{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:09:05Z","timestamp":1769213345131,"version":"3.49.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T00:00:00Z","timestamp":1591401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T00:00:00Z","timestamp":1591401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/DTP-PIC\/0419\/2012"],"award-info":[{"award-number":["PTDC\/DTP-PIC\/0419\/2012"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-028758"],"award-info":[{"award-number":["POCI-01-0145-FEDER-028758"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/EEA\/50008\/2020"],"award-info":[{"award-number":["UIDB\/EEA\/50008\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Health Technol."],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1007\/s12553-020-00445-2","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T23:04:23Z","timestamp":1591398263000},"page":"905-911","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A-scan ultrasonic system for real time automatic cataract detection"],"prefix":"10.1007","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2045-0741","authenticated-orcid":false,"given":"Lorena","family":"Petrella","sequence":"first","affiliation":[]},{"given":"Carlos","family":"Pinto","sequence":"additional","affiliation":[]},{"given":"Fernando","family":"Perdig\u00e3o","sequence":"additional","affiliation":[]},{"given":"Marco","family":"Gomes","sequence":"additional","affiliation":[]},{"given":"M\u00e1rio","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Sandrina","family":"Nunes","sequence":"additional","affiliation":[]},{"given":"Miguel","family":"Morgado","sequence":"additional","affiliation":[]},{"given":"Miguel","family":"Caixinha","sequence":"additional","affiliation":[]},{"given":"Jaime","family":"Santos","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,6,6]]},"reference":[{"key":"445_CR1","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1038\/nature14650","volume":"523","author":"L Zhao","year":"2015","unstructured":"Zhao L, Chen X-J, Zhu J, Xi Y-B, Yang X, Hu L-D, et al. Lanosterol reverses protein aggregation in cataracts. Nature [Internet]. 2015;523:607\u201311 Available from: http:\/\/www.nature.com\/articles\/nature14650.","journal-title":"Nature [Internet]"},{"key":"445_CR2","unstructured":"World Health Organization. State of the World sight: Vision 2020: the Right to Sight. WHO Press; 2005."},{"key":"445_CR3","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/j.1444-0938.2010.00516.x","volume":"93","author":"E Chan","year":"2010","unstructured":"Chan E, Mahroo OAR, Spalton DJ. Complications of cataract surgery. Clin Exp Optom [Internet]. 2010;93:379\u201389 Available from: http:\/\/doi.wiley.com\/10.1111\/j.1444-0938.2010.00516.x.","journal-title":"Clin Exp Optom [Internet]"},{"key":"445_CR4","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1111\/jphp.12355","volume":"67","author":"H Abdelkader","year":"2015","unstructured":"Abdelkader H, Alany RG, Pierscionek B. Age-related cataract and drug therapy: opportunities and challenges for topical antioxidant delivery to the lens. J Pharm Pharmacol. 2015;67:537\u201350.","journal-title":"J Pharm Pharmacol"},{"key":"445_CR5","doi-asserted-by":"crossref","unstructured":"Silverman R. Focused ultrasound in ophthalmology. Clin. Ophthalmol. [Internet]. 2016;Volume 10:1865\u201375. Available from: https:\/\/www.dovepress.com\/focused-ultrasound-in-ophthalmology-peer-reviewed-article-OPTH","DOI":"10.2147\/OPTH.S99535"},{"key":"445_CR6","doi-asserted-by":"publisher","first-page":"267","DOI":"10.15388\/Informatica.2007.176","volume":"18","author":"A Paunksnis","year":"2007","unstructured":"Paunksnis A, Kurapkiene S, Maciulis A, Kopustinskas A, Paunksniene M. Ultrasound quantitative evaluation of human eye cataract. Informatica. 2007;18:267\u201378.","journal-title":"Informatica."},{"key":"445_CR7","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1016\/j.ultrasmedbio.2007.05.002","volume":"33","author":"CC Huang","year":"2007","unstructured":"Huang CC, Ameri H, DeBoer C, Rowley AP, Xu X, Sun L, et al. Evaluation of lens hardness in cataract surgery using high-frequency ultrasonic parameters in vitro. Ultrasound Med Biol. 2007;33:1609\u201316.","journal-title":"Ultrasound Med Biol"},{"key":"445_CR8","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1109\/TBME.2014.2335739","volume":"61","author":"M Caixinha","year":"2014","unstructured":"Caixinha M, Jesus DA, Velte E, Santos MJ, Santos JB. Using ultrasound backscattering signals and Nakagami statistical distribution to assess regional cataract hardness. IEEE Trans Biomed Eng. 2014;61:2921\u20139.","journal-title":"IEEE Trans Biomed Eng"},{"key":"445_CR9","doi-asserted-by":"crossref","unstructured":"Caixinha M, Jesus D, Santos M, Santos J, Velte E. Characterization of scatterers concentration in cataractous lens using Nakagami distribution by ultrasounds. IEEE Int Ultrason Symp IUS. 2013:425\u20138.","DOI":"10.1109\/ULTSYM.2013.0110"},{"key":"445_CR10","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.ultrasmedbio.2015.11.021","volume":"42","author":"M Caixinha","year":"2016","unstructured":"Caixinha M, Santos M, Santos J. Automatic cataract hardness classification ex vivo by ultrasound techniques. Ultrasound Med Biol. 2016;42:989\u201398.","journal-title":"Ultrasound Med Biol"},{"key":"445_CR11","doi-asserted-by":"crossref","unstructured":"Caixinha M, Velte E, Santos M, Santos JB. New approach for objective cataract classification based on ultrasound techniques using multiclass SVM classifiers. IEEE Int Ultrason Symp IUS. 2014:2402\u20135.","DOI":"10.1109\/ULTSYM.2014.0599"},{"key":"445_CR12","doi-asserted-by":"crossref","unstructured":"Caxinha M, Velte E, Santos M, Perdig\u00e3o F, Amaro J, Gomes M, et al. Automatic cataract classification based on ultrasound technique using machine learning: a comparative study. Phys. Procedia. Elsevier B.V.; 2015;70:1221\u20134.","DOI":"10.1016\/j.phpro.2015.08.263"},{"key":"445_CR13","doi-asserted-by":"publisher","first-page":"2326","DOI":"10.1109\/TBME.2016.2527787","volume":"63","author":"M Caixinha","year":"2016","unstructured":"Caixinha M, Amaro J, Santos M, Perdigao F, Gomes M, Santos J. In-vivo automatic nuclear cataract detection and classification in an animal model by ultrasounds. IEEE Trans Biomed Eng. 2016;63:2326\u201335.","journal-title":"IEEE Trans Biomed Eng"},{"key":"445_CR14","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.pathophys.2006.05.006","volume":"13","author":"JA Vinson","year":"2006","unstructured":"Vinson JA. Oxidative stress in cataracts. Pathophysiology. 2006;13:151\u201362.","journal-title":"Pathophysiology."},{"key":"445_CR15","volume-title":"ISO 14155:2018 clinical investigation of medical devices for human subjects - good clinical practice","author":"International Organization for Standarization","year":"2018","unstructured":"International Organization for Standarization. ISO 14155:2018 clinical investigation of medical devices for human subjects - good clinical practice. Geneva: International Organization for Standarization; 2018."},{"key":"445_CR16","unstructured":"Council of the European Union, European Parlament. Regulation (EU) 2017\/745 of the European Parliament and of the Council. Brussels: Official Journal of the European Union; 2017."},{"key":"445_CR17","doi-asserted-by":"crossref","unstructured":"Petrella L, Gomes M, Perdig\u00e3o F, Santos M, Fernandes P, Pinto C, et al. Eye scan ultrasound system for automatic cataract detection: from a preclinical to a clinical prototype. medicon [Internet]. Coimbra: Springer; 2020. p. 811\u2013819. Available from: http:\/\/link.springer.com\/10.1007\/978-3-030-31635-8_97","DOI":"10.1007\/978-3-030-31635-8_97"},{"key":"445_CR18","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1001\/archopht.1993.01090060119035","volume":"111","author":"LT Chylack","year":"1993","unstructured":"Chylack LT, Wolfe JK, Singer DM, Leske MC, Bullimore MA, Bailey IL, et al. The lens opacities classification system III. Arch Ophthalmol. 1993;111:831\u20136.","journal-title":"Arch Ophthalmol"},{"key":"445_CR19","unstructured":"Martin A, Martin A, Doddington G, Kamm T, Ordowski M, Przybocki M. The DET curve in assessment of detection task performance. Eur. Conf. Speech Commun. Technol. [Internet]. Rhodes; 1997. p. 1895\u20131898. Available from: http:\/\/citeseerx.ist.psu.edu\/viewdoc\/summary?doi=10.1.1.117.4489"}],"container-title":["Health and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12553-020-00445-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12553-020-00445-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12553-020-00445-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T23:24:02Z","timestamp":1622935442000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12553-020-00445-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,6]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["445"],"URL":"https:\/\/doi.org\/10.1007\/s12553-020-00445-2","relation":{},"ISSN":["2190-7188","2190-7196"],"issn-type":[{"value":"2190-7188","type":"print"},{"value":"2190-7196","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,6]]},"assertion":[{"value":"1 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All the experiments were carried out in accordance with the European regulation on the protection of animals used for scientific purposes (Directive 2010\/63\/EU). The experiments were approved by the National Directorate General of Food and Veterinary Medicine and by the Animal Welfare Office of the University of Coimbra. The animal experiments were made with care to minimize its suffering.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Animal rights"}}]}}