{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:42:47Z","timestamp":1777502567925,"version":"3.51.4"},"reference-count":192,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/129312\/2017"],"award-info":[{"award-number":["SFRH\/BD\/129312\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/EQU\/00511\/2019 - Laboratory for Process Engineering, Environment, Biotechnology and Energy \u2013 LEPABE"],"award-info":[{"award-number":["UID\/EQU\/00511\/2019 - Laboratory for Process Engineering, Environment, Biotechnology and Energy \u2013 LEPABE"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-006939"],"award-info":[{"award-number":["POCI-01-0145-FEDER-006939"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["LEPABE-2-ECO-INNOVATION\u201d \u2013 NORTE\u201001\u20100145\u2010FEDER\u2010000005"],"award-info":[{"award-number":["LEPABE-2-ECO-INNOVATION\u201d \u2013 NORTE\u201001\u20100145\u2010FEDER\u2010000005"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drug Deliv. and Transl. Res."],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s13346-019-00694-3","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T19:02:48Z","timestamp":1574794968000},"page":"380-402","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Nanotechnology to improve the Alzheimer\u2019s disease therapy with natural compounds"],"prefix":"10.1007","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2428-7520","authenticated-orcid":false,"given":"Maria Jo\u00e3o","family":"Ramalho","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6918-8775","authenticated-orcid":false,"given":"Stephanie","family":"Andrade","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9841-3967","authenticated-orcid":false,"given":"Joana Ang\u00e9lica","family":"Loureiro","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8505-3432","authenticated-orcid":false,"given":"Maria","family":"do Carmo Pereira","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,11,26]]},"reference":[{"issue":"6","key":"694_CR1","doi-asserted-by":"publisher","first-page":"529","DOI":"10.2174\/1567205016666190315093520","volume":"16","author":"R Gaudreault","year":"2019","unstructured":"Gaudreault R, Mousseau N. Mitigating Alzheimer\u2019s disease with natural polyphenols: a review. Curr Alzheimer Res. 2019;16(6):529\u201343.","journal-title":"Curr Alzheimer Res"},{"issue":"16","key":"694_CR2","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1039\/C3TB21483D","volume":"2","author":"JA Loureiro","year":"2014","unstructured":"Loureiro JA, et al. Fluorinated beta-sheet breaker peptides. J Mater Chem B. 2014;2(16):2259\u201364.","journal-title":"J Mater Chem B"},{"key":"694_CR3","doi-asserted-by":"crossref","unstructured":"Yuan HD, et al. The traditional medicine and modern medicine from natural products. Molecules. 2016:21(5).","DOI":"10.3390\/molecules21050559"},{"issue":"2","key":"694_CR4","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s11101-014-9367-z","volume":"14","author":"B David","year":"2015","unstructured":"David B, Wolfender JL, Dias DA. The pharmaceutical industry and natural products: historical status and new trends. Phytochem Rev. 2015;14(2):299\u2013315.","journal-title":"Phytochem Rev"},{"key":"694_CR5","doi-asserted-by":"crossref","unstructured":"Andrade S, et al. Natural compounds for Alzheimer\u2019s disease therapy: a systematic review of preclinical and clinical studies. Int J Mol Sci. 2019;20(9).","DOI":"10.3390\/ijms20092313"},{"key":"694_CR6","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.colsurfb.2019.04.019","volume":"180","author":"S Andrade","year":"2019","unstructured":"Andrade S, Ramalho MJ, Loureiro JA, Pereira MC. Interaction of natural compounds with biomembrane models: a biophysical approach for the Alzheimer\u2019s disease therapy. Colloids Surf B: Biointerfaces. 2019;180:83\u201392.","journal-title":"Colloids Surf B: Biointerfaces"},{"key":"694_CR7","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.jconrel.2015.10.048","volume":"240","author":"K Park","year":"2016","unstructured":"Park K. Drug delivery of the future: chasing the invisible gorilla. J Control Release. 2016;240:2\u20138.","journal-title":"J Control Release"},{"key":"694_CR8","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.jconrel.2016.05.044","volume":"235","author":"C Saraiva","year":"2016","unstructured":"Saraiva C, Pra\u00e7a C, Ferreira R, Santos T, Ferreira L, Bernardino L. Nanoparticle-mediated brain drug delivery: overcoming blood-brain barrier to treat neurodegenerative diseases. J Control Release. 2016;235:34\u201347.","journal-title":"J Control Release"},{"issue":"4","key":"694_CR9","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1039\/C5NR07161E","volume":"8","author":"U Wais","year":"2016","unstructured":"Wais U, Jackson AW, He T, Zhang H. Nanoformulation and encapsulation approaches for poorly water-soluble drug nanoparticles. Nanoscale. 2016;8(4):1746\u201369.","journal-title":"Nanoscale"},{"key":"694_CR10","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.colsurfb.2016.04.041","volume":"145","author":"JA Loureiro","year":"2016","unstructured":"Loureiro JA, Gomes B, Fricker G, Coelho MAN, Rocha S, Pereira MC. Cellular uptake of PLGA nanoparticles targeted with anti-amyloid and anti-transferrin receptor antibodies for Alzheimer\u2019s disease treatment. Colloids Surf B: Biointerfaces. 2016;145:8\u201313.","journal-title":"Colloids Surf B: Biointerfaces"},{"key":"694_CR11","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.3762\/bjnano.6.135","volume":"6","author":"MJ Ramalho","year":"2015","unstructured":"Ramalho MJ, Loureiro JA, Gomes B, Frasco MF, Coelho MA, Pereira MC. PLGA nanoparticles as a platform for vitamin D-based cancer therapy. Beilstein J Nanotechnol. 2015;6:1306\u201318.","journal-title":"Beilstein J Nanotechnol"},{"issue":"3","key":"694_CR12","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/nrneurol.2017.188","volume":"14","author":"MD Sweeney","year":"2018","unstructured":"Sweeney MD, Sagare AP, Zlokovic BV. Blood\u2013brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. Nat Rev Neurol. 2018;14(3):133\u201350.","journal-title":"Nat Rev Neurol"},{"key":"694_CR13","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1146\/annurev-pharmtox-010814-124852","volume":"55","author":"JM Lajoie","year":"2015","unstructured":"Lajoie JM, Shusta EV. Targeting receptor-mediated transport for delivery of biologics across the blood-brain barrier. Annu Rev Pharmacol Toxicol. 2015;55:613\u201331.","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"11","key":"694_CR14","doi-asserted-by":"publisher","first-page":"2881","DOI":"10.1002\/jbm.a.36477","volume":"106","author":"TM Brenza","year":"2018","unstructured":"Brenza TM, Schlichtmann BW, Bhargavan B, Vela Ramirez JE, Nelson RD, Panthani MG, et al. Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery. J Biomed Mater Res A. 2018;106(11):2881\u201390.","journal-title":"J Biomed Mater Res A"},{"key":"694_CR15","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/nbt.1602","volume":"28","author":"SC Semple","year":"2010","unstructured":"Semple SC, et al. Rational design of cationic lipids for siRNA delivery. Nat Biotechnol. 2010;28:172.","journal-title":"Nat Biotechnol"},{"issue":"2","key":"694_CR16","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.ejpb.2005.09.003","volume":"62","author":"N Pedersen","year":"2006","unstructured":"Pedersen N, Hansen S, Heydenreich AV, Kristensen HG, Poulsen HS. Solid lipid nanoparticles can effectively bind DNA, streptavidin and biotinylated ligands. Eur J Pharm Biopharm. 2006;62(2):155\u201362.","journal-title":"Eur J Pharm Biopharm"},{"issue":"1","key":"694_CR17","doi-asserted-by":"publisher","first-page":"8278","DOI":"10.1038\/s41598-019-44569-6","volume":"9","author":"M Khongkow","year":"2019","unstructured":"Khongkow M, et al. Surface modification of gold nanoparticles with neuron-targeted exosome for enhanced blood\u2013brain barrier penetration. Sci Rep. 2019;9(1):8278.","journal-title":"Sci Rep"},{"key":"694_CR18","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.ijbiomac.2017.08.155","volume":"107","author":"H Li","year":"2018","unstructured":"Li H, et al. Lactoferrin functionalized PEG-PLGA nanoparticles of shikonin for brain targeting therapy of glioma. Int J Biol Macromol. 2018;107:204\u201311.","journal-title":"Int J Biol Macromol"},{"issue":"5","key":"694_CR19","doi-asserted-by":"publisher","first-page":"709","DOI":"10.2217\/nnm.14.27","volume":"9","author":"JA Loureiro","year":"2014","unstructured":"Loureiro JA, Gomes B, Coelho MA, do Carmo Pereira M, Rocha S. Targeting nanoparticles across the blood-brain barrier with monoclonal antibodies. Nanomedicine. 2014;9(5):709\u201322.","journal-title":"Nanomedicine"},{"issue":"4","key":"694_CR20","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.apsb.2016.05.013","volume":"6","author":"H Gao","year":"2016","unstructured":"Gao H. Progress and perspectives on targeting nanoparticles for brain drug delivery. Acta Pharm Sin B. 2016;6(4):268\u201386.","journal-title":"Acta Pharm Sin B"},{"issue":"6","key":"694_CR21","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.7150\/thno.21254","volume":"8","author":"X Dong","year":"2018","unstructured":"Dong X. Current strategies for brain drug delivery. Theranostics. 2018;8(6):1481\u201393.","journal-title":"Theranostics"},{"issue":"23","key":"694_CR22","doi-asserted-by":"publisher","first-page":"2360","DOI":"10.2174\/1385272820666161031161101","volume":"21","author":"DP Gaspar","year":"2017","unstructured":"Gaspar DP, et al. Targeted delivery of lipid nanoparticles by means of surface chemical modification. Curr Org Chem. 2017;21(23):2360\u201375.","journal-title":"Curr Org Chem"},{"issue":"7","key":"694_CR23","doi-asserted-by":"publisher","first-page":"5892","DOI":"10.1074\/jbc.M404751200","volume":"280","author":"F Yang","year":"2005","unstructured":"Yang F, et al. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. 2005;280(7):5892\u2013901.","journal-title":"J Biol Chem"},{"issue":"2","key":"694_CR24","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1002\/jnr.23322","volume":"92","author":"P Wang","year":"2014","unstructured":"Wang P, Su C, Li R, Wang H, Ren Y, Sun H, et al. Mechanisms and effects of curcumin on spatial learning and memory improvement in APPswe\/PS1dE9 mice. J Neurosci Res. 2014;92(2):218\u201331.","journal-title":"J Neurosci Res"},{"issue":"8","key":"694_CR25","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1136\/jim-2016-000240","volume":"64","author":"PH Reddy","year":"2016","unstructured":"Reddy PH, Manczak M, Yin X, Grady MC, Mitchell A, Kandimalla R, et al. Protective effects of a natural product, curcumin, against amyloid beta induced mitochondrial and synaptic toxicities in Alzheimer\u2019s disease. J Investig Med. 2016;64(8):1220\u201334.","journal-title":"J Investig Med"},{"key":"694_CR26","doi-asserted-by":"crossref","unstructured":"Liu Z-J, et al. Curcumin attenuates beta-amyloid-induced neuroinflammation via activation of peroxisome proliferator-activated receptor-gamma function in a rat model of Alzheimer\u2019s disease. Front Pharmacol. 2016:7(261).","DOI":"10.3389\/fphar.2016.00261"},{"issue":"1","key":"694_CR27","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1097\/jcp.0b013e318160862c","volume":"28","author":"L Baum","year":"2008","unstructured":"Baum L, Lam CW, Cheung SK, Kwok T, Lui V, Tsoh J, et al. Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease. J Clin Psychopharmacol. 2008;28(1):110\u20133.","journal-title":"J Clin Psychopharmacol"},{"issue":"6","key":"694_CR28","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1038\/nsmb.1437","volume":"15","author":"DE Ehrnhoefer","year":"2008","unstructured":"Ehrnhoefer DE, Bieschke J, Boeddrich A, Herbst M, Masino L, Lurz R, et al. EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers. Nat Struct Mol Biol. 2008;15(6):558\u201366.","journal-title":"Nat Struct Mol Biol"},{"issue":"4","key":"694_CR29","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1016\/j.foodchem.2011.06.040","volume":"129","author":"BS Harvey","year":"2011","unstructured":"Harvey BS, et al. The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits amyloid-\u03b2 evoked fibril formation and neuronal cell death in vitro. Food Chem. 2011;129(4):1729\u201336.","journal-title":"Food Chem"},{"issue":"11","key":"694_CR30","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1016\/j.phymed.2010.03.008","volume":"17","author":"S Abbas","year":"2010","unstructured":"Abbas S, Wink M. Epigallocatechin gallate inhibits beta amyloid oligomerization in Caenorhabditis elegans and affects the daf-2\/insulin-like signaling pathway. Phytomedicine. 2010;17(11):902\u20139.","journal-title":"Phytomedicine"},{"issue":"2","key":"694_CR31","doi-asserted-by":"publisher","first-page":"561","DOI":"10.3233\/JAD-140981","volume":"44","author":"JM Walker","year":"2015","unstructured":"Walker JM, Klakotskaia D, Ajit D, Weisman GA, Wood WG, Sun GY, et al. Beneficial effects of dietary EGCG and voluntary exercise on behavior in an Alzheimer\u2019s disease mouse model. J Alzheimers Dis. 2015;44(2):561\u201372.","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"694_CR32","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.bbr.2012.08.039","volume":"236","author":"R Biasibetti","year":"2013","unstructured":"Biasibetti R, et al. Green tea (-)epigallocatechin-3-gallate reverses oxidative stress and reduces acetylcholinesterase activity in a streptozotocin-induced model of dementia. Behav Brain Res. 2013;236(1):186\u201393.","journal-title":"Behav Brain Res"},{"issue":"1","key":"694_CR33","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.jnutbio.2012.06.011","volume":"24","author":"YJ Lee","year":"2013","unstructured":"Lee YJ, Choi DY, Yun YP, Han SB, Oh KW, Hong JT. Epigallocatechin-3-gallate prevents systemic inflammation-induced memory deficiency and amyloidogenesis via its anti-neuroinflammatory properties. J Nutr Biochem. 2013;24(1):298\u2013310.","journal-title":"J Nutr Biochem"},{"issue":"02","key":"694_CR34","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1142\/S0192415X15500214","volume":"43","author":"F-S Tsai","year":"2015","unstructured":"Tsai F-S, et al. Ferulic acid reverses the cognitive dysfunction caused by amyloid \u03b2 peptide 1-40 through anti-oxidant activity and cholinergic activation in rats. Am J Chin Med. 2015;43(02):319\u201335.","journal-title":"Am J Chin Med"},{"issue":"2","key":"694_CR35","doi-asserted-by":"publisher","first-page":"e55774","DOI":"10.1371\/journal.pone.0055774","volume":"8","author":"T Mori","year":"2013","unstructured":"Mori T, Koyama N, Guillot-Sestier MV, Tan J, Town T. Ferulic acid is a nutraceutical beta-secretase modulator that improves behavioral impairment and Alzheimer-like pathology in transgenic mice. PLoS One. 2013;8(2):e55774.","journal-title":"PLoS One"},{"issue":"1","key":"694_CR36","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3233\/JAD-130164","volume":"37","author":"Y Zhang","year":"2013","unstructured":"Zhang Y, et al. Ferulic acid inhibits the transition of amyloid-\u03b242 monomers to oligomers but accelerates the transition from oligomers to fibrils. J Alzheimers Dis. 2013;37(1):19\u201328.","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"694_CR37","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.bbrc.2005.08.148","volume":"336","author":"K Ono","year":"2005","unstructured":"Ono K, Hirohata M, Yamada M. Ferulic acid destabilizes preformed beta-amyloid fibrils in vitro. Biochem Biophys Res Commun. 2005;336(2):444\u20139.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"694_CR38","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1248\/bpb.b12-00798","volume":"36","author":"JJ Yan","year":"2013","unstructured":"Yan JJ, Jung JS, Kim TK, Hasan A, Hong CW, Nam JS, et al. Protective effects of ferulic acid in amyloid precursor protein plus presenilin-1 transgenic mouse model of Alzheimer disease. Biol Pharm Bull. 2013;36(1):140\u20133.","journal-title":"Biol Pharm Bull"},{"key":"694_CR39","doi-asserted-by":"crossref","unstructured":"Bhattacharya S, et al. Galantamine slows down plaque formation and behavioral decline in the 5XFAD mouse model of Alzheimer\u2019s disease. PLoS One. 2014;9(2).","DOI":"10.1371\/journal.pone.0089454"},{"key":"694_CR40","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.exger.2015.10.015","volume":"72","author":"Z Wu","year":"2015","unstructured":"Wu Z, Zhao L, Chen X, Cheng X, Zhang Y. Galantamine attenuates amyloid-beta deposition and astrocyte activation in APP\/PS1 transgenic mice. Exp Gerontol. 2015;72:244\u201350.","journal-title":"Exp Gerontol"},{"issue":"51","key":"694_CR41","doi-asserted-by":"publisher","first-page":"40180","DOI":"10.1074\/jbc.M110.142356","volume":"285","author":"K Takata","year":"2010","unstructured":"Takata K, Kitamura Y, Saeki M, Terada M, Kagitani S, Kitamura R, et al. Galantamine-induced amyloid-\u03b2 clearance mediated via stimulation of microglial nicotinic acetylcholine receptors. J Biol Chem. 2010;285(51):40180\u201391.","journal-title":"J Biol Chem"},{"issue":"1","key":"694_CR42","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1002\/jnr.10075","volume":"67","author":"XQ Xiao","year":"2002","unstructured":"Xiao XQ, Zhang HY, Tang XC. Huperzine A attenuates amyloid beta-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation. J Neurosci Res. 2002;67(1):30\u20136.","journal-title":"J Neurosci Res"},{"issue":"4","key":"694_CR43","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1002\/jnr.20987","volume":"84","author":"Y Peng","year":"2006","unstructured":"Peng Y, Jiang L, Lee DY, Schachter SC, Ma Z, Lemere CA. Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells. J Neurosci Res. 2006;84(4):903\u201311.","journal-title":"J Neurosci Res"},{"issue":"6","key":"694_CR44","first-page":"486","volume":"20","author":"SS Xu","year":"1999","unstructured":"Xu SS, et al. Huperzine-A in capsules and tablets for treating patients with Alzheimer disease. Zhongguo Yao Li Xue Bao. 1999;20(6):486\u201390.","journal-title":"Zhongguo Yao Li Xue Bao"},{"issue":"5","key":"694_CR45","first-page":"391","volume":"16","author":"SS Xu","year":"1995","unstructured":"Xu SS, et al. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer\u2019s disease. Zhongguo Yao Li Xue Bao. 1995;16(5):391\u20135.","journal-title":"Zhongguo Yao Li Xue Bao"},{"issue":"16","key":"694_CR46","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1212\/WNL.0b013e318216eb7b","volume":"76","author":"MS Rafii","year":"2011","unstructured":"Rafii MS, et al. A phase II trial of huperzine A in mild to moderate Alzheimer disease. Neurology. 2011;76(16):1389\u201394.","journal-title":"Neurology"},{"issue":"3","key":"694_CR47","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/j.fct.2009.12.009","volume":"48","author":"P Chonpathompikunlert","year":"2010","unstructured":"Chonpathompikunlert P, Wattanathorn J, Muchimapura S. Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer\u2019s disease. Food Chem Toxicol. 2010;48(3):798\u2013802.","journal-title":"Food Chem Toxicol"},{"issue":"4","key":"694_CR48","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.jnutbio.2012.03.018","volume":"24","author":"P Shrivastava","year":"2013","unstructured":"Shrivastava P, Vaibhav K, Tabassum R, Khan A, Ishrat T, Khan MM, et al. Anti-apoptotic and anti-inflammatory effect of piperine on 6-OHDA induced Parkinson\u2019s rat model. J Nutr Biochem. 2013;24(4):680\u20137.","journal-title":"J Nutr Biochem"},{"issue":"25-26","key":"694_CR49","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.lfs.2011.09.023","volume":"89","author":"K Jimenez-Aliaga","year":"2011","unstructured":"Jimenez-Aliaga K, et al. Quercetin and rutin exhibit antiamyloidogenic and fibril-disaggregating effects in vitro and potent antioxidant activity in APPswe cells. Life Sci. 2011;89(25-26):939\u201345.","journal-title":"Life Sci"},{"issue":"10","key":"694_CR50","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1002\/mnfr.201400014","volume":"58","author":"C Regitz","year":"2014","unstructured":"Regitz C, Dussling LM, Wenzel U. Amyloid-beta (Abeta(1)(-)(4)(2))-induced paralysis in Caenorhabditis elegans is inhibited by the polyphenol quercetin through activation of protein degradation pathways. Mol Nutr Food Res. 2014;58(10):1931\u201340.","journal-title":"Mol Nutr Food Res"},{"key":"694_CR51","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.neuropharm.2016.04.032","volume":"108","author":"X Zhang","year":"2016","unstructured":"Zhang X, Hu J, Zhong L, Wang N, Yang L, Liu CC, et al. Quercetin stabilizes apolipoprotein e and reduces brain A\u03b2 levels in amyloid model mice. Neuropharmacology. 2016;108:179\u201392.","journal-title":"Neuropharmacology"},{"issue":"5","key":"694_CR52","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1007\/s13765-016-0217-0","volume":"59","author":"JH Kim","year":"2016","unstructured":"Kim JH, et al. Quercetin and quercetin-3-\u03b2-d-glucoside improve cognitive and memory function in Alzheimer\u2019s disease mouse. Appl Biol Chem. 2016;59(5):721\u20138.","journal-title":"Appl Biol Chem"},{"key":"694_CR53","doi-asserted-by":"crossref","unstructured":"Andrade S, et al. Resveratrol brain delivery for neurological disorders prevention and treatment. Front Pharmacol. 2018;9(1261).","DOI":"10.3389\/fphar.2018.01261"},{"key":"694_CR54","doi-asserted-by":"crossref","unstructured":"Andrade S, et al. Interaction studies of amyloid beta-peptide with the natural compound resveratrol. In: 2015 IEEE 4th Portuguese Meeting on Bioengineering (ENBENG). 2015.","DOI":"10.1109\/ENBENG.2015.7088833"},{"issue":"45","key":"694_CR55","doi-asserted-by":"publisher","first-page":"37377","DOI":"10.1074\/jbc.M508246200","volume":"280","author":"P Marambaud","year":"2005","unstructured":"Marambaud P, Zhao H, Davies P. Resveratrol promotes clearance of Alzheimer\u2019s disease amyloid-beta peptides. J Biol Chem. 2005;280(45):37377\u201382.","journal-title":"J Biol Chem"},{"issue":"31","key":"694_CR56","doi-asserted-by":"publisher","first-page":"24228","DOI":"10.1074\/jbc.M110.133108","volume":"285","author":"ARA Ladiwala","year":"2010","unstructured":"Ladiwala ARA, et al. Resveratrol selectively remodels soluble oligomers and fibrils of amyloid A\u03b2 into off-pathway conformers. J Biol Chem. 2010;285(31):24228\u201337.","journal-title":"J Biol Chem"},{"key":"694_CR57","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.neuroscience.2015.10.006","volume":"310","author":"HF Zhao","year":"2015","unstructured":"Zhao HF, Li N, Wang Q, Cheng XJ, Li XM, Liu TT. Resveratrol decreases the insoluble A\u03b21-42 level in hippocampus and protects the integrity of the blood-brain barrier in AD rats. Neuroscience. 2015;310:641\u20139.","journal-title":"Neuroscience"},{"issue":"2","key":"694_CR58","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.neuint.2008.10.008","volume":"54","author":"SS Karuppagounder","year":"2009","unstructured":"Karuppagounder SS, Pinto JT, Xu H, Chen HL, Beal MF, Gibson GE. Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer\u2019s disease. Neurochem Int. 2009;54(2):111\u20138.","journal-title":"Neurochem Int"},{"issue":"22","key":"694_CR59","first-page":"2050","volume":"8","author":"XR Ma","year":"2013","unstructured":"Ma XR, et al. Resveratrol improves cognition and reduces oxidative stress in rats with vascular dementia. Neural Regen Res. 2013;8(22):2050\u20139.","journal-title":"Neural Regen Res"},{"issue":"2","key":"694_CR60","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1034\/j.1600-079X.2003.00057.x","volume":"35","author":"S Rosales-Corral","year":"2003","unstructured":"Rosales-Corral S, Tan DX, Reiter RJ, Valdivia-Vel\u00e1zquez M, Mart\u00ednez-Barboza G, Acosta-Mart\u00ednez JP, et al. Orally administered melatonin reduces oxidative stress and proinflammatory cytokines induced by amyloid-beta peptide in rat brain: a comparative, in vivo study versus vitamin C and E. J Pineal Res. 2003;35(2):80\u20134.","journal-title":"J Pineal Res"},{"issue":"2","key":"694_CR61","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1096\/fj.03-0961fje","volume":"18","author":"S Sung","year":"2004","unstructured":"Sung S, Yao Y, Uryu K, Yang H, Lee VM, Trojanowski JQ, et al. Early vitamin E supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimer\u2019s disease. FASEB J. 2004;18(2):323\u20135.","journal-title":"FASEB J"},{"issue":"3","key":"694_CR62","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S0891-5849(01)00595-0","volume":"31","author":"A Kontush","year":"2001","unstructured":"Kontush A, et al. Influence of vitamin E and C supplementation on lipoprotein oxidation in patients with Alzheimer\u2019s disease. Free Radic Biol Med. 2001;31(3):345\u201354.","journal-title":"Free Radic Biol Med"},{"issue":"17","key":"694_CR63","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1056\/NEJM199704243361704","volume":"336","author":"M Sano","year":"1997","unstructured":"Sano M, Ernesto C, Thomas RG, Klauber MR, Schafer K, Grundman M, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer\u2019s disease. N Engl J Med. 1997;336(17):1216\u201322.","journal-title":"N Engl J Med"},{"issue":"1","key":"694_CR64","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1001\/jama.2013.282834","volume":"311","author":"MW Dysken","year":"2014","unstructured":"Dysken MW, Sano M, Asthana S, Vertrees JE, Pallaki M, Llorente M, et al. Effect of vitamin e and memantine on functional decline in alzheimer disease: the team-ad va cooperative randomized trial. JAMA. 2014;311(1):33\u201344.","journal-title":"JAMA"},{"issue":"5","key":"694_CR65","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1001\/jamaneurol.2016.5778","volume":"74","author":"RJ Kryscio","year":"2017","unstructured":"Kryscio RJ, Abner EL, Caban-Holt A, Lovell M, Goodman P, Darke AK, et al. Association of antioxidant supplement use and dementia in the Prevention of Alzheimer\u2019s Disease by Vitamin E and Selenium Trial (PREADViSE). JAMA Neurol. 2017;74(5):567\u201373.","journal-title":"JAMA Neurol"},{"key":"694_CR66","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.ejpb.2019.01.015","volume":"136","author":"MJ Ramalho","year":"2019","unstructured":"Ramalho MJ, Andrade S, Coelho M\u00c1N, Loureiro JA, Pereira MC. Biophysical interaction of temozolomide and its active metabolite with biomembrane models: the relevance of drug-membrane interaction for Glioblastoma Multiforme therapy. Eur J Pharm Biopharm. 2019;136:156\u201363.","journal-title":"Eur J Pharm Biopharm"},{"key":"694_CR67","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.ejpb.2015.04.002","volume":"93","author":"\u0160 Zupan\u010di\u010d","year":"2015","unstructured":"Zupan\u010di\u010d \u0160, Lavri\u010d Z, Kristl J. Stability and solubility of trans-resveratrol are strongly influenced by pH and temperature. Eur J Pharm Biopharm. 2015;93:196\u2013204.","journal-title":"Eur J Pharm Biopharm"},{"key":"694_CR68","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.jcis.2013.08.041","volume":"411","author":"AH Saberi","year":"2013","unstructured":"Saberi AH, Fang Y, McClements DJ. Effect of glycerol on formation, stability, and properties of vitamin-E enriched nanoemulsions produced using spontaneous emulsification. J Colloid Interface Sci. 2013;411:105\u201313.","journal-title":"J Colloid Interface Sci"},{"issue":"7","key":"694_CR69","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.molmed.2012.05.002","volume":"18","author":"L Shen","year":"2012","unstructured":"Shen L, Ji H-F. Low stability remedies the low bioavailability of curcumin. Trends Mol Med. 2012;18(7):363\u20134.","journal-title":"Trends Mol Med"},{"issue":"20","key":"694_CR70","doi-asserted-by":"publisher","first-page":"5228","DOI":"10.1021\/acs.jpcb.7b02914","volume":"121","author":"BJ Bennion","year":"2017","unstructured":"Bennion BJ, Be NA, McNerney M, Lao V, Carlson EM, Valdez CA, et al. Predicting a drug\u2019s membrane permeability: a computational model validated with in vitro permeability assay data. J Phys Chem B. 2017;121(20):5228\u201337.","journal-title":"J Phys Chem B"},{"key":"694_CR71","doi-asserted-by":"crossref","unstructured":"Ramalho MJ, Coelho MAN, Pereira MC. Chapter 18 - Nanocarriers for the delivery of temozolomide in the treatment of glioblastoma: a review. In: Grumezescu AM, editor. Design and Development of New Nanocarriers: William Andrew Publishing; 2018. p. 687\u2013722.","DOI":"10.1016\/B978-0-12-813627-0.00018-1"},{"issue":"8","key":"694_CR72","doi-asserted-by":"publisher","first-page":"694","DOI":"10.3109\/1061186X.2016.1157883","volume":"24","author":"W Liu","year":"2016","unstructured":"Liu W, Zhai Y, Heng X, Che FY, Chen W, Sun D, et al. Oral bioavailability of curcumin: problems and advancements. J Drug Target. 2016;24(8):694\u2013702.","journal-title":"J Drug Target"},{"key":"694_CR73","doi-asserted-by":"crossref","unstructured":"Fong Yen W, et al. Formulation and evaluation of galantamine gel as drug reservoir in transdermal patch delivery system. Sci World J. 2015;2015.","DOI":"10.1155\/2015\/495271"},{"key":"694_CR74","doi-asserted-by":"crossref","unstructured":"Gambini J, et al. Properties of resveratrol: in vitro and in vivo studies about metabolism, bioavailability, and biological effects in animal models and humans. Oxidative Med Cell Longev. 2015;2015.","DOI":"10.1155\/2015\/837042"},{"issue":"2","key":"694_CR75","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1021\/acs.molpharmaceut.5b00611","volume":"13","author":"G Djiokeng Paka","year":"2016","unstructured":"Djiokeng Paka G, Doggui S, Zaghmi A, Safar R, Dao L, Reisch A, et al. Neuronal uptake and neuroprotective properties of curcumin-loaded nanoparticles on SK-N-SH Cell Line: role of poly(lactide-co-glycolide) polymeric matrix composition. Mol Pharm. 2016;13(2):391\u2013403.","journal-title":"Mol Pharm"},{"issue":"2","key":"694_CR76","doi-asserted-by":"publisher","first-page":"377","DOI":"10.3233\/JAD-2012-112141","volume":"30","author":"S Doggui","year":"2012","unstructured":"Doggui S, et al. Neuronal uptake and neuroprotective effect of curcumin-loaded PLGA nanoparticles on the human SK-N-SH cell line. J Alzheimers Dis. 2012;30(2):377\u201392.","journal-title":"J Alzheimers Dis"},{"key":"694_CR77","doi-asserted-by":"crossref","unstructured":"Mathew A, et al. Curcumin nanoparticles- a gateway for multifaceted approach to tackle Alzheimer\u2019s disease. In: 11th IEEE International Conference on Nanotechnology. 2011.","DOI":"10.1109\/NANO.2011.6144336"},{"issue":"3","key":"694_CR78","first-page":"1","volume":"7","author":"A Mathew","year":"2012","unstructured":"Mathew A, et al. Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer\u2019s disease. PLoS One. 2012;7(3):1\u201310.","journal-title":"PLoS One"},{"issue":"1","key":"694_CR79","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1080\/10717544.2018.1461955","volume":"25","author":"S Fan","year":"2018","unstructured":"Fan S, et al. Curcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimer\u2019s disease. Drug Deliv. 2018;25(1):1091\u2013102.","journal-title":"Drug Deliv"},{"key":"694_CR80","doi-asserted-by":"publisher","first-page":"3765","DOI":"10.2147\/IJN.S94622","volume":"11","author":"T Jia","year":"2016","unstructured":"Jia T, et al. A dual brain-targeting curcumin-loaded polymersomes ameliorated cognitive dysfunction in intrahippocampal amyloid-beta1-42-injected mice. Int J Nanomedicine. 2016;11:3765\u201375.","journal-title":"Int J Nanomedicine"},{"issue":"3","key":"694_CR81","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1021\/mp900306x","volume":"7","author":"RS Mulik","year":"2010","unstructured":"Mulik RS, M\u00f6nkk\u00f6nen J, Juvonen RO, Mahadik KR, Paradkar AR. ApoE3 Mediated poly(butyl) cyanoacrylate nanoparticles containing curcumin: study of enhanced activity of curcumin against beta amyloid induced cytotoxicity using in vitro cell culture model. Mol Pharm. 2010;7(3):815\u201325.","journal-title":"Mol Pharm"},{"issue":"8","key":"694_CR82","doi-asserted-by":"publisher","first-page":"3111","DOI":"10.1007\/s11051-010-9907-4","volume":"12","author":"M Sun","year":"2010","unstructured":"Sun M, et al. Enhancement of transport of curcumin to brain in mice by poly( n-butylcyanoacrylate) nanoparticle. J Nanopart Res. 2010;12(8):3111\u201322.","journal-title":"J Nanopart Res"},{"key":"694_CR83","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.ejps.2015.11.010","volume":"82","author":"S Kumar","year":"2016","unstructured":"Kumar S, Kesharwani SS, Mathur H, Tyagi M, Bhat GJ, Tummala H. Molecular complexation of curcumin with pH sensitive cationic copolymer enhances the aqueous solubility, stability and bioavailability of curcumin. Eur J Pharm Sci. 2016;82:86\u201396.","journal-title":"Eur J Pharm Sci"},{"issue":"2","key":"694_CR84","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1208\/s12248-012-9444-4","volume":"15","author":"KK Cheng","year":"2013","unstructured":"Cheng KK, Yeung CF, Ho SW, Chow SF, Chow AH, Baum L. Highly stabilized curcumin nanoparticles tested in an in vitro blood\u2013brain barrier model and in Alzheimer\u2019s disease Tg2576 Mice. AAPS J. 2013;15(2):324\u201336.","journal-title":"AAPS J"},{"issue":"1","key":"694_CR85","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3233\/JAD-2010-101374","volume":"23","author":"B Ray","year":"2011","unstructured":"Ray B, Bisht S, Maitra A, Maitra A, Lahiri DK. Neuroprotective and neurorescue effects of a novel polymeric nanoparticle formulation of curcumin (NanoCurc\u2122) in the neuronal cell culture and animal model: implications for Alzheimer\u2019s disease. J Alzheimers Dis. 2011;23(1):61\u201377.","journal-title":"J Alzheimers Dis"},{"issue":"6","key":"694_CR86","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1016\/j.biomaterials.2010.10.027","volume":"32","author":"S Mourtas","year":"2011","unstructured":"Mourtas S, Canovi M, Zona C, Aurilia D, Niarakis A, la Ferla B, et al. Curcumin-decorated nanoliposomes with very high affinity for amyloid-\u03b21-42 peptide. Biomaterials. 2011;32(6):1635\u201345.","journal-title":"Biomaterials"},{"key":"694_CR87","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.ejmech.2014.04.050","volume":"80","author":"S Mourtas","year":"2014","unstructured":"Mourtas S, Lazar AN, Markoutsa E, Duyckaerts C, Antimisiaris SG. Multifunctional nanoliposomes with curcumin\u2013lipid derivative and brain targeting functionality with potential applications for Alzheimer disease. Eur J Med Chem. 2014;80:175\u201383.","journal-title":"Eur J Med Chem"},{"issue":"5","key":"694_CR88","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.nano.2012.11.004","volume":"9","author":"AN Lazar","year":"2013","unstructured":"Lazar AN, et al. Curcumin-conjugated nanoliposomes with high affinity for A\u03b2 deposits: Possible applications to Alzheimer disease. Nanomedicine. 2013;9(5):712\u201321.","journal-title":"Nanomedicine"},{"issue":"4","key":"694_CR89","first-page":"1","volume":"7","author":"VV Sokolik","year":"2017","unstructured":"Sokolik VV, Berchenko OG, Shulga SM. Comparative analysis of nasal therapy with soluble and liposomal forms of curcumin on rats with Alzheimer\u2019s disease model. J Alzheimers Dis Parkinsonism. 2017;7(4):1\u20136.","journal-title":"J Alzheimers Dis Parkinsonism"},{"issue":"5","key":"694_CR90","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.nano.2011.06.015","volume":"7","author":"M Taylor","year":"2011","unstructured":"Taylor M, et al. Effect of curcumin-associated and lipid ligand-functionalized nanoliposomes on aggregation of the Alzheimer\u2019s A\u03b2 peptide. Nanomedicine. 2011;7(5):541\u201350.","journal-title":"Nanomedicine"},{"issue":"2","key":"694_CR91","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s11095-014-1469-1","volume":"32","author":"P Ramalingam","year":"2015","unstructured":"Ramalingam P, Ko YT. Enhanced oral delivery of curcumin from N-trimethyl chitosan surface-modified solid lipid nanoparticles: pharmacokinetic and brain distribution evaluations. Pharm Res. 2015;32(2):389\u2013402.","journal-title":"Pharm Res"},{"issue":"5","key":"694_CR92","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1007\/s00418-016-1464-1","volume":"146","author":"P Maiti","year":"2016","unstructured":"Maiti P, Hall TC, Paladugu L, Kolli N, Learman C, Rossignol J, et al. A comparative study of dietary curcumin, nanocurcumin, and other classical amyloid-binding dyes for labeling and imaging of amyloid plaques in brain tissue of 5\u00d7-familial Alzheimer\u2019s disease mice. Histochem Cell Biol. 2016;146(5):609\u201325.","journal-title":"Histochem Cell Biol"},{"key":"694_CR93","first-page":"4164872","volume":"2017","author":"P Maiti","year":"2017","unstructured":"Maiti P, Dunbar GL. Comparative neuroprotective effects of dietary curcumin and solid lipid curcumin particles in cultured mouse neuroblastoma cells after exposure to A\u03b242. Int J Alzheimers Dis. 2017;2017:4164872.","journal-title":"Int J Alzheimers Dis"},{"key":"694_CR94","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.colsurfb.2015.06.025","volume":"134","author":"F Meng","year":"2015","unstructured":"Meng F, Asghar S, Gao S, Su Z, Song J, Huo M, et al. A novel LDL-mimic nanocarrier for the targeted delivery of curcumin into the brain to treat Alzheimer\u2019s disease. Colloids Surf B: Biointerfaces. 2015;134:88\u201397.","journal-title":"Colloids Surf B: Biointerfaces"},{"key":"694_CR95","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.nlm.2013.08.001","volume":"106","author":"JB Hoppe","year":"2013","unstructured":"Hoppe JB, Coradini K, Frozza RL, Oliveira CM, Meneghetti AB, Bernardi A, et al. Free and nanoencapsulated curcumin suppress \u03b2-amyloid-induced cognitive impairments in rats: involvement of BDNF and Akt\/GSK-3\u03b2 signaling pathway. Neurobiol Learn Mem. 2013;106:134\u201344.","journal-title":"Neurobiol Learn Mem"},{"key":"694_CR96","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.neuint.2015.07.026","volume":"89","author":"S Hagl","year":"2015","unstructured":"Hagl S, Kocher A, Schiborr C, Kolesova N, Frank J, Eckert GP. Curcumin micelles improve mitochondrial function in neuronal PC12 cells and brains of NMRI mice \u2013 impact on bioavailability. Neurochem Int. 2015;89:234\u201342.","journal-title":"Neurochem Int"},{"key":"694_CR97","doi-asserted-by":"publisher","first-page":"2653","DOI":"10.2147\/IJN.S79528","volume":"10","author":"Y-C Kuo","year":"2015","unstructured":"Kuo Y-C, Lin C-C. Rescuing apoptotic neurons in Alzheimer\u2019s disease using wheat germ agglutinin-conjugated and cardiolipin-conjugated liposomes with encapsulated nerve growth factor and curcumin. Int J Nanomedicine. 2015;10:2653.","journal-title":"Int J Nanomedicine"},{"issue":"46","key":"694_CR98","doi-asserted-by":"crossref","first-page":"81001","DOI":"10.18632\/oncotarget.20944","volume":"8","author":"N Huang","year":"2017","unstructured":"Huang N, et al. PLGA nanoparticles modified with a BBB-penetrating peptide co-delivering A\u03b2 generation inhibitor and curcumin attenuate memory deficits and neuropathology in Alzheimer\u2019s disease mice. Oncotarget. 2017;8(46):81001.","journal-title":"Oncotarget"},{"issue":"31","key":"694_CR99","doi-asserted-by":"publisher","first-page":"20309","DOI":"10.1021\/acsami.6b06853","volume":"8","author":"K Debnath","year":"2016","unstructured":"Debnath K, Shekhar S, Kumar V, Jana NR, Jana NR. Efficient inhibition of protein aggregation, disintegration of aggregates, and lowering of cytotoxicity by green tea polyphenol-based self-assembled polymer nanoparticles. ACS Appl Mater Interfaces. 2016;8(31):20309\u201318.","journal-title":"ACS Appl Mater Interfaces"},{"issue":"11","key":"694_CR100","doi-asserted-by":"publisher","first-page":"8475","DOI":"10.1021\/am501341u","volume":"6","author":"J Zhang","year":"2014","unstructured":"Zhang J, Zhou X, Yu Q, Yang L, Sun D, Zhou Y, et al. Epigallocatechin-3-gallate (EGCG)-Stabilized selenium nanoparticles coated with Tet-1 peptide to reduce amyloid-\u03b2 aggregation and cytotoxicity. ACS Appl Mater Interfaces. 2014;6(11):8475\u201387.","journal-title":"ACS Appl Mater Interfaces"},{"issue":"1","key":"694_CR101","doi-asserted-by":"publisher","first-page":"26","DOI":"10.2174\/157341309787314656","volume":"5","author":"ML Bondi","year":"2009","unstructured":"Bondi ML, et al. Ferulic acid-loaded lipid nanostructures as drug delivery systems for Alzheimers disease: preparation, characterization and cytotoxicity studies. Curr Nanosci. 2009;5(1):26\u201332.","journal-title":"Curr Nanosci"},{"issue":"11","key":"694_CR102","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1080\/10715760903214454","volume":"43","author":"P Picone","year":"2009","unstructured":"Picone P, Bondi ML, Montana G, Bruno A, Pitarresi G, Giammona G, et al. Ferulic acid inhibits oxidative stress and cell death induced by Ab oligomers: Improved delivery by solid lipid nanoparticles. Free Radic Res. 2009;43(11):1133\u201345.","journal-title":"Free Radic Res"},{"issue":"28","key":"694_CR103","doi-asserted-by":"publisher","first-page":"12076","DOI":"10.1039\/C5NR03474D","volume":"7","author":"C Fornaguera","year":"2015","unstructured":"Fornaguera C, Feiner-Gracia N, Calder\u00f3 G, Garc\u00eda-Celma MJ, Solans C. Galantamine-loaded PLGA nanoparticles, from nano-emulsion templating, as novel advanced drug delivery systems to treat neurodegenerative diseases. Nanoscale. 2015;7(28):12076\u201384.","journal-title":"Nanoscale"},{"issue":"8","key":"694_CR104","doi-asserted-by":"publisher","first-page":"3111","DOI":"10.3109\/10717544.2016.1153748","volume":"23","author":"AS Hanafy","year":"2016","unstructured":"Hanafy AS, Farid RM, Helmy MW, ElGamal S. Pharmacological, toxicological and neuronal localization assessment of galantamine\/chitosan complex nanoparticles in rats: future potential contribution in Alzheimer\u2019s disease management. Drug Deliv. 2016;23(8):3111\u201322.","journal-title":"Drug Deliv"},{"issue":"1","key":"694_CR105","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.ijpharm.2013.03.037","volume":"448","author":"MS Mufamadi","year":"2013","unstructured":"Mufamadi MS, Choonara YE, Kumar P, Modi G, Naidoo D, van Vuuren S, et al. Ligand-functionalized nanoliposomes for targeted delivery of galantamine. Int J Pharm. 2013;448(1):267\u201381.","journal-title":"Int J Pharm"},{"issue":"2","key":"694_CR106","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.etap.2012.04.012","volume":"34","author":"W Li","year":"2012","unstructured":"Li W, Zhou Y, Zhao N, Hao B, Wang X, Kong P. Pharmacokinetic behavior and efficiency of acetylcholinesterase inhibition in rat brain after intranasal administration of galanthamine hydrobromide loaded flexible liposomes. Environ Toxicol Pharmacol. 2012;34(2):272\u20139.","journal-title":"Environ Toxicol Pharmacol"},{"issue":"4","key":"694_CR107","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.3109\/10717544.2015.1089956","volume":"23","author":"S Misra","year":"2016","unstructured":"Misra S, Chopra K, Sinha VR, Medhi B. Galantamine-loaded solid\u2013lipid nanoparticles for enhanced brain delivery: preparation, characterization, in vitro and in vivo evaluations. Drug Deliv. 2016;23(4):1434\u201343.","journal-title":"Drug Deliv"},{"key":"694_CR108","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.msec.2016.04.041","volume":"65","author":"SMR Wahba","year":"2016","unstructured":"Wahba SMR, Darwish AS, Kamal SM. Ceria-containing uncoated and coated hydroxyapatite-based galantamine nanocomposites for formidable treatment of Alzheimer\u2019s disease in ovariectomized albino-rat model. Mater Sci Eng C. 2016;65:151\u201363.","journal-title":"Mater Sci Eng C"},{"issue":"2","key":"694_CR109","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3390\/molecules22020277","volume":"22","author":"J Loureiro","year":"2017","unstructured":"Loureiro J, et al. Resveratrol and Grape extract-loaded solid lipid nanoparticles for the treatment of Alzheimer\u2019s disease. Molecules. 2017;22(2):277.","journal-title":"Molecules"},{"key":"694_CR110","doi-asserted-by":"publisher","first-page":"705","DOI":"10.2147\/IJN.S151474","volume":"13","author":"Q Meng","year":"2018","unstructured":"Meng Q, Wang A, Hua H, Jiang Y, Wang Y, Mu H, et al. Intranasal delivery of Huperzine A to the brain using lactoferrin-conjugated N-trimethylated chitosan surface-modified PLGA nanoparticles for treatment of Alzheimer\u2019s disease. Int J Nanomedicine. 2018;13:705\u201318.","journal-title":"Int J Nanomedicine"},{"issue":"1","key":"694_CR111","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1248\/cpb.54.89","volume":"54","author":"P Gao","year":"2006","unstructured":"Gao P, Ding P, Xu H, Yuan Z, Chen D, Wei J, et al. In vitro and in vivo characterization of huperzine a loaded microspheres made from end-group uncapped poly(d,l-lactide acid) and poly(d,l-lactide-co-glycolide acid). Chem Pharm Bull. 2006;54(1):89\u201393.","journal-title":"Chem Pharm Bull"},{"issue":"1\u20132","key":"694_CR112","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijpharm.2006.08.030","volume":"330","author":"P Gao","year":"2007","unstructured":"Gao P, Xu H, Ding P, Gao Q, Sun J, Chen D. Controlled release of huperzine A from biodegradable microspheres: in vitro and in vivo studies. Int J Pharm. 2007;330(1\u20132):1\u20135.","journal-title":"Int J Pharm"},{"issue":"1\u20132","key":"694_CR113","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ijpharm.2013.02.014","volume":"446","author":"PA Patel","year":"2013","unstructured":"Patel PA, Patil SC, Kalaria DR, Kalia YN, Patravale VB. Comparative in vitro and in vivo evaluation of lipid based nanocarriers of Huperzine A. Int J Pharm. 2013;446(1\u20132):16\u201323.","journal-title":"Int J Pharm"},{"issue":"10","key":"694_CR114","doi-asserted-by":"publisher","first-page":"3544","DOI":"10.1002\/jps.24557","volume":"104","author":"YSR Elnaggar","year":"2015","unstructured":"Elnaggar YSR, Etman SM, Abdelmonsif DA, Abdallah OY. Intranasal Piperine-loaded chitosan nanoparticles as brain-targeted therapy in Alzheimer\u2019s disease: optimization, biological efficacy, and potential toxicity. J Pharm Sci. 2015;104(10):3544\u201356.","journal-title":"J Pharm Sci"},{"issue":"33","key":"694_CR115","doi-asserted-by":"publisher","first-page":"8605","DOI":"10.1016\/j.biomaterials.2011.07.024","volume":"32","author":"P Chonpathompikunlert","year":"2011","unstructured":"Chonpathompikunlert P, Yoshitomi T, Han J, Isoda H, Nagasaki Y. The use of nitroxide radical-containing nanoparticles coupled with piperine to protect neuroblastoma SH-SY5Y cells from A\u03b2-induced oxidative stress. Biomaterials. 2011;32(33):8605\u201312.","journal-title":"Biomaterials"},{"issue":"3","key":"694_CR116","doi-asserted-by":"publisher","first-page":"300","DOI":"10.3109\/1061186X.2012.747529","volume":"21","author":"M Yusuf","year":"2013","unstructured":"Yusuf M, et al. Preparation, characterization, in vivo and biochemical evaluation of brain targeted Piperine solid lipid nanoparticles in an experimentally induced Alzheimer\u2019s disease model. J Drug Target. 2013;21(3):300\u201311.","journal-title":"J Drug Target"},{"key":"694_CR117","doi-asserted-by":"publisher","first-page":"5459","DOI":"10.2147\/IJN.S87336","volume":"10","author":"YS Elnaggar","year":"2015","unstructured":"Elnaggar YS, et al. Novel piperine-loaded Tween-integrated monoolein cubosomes as brain-targeted oral nanomedicine in Alzheimer\u2019s disease: pharmaceutical, biological, and toxicological studies. Int J Nanomedicine. 2015;10:5459\u201373.","journal-title":"Int J Nanomedicine"},{"issue":"6","key":"694_CR118","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1016\/j.nano.2014.03.015","volume":"10","author":"M Mizrahi","year":"2014","unstructured":"Mizrahi M, et al. Pomegranate seed oil nanoemulsions for the prevention and treatment of neurodegenerative diseases: the case of genetic CJD. Nanomedicine. 2014;10(6):1353\u201363.","journal-title":"Nanomedicine"},{"key":"694_CR119","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.colsurfb.2016.08.052","volume":"148","author":"D Sun","year":"2016","unstructured":"Sun D, Li N, Zhang W, Zhao Z, Mou Z, Huang D, et al. Design of PLGA-functionalized quercetin nanoparticles for potential use in Alzheimer\u2019s disease. Colloids Surf B: Biointerfaces. 2016;148:116\u201329.","journal-title":"Colloids Surf B: Biointerfaces"},{"key":"694_CR120","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.2147\/IJN.S132472","volume":"12","author":"Y-C Kuo","year":"2017","unstructured":"Kuo Y-C, Tsao C-W. Neuroprotection against apoptosis of SK-N-MC cells using RMP-7- and lactoferrin-grafted liposomes carrying quercetin. Int J Nanomedicine. 2017;12:2857\u201369.","journal-title":"Int J Nanomedicine"},{"issue":"3","key":"694_CR121","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/j.2042-7158.2010.01225.x","volume":"63","author":"S Dhawan","year":"2011","unstructured":"Dhawan S, Kapil R, Singh B. Formulation development and systematic optimization of solid lipid nanoparticles of quercetin for improved brain delivery. J Pharm Pharmacol. 2011;63(3):342\u201351.","journal-title":"J Pharm Pharmacol"},{"key":"694_CR122","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.lfs.2018.03.010","volume":"199","author":"N Rishitha","year":"2018","unstructured":"Rishitha N, Muthuraman A. Therapeutic evaluation of solid lipid nanoparticle of quercetin in pentylenetetrazole induced cognitive impairment of zebrafish. Life Sci. 2018;199:80\u20137.","journal-title":"Life Sci"},{"key":"694_CR123","doi-asserted-by":"crossref","unstructured":"Moreno LCGEI, et al. Effect of the oral administration of nanoencapsulated quercetin on a mouse model of Alzheimer\u2019s disease. International Journal of Pharmaceutics. 2017;517(1\u20132):50\u20137.","DOI":"10.1016\/j.ijpharm.2016.11.061"},{"key":"694_CR124","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jinorgbio.2015.01.001","volume":"145","author":"CM Nday","year":"2015","unstructured":"Nday CM, et al. Quercetin encapsulation in modified silica nanoparticles: potential use against Cu(II)-induced oxidative stress in neurodegeneration. J Inorg Biochem. 2015;145:51\u201364.","journal-title":"J Inorg Biochem"},{"key":"694_CR125","unstructured":"Halevas E. Encapsulation of flavonoid quercetin in PEGylated SiO2 nanoparticles against Cu(II)-induced oxidative stress. In: Proceedings of the 10th Panhellenic Interdisciplinary Conference on Alzheimer\u2019s Disease and Related Disorders and 2nd Mediterranean Conference on Neurodegenerative Diseases. 2017. Thessaloniki, Greece."},{"issue":"17","key":"694_CR126","doi-asserted-by":"publisher","first-page":"15322","DOI":"10.1021\/acsami.9b02797","volume":"11","author":"C-S Cheng","year":"2019","unstructured":"Cheng C-S, Liu TP, Chien FC, Mou CY, Wu SH, Chen YP. Codelivery of Plasmid and curcumin with mesoporous silica nanoparticles for promoting neurite outgrowth. ACS Appl Mater Interfaces. 2019;11(17):15322\u201331.","journal-title":"ACS Appl Mater Interfaces"},{"issue":"1","key":"694_CR127","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.ijpharm.2009.03.021","volume":"375","author":"X Lu","year":"2009","unstructured":"Lu X, et al. Resveratrol-loaded polymeric micelles protect cells from A\u03b2-induced oxidative stress. Int J Pharm. 2009;375(1):89\u201396.","journal-title":"Int J Pharm"},{"issue":"3","key":"694_CR128","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1007\/s12035-013-8401-2","volume":"47","author":"RL Frozza","year":"2013","unstructured":"Frozza RL, Bernardi A, Hoppe JB, Meneghetti AB, Matt\u00e9 A, Battastini AM, et al. Neuroprotective effects of resveratrol against A\u03b2 administration in rats are improved by lipid-core nanocapsules. Mol Neurobiol. 2013;47(3):1066\u201380.","journal-title":"Mol Neurobiol"},{"issue":"12","key":"694_CR129","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1166\/jbn.2013.1709","volume":"9","author":"RL Frozza","year":"2013","unstructured":"Frozza RL, et al. Lipid-core nanocapsules improve the effects of resveratrol against A&#946;-induced neuroinflammation. J Biomed Nanotechnol. 2013;9(12):2086\u2013104.","journal-title":"J Biomed Nanotechnol"},{"issue":"6","key":"694_CR130","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1166\/jbn.2010.1161","volume":"6","author":"RL Frozza","year":"2010","unstructured":"Frozza RL, Bernardi A, Paese K, Hoppe JB, da Silva T, Battastini AM, et al. Characterization of trans-resveratrol-loaded lipid-core nanocapsules and tissue distribution studies in rats. J Biomed Nanotechnol. 2010;6(6):694\u2013703.","journal-title":"J Biomed Nanotechnol"},{"issue":"4","key":"694_CR131","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3233\/JAD-2005-7405","volume":"7","author":"TB Shea","year":"2005","unstructured":"Shea TB, et al. Nanosphere-mediated delivery of vitamin E increases its efficacy against oxidative stress resulting from exposure to amyloid beta. J Alzheimers Dis. 2005;7(4):297\u2013301.","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"694_CR132","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1002\/wnan.1364","volume":"8","author":"BL Banik","year":"2016","unstructured":"Banik BL, Fattahi P, Brown JL. Polymeric nanoparticles: the future of nanomedicine. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016;8(2):271\u201399.","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"issue":"4","key":"694_CR133","doi-asserted-by":"publisher","first-page":"2602","DOI":"10.1021\/acs.chemrev.5b00346","volume":"116","author":"N Kamaly","year":"2016","unstructured":"Kamaly N, Yameen B, Wu J, Farokhzad OC. Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release. Chem Rev. 2016;116(4):2602\u201363.","journal-title":"Chem Rev"},{"issue":"8","key":"694_CR134","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1021\/acs.jchemed.5b00837","volume":"93","author":"MJ Ramalho","year":"2016","unstructured":"Ramalho MJ, Pereira MC. Preparation and characterization of polymeric nanoparticles: an interdisciplinary experiment. J Chem Educ. 2016;93(8):1446\u201351.","journal-title":"J Chem Educ"},{"key":"694_CR135","first-page":"Ch 11","volume-title":"A critical evaluation of vitamin D - clinical overview","author":"MJ Ramalho","year":"2017","unstructured":"Ramalho MJ, Coelho MAN, Pereira MC. Nanoparticles for delivery of vitamin D: challenges and opportunities. In: Gowder S, editor. A critical evaluation of vitamin D - clinical overview. Rijeka: InTech; 2017. p. Ch 11."},{"key":"694_CR136","doi-asserted-by":"crossref","unstructured":"Ramalho MJ, et al. PLGA nanoparticles for calcitriol delivery. in 2015 IEEE 4th Portuguese Meeting on Bioengineering (ENBENG). 2015.","DOI":"10.1109\/ENBENG.2015.7088884"},{"issue":"1","key":"694_CR137","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.ijpharm.2018.04.062","volume":"545","author":"MJ Ramalho","year":"2018","unstructured":"Ramalho MJ, et al. Receptor-mediated PLGA nanoparticles for glioblastoma multiforme treatment. Int J Pharm. 2018;545(1):84\u201392.","journal-title":"Int J Pharm"},{"key":"694_CR138","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.trac.2015.06.014","volume":"80","author":"S Sharma","year":"2016","unstructured":"Sharma S, et al. PLGA-based nanoparticles: a new paradigm in biomedical applications. TrAC Trends Anal Chem. 2016;80:30\u201340.","journal-title":"TrAC Trends Anal Chem"},{"issue":"4","key":"694_CR139","doi-asserted-by":"publisher","first-page":"447","DOI":"10.15171\/apb.2015.061","volume":"5","author":"J Khalili Fard","year":"2015","unstructured":"Khalili Fard J, Jafari S, Eghbal MA. A review of molecular mechanisms involved in toxicity of nanoparticles. Adv Pharm Bull. 2015;5(4):447\u201354.","journal-title":"Adv Pharm Bull"},{"key":"694_CR140","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/B978-0-12-804598-5.00012-X","volume-title":"Neurotoxicity of Nanomaterials and Nanomedicine","author":"Y Li","year":"2017","unstructured":"Li Y, Ju D. Chapter 12 - The application, neurotoxicity, and related mechanism of cationic polymers\u2217\u2217Conflict of Interests: All the Figures and Table in \u201cThe application, neurotoxicity, and related mechanism of cationic polymers\u201d are original, unpublished materials designed and prepared by Yubin Li and Dianwen Ju. The authors declared that there\u2019s no conflict of interests. In: Jiang X, Gao H, editors. Neurotoxicity of Nanomaterials and Nanomedicine. United States: Academic Press; 2017. p. 285\u2013329."},{"issue":"6","key":"694_CR141","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1007\/s00204-012-0938-8","volume":"87","author":"S Xiong","year":"2013","unstructured":"Xiong S, et al. Size influences the cytotoxicity of poly (lactic-co-glycolic acid) (PLGA) and titanium dioxide (TiO(2)) nanoparticles. Arch Toxicol. 2013;87(6):1075\u201386.","journal-title":"Arch Toxicol"},{"issue":"1","key":"694_CR142","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.ijpharm.2017.08.118","volume":"532","author":"C Rodrigues de Azevedo","year":"2017","unstructured":"Rodrigues de Azevedo C, et al. Modeling of the burst release from PLGA micro- and nanoparticles as function of physicochemical parameters and formulation characteristics. Int J Pharm. 2017;532(1):229\u201340.","journal-title":"Int J Pharm"},{"issue":"2","key":"694_CR143","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.ijpharm.2015.10.057","volume":"496","author":"M Iqbal","year":"2015","unstructured":"Iqbal M, Zafar N, Fessi H, Elaissari A. Double emulsion solvent evaporation techniques used for drug encapsulation. Int J Pharm. 2015;496(2):173\u201390.","journal-title":"Int J Pharm"},{"key":"694_CR144","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1159\/000339189","volume-title":"Genetically modified organisms and genetic engineering in research and therapy","author":"C Patte-Mensah","year":"2012","unstructured":"Patte-Mensah C, et al. Transfection of human neuroblastoma cells with Alzheimer\u2019s disease brain hallmarks as a promising strategy to investigate the role of neurosteroidogenesis in neuroprotection. In: Genetically modified organisms and genetic engineering in research and therapy. Berlin: Karger Publishers; 2012. p. 50\u20139."},{"issue":"11","key":"694_CR145","doi-asserted-by":"publisher","first-page":"e48540","DOI":"10.1371\/journal.pone.0048540","volume":"7","author":"S-G Yang","year":"2012","unstructured":"Yang S-G, et al. A peptide binding to the \u03b2-site of APP improves spatial memory and attenuates A\u03b2 burden in Alzheimer\u2019s disease transgenic mice. PLoS One. 2012;7(11):e48540.","journal-title":"PLoS One"},{"key":"694_CR146","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.lfs.2017.12.025","volume":"195","author":"TP Crowe","year":"2018","unstructured":"Crowe TP, Greenlee MHW, Kanthasamy AG, Hsu WH. Mechanism of intranasal drug delivery directly to the brain. Life Sci. 2018;195:44\u201352.","journal-title":"Life Sci"},{"key":"694_CR147","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.foodres.2016.10.038","volume":"90","author":"DRB Oliveira","year":"2016","unstructured":"Oliveira DRB, et al. \u03b2-Carotene-loaded nanostructured lipid carriers produced by solvent displacement method. Food Res Int. 2016;90:139\u201346.","journal-title":"Food Res Int"},{"issue":"4","key":"694_CR148","doi-asserted-by":"publisher","first-page":"521","DOI":"10.4155\/tde.14.125","volume":"6","author":"T Anajafi","year":"2015","unstructured":"Anajafi T, Mallik S. Polymersome-based drug-delivery strategies for cancer therapeutics. Ther Deliv. 2015;6(4):521\u201334.","journal-title":"Ther Deliv"},{"issue":"2","key":"694_CR149","doi-asserted-by":"publisher","first-page":"124","DOI":"10.2174\/1573413712666161018144519","volume":"13","author":"X-Y Zhang","year":"2017","unstructured":"Zhang X-Y, Zhang P-Y. Polymersomes in nanomedicine-a review. Curr Nanosci. 2017;13(2):124\u20139.","journal-title":"Curr Nanosci"},{"issue":"23","key":"694_CR150","doi-asserted-by":"publisher","first-page":"8572","DOI":"10.1039\/C8CS00162F","volume":"47","author":"E Rideau","year":"2018","unstructured":"Rideau E, Dimova R, Schwille P, Wurm FR, Landfester K. Liposomes and polymersomes: a comparative review towards cell mimicking. Chem Soc Rev. 2018;47(23):8572\u2013610.","journal-title":"Chem Soc Rev"},{"issue":"1","key":"694_CR151","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1002\/elsc.201600100","volume":"17","author":"ST Poschenrieder","year":"2017","unstructured":"Poschenrieder ST, Schiebel SK, Castiglione K. Polymersomes for biotechnological applications: large-scale production of nano-scale vesicles. Eng Life Sci. 2017;17(1):58\u201370.","journal-title":"Eng Life Sci"},{"issue":"3","key":"694_CR152","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1002\/cben.201400025","volume":"2","author":"V Zargar","year":"2015","unstructured":"Zargar V, Asghari M, Dashti A. A review on chitin and chitosan polymers: structure, chemistry, solubility, derivatives, and applications. ChemBioEng Rev. 2015;2(3):204\u201326.","journal-title":"ChemBioEng Rev"},{"key":"694_CR153","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.ejpb.2017.04.020","volume":"117","author":"C Palazzo","year":"2017","unstructured":"Palazzo C, Trapani G, Ponchel G, Trapani A, Vauthier C. Mucoadhesive properties of low molecular weight chitosan- or glycol chitosan- and corresponding thiomer-coated poly (isobutylcyanoacrylate) core-shell nanoparticles. Eur J Pharm Biopharm. 2017;117:315\u201323.","journal-title":"Eur J Pharm Biopharm"},{"issue":"4","key":"694_CR154","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.jfda.2014.10.008","volume":"23","author":"MA Elgadir","year":"2015","unstructured":"Elgadir MA, Uddin MS, Ferdosh S, Adam A, Chowdhury AJK, Sarker MZI. Impact of chitosan composites and chitosan nanoparticle composites on various drug delivery systems: a review. J Food Drug Anal. 2015;23(4):619\u201329.","journal-title":"J Food Drug Anal"},{"key":"694_CR155","doi-asserted-by":"crossref","unstructured":"Hussein-Al-Ali SH, et al. Preparation of chitosan nanoparticles as a drug delivery system for perindopril erbumine. Polym Compos. 2016; p. n\/a-n\/a.","DOI":"10.1002\/pc.23967"},{"key":"694_CR156","doi-asserted-by":"publisher","first-page":"483","DOI":"10.2147\/DDDT.S99651","volume":"10","author":"TA Ahmed","year":"2016","unstructured":"Ahmed TA, Aljaeid BM. Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery. Drug Des Dev Ther. 2016;10:483\u2013507.","journal-title":"Drug Des Dev Ther"},{"issue":"29","key":"694_CR157","doi-asserted-by":"publisher","first-page":"5691","DOI":"10.1016\/j.biomaterials.2009.06.055","volume":"30","author":"L Yin","year":"2009","unstructured":"Yin L, et al. Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery. Biomaterials. 2009;30(29):5691\u2013700.","journal-title":"Biomaterials"},{"key":"694_CR158","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.msec.2015.12.024","volume":"61","author":"D Zhu","year":"2016","unstructured":"Zhu D, Cheng H, Li J, Zhang W, Shen Y, Chen S, et al. Enhanced water-solubility and antibacterial activity of novel chitosan derivatives modified with quaternary phosphonium salt. Mater Sci Eng C Mater Biol Appl. 2016;61:79\u201384.","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"issue":"4","key":"694_CR159","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.3390\/md13041819","volume":"13","author":"E Szymanska","year":"2015","unstructured":"Szymanska E, Winnicka K. Stability of chitosan-a challenge for pharmaceutical and biomedical applications. Mar Drugs. 2015;13(4):1819\u201346.","journal-title":"Mar Drugs"},{"key":"694_CR160","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jiec.2015.10.028","volume":"33","author":"C Choi","year":"2016","unstructured":"Choi C, Nam JP, Nah JW. Application of chitosan and chitosan derivatives as biomaterials. J Ind Eng Chem. 2016;33:1\u201310.","journal-title":"J Ind Eng Chem"},{"issue":"1","key":"694_CR161","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1477-3155-5-3","volume":"5","author":"S Bisht","year":"2007","unstructured":"Bisht S, et al. Polymeric nanoparticle-encapsulated curcumin (\u201cnanocurcumin\u201d): a novel strategy for human cancer therapy. J Nanobiotechnol. 2007;5(1):3.","journal-title":"J Nanobiotechnol"},{"key":"694_CR162","first-page":"10","volume":"2014","author":"H Shrestha","year":"2014","unstructured":"Shrestha H, Bala R, Arora S. Lipid-based drug delivery systems. J Pharm. 2014;2014:10.","journal-title":"J Pharm"},{"key":"694_CR163","doi-asserted-by":"crossref","unstructured":"Sercombe L, et al. Advances and challenges of liposome assisted drug delivery. Front Pharmacol. 2015:6(286).","DOI":"10.3389\/fphar.2015.00286"},{"issue":"1","key":"694_CR164","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3109\/21691401.2014.953633","volume":"44","author":"H Daraee","year":"2016","unstructured":"Daraee H, et al. Application of liposomes in medicine and drug delivery. Artif Cells Nanomed Biotechnol. 2016;44(1):381\u201391.","journal-title":"Artif Cells Nanomed Biotechnol"},{"issue":"1-2","key":"694_CR165","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.ijpharm.2013.11.005","volume":"460","author":"C Goncalves","year":"2014","unstructured":"Goncalves C, et al. Lipopolyplexes comprising imidazole\/imidazolium lipophosphoramidate, histidinylated polyethyleneimine and siRNA as efficient formulation for siRNA transfection. Int J Pharm. 2014;460(1-2):264\u201372.","journal-title":"Int J Pharm"},{"issue":"1","key":"694_CR166","doi-asserted-by":"publisher","first-page":"3","DOI":"10.15171\/apb.2017.002","volume":"7","author":"M Alavi","year":"2017","unstructured":"Alavi M, Karimi N, Safaei M. Application of various types of liposomes in drug delivery systems. Ad Pharm Bull. 2017;7(1):3\u20139.","journal-title":"Ad Pharm Bull"},{"key":"694_CR167","first-page":"869269","volume":"2014","author":"RK Upadhyay","year":"2014","unstructured":"Upadhyay RK. Drug delivery systems, CNS protection, and the blood brain barrier. Biomed Res Int. 2014;2014:869269.","journal-title":"Biomed Res Int"},{"issue":"25","key":"694_CR168","doi-asserted-by":"publisher","first-page":"6519","DOI":"10.1016\/j.biomaterials.2010.04.044","volume":"31","author":"M Gobbi","year":"2010","unstructured":"Gobbi M, Re F, Canovi M, Beeg M, Gregori M, Sesana S, et al. Lipid-based nanoparticles with high binding affinity for amyloid-\u03b21\u201342 peptide. Biomaterials. 2010;31(25):6519\u201329.","journal-title":"Biomaterials"},{"issue":"1","key":"694_CR169","first-page":"195","volume":"41","author":"R Hu","year":"2018","unstructured":"Hu R, et al. A novel method of neural differentiation of PC12 cells by using Opti-MEM as a basic induction medium. Int J Mol Med. 2018;41(1):195\u2013201.","journal-title":"Int J Mol Med"},{"issue":"1","key":"694_CR170","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s12272-013-0272-6","volume":"37","author":"SR Hwang","year":"2014","unstructured":"Hwang SR, Kim K. Nano-enabled delivery systems across the blood\u2013brain barrier. Arch Pharm Res. 2014;37(1):24\u201330.","journal-title":"Arch Pharm Res"},{"key":"694_CR171","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.msec.2016.05.119","volume":"68","author":"M Geszke-Moritz","year":"2016","unstructured":"Geszke-Moritz M, Moritz M. Solid lipid nanoparticles as attractive drug vehicles: composition, properties and therapeutic strategies. Mater Sci Eng C. 2016;68:982\u201394.","journal-title":"Mater Sci Eng C"},{"issue":"3","key":"694_CR172","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.ejpb.2014.05.004","volume":"87","author":"L Gastaldi","year":"2014","unstructured":"Gastaldi L, et al. Solid lipid nanoparticles as vehicles of drugs to the brain: current state of the art. Eur J Pharm Biopharm. 2014;87(3):433\u201344.","journal-title":"Eur J Pharm Biopharm"},{"issue":"1","key":"694_CR173","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3109\/21691401.2014.909822","volume":"44","author":"P Jaiswal","year":"2016","unstructured":"Jaiswal P, Gidwani B, Vyas A. Nanostructured lipid carriers and their current application in targeted drug delivery. Artif Cells Nanomed Biotechnol. 2016;44(1):27\u201340.","journal-title":"Artif Cells Nanomed Biotechnol"},{"issue":"2","key":"694_CR174","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.ijpharm.2009.04.026","volume":"379","author":"NT Huynh","year":"2009","unstructured":"Huynh NT, Passirani C, Saulnier P, Benoit JP. Lipid nanocapsules: a new platform for nanomedicine. Int J Pharm. 2009;379(2):201\u20139.","journal-title":"Int J Pharm"},{"issue":"5","key":"694_CR175","doi-asserted-by":"publisher","first-page":"781","DOI":"10.4172\/pharmaceutical-sciences.1000422","volume":"80","author":"K Gurpreet","year":"2018","unstructured":"Gurpreet K, Singh SK. Review of nanoemulsion formulation and characterization techniques. Indian J Pharm Sci. 2018;80(5):781\u20139.","journal-title":"Indian J Pharm Sci"},{"issue":"1-2","key":"694_CR176","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.ijpharm.2017.05.005","volume":"526","author":"SP Callender","year":"2017","unstructured":"Callender SP, Mathews JA, Kobernyk K, Wettig SD. Microemulsion utility in pharmaceuticals: implications for multi-drug delivery. Int J Pharm. 2017;526(1-2):425\u201342.","journal-title":"Int J Pharm"},{"issue":"11","key":"694_CR177","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1055\/s-0043-125337","volume":"84","author":"Y Sangsen","year":"2018","unstructured":"Sangsen Y, Sooksawate T, Likhitwitayawuid K, Sritularak B, Wiwattanapatapee R. A self-microemulsifying formulation of oxyresveratrol prevents amyloid beta protein-induced neurodegeneration in mice. Planta Med. 2018;84(11):820\u20138.","journal-title":"Planta Med"},{"key":"694_CR178","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jconrel.2017.03.008","volume":"252","author":"Y Singh","year":"2017","unstructured":"Singh Y, Meher JG, Raval K, Khan FA, Chaurasia M, Jain NK, et al. Nanoemulsion: concepts, development and applications in drug delivery. J Control Release. 2017;252:28\u201349.","journal-title":"J Control Release"},{"issue":"6","key":"694_CR179","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1039\/C0SM00549E","volume":"7","author":"DJ McClements","year":"2011","unstructured":"McClements DJ. Edible nanoemulsions: fabrication, properties, and functional performance. Soft Matter. 2011;7(6):2297\u2013316.","journal-title":"Soft Matter"},{"issue":"3","key":"694_CR180","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.nbd.2006.08.006","volume":"24","author":"RE Hartman","year":"2006","unstructured":"Hartman RE, Shah A, Fagan AM, Schwetye KE, Parsadanian M, Schulman RN, et al. Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer\u2019s disease. Neurobiol Dis. 2006;24(3):506\u201315.","journal-title":"Neurobiol Dis"},{"issue":"9","key":"694_CR181","first-page":"834","volume":"11","author":"AH Ahmed","year":"2014","unstructured":"Ahmed AH, et al. Pomegranate extract modulates processing of amyloid-beta precursor protein in an aged Alzheimer\u2019s disease animal model. Curr Alzheimer Res. 2014;11(9):834\u201343.","journal-title":"Curr Alzheimer Res"},{"issue":"3","key":"694_CR182","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120964","volume":"10","author":"MM Essa","year":"2015","unstructured":"Essa MM, Subash S, Akbar M, al-Adawi S, Guillemin GJ. Long-term dietary supplementation of pomegranates, figs and dates alleviate neuroinflammation in a transgenic mouse model of Alzheimer\u2019s disease. PLoS One. 2015;10(3):e0120964.","journal-title":"PLoS One"},{"issue":"2","key":"694_CR183","first-page":"35","volume":"2","author":"J Zhou","year":"2013","unstructured":"Zhou J, Liu B. Alzheimer\u2019s disease and prion protein. Intractable Rare Dis Res. 2013;2(2):35\u201344.","journal-title":"Intractable Rare Dis Res"},{"issue":"6","key":"694_CR184","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1039\/C2SM06903B","volume":"8","author":"DJ McClements","year":"2012","unstructured":"McClements DJ. Nanoemulsions versus microemulsions: terminology, differences, and similarities. Soft Matter. 2012;8(6):1719\u201329.","journal-title":"Soft Matter"},{"issue":"3","key":"694_CR185","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.nurpra.2017.10.014","volume":"14","author":"MG Ulep","year":"2018","unstructured":"Ulep MG, Saraon SK, McLea S. Alzheimer disease. J Nurse Pract. 2018;14(3):129\u201335.","journal-title":"J Nurse Pract"},{"issue":"1","key":"694_CR186","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12951-018-0392-8","volume":"16","author":"JK Patra","year":"2018","unstructured":"Patra JK, Das G, Fraceto LF, Campos EVR, Rodriguez-Torres MDP, Acosta-Torres LS, et al. Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnol. 2018;16(1):71.","journal-title":"J Nanobiotechnol"},{"key":"694_CR187","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.jconrel.2016.05.044","volume":"235","author":"C Saraiva","year":"2016","unstructured":"Saraiva C, et al. Nanoparticle-mediated brain drug delivery: overcoming blood\u2013brain barrier to treat neurodegenerative diseases. J Control Release. 2016;235:34\u201347.","journal-title":"J Control Release"},{"issue":"1","key":"694_CR188","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jsps.2017.10.012","volume":"26","author":"SAA Rizvi","year":"2018","unstructured":"Rizvi SAA, Saleh AM. Applications of nanoparticle systems in drug delivery technology. Saudi Pharm J. 2018;26(1):64\u201370.","journal-title":"Saudi Pharm J"},{"issue":"2","key":"694_CR189","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1039\/C5BM00383K","volume":"4","author":"T-T Zhang","year":"2016","unstructured":"Zhang T-T, Li W, Meng G, Wang P, Liao W. Strategies for transporting nanoparticles across the blood\u2013brain barrier. Biomater Sci. 2016;4(2):219\u201329.","journal-title":"Biomater Sci"},{"key":"694_CR190","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1155\/2013\/238428","volume":"2013","author":"M Masserini","year":"2013","unstructured":"Masserini M. Nanoparticles for Brain Drug Delivery. ISRN Biochem. 2013;2013:18.","journal-title":"ISRN Biochem"},{"key":"694_CR191","doi-asserted-by":"publisher","first-page":"101665","DOI":"10.1016\/j.pneurobio.2019.101665","volume":"181","author":"KB Johnsen","year":"2019","unstructured":"Johnsen KB, et al. Targeting the transferrin receptor for brain drug delivery. Prog Neurobiol. 2019;181:101665.","journal-title":"Prog Neurobiol"},{"key":"694_CR192","doi-asserted-by":"crossref","unstructured":"Ramalho MJ, et al. Factorial design as a tool for the optimization of PLGA nanoparticles for the co-delivery of temozolomide and O6-benzylguanine. 2019;11(8):401.","DOI":"10.3390\/pharmaceutics11080401"}],"container-title":["Drug Delivery and Translational Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-019-00694-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13346-019-00694-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-019-00694-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T01:17:10Z","timestamp":1606267030000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13346-019-00694-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,26]]},"references-count":192,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["694"],"URL":"https:\/\/doi.org\/10.1007\/s13346-019-00694-3","relation":{},"ISSN":["2190-393X","2190-3948"],"issn-type":[{"value":"2190-393X","type":"print"},{"value":"2190-3948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,26]]},"assertion":[{"value":"26 November 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}