et al. The burden of PCV13 serotypes in hospitalized pneumococcal pneumonia in Spain using a novel urinary antigen detection test. CAPA study. Vaccine. 2017;35(39):5264\u201370.","journal-title":"Vaccine"},{"issue":"11","key":"1248_CR95","doi-asserted-by":"crossref","first-page":"6484","DOI":"10.1128\/AAC.03344-14","volume":"58","author":"SS Richter","year":"2014","unstructured":"Richter SS, Diekema DJ, Heilmann KP, Dohrn CL, Riahi F, Doern GV. Changes in pneumococcal serotypes and antimicrobial resistance after introduction of the 13-valent conjugate vaccine in the United States. Antimicrob Agents Chemother. 2014;58(11):6484\u20139.","journal-title":"Antimicrob Agents Chemother"},{"key":"1248_CR96","doi-asserted-by":"crossref","unstructured":"Moberley S, Holden J, Tatham DP, Andrews RM. Vaccines for preventing pneumococcal infection in adults. Cochrane Database Syst Rev. 2013;(1):CD000422.","DOI":"10.1002\/14651858.CD000422.pub3"},{"issue":"12","key":"1248_CR97","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1056\/NEJMoa1408544","volume":"372","author":"MJ Bonten","year":"2015","unstructured":"Bonten MJ, Huijts SM, Bolkenbaas M, et al. Polysaccharide conjugate vaccine against pneumococcal pneumonia in adults. N Engl J Med. 2015;372(12):1114\u201325.","journal-title":"N Engl J Med"},{"issue":"20","key":"1248_CR98","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1016\/j.vaccine.2014.02.002","volume":"32","author":"RN Greenberg","year":"2014","unstructured":"Greenberg RN, Gurtman A, Frenck RW, et al. Sequential administration of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine in pneumococcal vaccine-na\u00efve adults 60\u201364\u00a0years of age. Vaccine. 2014;32(20):2364\u201374.","journal-title":"Vaccine"},{"issue":"4","key":"1248_CR99","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.ccm.2018.07.007","volume":"39","author":"CH van Werkhoven","year":"2018","unstructured":"van Werkhoven CH, Huijts SM. Vaccines to prevent pneumococcal community-acquired pneumonia. Clin Chest Med. 2018;39(4):733\u201352.","journal-title":"Clin Chest Med"},{"issue":"11","key":"1248_CR100","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1136\/thoraxjnl-2013-204282","volume":"68","author":"A Torres","year":"2013","unstructured":"Torres A, Peetermans WE, Viegi G, Blasi F. Risk factors for community-acquired pneumonia in adults in Europe: a literature review. Thorax. 2013;68(11):1057\u201365.","journal-title":"Thorax"},{"issue":"1","key":"1248_CR101","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1186\/s12879-016-1974-4","volume":"16","author":"I Rivero-Calle","year":"2016","unstructured":"Rivero-Calle I, Pardo-Seco J, Aldaz P, et al. Incidence and risk factor prevalence of community-acquired pneumonia in adults in primary care in Spain (NEUMO-ES-RISK project). BMC Infect Dis. 2016;16(1):645.","journal-title":"BMC Infect Dis"},{"key":"1248_CR102","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.rmed.2016.10.015","volume":"121","author":"M Kolditz","year":"2016","unstructured":"Kolditz M, Tesch F, Mocke L, H\u00f6ffken G, Ewig S, Schmitt J. Burden and risk factors of ambulatory or hospitalized CAP: a population based cohort study. Respir Med. 2016;121:32\u20138.","journal-title":"Respir Med"},{"issue":"5","key":"1248_CR103","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.chest.2017.04.162","volume":"152","author":"RE Corrado","year":"2017","unstructured":"Corrado RE, Lee D, Lucero DE, Varma JK, Vora NM. Burden of adult community-acquired, health-care-associated, hospital-acquired, and ventilator-associated pneumonia: New York City, 2010 to 2014. Chest. 2017;152(5):930\u201342.","journal-title":"Chest"},{"issue":"1196","key":"1248_CR104","first-page":"U933","volume":"117","author":"G Scott","year":"2004","unstructured":"Scott G, Scott H, Turley M, Baker M. Economic cost of community-acquired pneumonia in New Zealand adults. N Z Med J. 2004;117(1196):U933.","journal-title":"N Z Med J"},{"issue":"3","key":"1248_CR105","doi-asserted-by":"crossref","first-page":"e0122247","DOI":"10.1371\/journal.pone.0122247","volume":"10","author":"K Morimoto","year":"2015","unstructured":"Morimoto K, Suzuki M, Ishifuji T, et al. The burden and etiology of community-onset pneumonia in the aging Japanese population: a multicenter prospective study. PLoS One. 2015;10(3):e0122247.","journal-title":"PLoS One"},{"issue":"3","key":"1248_CR106","doi-asserted-by":"crossref","first-page":"e0194598","DOI":"10.1371\/journal.pone.0194598","volume":"13","author":"JY Heo","year":"2018","unstructured":"Heo JY, Seo YB, Choi WS, et al. Incidence and case fatality rates of community-acquired pneumonia and pneumococcal diseases among Korean adults: catchment population-based analysis. PLoS One. 2018;13(3):e0194598.","journal-title":"PLoS One"},{"issue":"6","key":"1248_CR107","first-page":"458","volume":"49","author":"V Poulose","year":"2008","unstructured":"Poulose V. Severe community-acquired pneumonia requiring intensive care: a study of 80 cases from Singapore. Singap Med J. 2008;49(6):458\u201361.","journal-title":"Singap Med J"},{"issue":"1","key":"1248_CR108","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.amjms.2018.03.024","volume":"356","author":"H Seo","year":"2018","unstructured":"Seo H, Cha SI, Shin KM, et al. Relationship between clinical features and computed tomographic findings in hospitalized adult patients with community-acquired pneumonia. Am J Med Sci. 2018;356(1):30\u20138.","journal-title":"Am J Med Sci"},{"issue":"3","key":"1248_CR109","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1164\/rccm.201807-1333OC","volume":"200","author":"SJ Aston","year":"2019","unstructured":"Aston SJ, Ho A, Jary H, et al. Etiology and risk factors for mortality in an adult community-acquired pneumonia cohort in Malawi. Am J Respir Crit Care Med. 2019;200(3):359\u201369.","journal-title":"Am J Respir Crit Care Med"},{"issue":"9","key":"1248_CR110","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1093\/cid\/ciy723","volume":"68","author":"MF Di Pasquale","year":"2019","unstructured":"Di Pasquale MF, Sotgiu G, Gramegna A, et al. Prevalence and etiology of community-acquired pneumonia in immunocompromised patients. Clin Infect Dis. 2019;68(9):1482\u201393.","journal-title":"Clin Infect Dis"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-020-01248-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12325-020-01248-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-020-01248-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T01:45:35Z","timestamp":1695779135000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12325-020-01248-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,18]]},"references-count":110,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["1248"],"URL":"https:\/\/doi.org\/10.1007\/s12325-020-01248-7","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,18]]},"assertion":[{"value":"23 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2020","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}