{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T17:41:23Z","timestamp":1776102083393,"version":"3.50.1"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006752","name":"Universidade do Porto","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006752","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drug Deliv. and Transl. Res."],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>New wound dressings based on polymeric membranes have been widely exploited for clinical applications to assist in the healing process and prevent additional complications (e.g., bacterial infections). Here we propose the development of a new production method of polymeric membranes based on chitosan, incorporating glycolic extract of <jats:italic>Aloe vera<\/jats:italic> with joint synthesis of silver nanoparticles for use as a new bioactive dressing. The membranes were obtained by casting technique, and their morphological, physicochemical characteristics, degree of swelling, degradation profile and antimicrobial activity evaluated. Morphological analyzes confirmed the synthesis and presence of silver nanoparticles in the polymeric membrane. The chemical compatibility between the materials was demonstrated through thermal analysis (TGA and DSC) combined with ATR-FTIR tests, showing the complexation of the membranes (Mb-Ch-Ex.Av-NPs). All membranes were characterized as hydrophilic material (with a contact angle (\u04e9)\u2009&lt;\u200990\u00b0); however, the highest degree of swelling was obtained for the chitosan. (Mb-Ch) membrane (69.91\u2009\u00b1\u20095.75%) and the lowest for Mb-Ch-Ex.Av-NPs (26.62\u2009\u00b1\u20098.93%). On the other hand, the degradation profile was higher for Mb-Ch-Ex.Av-NPs (77.85\u2009\u00b1\u20097.51%) and lower for Mb-Ch (57.60\u2009\u00b1\u20092.29%). The manufactured bioactive dressings showed activity against <jats:italic>Escherichia coli<\/jats:italic> and <jats:italic>Staphylococcus aureus<\/jats:italic>. Our work confirmed the development of translucent and flexible chitosan-based membranes, incorporating <jats:italic>Aloe vera<\/jats:italic> glycolic extract with joint synthesis of silver nanoparticles for use as a new bioactive dressing, with proven antimicrobial activity.<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical Abstract<\/jats:bold>\n          <\/jats:p>","DOI":"10.1007\/s13346-024-01683-x","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T20:01:38Z","timestamp":1722369698000},"page":"1376-1392","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Chitosan membranes incorporating Aloe vera glycolic extract with joint synthesis of silver nanoparticles for the treatment of skin lesions"],"prefix":"10.1007","volume":"15","author":[{"given":"Ven\u00e2ncio A.","family":"Amaral","sequence":"first","affiliation":[]},{"given":"Victoria L.","family":"Santana","sequence":"additional","affiliation":[]},{"given":"Erika S.","family":"Lisboa","sequence":"additional","affiliation":[]},{"given":"Fredrico S.","family":"Martins","sequence":"additional","affiliation":[]},{"given":"Marco V.","family":"Chaud","sequence":"additional","affiliation":[]},{"given":"Ricardo L. C.","family":"de Albuquerque-J\u00fanior","sequence":"additional","affiliation":[]},{"given":"Wanessa","family":"Santana","sequence":"additional","affiliation":[]},{"given":"Cochiran","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Adriana","family":"de Jesus Santos","sequence":"additional","affiliation":[]},{"given":"Juliana C.","family":"Cardoso","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-6017","authenticated-orcid":false,"given":"Eliana B.","family":"Souto","sequence":"additional","affiliation":[]},{"given":"Patr\u00edcia","family":"Severino","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"issue":"5","key":"1683_CR1","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1089\/ten.TEB.2020.0236","volume":"27","author":"J Liang","year":"2021","unstructured":"Liang J, Cui L, Li J, Guan S, Zhang K, Li J. Aloe vera: a Medicinal Plant used in skin Wound Healing. Tissue Eng Part B Reviews. 2021;27(5):455\u201374. https:\/\/doi.org\/10.1089\/ten.TEB.2020.0236.","journal-title":"Tissue Eng Part B Reviews"},{"key":"1683_CR2","doi-asserted-by":"publisher","unstructured":"de Almeida BM, Dos Santos IDD, de Carvalho FMA, Correa LC, Cunha JLS, Dariva C, et al. Himatanthus Bracteatus-composed in situ polymerizable hydrogel for Wound Healing. Int J Mol Sci. 2022;23(23). https:\/\/doi.org\/10.3390\/ijms232315176.","DOI":"10.3390\/ijms232315176"},{"issue":"20","key":"1683_CR3","doi-asserted-by":"publisher","first-page":"3861","DOI":"10.1007\/s00018-016-2268-0","volume":"73","author":"NX Land\u00e9n","year":"2016","unstructured":"Land\u00e9n NX, Li D, St\u00e5hle M. Transition from inflammation to proliferation: a critical step during wound healing. Cell Mol Life Sci. 2016;73(20):3861\u201385. https:\/\/doi.org\/10.1007\/s00018-016-2268-0.","journal-title":"Cell Mol Life Sci"},{"issue":"7","key":"1683_CR4","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.it.2019.05.001","volume":"40","author":"M Phillipson","year":"2019","unstructured":"Phillipson M, Kubes P. The Healing Power of neutrophils. Trends Immunol. 2019;40(7):635\u201347. https:\/\/doi.org\/10.1016\/j.it.2019.05.001.","journal-title":"Trends Immunol"},{"key":"1683_CR5","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.addr.2018.09.010","volume":"146","author":"AP Veith","year":"2019","unstructured":"Veith AP, Henderson K, Spencer A, Sligar AD, Baker AB. Therapeutic strategies for enhancing angiogenesis in wound healing. Adv Drug Deliv Rev. 2019;146:97\u2013125. https:\/\/doi.org\/10.1016\/j.addr.2018.09.010.","journal-title":"Adv Drug Deliv Rev"},{"key":"1683_CR6","doi-asserted-by":"publisher","first-page":"112061","DOI":"10.1016\/j.msec.2021.112061","volume":"124","author":"R Barbosa","year":"2021","unstructured":"Barbosa R, Villarreal A, Rodriguez C, De Leon H, Gilkerson R, Lozano K. Aloe Vera extract-based composite nanofibers for wound dressing applications. Mater Sci Eng C. 2021;124:112061. https:\/\/doi.org\/10.1016\/j.msec.2021.112061.","journal-title":"Mater Sci Eng C"},{"issue":"3","key":"1683_CR7","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1177\/0022034509359125","volume":"89","author":"S Guo","year":"2010","unstructured":"Guo S, Dipietro LA. Factors affecting wound healing. J Dent Res. 2010;89(3):219\u201329. https:\/\/doi.org\/10.1177\/0022034509359125.","journal-title":"J Dent Res"},{"key":"1683_CR8","doi-asserted-by":"publisher","unstructured":"Dreno B, Amici JM, Demessant-Flavigny AL, Wright C, Taieb C, Desai SR et al. The impact of Acne, atopic dermatitis, skin toxicities and scars on quality of life and the importance of a Holistic Treatment Approach. Clinical, cosmetic and investigational dermatology. 2021;14:623\u201332. https:\/\/doi.org\/10.2147\/ccid.S315846","DOI":"10.2147\/ccid.S315846"},{"issue":"1","key":"1683_CR9","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41572-022-00377-3","volume":"8","author":"V Falanga","year":"2022","unstructured":"Falanga V, Isseroff RR, Soulika AM, Romanelli M, Margolis D, Kapp S, et al. Chronic wounds. Nat Rev Dis Primers. 2022;8(1):50. https:\/\/doi.org\/10.1038\/s41572-022-00377-3.","journal-title":"Nat Rev Dis Primers"},{"key":"1683_CR10","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.memsci.2018.07.059","volume":"564","author":"F Galiano","year":"2018","unstructured":"Galiano F, Brice\u00f1o K, Marino T, Molino A, Christensen KV, Figoli A. Advances in biopolymer-based membrane preparation and applications. J Membr Sci. 2018;564:562\u201386. https:\/\/doi.org\/10.1016\/j.memsci.2018.07.059.","journal-title":"J Membr Sci"},{"key":"1683_CR11","doi-asserted-by":"publisher","first-page":"109047","DOI":"10.1016\/j.compositesb.2021.109047","volume":"222","author":"Y Wang","year":"2021","unstructured":"Wang Y, Zhang Y, Lin Z, Huang T, Li W, Gong W, et al. A green method of preparing a natural and degradable wound dressing containing aloe vera as an active ingredient. Compos B Eng. 2021;222:109047. https:\/\/doi.org\/10.1016\/j.compositesb.2021.109047.","journal-title":"Compos B Eng"},{"issue":"1","key":"1683_CR12","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0376-7388(02)00505-7","volume":"212","author":"F-L Mi","year":"2003","unstructured":"Mi F-L, Wu Y-B, Shyu S-S, Chao A-C, Lai J-Y, Su C-C. Asymmetric chitosan membranes prepared by dry\/wet phase separation: a new type of wound dressing for controlled antibacterial release. J Membr Sci. 2003;212(1):237\u201354. https:\/\/doi.org\/10.1016\/S0376-7388(02)00505-7.","journal-title":"J Membr Sci"},{"key":"1683_CR13","doi-asserted-by":"publisher","unstructured":"Yoshida CMP, Pacheco MS, de Moraes MA, Lopes PS, Severino P, Souto EB, et al. Effect of Chitosan and Aloe Vera Extract concentrations on the Physicochemical properties of Chitosan Biofilms. Polym (Basel). 2021;13(8). https:\/\/doi.org\/10.3390\/polym13081187.","DOI":"10.3390\/polym13081187"},{"issue":"34","key":"1683_CR14","doi-asserted-by":"publisher","first-page":"1902834","DOI":"10.1002\/adfm.201902834","volume":"29","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Ding J, Qi B, Tao W, Wang J, Zhao C, et al. Multifunctional fibers to shape future Biomedical devices. Adv Funct Mater. 2019;29(34):1902834. https:\/\/doi.org\/10.1002\/adfm.201902834.","journal-title":"Adv Funct Mater"},{"key":"1683_CR15","doi-asserted-by":"publisher","unstructured":"Genesi BP, de Melo Barbosa R, Severino P, Rodas ACD, Yoshida CMP, Mathor MB et al. Corrigendum to Aloe vera and copaiba oleoresin-loaded chitosan films for wound dressings: Microbial permeation, cytotoxicity, and in vivo proof of concept [Int. J. Pharm. 634 (2023) 122648]. Int J Pharm. 2024;652:123823. https:\/\/doi.org\/10.1016\/j.ijpharm.2024.123823","DOI":"10.1016\/j.ijpharm.2024.123823"},{"key":"1683_CR16","doi-asserted-by":"publisher","first-page":"122648","DOI":"10.1016\/j.ijpharm.2023.122648","volume":"634","author":"BP Genesi","year":"2023","unstructured":"Genesi BP, de Melo Barbosa R, Severino P, Rodas ACD, Yoshida CMP, Mathor MB, et al. Aloe vera and copaiba oleoresin-loaded chitosan films for wound dressings: microbial permeation, cytotoxicity, and in vivo proof of concept. Int J Pharm. 2023;634:122648. https:\/\/doi.org\/10.1016\/j.ijpharm.2023.122648.","journal-title":"Int J Pharm"},{"key":"1683_CR17","doi-asserted-by":"publisher","first-page":"118891","DOI":"10.1016\/j.carbpol.2021.118891","volume":"277","author":"L Jiang","year":"2022","unstructured":"Jiang L, Wang Y, Wei X, Yang L, Liu S, Wang Y, et al. Improvement in phenotype homeostasis of macrophages by chitosan nanoparticles and subsequent impacts on liver injury and tumor treatment. Carbohydr Polym. 2022;277:118891. https:\/\/doi.org\/10.1016\/j.carbpol.2021.118891.","journal-title":"Carbohydr Polym"},{"issue":"3","key":"1683_CR18","doi-asserted-by":"publisher","first-page":"81","DOI":"10.29252\/jabr.05.03.01","volume":"5","author":"H Nosrati","year":"2018","unstructured":"Nosrati H, Pourmotabed S, Sharifi E. A review on some natural biopolymers and their applications in angiogenesis and tissue Engineering %J Journal of Applied Biotechnology reports. App Biotechnol Rep. 2018;5(3):81\u201391. https:\/\/doi.org\/10.29252\/jabr.05.03.01.","journal-title":"App Biotechnol Rep"},{"issue":"22","key":"1683_CR19","doi-asserted-by":"publisher","first-page":"2959","DOI":"10.1016\/s0142-9612(01)00042-4","volume":"22","author":"GI Howling","year":"2001","unstructured":"Howling GI, Dettmar PW, Goddard PA, Hampson FC, Dornish M, Wood EJ. The effect of chitin and chitosan on the proliferation of human skin fibroblasts and keratinocytes in vitro. Biomaterials. 2001;22(22):2959\u201366. https:\/\/doi.org\/10.1016\/s0142-9612(01)00042-4.","journal-title":"Biomaterials"},{"issue":"2","key":"1683_CR20","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1016\/j.jece.2018.02.031","volume":"6","author":"A Behboudi","year":"2018","unstructured":"Behboudi A, Jafarzadeh Y, Yegani R. Enhancement of antifouling and antibacterial properties of PVC hollow fiber ultrafiltration membranes using pristine and modified silver nanoparticles. J Environ Chem Eng. 2018;6(2):1764\u201373. https:\/\/doi.org\/10.1016\/j.jece.2018.02.031.","journal-title":"J Environ Chem Eng"},{"key":"1683_CR21","doi-asserted-by":"publisher","first-page":"2555","DOI":"10.2147\/ijn.S246764","volume":"15","author":"IX Yin","year":"2020","unstructured":"Yin IX, Zhang J, Zhao IS, Mei ML, Li Q, Chu CH. The Antibacterial mechanism of silver nanoparticles and its application in Dentistry. Int J Nanomed. 2020;15:2555\u201362. https:\/\/doi.org\/10.2147\/ijn.S246764.","journal-title":"Int J Nanomed"},{"key":"1683_CR22","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.ijpharm.2018.11.054","volume":"555","author":"HS Debone","year":"2019","unstructured":"Debone HS, Lopes PS, Severino P, Yoshida CMP, Souto EB, da Silva CF. Chitosan\/Copaiba oleoresin films for would dressing application. Int J Pharm. 2019;555:146\u201352. https:\/\/doi.org\/10.1016\/j.ijpharm.2018.11.054.","journal-title":"Int J Pharm"},{"key":"1683_CR23","doi-asserted-by":"publisher","first-page":"106039","DOI":"10.1016\/j.polymertesting.2019.106039","volume":"79","author":"L Xing","year":"2019","unstructured":"Xing L, Ma Y, Tan H, Yuan G, Li S, Li J, et al. Alginate membrane dressing toughened by chitosan floccule to load antibacterial drugs for wound healing. Polym Test. 2019;79:106039. https:\/\/doi.org\/10.1016\/j.polymertesting.2019.106039.","journal-title":"Polym Test"},{"key":"1683_CR24","doi-asserted-by":"publisher","first-page":"104907","DOI":"10.1016\/j.jddst.2023.104907","volume":"88","author":"VA Amaral","year":"2023","unstructured":"Amaral VA, de Souza JF, Alves TFR, Batain F, Baldo DA, de Oliveira Junior JM, et al. Dense lamellar scaffold based on collagen, silk fibroin and polyethylene glycol 400 produced by a novel plastic compression technique. J Drug Deliv Sci Technol. 2023;88:104907. https:\/\/doi.org\/10.1016\/j.jddst.2023.104907.","journal-title":"J Drug Deliv Sci Technol"},{"issue":"7","key":"1683_CR25","doi-asserted-by":"publisher","first-page":"961","DOI":"10.3390\/pharmaceutics13070961","volume":"13","author":"S Alven","year":"2021","unstructured":"Alven S, Khwaza V, Oyedeji OO, Aderibigbe BA. Polymer-based scaffolds loaded with Aloe vera Extract for the treatment of wounds. Pharmaceutics. 2021;13(7):961. https:\/\/doi.org\/10.3390\/pharmaceutics13070961.","journal-title":"Pharmaceutics"},{"issue":"7","key":"1683_CR26","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1080\/00222348.2017.1330183","volume":"56","author":"M Hajian","year":"2017","unstructured":"Hajian M, Mahmoodi M, Imani R. In Vitro Assessment of Poly (Vinyl Alcohol) Film incorporating Aloe Vera for potential application as a Wound Dressing. J Macromol Sci B. 2017;56(7):435\u201350. https:\/\/doi.org\/10.1080\/00222348.2017.1330183.","journal-title":"J Macromol Sci B"},{"issue":"1","key":"1683_CR27","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.carbpol.2013.05.076","volume":"98","author":"RF Pereira","year":"2013","unstructured":"Pereira RF, Carvalho A, Gil MH, Mendes A, B\u00e1rtolo PJ. Influence of Aloe vera on water absorption and enzymatic in vitro degradation of alginate hydrogel films. Carbohydr Polym. 2013;98(1):311\u201320. https:\/\/doi.org\/10.1016\/j.carbpol.2013.05.076.","journal-title":"Carbohydr Polym"},{"issue":"5","key":"1683_CR28","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1080\/10837450.2021.1898634","volume":"26","author":"DM de Oliveira","year":"2021","unstructured":"de Oliveira DM, Menezes DB, Andrade LR, Lima FDC, Hollanda L, Zielinska A, et al. Silver nanoparticles obtained from Brazilian pepper extracts with synergistic anti-microbial effect: production, characterization, hydrogel formulation, cell viability, and in vitro efficacy. Pharm Dev Technol. 2021;26(5):539\u201348. https:\/\/doi.org\/10.1080\/10837450.2021.1898634.","journal-title":"Pharm Dev Technol"},{"issue":"3","key":"1683_CR29","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.1016\/j.carbpol.2011.10.020","volume":"87","author":"S Khoshgozaran-Abras","year":"2012","unstructured":"Khoshgozaran-Abras S, Azizi MH, Hamidy Z, Bagheripoor-Fallah N. Mechanical, physicochemical and color properties of Chitosan based-films as a function of Aloe vera gel incorporation. Carbohydr Polym. 2012;87(3):2058\u201362. https:\/\/doi.org\/10.1016\/j.carbpol.2011.10.020.","journal-title":"Carbohydr Polym"},{"issue":"5","key":"1683_CR30","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.foodhyd.2010.08.008","volume":"25","author":"LE Abugoch","year":"2011","unstructured":"Abugoch LE, Tapia C, Villam\u00e1n MC, Yazdani-Pedram M, D\u00edaz-Dosque M. Characterization of quinoa protein\u2013chitosan blend edible films. Food Hydrocol. 2011;25(5):879\u201386. https:\/\/doi.org\/10.1016\/j.foodhyd.2010.08.008.","journal-title":"Food Hydrocol"},{"issue":"3","key":"1683_CR31","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1021\/jf062013n","volume":"55","author":"I Sebti","year":"2007","unstructured":"Sebti I, Chollet E, Degraeve P, Noel C, Peyrol E. Water Sensitivity, Antimicrobial, and Physicochemical Analyses of Edible Films Based on HPMC and\/or Chitosan. J Agric Food Chem. 2007;55(3):693\u20139. https:\/\/doi.org\/10.1021\/jf062013n.","journal-title":"J Agric Food Chem"},{"issue":"4","key":"1683_CR32","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s42452-020-2261-y","volume":"2","author":"PK Dara","year":"2020","unstructured":"Dara PK, Mahadevan R, Digita PA, Visnuvinayagam S, Kumar LRG, Mathew S, et al. Synthesis and biochemical characterization of silver nanoparticles grafted Chitosan (Chi-Ag-NPs): in vitro studies on antioxidant and antibacterial applications. SN Appl Sci. 2020;2(4):665. https:\/\/doi.org\/10.1007\/s42452-020-2261-y.","journal-title":"SN Appl Sci"},{"issue":"3","key":"1683_CR33","doi-asserted-by":"publisher","first-page":"672","DOI":"10.9767\/bcrec.14.3.4250.672-677","volume":"14","author":"M Marwan","year":"2019","unstructured":"Marwan M, Indarti E, Darmadi D, Rinaldi W, Hamzah D, Rinaldi T. Production of triacetin by microwave assisted esterification of glycerol using activated natural zeolite. Bull Chem React Eng Catal. 2019;14(3):672\u20137. https:\/\/doi.org\/10.9767\/bcrec.14.3.4250.672-677.","journal-title":"Bull Chem React Eng Catal"},{"issue":"1","key":"1683_CR34","doi-asserted-by":"publisher","first-page":"012015","DOI":"10.1088\/1757-899X\/523\/1\/012015","volume":"523","author":"H Saiful, Helwati","year":"2019","unstructured":"Saiful, Helwati H, Saleha S, Iqbalsyah TM. Development of bioplastic from wheat Janeng starch for food packaging. IOP Conf Ser Mater Sci Eng. 2019;523(1):012015. https:\/\/doi.org\/10.1088\/1757-899X\/523\/1\/012015.","journal-title":"IOP Conf Ser Mater Sci Eng"},{"key":"1683_CR35","unstructured":"Danish M, Mumtaz MW, Fakhar M, Rashid U. Response surface methodology based optimized purification of the residual glycerol from biodiesel production process. Chiang Mai J Sci. 2017;44(4):1570\u201382. https:\/\/epg.science.cmu.ac.th\/ejournal\/"},{"issue":"24","key":"1683_CR36","doi-asserted-by":"publisher","first-page":"50563","DOI":"10.1002\/app.50563","volume":"138","author":"F Hosseini Chenani","year":"2021","unstructured":"Hosseini Chenani F, Rezaei VF, Fakhri V, Wurm FR, Uzun L, Goodarzi V. Green synthesis and characterization of poly(glycerol-azelaic acid) and its nanocomposites for applications in regenerative medicine. J Appl Polym Sci. 2021;138(24):50563. https:\/\/doi.org\/10.1002\/app.50563.","journal-title":"J Appl Polym Sci"},{"key":"1683_CR37","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.sajb.2021.02.027","volume":"139","author":"S Akbari","year":"2021","unstructured":"Akbari S, Abdurahman NH, Yunus RM, Alsaggaf AHA, Ahmed N. LC-QTOF-MS analysis of phenolics and saponins extracted from Aloe vera leaves via microwave technology in optimal condition. S Afr J Bot. 2021;139:362\u201373. https:\/\/doi.org\/10.1016\/j.sajb.2021.02.027.","journal-title":"S Afr J Bot"},{"issue":"1","key":"1683_CR38","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jaim.2017.11.003","volume":"11","author":"AK Keshari","year":"2020","unstructured":"Keshari AK, Srivastava R, Singh P, Yadav VB, Nath G. Antioxidant and antibacterial activity of silver nanoparticles synthesized by Cestrum nocturnum. J Ayurveda Integr Med. 2020;11(1):37\u201344. https:\/\/doi.org\/10.1016\/j.jaim.2017.11.003.","journal-title":"J Ayurveda Integr Med"},{"key":"1683_CR39","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.dyepig.2017.01.031","volume":"140","author":"K Samal","year":"2017","unstructured":"Samal K, Das C, Mohanty K. Eco-friendly biosurfactant saponin for the solubilization of cationic and anionic dyes in aqueous system. Dyes Pigm. 2017;140:100\u20138. https:\/\/doi.org\/10.1016\/j.dyepig.2017.01.031.","journal-title":"Dyes Pigm"},{"key":"1683_CR40","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.ijbiomac.2019.05.158","volume":"135","author":"X Ma","year":"2019","unstructured":"Ma X, Qiao C, Wang X, Yao J, Xu J. Structural characterization and properties of polyols plasticized chitosan films. Int J Biol Macromol. 2019;135:240\u20135. https:\/\/doi.org\/10.1016\/j.ijbiomac.2019.05.158.","journal-title":"Int J Biol Macromol"},{"key":"1683_CR41","doi-asserted-by":"publisher","first-page":"127425","DOI":"10.1016\/j.ijbiomac.2023.127425","volume":"253","author":"KML Pacheco","year":"2023","unstructured":"Pacheco KML, Torres BBM, Sanfelice RC, da Costa MM, Assis L, Marques RB, et al. Chitosan and chitosan\/turmeric-based membranes for wound healing: production, characterization and application. Int J Biol Macromol. 2023;253:127425. https:\/\/doi.org\/10.1016\/j.ijbiomac.2023.127425.","journal-title":"Int J Biol Macromol"},{"key":"1683_CR42","doi-asserted-by":"publisher","first-page":"100338","DOI":"10.1016\/j.carpta.2023.100338","volume":"6","author":"A Karydis-Messinis","year":"2023","unstructured":"Karydis-Messinis A, Moschovas D, Markou M, Gkantzou E, Vasileiadis A, Tsirka K, et al. Development, physicochemical characterization and in vitro evaluation of chitosan-fish gelatin-glycerol hydrogel membranes for wound treatment applications. Carbohydr Polym Technol Appl. 2023;6:100338. https:\/\/doi.org\/10.1016\/j.carpta.2023.100338.","journal-title":"Carbohydr Polym Technol Appl"},{"key":"1683_CR43","doi-asserted-by":"publisher","first-page":"2804165","DOI":"10.1155\/2024\/2804165","volume":"2024","author":"YMS Jamil","year":"2024","unstructured":"Jamil YMS, Al-Hakimi AN, Al-Maydama HMA, Almahwiti GY, Qasem A, Saleh SM. Optimum green synthesis, characterization, and antibacterial activity of silver nanoparticles prepared from an extract of Aloe fleurentinorum. Int J Chem Eng. 2024;2024:2804165. https:\/\/doi.org\/10.1155\/2024\/2804165.","journal-title":"Int J Chem Eng"},{"key":"1683_CR44","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-024-04105-8","author":"T Nauroze","year":"2024","unstructured":"Nauroze T, Ali S, Andleeb S, Ara C, Liaqat I, Mushtaq H, et al. Therapeutic potential of Aloe vera and Aloe vera\u2013conjugated silver nanoparticles on mice exposed to Hexavalent Chromium. Biol Trace Elem Res. 2024. https:\/\/doi.org\/10.1007\/s12011-024-04105-8.","journal-title":"Biol Trace Elem Res"},{"issue":"13","key":"1683_CR45","doi-asserted-by":"publisher","first-page":"10645","DOI":"10.1007\/s10854-022-08048-5","volume":"33","author":"N Algethami","year":"2022","unstructured":"Algethami N, Rajeh A, Ragab HM, Tarabiah AE, Gami F. Characterization, optical, and electrical properties of chitosan\/polyacrylamide blend doped silver nanoparticles. J Mater Sci: Mater Electron. 2022;33(13):10645\u201356. https:\/\/doi.org\/10.1007\/s10854-022-08048-5.","journal-title":"J Mater Sci: Mater Electron"},{"issue":"1","key":"1683_CR46","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/cjce.23673","volume":"98","author":"N Saadatkhah","year":"2020","unstructured":"Saadatkhah N, Carillo Garcia A, Ackermann S, Leclerc P, Latifi M, Samih S, et al. Experimental methods in chemical engineering: thermogravimetric analysis\u2014TGA. Can J Chem Eng. 2020;98(1):34\u201343. https:\/\/doi.org\/10.1002\/cjce.23673.","journal-title":"Can J Chem Eng"},{"issue":"8","key":"1683_CR47","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1016\/j.polymdegradstab.2012.05.039","volume":"97","author":"M Kurek","year":"2012","unstructured":"Kurek M, Brachais C-H, Nguimjeu CM, Bonnotte A, Voilley A, Gali\u0107 K, et al. Structure and thermal properties of a chitosan coated polyethylene bilayer film. Polym Degrad Stab. 2012;97(8):1232\u201340. https:\/\/doi.org\/10.1016\/j.polymdegradstab.2012.05.039.","journal-title":"Polym Degrad Stab"},{"issue":"2","key":"1683_CR48","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.tca.2006.03.003","volume":"444","author":"LS Guinesi","year":"2006","unstructured":"Guinesi LS, Cavalheiro \u00c9TG. The use of DSC curves to determine the acetylation degree of chitin\/chitosan samples. Thermochim Acta. 2006;444(2):128\u201333. https:\/\/doi.org\/10.1016\/j.tca.2006.03.003.","journal-title":"Thermochim Acta"},{"issue":"8","key":"1683_CR49","doi-asserted-by":"publisher","first-page":"3941","DOI":"10.1039\/C7RA12070B","volume":"8","author":"M Kaya","year":"2018","unstructured":"Kaya M, Khadem S, Cakmak YS, Mujtaba M, Ilk S, Akyuz L, et al. Antioxidative and antimicrobial edible chitosan films blended with stem, leaf and seed extracts of Pistacia terebinthus for active food packaging. RSC Adv. 2018;8(8):3941\u201350. https:\/\/doi.org\/10.1039\/C7RA12070B.","journal-title":"RSC Adv"},{"issue":"6","key":"1683_CR50","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.3390\/polym12061323","volume":"12","author":"I Solaberrieta","year":"2020","unstructured":"Solaberrieta I, Jim\u00e9nez A, Cacciotti I, Garrig\u00f3s MC. Encapsulation of Bioactive compounds from Aloe Vera agrowastes in Electrospun Poly (Ethylene Oxide) nanofibers. Polym (Basel). 2020;12(6):1323. https:\/\/doi.org\/10.3390\/polym12061323.","journal-title":"Polym (Basel)"},{"key":"1683_CR51","doi-asserted-by":"publisher","unstructured":"Leyva-Porras C, Cruz-Alcantar P, Espinosa-Sol\u00eds V, Mart\u00ednez-Guerra E, Balderrama CIP, Mart\u00ednez IC, et al. Application of Differential scanning calorimetry (DSC) and modulated Differential scanning calorimetry (MDSC) in Food and Drug industries. Polym (Basel). 2019;12(1). https:\/\/doi.org\/10.3390\/polym12010005.","DOI":"10.3390\/polym12010005"},{"issue":"1","key":"1683_CR52","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s40779-024-00519-6","volume":"11","author":"Y-Y Li","year":"2024","unstructured":"Li Y-Y, Ji S-F, Fu X-B, Jiang Y-F, Sun X-Y. Biomaterial-based mechanical regulation facilitates scarless wound healing with functional skin appendage regeneration. Mil Med Res. 2024;11(1):13. https:\/\/doi.org\/10.1186\/s40779-024-00519-6.","journal-title":"Mil Med Res"},{"key":"1683_CR53","doi-asserted-by":"publisher","first-page":"109984","DOI":"10.1016\/j.lwt.2020.109984","volume":"135","author":"C Qiao","year":"2021","unstructured":"Qiao C, Ma X, Wang X, Liu L. Structure and properties of chitosan films: Effect of the type of solvent acid. LWT - Food Sci Technol. 2021;135:109984. https:\/\/doi.org\/10.1016\/j.lwt.2020.109984.","journal-title":"LWT - Food Sci Technol"},{"key":"1683_CR54","doi-asserted-by":"publisher","first-page":"107772","DOI":"10.1016\/j.porgcoat.2023.107772","volume":"183","author":"TA Dinh","year":"2023","unstructured":"Dinh TA, Le YN, Pham NQ, Ton-That P, Van-Xuan T, Ho TG-T, et al. Fabrication of antimicrobial edible films from Chitosan incorporated with guava leaf extract. Prog Org Coat. 2023;183:107772. https:\/\/doi.org\/10.1016\/j.porgcoat.2023.107772.","journal-title":"Prog Org Coat"},{"issue":"2","key":"1683_CR55","doi-asserted-by":"publisher","first-page":"100213","DOI":"10.1016\/j.afres.2022.100213","volume":"2","author":"MM Frota","year":"2022","unstructured":"Frota MM, Mattos ALA, Miranda KWE, Cheng HN, Biswas A, Bastos MSR. Superhydrophobic systems in food science and technology: concepts, trends, challenges, and technological innovations. Appl Food Res. 2022;2(2):100213. https:\/\/doi.org\/10.1016\/j.afres.2022.100213.","journal-title":"Appl Food Res"},{"key":"1683_CR56","doi-asserted-by":"publisher","unstructured":"Ma Y, Xin L, Tan H, Fan M, Li J, Jia Y et al. Chitosan membrane dressings toughened by glycerol to load antibacterial drugs for wound healing. Materials science & engineering C, Materials for biological applications. 2017;81:522\u2013\u200931. https:\/\/doi.org\/10.1016\/j.msec.2017.08.052","DOI":"10.1016\/j.msec.2017.08.052"},{"key":"1683_CR57","doi-asserted-by":"publisher","unstructured":"Jiang Z, Wang J, Xiang D, Zhang Z. Functional properties and Preservative Effect of P-Hydroxybenzoic Acid Grafted Chitosan films on Fresh-Cut Jackfruit. Foods (Basel Switzerland). 2022;11(9). https:\/\/doi.org\/10.3390\/foods11091360.","DOI":"10.3390\/foods11091360"},{"issue":"6","key":"1683_CR58","doi-asserted-by":"publisher","first-page":"450","DOI":"10.3390\/membranes11060450","volume":"11","author":"S Ahmed","year":"2021","unstructured":"Ahmed S, Arshad T, Zada A, Afzal A, Khan M, Hussain A, et al. Preparation and characterization of a Novel Sulfonated Titanium Oxide Incorporated Chitosan Nanocomposite membranes for fuel cell application. Membranes. 2021;11(6):450. https:\/\/doi.org\/10.3390\/membranes11060450.","journal-title":"Membranes"},{"issue":"2","key":"1683_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/15593258231169387","volume":"21","author":"DN Iqbal","year":"2023","unstructured":"Iqbal DN, Munir A, Abbas M, Nazir A, Ali Z, Alshawwa SZ, et al. Polymeric membranes of Chitosan\/Aloe Vera Gel Fabrication with enhanced swelling and Antimicrobial properties for Biomedical Applications. Dose-Response. 2023;21(2):1\u201312. https:\/\/doi.org\/10.1177\/15593258231169387.","journal-title":"Dose-Response"},{"key":"1683_CR60","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.ijbiomac.2019.04.067","volume":"133","author":"L Wang","year":"2019","unstructured":"Wang L, Guo H, Wang J, Jiang G, Du F, Liu X. Effects of Herba Lophatheri extract on the physicochemical properties and biological activities of the chitosan film. Int J Biol Macromol. 2019;133:51\u20137. https:\/\/doi.org\/10.1016\/j.ijbiomac.2019.04.067.","journal-title":"Int J Biol Macromol"},{"issue":"9","key":"1683_CR61","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.3390\/polym12091937","volume":"12","author":"AK Thompson","year":"2020","unstructured":"Thompson AK, Hackett C, Grady TL, Enyinnia S, Moore QC, Nave FM. Development and characterization of membranes with PVA containing silver particles: a study of the Addition and Stability. Polym (Basel). 2020;12(9):1937. https:\/\/doi.org\/10.3390\/polym12091937.","journal-title":"Polym (Basel)"},{"key":"1683_CR62","doi-asserted-by":"publisher","first-page":"103084","DOI":"10.1016\/j.bcab.2024.103084","volume":"57","author":"S Kumar","year":"2024","unstructured":"Kumar S, Kalita S, Basumatary IB, Kumar S, Ray S, Mukherjee A. Recent advances in therapeutic and biological activities of Aloe vera. Biocatal Agric Biotechnol. 2024;57:103084. https:\/\/doi.org\/10.1016\/j.bcab.2024.103084.","journal-title":"Biocatal Agric Biotechnol"},{"key":"1683_CR63","doi-asserted-by":"publisher","first-page":"132631","DOI":"10.1016\/j.molstruc.2022.132631","volume":"1257","author":"F Gami","year":"2022","unstructured":"Gami F, Algethami N, Ragab HM, rajah A, Tarabiah AE. Structural, optical and electrical studies of chitosan\/polyacrylamide blend filled with synthesized selenium nanoparticles. J Mol Struct. 2022;1257:132631. https:\/\/doi.org\/10.1016\/j.molstruc.2022.132631.","journal-title":"J Mol Struct"},{"key":"1683_CR64","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.indcrop.2016.08.034","volume":"94","author":"A Baruah","year":"2016","unstructured":"Baruah A, Bordoloi M, Deka Baruah HP. Aloe vera: a multipurpose industrial crop. Ind Crops Prod. 2016;94:951\u201363. https:\/\/doi.org\/10.1016\/j.indcrop.2016.08.034.","journal-title":"Ind Crops Prod"},{"key":"1683_CR65","doi-asserted-by":"publisher","unstructured":"Salehi B, Albayrak S, Antolak H, Kr\u0119giel D, Pawlikowska E, Sharifi-Rad M, et al. Aloe Genus plants: from farm to Food Applications and Phytopharmacotherapy. Int J Mol Sci. 2018;19(9). https:\/\/doi.org\/10.3390\/ijms19092843.","DOI":"10.3390\/ijms19092843"},{"key":"1683_CR66","doi-asserted-by":"publisher","first-page":"100148","DOI":"10.1016\/j.onano.2023.100148","volume":"12","author":"G Franceschinis","year":"2023","unstructured":"Franceschinis G, Beverina M, Corleto M, Sosa AM, Lillo C, Arias Casar\u00e1 L, et al. Green-synthesized silver nanoparticles using Aloe maculata extract as antibacterial agent for potential topical application. OpenNano. 2023;12:100148. https:\/\/doi.org\/10.1016\/j.onano.2023.100148.","journal-title":"OpenNano"},{"key":"1683_CR67","doi-asserted-by":"publisher","first-page":"100426","DOI":"10.1016\/j.apsadv.2023.100426","volume":"16","author":"MM Ghatage","year":"2023","unstructured":"Ghatage MM, Mane PA, Gambhir RP, Parkhe VS, Kamble PA, Lokhande CD, et al. Green synthesis of silver nanoparticles via Aloe barbadensis Miller leaves: Anticancer, antioxidative, antimicrobial and photocatalytic properties. Appl Surf Sci Adv. 2023;16:100426. https:\/\/doi.org\/10.1016\/j.apsadv.2023.100426.","journal-title":"Appl Surf Sci Adv"},{"key":"1683_CR68","doi-asserted-by":"publisher","unstructured":"Taqveem H, Rahman KU, Khan S, Khan A, Al-Ansi W, Fahad S, et al. Antibacterial activity of silver nanoparticles synthesized from Aloe Vera Extract. Int J Environ Agric Biotech. 2024;9(2). https:\/\/doi.org\/10.22161\/ijeab.","DOI":"10.22161\/ijeab"}],"container-title":["Drug Delivery and Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-024-01683-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13346-024-01683-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13346-024-01683-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T18:13:02Z","timestamp":1740766382000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13346-024-01683-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,30]]},"references-count":68,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["1683"],"URL":"https:\/\/doi.org\/10.1007\/s13346-024-01683-x","relation":{},"ISSN":["2190-393X","2190-3948"],"issn-type":[{"value":"2190-393X","type":"print"},{"value":"2190-3948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,30]]},"assertion":[{"value":"22 July 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors agreed with the final version of this manuscript and with the current submission.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}