{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:10:01Z","timestamp":1764252601759,"version":"3.46.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs Aging"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s40266-025-01259-5","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T18:42:01Z","timestamp":1762022521000},"page":"1169-1183","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of a Collaborative Deprescribing Intervention of Proton Pump Inhibitors on Community-Dwelling Older Adults: The C-SENIoR Pragmatic Non-randomised Controlled Trial"],"prefix":"10.1007","volume":"42","clinical-trial-number":[{"clinical-trial-number":"isrctn49637686","registry":"10.18810\/isrctn"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2055-0996","authenticated-orcid":false,"given":"S\u00f3nia","family":"Romano","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8161-9264","authenticated-orcid":false,"given":"Ant\u00f3nio Teixeira","family":"Rodrigues","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0690-4484","authenticated-orcid":false,"given":"Jos\u00e9 Pedro","family":"Guerreiro","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3646-8460","authenticated-orcid":false,"given":"Jo\u00e3o Braga","family":"Sim\u00f5es","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2786-0375","authenticated-orcid":false,"given":"Isabel","family":"Guerreiro","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0784-5770","authenticated-orcid":false,"given":"Luis","family":"Monteiro","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1870-1430","authenticated-orcid":false,"given":"Nuno","family":"Lunet","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6634-9000","authenticated-orcid":false,"given":"Julian","family":"Perelman","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,11,1]]},"reference":[{"key":"1259_CR1","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1007\/S00228-023-03534-Z","volume":"79","author":"LGT Shanika","year":"2023","unstructured":"Shanika LGT, Reynolds A, Pattison S, Braund R. Proton pump inhibitor use: systematic review of global trends and practices. Eur J Clin Pharmacol. 2023;79:1159\u201372. https:\/\/doi.org\/10.1007\/S00228-023-03534-Z.","journal-title":"Eur J Clin Pharmacol"},{"key":"1259_CR2","unstructured":"Portugal. Minist\u00e9rio da Sa\u00fade. Dire\u00e7\u00e3o-Geral da Sa\u00fade. Norma no 036\/2011: supress\u00e3o \u00e1cida: utiliza\u00e7\u00e3o dos inibidores da bomba de prot\u00f5es e das suas alternativas terap\u00eauticas. Lisboa: DGS; 2011."},{"key":"1259_CR3","first-page":"354","volume":"63","author":"B Farrell","year":"2017","unstructured":"Farrell B, Pottie K, Thompson W, Boghossian T, Pizzola L, Rashid FJ, et al. Deprescribing proton pump inhibitors: evidence-based clinical practice guideline. Can Fam Physician. 2017;63:354.","journal-title":"Can Fam Physician"},{"key":"1259_CR4","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.repce.2017.10.014","volume":"37","author":"N Cunha","year":"2018","unstructured":"Cunha N, Machado AP. Proton pump inhibitors and the risk of severe adverse events: a cardiovascular bombshell? Rev Port Cardiol. 2018;37:859\u201363. https:\/\/doi.org\/10.1016\/j.repce.2017.10.014.","journal-title":"Rev Port Cardiol"},{"key":"1259_CR5","doi-asserted-by":"publisher","first-page":"182","DOI":"10.5056\/JNM18001","volume":"24","author":"Y Kinoshita","year":"2018","unstructured":"Kinoshita Y, Ishimura N, Ishihara S. Advantages and disadvantages of long-term proton pump inhibitor use. J Neurogastroenterol Motil. 2018;24:182. https:\/\/doi.org\/10.5056\/JNM18001.","journal-title":"J Neurogastroenterol Motil"},{"key":"1259_CR6","doi-asserted-by":"publisher","DOI":"10.4068\/CMJ.2023.59.2.115","volume":"59","author":"NMP Maideen","year":"2023","unstructured":"Maideen NMP. Adverse effects associated with long-term use of proton pump inhibitors. Chonnam Med J. 2023;59:115. https:\/\/doi.org\/10.4068\/CMJ.2023.59.2.115.","journal-title":"Chonnam Med J"},{"key":"1259_CR7","doi-asserted-by":"publisher","first-page":"e069211","DOI":"10.1136\/BMJ-2021-069211","volume":"379","author":"B Farrell","year":"2022","unstructured":"Farrell B, Lass E, Moayyedi P, Ward D, Thompson W. Reduce unnecessary use of proton pump inhibitors. BMJ. 2022;379:e069211. https:\/\/doi.org\/10.1136\/BMJ-2021-069211.","journal-title":"BMJ"},{"key":"1259_CR8","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.2147\/PPA.S219346","volume":"13","author":"PA Sim\u00f5es","year":"2019","unstructured":"Sim\u00f5es PA, Santiago LM, Maur\u00edcio K, Sim\u00f5es JA. Prevalence of potentially inappropriate medication in the older adult population within primary care in Portugal: a nationwide cross-sectional study. Patient Prefer Adherence. 2019;13:1569\u201376. https:\/\/doi.org\/10.2147\/PPA.S219346.","journal-title":"Patient Prefer Adherence"},{"key":"1259_CR9","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1111\/bcp.12732","volume":"80","author":"E Reeve","year":"2015","unstructured":"Reeve E, Gnjidic D, Long J, Hilmer S. A systematic review of the emerging definition of \u2018deprescribing\u2019 with network analysis: implications for future research and clinical practice. Br J Clin Pharmacol. 2015;80:1254\u201368. https:\/\/doi.org\/10.1111\/bcp.12732.","journal-title":"Br J Clin Pharmacol"},{"key":"1259_CR10","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1001\/jamainternmed.2015.0324","volume":"175","author":"IA Scott","year":"2015","unstructured":"Scott IA, Hilmer SN, Reeve E, Potter K, Couteur DL, Rigby D, et al. Reducing inappropriate polypharmacy: the process of deprescribing. JAMA Intern Med. 2015;175:827\u201334. https:\/\/doi.org\/10.1001\/jamainternmed.2015.0324.","journal-title":"JAMA Intern Med"},{"key":"1259_CR11","volume-title":"Medication safety in polypharmacy","author":"World Health Organization","year":"2019","unstructured":"World Health Organization. Medication safety in polypharmacy. Geneva: World Health Organization; 2019."},{"key":"1259_CR12","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1016\/j.jamda.2023.07.016","volume":"24","author":"D Zhou","year":"2023","unstructured":"Zhou D, Chen Z, Tian F. Deprescribing interventions for older patients: a systematic review and meta-analysis. J Am Med Dir Assoc. 2023;24:1718\u201325. https:\/\/doi.org\/10.1016\/j.jamda.2023.07.016.","journal-title":"J Am Med Dir Assoc"},{"key":"1259_CR13","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1001\/jama.2018.16131","volume":"320","author":"P Martin","year":"2018","unstructured":"Martin P, Tamblyn R, Benedetti A, Ahmed S, Tannenbaum C. Effect of a pharmacist-led educational intervention on inappropriate medication prescriptions in older adults: the D-PRESCRIBE randomized clinical trial. JAMA. 2018;320:1889\u201398. https:\/\/doi.org\/10.1001\/jama.2018.16131.","journal-title":"JAMA"},{"key":"1259_CR14","doi-asserted-by":"publisher","first-page":"2913","DOI":"10.1016\/J.SAPHARM.2021.07.012","volume":"18","author":"JD Niznik","year":"2022","unstructured":"Niznik JD, Collins BJ, Armistead LT, Larson CK, Kelley CJ, Hughes TD, et al. Pharmacist interventions to deprescribe opioids and benzodiazepines in older adults: a rapid review. Res Social Adm Pharm. 2022;18:2913\u201321. https:\/\/doi.org\/10.1016\/J.SAPHARM.2021.07.012.","journal-title":"Res Social Adm Pharm"},{"key":"1259_CR15","doi-asserted-by":"publisher","first-page":"927","DOI":"10.18553\/JMCP.2019.25.8.927","volume":"25","author":"RL Hui","year":"2019","unstructured":"Hui RL, Chang CC, Niu F, Tang YK, Harano D, Deguzman L, et al. Evaluation of a pharmacist-managed antidiabetic deprescribing program in an integrated health care system. J Manag Care Spec Pharm. 2019;25:927\u201334. https:\/\/doi.org\/10.18553\/JMCP.2019.25.8.927.","journal-title":"J Manag Care Spec Pharm"},{"key":"1259_CR16","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s12875-020-01166-1","volume":"21","author":"A Olry de Labry Lima","year":"2020","unstructured":"Olry de Labry Lima A, Marcos Marcos J, Marquina Marquez A, de los Gonz\u00e1lez Vera M\u00c1, Matas Hoces A, Berm\u00fadez Tamayo C. Evidence for deprescription in primary care through an umbrella review. BMC Fam Pract. 2020;21:100. https:\/\/doi.org\/10.1186\/s12875-020-01166-1.","journal-title":"BMC Fam Pract"},{"key":"1259_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S12875-024-02459-5","volume":"25","author":"LC van Gestel","year":"2024","unstructured":"van Gestel LC, Adriaanse MA, Kanis SL, Mensink-Bout SM, Schoones JW, Numans ME, et al. Determinants of and interventions for proton pump inhibitor prescription behavior: a systematic scoping review. BMC Prim Care. 2024;25:1\u201311. https:\/\/doi.org\/10.1186\/S12875-024-02459-5.","journal-title":"BMC Prim Care."},{"key":"1259_CR18","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.ED000159","author":"D Gnjidic","year":"2022","unstructured":"Gnjidic D, Johansson M, Meng DM, Farrell B, Langford A, Reeve E. Achieving sustainable healthcare through deprescribing. Cochrane Database Syst Rev. 2022. https:\/\/doi.org\/10.1002\/14651858.ED000159.","journal-title":"Cochrane Database Syst Rev"},{"key":"1259_CR19","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1002\/jgf2.464","volume":"22","author":"K Ie","year":"2021","unstructured":"Ie K, Aoshima S, Yabuki T, Albert SM. A narrative review of evidence to guide deprescribing among older adults. J Gen Fam Med. 2021;22:182\u201396. https:\/\/doi.org\/10.1002\/jgf2.464.","journal-title":"J Gen Fam Med"},{"key":"1259_CR20","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0298181","volume":"19","author":"S Romano","year":"2024","unstructured":"Romano S, Monteiro L, Guerreiro JP, Sim\u00f5es JB, Rodrigues AT, Lunet N, et al. Effectiveness and cost-effectiveness of a collaborative deprescribing intervention of proton-pump-inhibitors on community-dwelling older adults: protocol for the C-SENIoR, a pragmatic non-randomized controlled trial. PLoS ONE. 2024;19:e0298181. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0298181.","journal-title":"PLoS ONE"},{"key":"1259_CR21","unstructured":"Statistics Portugal. Web portal [Internet]. Lisbon: Statistics Portugal; 2022. [cited 2022 Aug 8]."},{"key":"1259_CR22","unstructured":"World Health Organization. ATC-DDD Toolkit [Internet]. Geneva. WHO; 2024. [cited 2022 Dec 3]."},{"key":"1259_CR23","doi-asserted-by":"publisher","first-page":"6496","DOI":"10.3390\/IJERPH20156496\/S1","volume":"20","author":"S Costa","year":"2023","unstructured":"Costa S, Biscaia JL, Horta MR, Romano S, Guerreiro J, Heudtlass P, et al. Real-world effectiveness in hypertension and hyperlipidemia collaborative management between pharmacies and primary care in portugal: a multicenter pragmatic controlled trial (USFarm\u00e1cia\u00ae). Int J Environ Res Public Health. 2023;20:6496. https:\/\/doi.org\/10.3390\/IJERPH20156496\/S1.","journal-title":"Int J Environ Res Public Health"},{"key":"1259_CR24","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1590\/s0103-166x2004000200007","volume":"2","author":"AB Delgado","year":"2001","unstructured":"Delgado AB, Lima ML. Contributo para a valida\u00e7\u00e3o concorrente de uma medida de ades\u00e3o aos tratamentos. Psicologia Sa\u00fade Doen\u00e7as. 2001;2:81\u2013100. https:\/\/doi.org\/10.1590\/s0103-166x2004000200007.","journal-title":"Psicologia Sa\u00fade Doen\u00e7as."},{"key":"1259_CR25","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1590\/S1516-31802013000100018","volume":"131","author":"T Salgado","year":"2013","unstructured":"Salgado T, Marques A, Geraldes L, Benrimoj S, Horne R, Fernandez-Llimos F. Cross-cultural adaptation of the beliefs about medicines questionnaire into Portuguese. Sao Paulo Med J. 2013;131:88\u201394. https:\/\/doi.org\/10.1590\/S1516-31802013000100018.","journal-title":"Sao Paulo Med J"},{"key":"1259_CR26","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1007\/S11136-011-9903-X","volume":"20","author":"M Herdman","year":"2011","unstructured":"Herdman M, Gudex C, Lloyd A, Janssen M, Kind P, Parkin D, et al. Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L). Qual Life Res. 2011;20:1727\u201336. https:\/\/doi.org\/10.1007\/S11136-011-9903-X.","journal-title":"Qual Life Res"},{"key":"1259_CR27","doi-asserted-by":"publisher","first-page":"3163","DOI":"10.1007\/s11136-019-02226-5","volume":"28","author":"PL Ferreira","year":"2019","unstructured":"Ferreira PL, Antunes P, Ferreira LN, Pereira LN, Ramos-Go\u00f1i JM. A hybrid modelling approach for eliciting health state preferences: the Portuguese EQ-5D-5L value set. Qual Life Res. 2019;28:3163\u201375. https:\/\/doi.org\/10.1007\/s11136-019-02226-5.","journal-title":"Qual Life Res"},{"key":"1259_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12877-017-0621-2","volume":"17","author":"N Masnoon","year":"2017","unstructured":"Masnoon N, Shakib S, Kalisch-Ellett L, Caughey GE. What is polypharmacy? A systematic review of definitions. BMC Geriatr. 2017;17:1\u201310. https:\/\/doi.org\/10.1186\/s12877-017-0621-2.","journal-title":"BMC Geriatr"},{"key":"1259_CR29","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1370\/afm.1838","volume":"13","author":"B Clyne","year":"2015","unstructured":"Clyne B, Smith SM, Hughes CM, Boland F, Bradley M, Cooper JA, et al. Effectiveness of a multifaceted intervention for potentially inappropriate prescribing in older patients in primary care: a cluster-randomized controlled trial (OPTI-SCRIPT study). Ann Fam Med. 2015;13:545\u201353. https:\/\/doi.org\/10.1370\/afm.1838.","journal-title":"Ann Fam Med"},{"key":"1259_CR30","unstructured":"Eurostat. Glossary: self-perceived health. Statistics Explained [Internet]. Luxembourg: Eurostat; 2022. [cited 2022 Nov 19]."},{"key":"1259_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-016-0442-2","volume":"11","author":"B Clyne","year":"2016","unstructured":"Clyne B, Smith SM, Hughes CM, Boland F, Cooper JA, Fahey T. Sustained effectiveness of a multifaceted intervention to reduce potentially inappropriate prescribing in older patients in primary care (OPTI-SCRIPT study). Implement Sci. 2016;11:79. https:\/\/doi.org\/10.1186\/s13012-016-0442-2.","journal-title":"Implement Sci"},{"key":"1259_CR32","doi-asserted-by":"publisher","first-page":"87","DOI":"10.51866\/OA1153","volume":"16","author":"SL Wong","year":"2021","unstructured":"Wong SL, Binti Sulaiman N, Ng KM, Lee ZY. Pharmacist-structured review of proton pump inhibitor utilisation in primary care: a nonrandomised control study. Malays Fam Physician. 2021;16:87\u201396. https:\/\/doi.org\/10.51866\/OA1153.","journal-title":"Malays Fam Physician."},{"key":"1259_CR33","doi-asserted-by":"publisher","first-page":"118","DOI":"10.24950\/rspmi.2513","volume":"31","author":"CB Chaves","year":"2024","unstructured":"Chaves CB, Santos S, Sim\u00f5es S, Fortuna J, Ribeiro P. Proton pump inhibitors prescription patterns: a retrospective analysis of internal medicine wards admissions of a tertiary hospital. Med Interna (Bucur). 2024;31:118\u201323. https:\/\/doi.org\/10.24950\/rspmi.2513.","journal-title":"Med Interna (Bucur)."},{"key":"1259_CR34","doi-asserted-by":"publisher","first-page":"e54","DOI":"10.1016\/j.clinthera.2023.11.011","volume":"46","author":"DA Rodrigues","year":"2023","unstructured":"Rodrigues DA, Herdeiro MT, Mateos-Campos R, Figueiras A, Roque F. Magnitude and determinants of long-term use of proton pump inhibitors among Portuguese older adults in primary health care. Clin Ther. 2023;46:e54\u20138. https:\/\/doi.org\/10.1016\/j.clinthera.2023.11.011.","journal-title":"Clin Ther"},{"key":"1259_CR35","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1111\/bcp.14947","volume":"88","author":"I Bu\u017ean\u010di\u0107","year":"2021","unstructured":"Bu\u017ean\u010di\u0107 I, Kummer I, Dr\u017eai\u0107 M, Ortner Had\u017eiabdi\u0107 M. Community-based pharmacists\u2019 role in deprescribing: a systematic review. Br J Clin Pharmacol. 2021;88:452\u201363. https:\/\/doi.org\/10.1111\/bcp.14947.","journal-title":"Br J Clin Pharmacol"},{"key":"1259_CR36","doi-asserted-by":"publisher","first-page":"e001322","DOI":"10.1038\/s41514-023-00132-2","volume":"10","author":"M Robinson","year":"2024","unstructured":"Robinson M, Mokrzecki S, Mallett AJ. Attitudes and barriers towards deprescribing in older patients experiencing polypharmacy: a narrative review. Npj Aging. 2024;10:e001322. https:\/\/doi.org\/10.1038\/s41514-023-00132-2.","journal-title":"Npj Aging."},{"key":"1259_CR37","doi-asserted-by":"publisher","DOI":"10.3399\/BJGPOPEN20X101096","volume":"4","author":"AJ Doherty","year":"2020","unstructured":"Doherty AJ, Boland P, Reed J, Clegg AJ, Stephani AM, Williams NH, et al. Barriers and facilitators to deprescribing in primary care: a systematic review. BJGP Open. 2020;4:bjgpopen20X101096. https:\/\/doi.org\/10.3399\/BJGPOPEN20X101096.","journal-title":"BJGP Open"},{"issue":"2","key":"1259_CR38","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1093\/IJPP\/RIAD001","volume":"31","author":"DA Okeowo","year":"2023","unstructured":"Okeowo DA, Zaidi STR, Fylan B. Barriers and facilitators of implementing proactive deprescribing within primary care: a systematic review. Int J Pharm Pract. 2023;31(2):126\u201352. https:\/\/doi.org\/10.1093\/IJPP\/RIAD001.","journal-title":"Int J Pharm Pract"},{"key":"1259_CR39","doi-asserted-by":"publisher","DOI":"10.1136\/FMCH-2021-001325","volume":"9","author":"Z Xu","year":"2021","unstructured":"Xu Z, Liang X, Zhu Y, Lu Y, Ye Y, Fang L, et al. Factors associated with potentially inappropriate prescriptions and barriers to medicines optimisation among older adults in primary care settings: a systematic review. Fam Med Community Health. 2021;9:1325. https:\/\/doi.org\/10.1136\/FMCH-2021-001325.","journal-title":"Fam Med Community Health"},{"key":"1259_CR40","doi-asserted-by":"publisher","first-page":"2853","DOI":"10.1111\/hex.12269","volume":"18","author":"FG Nunes","year":"2015","unstructured":"Nunes FG, Anderson JE, Martins LM. Patient reactions to community pharmacies\u2019 roles: evidence from the Portuguese market. Health Expect. 2015;18:2853\u201364. https:\/\/doi.org\/10.1111\/hex.12269.","journal-title":"Health Expect"},{"key":"1259_CR41","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1111\/JAN.14283","volume":"76","author":"DC Visentin","year":"2020","unstructured":"Visentin DC, Cleary M, Hunt GE. The earnestness of being important: reporting non-significant statistical results. J Adv Nurs. 2020;76:917\u20139. https:\/\/doi.org\/10.1111\/JAN.14283.","journal-title":"J Adv Nurs"},{"key":"1259_CR42","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1007\/s40266-019-00717-1","volume":"36","author":"JA Pruskowski","year":"2019","unstructured":"Pruskowski JA, Springer S, Thorpe CT, Klein-Fedyshin M, Handler SM. Does deprescribing improve quality of life? A systematic review of the literature. Drugs Aging. 2019;36:1097\u2013110. https:\/\/doi.org\/10.1007\/s40266-019-00717-1.","journal-title":"Drugs Aging"},{"key":"1259_CR43","doi-asserted-by":"publisher","first-page":"3323","DOI":"10.1007\/s11606-020-06089-2","volume":"35","author":"HE Bloomfield","year":"2020","unstructured":"Bloomfield HE, Greer N, Linsky AM, Bolduc J, Naidl T, Vardeny O, et al. Deprescribing for community-dwelling older adults: a systematic review and meta-analysis. J Gen Intern Med. 2020;35:3323\u201332. https:\/\/doi.org\/10.1007\/s11606-020-06089-2.","journal-title":"J Gen Intern Med"},{"key":"1259_CR44","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1111\/BCP.16200","volume":"90","author":"HW Quek","year":"2024","unstructured":"Quek HW, Page A, Lee K, Lee G, Hawthorne D, Clifford R, et al. The effect of deprescribing interventions on mortality and health outcomes in older people: an updated systematic review and meta-analysis. Br J Clin Pharmacol. 2024;90:2409\u201382. https:\/\/doi.org\/10.1111\/BCP.16200.","journal-title":"Br J Clin Pharmacol"},{"key":"1259_CR45","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0305215","volume":"19","author":"S Chua","year":"2024","unstructured":"Chua S, Todd A, Reeve E, Smith SM, Fox J, Elsisi Z, et al. Deprescribing interventions in older adults: an overview of systematic reviews. PLoS ONE. 2024;19:e0305215. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0305215.","journal-title":"PLoS ONE"},{"key":"1259_CR46","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1002\/AGM2.12045","volume":"1","author":"A Smaje","year":"2018","unstructured":"Smaje A, Weston-Clark M, Raj R, Orlu M, Davis D, Rawle M. Factors associated with medication adherence in older patients: a systematic review. Aging Med. 2018;1:254\u201366. https:\/\/doi.org\/10.1002\/AGM2.12045.","journal-title":"Aging Med"},{"key":"1259_CR47","volume":"55","author":"T Laubscher","year":"2009","unstructured":"Laubscher T, Evans C, Blackburn D, Taylor J, McKay S. Collaboration between family physicians and community pharmacists to enhance adherence to chronic medications: opinions of Saskatchewan family physicians. Can Fam Physician. 2009;55:e69.","journal-title":"Can Fam Physician"},{"key":"1259_CR48","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-019-1031-4","volume":"19","author":"J Ulley","year":"2019","unstructured":"Ulley J, Harrop D, Ali A, Alton S, Fowler Davis S. Deprescribing interventions and their impact on medication adherence in community-dwelling older adults with polypharmacy: a systematic review. BMC Geriatr. 2019;19:15. https:\/\/doi.org\/10.1186\/s12877-019-1031-4.","journal-title":"BMC Geriatr"},{"key":"1259_CR49","doi-asserted-by":"publisher","DOI":"10.3390\/JCM13206283","volume":"13","author":"A Rossi","year":"2024","unstructured":"Rossi A, Perrella L, Scotti S, Olmastroni E, Galimberti F, Ardoino I, et al. Approaches to deprescribing proton pump inhibitors in clinical practice: a systematic review. J Clin Med. 2024;13:6283. https:\/\/doi.org\/10.3390\/JCM13206283.","journal-title":"J Clin Med"},{"key":"1259_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S12877-023-04155","volume":"23","author":"P Nizet","year":"2023","unstructured":"Nizet P, Evin A, Brociero E, Vigneau CV, Huon JF. Outcomes in deprescribing implementation trials and compliance with expert recommendations: a systematic review. BMC Geriatr. 2023;23:1\u201316. https:\/\/doi.org\/10.1186\/S12877-023-04155.","journal-title":"BMC Geriatr"},{"key":"1259_CR51","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1097\/MAJ.0b013e31829f87d5","volume":"347","author":"AM Ladd","year":"2014","unstructured":"Ladd AM, Panagopoulos G, Cohen J, Mar N, Graham R. Potential costs of inappropriate use of proton pump inhibitors. Am J Med Sci. 2014;347:446\u201351.","journal-title":"Am J Med Sci"},{"key":"1259_CR52","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jamda.2020.09.046","volume":"22","author":"TS Dharmarajan","year":"2021","unstructured":"Dharmarajan TS. The use and misuse of proton pump inhibitors: an opportunity for deprescribing. J Am Med Dir Assoc. 2021;22:15\u201322. https:\/\/doi.org\/10.1016\/j.jamda.2020.09.046.","journal-title":"J Am Med Dir Assoc"},{"key":"1259_CR53","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s40266-019-00713-5","volume":"37","author":"SH Chau","year":"2020","unstructured":"Chau SH, Sluiter RL, Hugtenburg JG, Wensing M, Kievit W, Teichert M. Cost\u2013utility and budget impact analysis for stopping the inappropriate use of proton pump inhibitors after cessation of NSAID or low-dose acetylsalicylic acid treatment. Drugs Aging. 2020;37:67\u201374. https:\/\/doi.org\/10.1007\/s40266-019-00713-5.","journal-title":"Drugs Aging"}],"container-title":["Drugs & Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-025-01259-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40266-025-01259-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-025-01259-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:07:32Z","timestamp":1764252452000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40266-025-01259-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,1]]},"references-count":53,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1259"],"URL":"https:\/\/doi.org\/10.1007\/s40266-025-01259-5","relation":{},"ISSN":["1170-229X","1179-1969"],"issn-type":[{"type":"print","value":"1170-229X"},{"type":"electronic","value":"1179-1969"}],"subject":[],"published":{"date-parts":[[2025,11,1]]},"assertion":[{"value":"21 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The author(s) received no specific funding or grant for this work. The Portuguese National Association of Pharmacies (ANF) promoted this research. The C-SENIoR project won, in 2023, the Intervention Award of the Innovation Grant (BInov) from the Southern Regional Section and Autonomous Regions of the Portuguese Pharmaceutical Society.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"S\u00f3nia Romano, Ant\u00f3nio Teixeira Rodrigues, Isabel Guerreiro and Jos\u00e9 Guerreiro are researchers at CEFAR\/Infosa\u00fade, the research centre of the ANF, which has interests in collaborative public health interventions and supported the research. Luis Monteiro is a GP and a researcher with an interest in older adults\u2019 studies. Jo\u00e3o Braga Sim\u00f5es is a researcher and was a GP in one of the interventions FHUs. Nuno Lunet and Julian Perelman are academics. The involvement of academic independent researchers, who do not receive any fees for collaboration, ensures that these interests do not influence the analysis and interpretations of the study results. The trial results included in this manuscript are the exclusive responsibility of the research team.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest disclosure"}},{"value":"The data generated and\/or analysed in this study are available from the corresponding author on reasonable request.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"This study was approved by the Ethics Research Committee of Nova Medical School, NOVA University of Lisbon and the Ethics Committee of the Local Health Unit Alto Minho, Portugal. The study was performed in accordance with the Helsinki Declaration of 1964 and its later amendments, with the exception that this trial was retrospectively registered at ISRCTN registry (ISRCTN49637686). This occurred owing to multiple postponements of the study start date and site relocation. Registration was completed shortly after recruitment commenced.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained prior to enrolment from all participants.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"S\u00f3nia Romano: conceptualisation, formal analysis, methodology, investigation, supervision, project administration, writing\u2014original draft. Ant\u00f3nio Teixeira Rodrigues: conceptualisation, methodology, resources, writing\u2014review and editing. Jos\u00e9 Guerreiro: formal analysis, methodology, writing\u2014review and editing. Jo\u00e3o Braga Sim\u00f5es: investigation, supervision, writing\u2014review and editing .Isabel Guerreiro: resources, investigation, writing\u2014review and editing.Luis Monteiro: conceptualisation, methodology, writing\u2014review and editing. Nuno Lunet: formal analysis, methodology, writing\u2014review and editing. Julian Perelman: conceptualisation, methodology, investigation, writing\u2014review and editing.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors contribution"}}]}}