{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T16:26:59Z","timestamp":1751300819770,"version":"3.37.3"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin J Gastroenterol"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s12328-021-01495-3","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T10:02:48Z","timestamp":1627984968000},"page":"1612-1616","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A unique case of bleeding from esophageal varices as the first sign of essential thrombocythemia"],"prefix":"10.1007","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6739-6693","authenticated-orcid":false,"given":"Mariana","family":"Brito","sequence":"first","affiliation":[]},{"given":"Gon\u00e7alo","family":"Nunes","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Laranjo","sequence":"additional","affiliation":[]},{"given":"J\u00falia","family":"Sabino","sequence":"additional","affiliation":[]},{"given":"Carla","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Sara","family":"Valle","sequence":"additional","affiliation":[]},{"given":"Diogo","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Fonseca","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"1495_CR1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l536","author":"AJ Stanley","year":"2019","unstructured":"Stanley AJ, Laine L. Management of acute upper gastrointestinal bleeding. BMJ. 2019. https:\/\/doi.org\/10.1136\/bmj.l536.","journal-title":"BMJ"},{"key":"1495_CR2","doi-asserted-by":"publisher","DOI":"10.1586\/egh.12.83","author":"A Berzigotti","year":"2013","unstructured":"Berzigotti A, Seijo S, Reverter E, Bosch J. Assessing portal hypertension in liver diseases. Expert Rev Gastroenterol Hepatol. 2013. https:\/\/doi.org\/10.1586\/egh.12.83.","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"1495_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2016.08.001","author":"EP Tetangco","year":"2016","unstructured":"Tetangco EP, Silva RG, Lerma EV. Portal hypertension: etiology, evaluation, and management. Dis Mon. 2016. https:\/\/doi.org\/10.1016\/j.disamonth.2016.08.001.","journal-title":"Dis Mon"},{"key":"1495_CR4","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-020-01274-6","author":"K Iwaki","year":"2020","unstructured":"Iwaki K, Ueda Y, Mishima M, Narukami S, Shiokawa M, Sawada K, et al. Portal vein thrombosis due to essential thrombocythemia with limited cutaneous systemic sclerosis. Clin J Gastroenterol. 2020. https:\/\/doi.org\/10.1007\/s12328-020-01274-6.","journal-title":"Clin J Gastroenterol"},{"key":"1495_CR5","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25303","author":"A Tefferi","year":"2019","unstructured":"Tefferi A, Barbui T. Polycythemia vera and essential thrombocythemia: 2019 update on diagnosis, risk-stratification and management. Am J Hematol. 2019. https:\/\/doi.org\/10.1002\/ajh.25303.","journal-title":"Am J Hematol"},{"key":"1495_CR6","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-4-25","author":"K Tamaki","year":"2010","unstructured":"Tamaki K, Otaka M, Sakamoto N, Matsumoto K, Yamashina S, Watanabe S. Acute variceal bleeding in a patient with idiopathic myelofibrosis successfully treated with endoscopic variceal band ligation and chemotherapy: a case report. J Med Case Rep. 2010. https:\/\/doi.org\/10.1186\/1752-1947-4-25.","journal-title":"J Med Case Rep"},{"key":"1495_CR7","doi-asserted-by":"publisher","DOI":"10.1007\/BF02348672","author":"M Matsumoto","year":"1995","unstructured":"Matsumoto M, Matsumoto H, Miyake T, Nakao K, Iwata K, Yoshida N, et al. Endoscopic injection sclerotherapy for esophageal variceal hemorrhage in myeloproliferative disorder: case report. J Gastroenterol. 1995. https:\/\/doi.org\/10.1007\/BF02348672.","journal-title":"J Gastroenterol"},{"key":"1495_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2018.10.016","author":"AM Kesler","year":"2019","unstructured":"Kesler AM, Mousa OY, Toskich B, Frey G, Lewis M. Isolated gastric varices in a patient with essential thrombocythemia. Gastrointest Endosc. 2019. https:\/\/doi.org\/10.1016\/j.gie.2018.10.016.","journal-title":"Gastrointest Endosc"},{"key":"1495_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.03.007","author":"JC Garc\u00eda-Pag\u00e1n","year":"2012","unstructured":"Garc\u00eda-Pag\u00e1n JC, Gracia-Sancho J, Bosch J. Functional aspects on the pathophysiology of portal hypertension in cirrhosis. J Hepatol. 2012. https:\/\/doi.org\/10.1016\/j.jhep.2012.03.007.","journal-title":"J Hepatol"},{"key":"1495_CR10","first-page":"46","volume":"67","author":"J Hoekstra","year":"2009","unstructured":"Hoekstra J, Janssen HLA. Vascular liver disorders (II): portal vein thrombosis. Neth J Med. 2009;67:46\u201353.","journal-title":"Neth J Med"},{"key":"1495_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.01.001","author":"L Amitrano","year":"2004","unstructured":"Amitrano L, Guardascione MA, Brancaccio V, Margaglione M, Manguso F, Iannaccone L, et al. Risk factors and clinical presentation of portal vein thrombosis in patients with liver cirrhosis. J Hepatol. 2004. https:\/\/doi.org\/10.1016\/j.jhep.2004.01.001.","journal-title":"J Hepatol"},{"key":"1495_CR12","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13019","author":"A Kumar","year":"2015","unstructured":"Kumar A, Sharma P, Arora A. Review article: portal vein obstruction - Epidemiology, pathogenesis, natural history, prognosis and treatment. Aliment Pharmacol Ther. 2015. https:\/\/doi.org\/10.1111\/apt.13019.","journal-title":"Aliment Pharmacol Ther"},{"key":"1495_CR13","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.18.19548","author":"RC Jha","year":"2018","unstructured":"Jha RC, Khera SS, Kalaria AD. Portal vein thrombosis: imaging the spectrum of disease with an emphasis on MRI features. Am J Roentgenol. 2018. https:\/\/doi.org\/10.2214\/AJR.18.19548.","journal-title":"Am J Roentgenol"},{"key":"1495_CR14","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.89","author":"A Tefferi","year":"2015","unstructured":"Tefferi A, Pardanani A. Myeloproliferative neoplasms: a contemporary review. JAMA Oncol. 2015. https:\/\/doi.org\/10.1001\/jamaoncol.2015.89.","journal-title":"JAMA Oncol"},{"key":"1495_CR15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-376517","author":"JH Smalberg","year":"2012","unstructured":"Smalberg JH, Arends LR, Valla DC, Kiladjian JJ, Janssen HLA, Leebeek FWG. Myeloproliferative neoplasms in Budd-Chiari syndrome and portal vein thrombosis: a meta-analysis. Blood. 2012. https:\/\/doi.org\/10.1182\/blood-2011-09-376517.","journal-title":"Blood"},{"key":"1495_CR16","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2019-229387","author":"K Yoshida","year":"2019","unstructured":"Yoshida K, Kurihara I, Fukuchi T, Sugawara H. Acute splenic infarction presenting as an unusual manifestation of essential thrombocythaemia with normal platelet count. BMJ Case Rep. 2019. https:\/\/doi.org\/10.1136\/bcr-2019-229387.","journal-title":"BMJ Case Rep"},{"key":"1495_CR17","doi-asserted-by":"publisher","DOI":"10.11406\/rinketsu.60.387","author":"M Hatsuse","year":"2019","unstructured":"Hatsuse M, Taminishi Y, Maegawa-Matsui S, Fuchida S-I, Inaba T, Murakami S, et al. Latent essential thrombocythemia becoming perceptible after splenectomy. Jpn J Clin Hematol. 2019. https:\/\/doi.org\/10.11406\/rinketsu.60.387.","journal-title":"Jpn J Clin Hematol"},{"key":"1495_CR18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.2002.00234.x","author":"R Das","year":"2002","unstructured":"Das R, Kaur U, Garewal G. Splenectomy in a case of splenic vein thrombosis unmasks essential thrombocythemia. Clin Lab Haematol. 2002. https:\/\/doi.org\/10.1046\/j.1365-2257.2002.00234.x.","journal-title":"Clin Lab Haematol"},{"key":"1495_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.07.040","author":"JC Garcia-Pag\u00e1n","year":"2016","unstructured":"Garcia-Pag\u00e1n JC, Buscarini E, Janssen HLA, Leebeek FWG, Plessier A, Rubbia-Brandt L, et al. EASL clinical practice guidelines: vascular diseases of the liver. J Hepatol. 2016. https:\/\/doi.org\/10.1016\/j.jhep.2015.07.040.","journal-title":"J Hepatol"},{"key":"1495_CR20","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31646","author":"PG Northup","year":"2020","unstructured":"Northup PG, Garcia-Pagan JC, Garcia-Tsao G, Intagliata NM, Superina RA, Roberts LN, et al. Vascular liver disorders, portal vein thrombosis, and procedural bleeding in patients with liver disease: 2020 practice guidance by the American Association for the Study of Liver Diseases. Hepatology. 2020. https:\/\/doi.org\/10.1002\/hep.31646.","journal-title":"Hepatology"}],"container-title":["Clinical Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-021-01495-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12328-021-01495-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-021-01495-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T16:08:53Z","timestamp":1635610133000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12328-021-01495-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,3]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1495"],"URL":"https:\/\/doi.org\/10.1007\/s12328-021-01495-3","relation":{},"ISSN":["1865-7257","1865-7265"],"issn-type":[{"type":"print","value":"1865-7257"},{"type":"electronic","value":"1865-7265"}],"subject":[],"published":{"date-parts":[[2021,8,3]]},"assertion":[{"value":"10 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}},{"value":"The patient gave his informed consent for the present case report.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}