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Traditionally, cleaning validation protocols have focused on production lines. However, there is a growing trend toward extending these protocols to Quality Control (QC) laboratories, encompassing both glassware and stainless-steel equipment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This paper presents a systematic approach for developing cleaning validation protocols specifically designed for QC laboratory equipment, aimed at improving cleaning effectiveness and ensuring regulatory compliance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The proposed methodology includes: (i) identifying the worst-case API; (ii) performing recovery studies to optimize sampling methods and solvent selection; and (iii) employing statistical tools such as descriptive analysis and hypothesis testing to refine the protocol in line with current industry standards.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A case study involving Oxcarbazepine demonstrates the application of the proposed protocol, evaluating surface contamination across various QC instruments and assessing detergent residues to validate cleaning effectiveness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The proposed strategy provides a structured, statistically grounded framework for developing cleaning validation protocols in QC laboratories, promoting effective contamination control and adherence to regulatory standards.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s40199-025-00566-x","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T05:20:47Z","timestamp":1751520047000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cleaning validation in pharmaceutical quality control laboratories: a structured protocol for contamination risk mitigation"],"prefix":"10.1007","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5883-5516","authenticated-orcid":false,"given":"Maria J.","family":"Moura","sequence":"first","affiliation":[]},{"given":"Andr\u00e9 D.","family":"Pereira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2609-2113","authenticated-orcid":false,"given":"Daniel J. 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