{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T17:43:24Z","timestamp":1776534204422,"version":"3.51.2"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:00:00Z","timestamp":1727481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:00:00Z","timestamp":1727481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["3 Biotech"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s13205-024-04103-6","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T15:01:46Z","timestamp":1727535706000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrative bioinformatic and experimental analysis of benzoylbenzodioxol derivatives: hypoglycemic potential in diabetic mice"],"prefix":"10.1007","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5640-9700","authenticated-orcid":false,"given":"Mohammed","family":"Hawash","sequence":"first","affiliation":[]},{"given":"Nidal","family":"Jaradat","sequence":"additional","affiliation":[]},{"given":"Murad","family":"Abualhasan","sequence":"additional","affiliation":[]},{"given":"Jazeel","family":"Jadallah","sequence":"additional","affiliation":[]},{"given":"Lama","family":"Fashafsheh","sequence":"additional","affiliation":[]},{"given":"Salsabeela","family":"Zaid","sequence":"additional","affiliation":[]},{"given":"Naim","family":"Qamhia","sequence":"additional","affiliation":[]},{"given":"Mohammad","family":"Qneibi","sequence":"additional","affiliation":[]},{"given":"Mohammed T.","family":"Qaoud","sequence":"additional","affiliation":[]},{"given":"Ozden","family":"Tari","sequence":"additional","affiliation":[]},{"given":"Matthew","family":"Merski","sequence":"additional","affiliation":[]},{"given":"Ahmet S.","family":"Bo\u015fnak","sequence":"additional","affiliation":[]},{"given":"Ahmed","family":"Mousa","sequence":"additional","affiliation":[]},{"given":"Linda","family":"Issa","sequence":"additional","affiliation":[]},{"given":"Ahmad M.","family":"Eid","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,9,28]]},"reference":[{"issue":"W1","key":"4103_CR1","doi-asserted-by":"publisher","first-page":"W530","DOI":"10.1093\/nar\/gkab294","volume":"49","author":"MF Adasme","year":"2021","unstructured":"Adasme MF, Linnemann KL, Bolz SN, Kaiser F, Salentin S, Haupt VJ, Schroeder M (2021) PLIP 2021: expanding the scope of the protein\u2013ligand interaction profiler to DNA and RNA. Nucleic Acids Res 49(W1):W530\u2013W534","journal-title":"Nucleic Acids Res"},{"key":"4103_CR2","unstructured":"Al-Ani IM, Al-Mishadani N, Muslih RK, Hamoodi SR (2009) Histological liver changes in streptozotocin induced diabetic mice. Int Med J Malaysia 8 (1):1\u20134"},{"issue":"1","key":"4103_CR3","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.saa.2011.07.076","volume":"82","author":"AM Asiri","year":"2011","unstructured":"Asiri AM, Karabacak M, Kurt M, Alamry KA (2011) Synthesis, molecular conformation, vibrational and electronic transition, isometric chemical shift, polarizability and hyperpolarizability analysis of 3-(4-Methoxy-phenyl)-2-(4-nitro-phenyl)-acrylonitrile: a combined experimental and theoretical analysis. Spectrochim Acta Part A Mol Biomol Spectrosc 82(1):444\u2013455","journal-title":"Spectrochim Acta Part A Mol Biomol Spectrosc"},{"key":"4103_CR4","doi-asserted-by":"crossref","unstructured":"Azzam KA (2023) SwissADME and pkCSM webservers predictors: An integrated online platform for accurate and comprehensive predictions for in silico ADME\/T properties of artemisinin and its derivatives. Kompleksnoe Ispolzovanie Mineralnogo Syra= Complex use of mineral resources 325 (2):14\u201321","DOI":"10.31643\/2023\/6445.13"},{"key":"4103_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.132712","volume":"1259","author":"B Bakchi","year":"2022","unstructured":"Bakchi B, Krishna AD, Sreecharan E, Ganesh VBJ, Niharika M, Maharshi S, Puttagunta SB, Sigalapalli DK, Bhandare RR, Shaik AB (2022) An overview on applications of SwissADME web tool in the design and development of anticancer, antitubercular and antimicrobial agents: a medicinal chemist\u2019s perspective. J Mol Struct 1259:132712","journal-title":"J Mol Struct"},{"key":"4103_CR6","unstructured":"Balaji R, Duraisamy R, Kumar M (2019) Complications of diabetes mellitus: a review. Drug Invent Today 12(1):98\u2013103"},{"key":"4103_CR7","doi-asserted-by":"crossref","unstructured":"\u00c7al\u0131\u015fkan E, Kaplan A, \u015eekerci G, \u00c7apan \u0130, Tekin S, Erkan S, Koran K, Sandal S, G\u00f6rg\u00fcl\u00fc AO (2023) Synthesis, docking studies, in vitro cytotoxicity evaluation and DNA damage mechanism of new tyrosine\u2010based tripeptides. J Biochem Mol Toxicol 37(8):e23388","DOI":"10.1002\/jbt.23388"},{"issue":"2","key":"4103_CR8","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/0166-1280(95)04135-S","volume":"337","author":"BW Clare","year":"1995","unstructured":"Clare BW (1995) Charge transfer complexes and frontier orbital energies in QSAR: a congeneric series of electron acceptors. J Mol Struct (Thoechem) 337(2):139\u2013150","journal-title":"J Mol Struct (Thoechem)"},{"key":"4103_CR9","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.cbi.2018.01.016","volume":"283","author":"LMMG da Silva","year":"2018","unstructured":"da Silva LMMG, de Oliveira JF, Silva WL, da Silva AL, de Almeida Junior ASA, dos Santos VHB, Alves LC, dos Santos FAB, Costa VMA, de Lima AA (2018) New 1, 3-benzodioxole derivatives: synthesis, evaluation of in vitro schistosomicidal activity and ultrastructural analysis. Chem Biol Interact 283:20\u201329. https:\/\/doi.org\/10.1016\/j.cbi.2018.01.016","journal-title":"Chem Biol Interact"},{"issue":"1","key":"4103_CR10","doi-asserted-by":"publisher","first-page":"42717","DOI":"10.1038\/srep42717","volume":"7","author":"A Daina","year":"2017","unstructured":"Daina A, Michielin O, Zoete V (2017) SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Sci Rep 7(1):42717","journal-title":"Sci Rep"},{"issue":"1","key":"4103_CR11","doi-asserted-by":"publisher","first-page":"24","DOI":"10.4103\/0250-474x.151588","volume":"77","author":"SR Deshpande","year":"2015","unstructured":"Deshpande SR, Nagrale SN, Patil MV, Chavan SS (2015) Novel 3,4-methylenedioxybenzene scaffold incorporated 1,3,5-trisubstituted-2-pyrazolines: synthesis, characterization and evaluation for chemotherapeutic activity. Indian J Pharm Sci 77(1):24. https:\/\/doi.org\/10.4103\/0250-474x.151588","journal-title":"Indian J Pharm Sci"},{"key":"4103_CR12","doi-asserted-by":"crossref","unstructured":"Donovan J, Brown P (2006) Parenteral injections. Curr Protocols Immunol 73(1):1.6.1\u20131.6.10","DOI":"10.1002\/0471142735.im0106s73"},{"issue":"14","key":"4103_CR13","doi-asserted-by":"publisher","first-page":"3631","DOI":"10.1016\/j.bmc.2017.05.036","volume":"25","author":"M Espahbodinia","year":"2017","unstructured":"Espahbodinia M, Ettari R, Wen W, Wu A, Shen YC, Niu L, Grasso S, Zappala M (2017) Development of novel N-3-bromoisoxazolin-5-yl substituted 2,3-benzodiazepines as noncompetitive AMPAR antagonists. Bioorg Med Chem 25(14):3631\u20133637. https:\/\/doi.org\/10.1016\/j.bmc.2017.05.036","journal-title":"Bioorg Med Chem"},{"key":"4103_CR14","volume-title":"Molecular orbitals and organic chemical reactions","author":"I Fleming","year":"2011","unstructured":"Fleming I (2011) Molecular orbitals and organic chemical reactions. John Wiley & Sons"},{"issue":"21","key":"4103_CR15","doi-asserted-by":"publisher","first-page":"6177","DOI":"10.1021\/jm051256o","volume":"49","author":"RA Friesner","year":"2006","unstructured":"Friesner RA, Murphy RB, Repasky MP, Frye LL, Greenwood JR, Halgren TA, Sanschagrin PC, Mainz DT (2006) Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein\u2212 ligand complexes. J Med Chem 49(21):6177\u20136196","journal-title":"J Med Chem"},{"issue":"4\u20135","key":"4103_CR16","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/0009-2614(92)85807-M","volume":"197","author":"PM Gill","year":"1992","unstructured":"Gill PM, Johnson BG, Pople JA, Frisch MJ (1992) The performance of the Becke\u2014Lee\u2014Yang\u2014Parr (B\u2014LYP) density functional theory with various basis sets. Chem Phys Lett 197(4\u20135):499\u2013505","journal-title":"Chem Phys Lett"},{"key":"4103_CR17","doi-asserted-by":"crossref","unstructured":"Gupta RK, Kumar D, Chaudhary AK, Maithani M, Singh R (2012) Antidiabetic activity of Passiflora incarnata Linn. in streptozotocin-induced diabetes in mice. J Ethnopharmacol 139(3):801\u2013806","DOI":"10.1016\/j.jep.2011.12.021"},{"issue":"1","key":"4103_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13065-020-00706-1","volume":"14","author":"M Hawash","year":"2020","unstructured":"Hawash M, Jaradat N, Hameedi S, Mousa A (2020) Design, synthesis and biological evaluation of novel benzodioxole derivatives as COX inhibitors and cytotoxic agents. BMC Chemistry 14(1):1\u20139","journal-title":"BMC Chemistry"},{"issue":"1","key":"4103_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13065-021-00766-x","volume":"15","author":"M Hawash","year":"2021","unstructured":"Hawash M, Jaradat N, Shekfeh S, Abualhasan M, Eid AM, Issa L (2021) Molecular docking, chemo-informatic properties, alpha-amylase, and lipase inhibition studies of benzodioxol derivatives. BMC Chemistry 15(1):1\u201310","journal-title":"BMC Chemistry"},{"issue":"1","key":"4103_CR20","doi-asserted-by":"publisher","first-page":"18223","DOI":"10.1038\/s41598-022-23050-x","volume":"12","author":"M Hawash","year":"2022","unstructured":"Hawash M, Jaradat N, Abualhasan M, Thaher M, Sawalhi R, Younes N, Shanaa A, Nuseirat M, Mousa A (2022) In vitro and in vivo assessment of the antioxidant potential of isoxazole derivatives. Sci Rep 12(1):18223","journal-title":"Sci Rep"},{"issue":"10","key":"4103_CR21","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.3390\/biom13101486","volume":"13","author":"M Hawash","year":"2023","unstructured":"Hawash M, Al-Smadi D, Kumar A, Olech B, Dominiak PM, Jaradat N, Antari S, Mohammed S, Aa N, Abualhasan M (2023) Characterization and investigation of novel benzodioxol derivatives as antidiabetic agents: an in vitro and in vivo study in an animal model. Biomolecules 13(10):1486","journal-title":"Biomolecules"},{"key":"4103_CR22","doi-asserted-by":"publisher","DOI":"10.1021\/ed047pA862","author":"R Hill","year":"1970","unstructured":"Hill R (1970) The chemistry of life: eight lectures on the history of biochemistry, vol England. CUP Archive. https:\/\/doi.org\/10.1021\/ed047pA862","journal-title":"CUP Archive"},{"issue":"1","key":"4103_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41387-019-0099-4","volume":"9","author":"S Jeong","year":"2019","unstructured":"Jeong S, Cho JM, Kwon Y-I, Kim S-C, Shin DY, Lee JH (2019) Chitosan oligosaccharide (GO2KA1) improves postprandial glycemic response in subjects with impaired glucose tolerance and impaired fasting glucose and in healthy subjects: a crossover, randomized controlled trial. Nutr Diabetes 9(1):1\u20139. https:\/\/doi.org\/10.1038\/s41387-019-0099-4","journal-title":"Nutr Diabetes"},{"issue":"2","key":"4103_CR24","doi-asserted-by":"publisher","first-page":"527","DOI":"10.3390\/molecules28020527","volume":"28","author":"H Jin","year":"2023","unstructured":"Jin H, Wu C, Su R, Sun T, Li X, Guo C (2023) Identifying dopamine D3 receptor ligands through virtual screening and exploring the binding modes of hit compounds. Molecules 28(2):527","journal-title":"Molecules"},{"issue":"22","key":"4103_CR25","doi-asserted-by":"publisher","first-page":"5565","DOI":"10.1021\/jf300165j","volume":"60","author":"Y Kawamura-Konishi","year":"2012","unstructured":"Kawamura-Konishi Y, Watanabe N, Saito M, Nakajima N, Sakaki T, Katayama T, Enomoto T (2012) Isolation of a new phlorotannin, a potent inhibitor of carbohydrate-hydrolyzing enzymes, from the brown alga Sargassum patens. J Agric Food Chem 60(22):5565\u20135570","journal-title":"J Agric Food Chem"},{"issue":"1","key":"4103_CR26","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jscs.2011.07.014","volume":"17","author":"SA Khayyat","year":"2013","unstructured":"Khayyat SA (2013) Photosynthesis of dimeric cinnamaldehyde, eugenol, and safrole as antimicrobial agents. J Saudi Chem Soc 17(1):61\u201365. https:\/\/doi.org\/10.1016\/j.jscs.2011.07.014","journal-title":"J Saudi Chem Soc"},{"issue":"1","key":"4103_CR27","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.saa.2010.09.016","volume":"78","author":"B Kosar","year":"2011","unstructured":"Kosar B, Albayrak C (2011) Spectroscopic investigations and quantum chemical computational study of (E)-4-methoxy-2-[(p-tolylimino) methyl] phenol. Spectrochim Acta Part A Mol Biomol Spectrosc 78(1):160\u2013167","journal-title":"Spectrochim Acta Part A Mol Biomol Spectrosc"},{"issue":"10","key":"4103_CR28","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1039\/D1MD00202C","volume":"12","author":"S Kumar","year":"2021","unstructured":"Kumar S, Gupta Y, Zak SE, Upadhyay C, Sharma N, Herbert AS, Durvasula R, Potemkin V, Dye JM, Kempaiah P (2021) A novel compound active against SARS-CoV-2 targeting uridylate-specific endoribonuclease (NendoU\/NSP15): in silico and in vitro investigations. RSC Medicinal Chemistry 12(10):1757\u20131764","journal-title":"RSC Medicinal Chemistry"},{"key":"4103_CR29","doi-asserted-by":"crossref","unstructured":"Li J, Abel R, Zhu K, Cao Y, Zhao S, Friesner RA (2011) The VSGB 2.0 model: a next generation energy model for high resolution protein structure modeling. Proteins Struct Funct Bioinform 79(10):2794\u20132812","DOI":"10.1002\/prot.23106"},{"key":"4103_CR30","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S0223-5234(00)00120-3","volume":"35","author":"PC Lima","year":"2000","unstructured":"Lima PC, Lima LM, Silva KCM, L\u00e9da PHO, Miranda ALP, Fraga CAM, Barreiro EJ (2000) Synthesis and analgesic activity of novel N-acylarylhydrazones and isosters, derived from natural safrole. Eur J Med Chem 35:187\u2013203. https:\/\/doi.org\/10.1016\/S0223-5234(00)00120-3","journal-title":"Eur J Med Chem"},{"key":"4103_CR31","first-page":"1124","volume":"43","author":"EC Miller","year":"1983","unstructured":"Miller EC, Swanson AB, Phillips DH, Fletcher TL, Liem A, Miller JA (1983) Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragol. Cancer Res 43:1124\u20131134","journal-title":"Cancer Res"},{"key":"4103_CR32","doi-asserted-by":"crossref","unstructured":"Mosleh R, Hawash M, Jarrar Y (2020) The relationships among the organizational factors of a tertiary healthcare center for type 2 diabetic patients in Palestine. Endocr Metab Immune Disord Drug Targets 21(3):464\u2013471","DOI":"10.2174\/1871530320666200513083802"},{"issue":"2","key":"4103_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.47672\/ejb.409","volume":"5","author":"Y Mukhtar","year":"2020","unstructured":"Mukhtar Y, Galalain A, Yunusa U (2020) A modern overview on diabetes mellitus: a chronic endocrine disorder. Eur J Biol 5(2):1\u201314","journal-title":"Eur J Biol"},{"issue":"5","key":"4103_CR34","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1021\/ja00005a072","volume":"113","author":"RG Parr","year":"1991","unstructured":"Parr RG, Chattaraj PK (1991) Principle of maximum hardness. J Am Chem Soc 113(5):1854\u20131855","journal-title":"J Am Chem Soc"},{"issue":"1","key":"4103_CR35","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.jsb.2010.11.020","volume":"174","author":"X Qin","year":"2011","unstructured":"Qin X, Ren L, Yang X, Bai F, Wang L, Geng P, Bai G, Shen Y (2011) Structures of human pancreatic \u03b1-amylase in complex with acarviostatins: implications for drug design against type II diabetes. J Struct Biol 174(1):196\u2013202","journal-title":"J Struct Biol"},{"key":"4103_CR36","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.3390\/12081910","volume":"12","author":"S Rollas","year":"2007","unstructured":"Rollas S, K\u00fc\u00e7\u00fckg\u00fczel SG (2007) Biological activities of hydrazone derivatives. Molecules 12:1910\u20131939","journal-title":"Molecules"},{"key":"4103_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843","volume":"157","author":"P Saeedi","year":"2019","unstructured":"Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, Colagiuri S, Guariguata L, Motala AA, Ogurtsova K (2019) Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas. Diabetes Res Clin Pract 157:107843","journal-title":"Diabetes Res Clin Pract"},{"key":"4103_CR38","first-page":"67","volume":"3","author":"ND Salih","year":"2014","unstructured":"Salih ND, Kumar GH, Noah RM, Muslih RK (2014) The effect of streptozotocin induced diabetes mellitus on liver activity in mice. Glob J Adv Pure Appl Sci 3:67\u201375","journal-title":"Glob J Adv Pure Appl Sci"},{"key":"4103_CR39","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/BF02894253","volume":"19","author":"JG Satav","year":"2004","unstructured":"Satav JG, Katyare SS (2004) Effect of streptozotocin-induced diabetes on oxidative energy metabolism in rat liver mitochondria\u2014a comparative study of early and late effects. Indian J Clin Biochem 19:23\u201331","journal-title":"Indian J Clin Biochem"},{"issue":"2","key":"4103_CR40","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.jep.2009.10.013","volume":"127","author":"B Sharma","year":"2010","unstructured":"Sharma B, Salunke R, Balomajumder C, Daniel S, Roy P (2010) Antidiabetic potential of alkaloid rich fraction from Capparis decidua on diabetic mice. J Ethnopharmacol 127(2):457\u2013462","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"4103_CR41","doi-asserted-by":"publisher","first-page":"157","DOI":"10.2337\/diabetes.49.2.157","volume":"49","author":"B Soria","year":"2000","unstructured":"Soria B, Roche E, Bern\u00e1 G, Le\u00f3n-Quinto T, Reig JA, Mart\u00edn F (2000) Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 49(2):157\u2013162","journal-title":"Diabetes"},{"key":"4103_CR42","volume-title":"Biochemistry 2","year":"1998","unstructured":"Stenesh J (ed) (1998) Biochemistry 2. Elsevier, New York"},{"issue":"2","key":"4103_CR43","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1517\/17460441.2012.648612","volume":"7","author":"WP Walters","year":"2012","unstructured":"Walters WP (2012) Going further than Lipinski\u2019s rule in drug design. Expert Opin Drug Discov 7(2):99\u2013107","journal-title":"Expert Opin Drug Discov"},{"issue":"22","key":"4103_CR44","doi-asserted-by":"publisher","first-page":"10177","DOI":"10.1021\/jm301273u","volume":"55","author":"LK Williams","year":"2012","unstructured":"Williams LK, Li C, Withers SG, Brayer GD (2012) Order and disorder: differential structural impacts of myricetin and ethyl caffeate on human amylase, an antidiabetic target. J Med Chem 55(22):10177\u201310186","journal-title":"J Med Chem"},{"issue":"20","key":"4103_CR45","doi-asserted-by":"publisher","first-page":"4184","DOI":"10.1021\/jp0225774","volume":"107","author":"C-G Zhan","year":"2003","unstructured":"Zhan C-G, Nichols JA, Dixon DA (2003) Ionization potential, electron affinity, electronegativity, hardness, and electron excitation energy: molecular properties from density functional theory orbital energies. J Phys Chem A 107(20):4184\u20134195","journal-title":"J Phys Chem A"}],"container-title":["3 Biotech"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13205-024-04103-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13205-024-04103-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13205-024-04103-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T16:14:20Z","timestamp":1728490460000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13205-024-04103-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,28]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["4103"],"URL":"https:\/\/doi.org\/10.1007\/s13205-024-04103-6","relation":{},"ISSN":["2190-572X","2190-5738"],"issn-type":[{"value":"2190-572X","type":"print"},{"value":"2190-5738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,28]]},"assertion":[{"value":"2 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The mice-related investigations were meticulously conducted strictly according to the protocols outlined by the Association for Assessment and Accreditation of Laboratory Animal Care International. The ethical underpinning of these experiments was formally acknowledged, having secured the approval of the Institutional Review Board of the Animal House and Use Committee at An-Najah National University (approval number: Med. September. 2022\/2).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"255"}}