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While the most common way to enhance functional and structural muscle capacities is resistance training, there are scenarios in which a resistance training routine may not be feasible or may even be contraindicated. Recently published works showed the potential of high-volume static stretching programs when it comes to promoting muscle strength and hypertrophy, albeit with comparatively long stretching durations per bout in comparison with resistance training. Therefore, there is limited practical applicability of this training approach for healthy participants with access to dynamic training facilities and supervised training. However, there are potential settings in which stretch-mediated hypertrophy could be useful and should be investigated. This current opinion paper explores such potential settings, including in immobilization-induced atrophy, in patients with type 2 diabetes, and as a supplement to common resistance training routines to increase the accumulated volume of mechanical overload of the muscle in healthy or athletic populations. Static stretching might also be used to counteract atrophy in spaceflight because other forms of training that may induce sufficient levels of mechanical strain seem infeasible or impractical. Thus, we explore the potential applications of static stretching routines while considering the feasibility and opportunity for their practical implementation. Consequently, this current opinion paper provides a demand for further investigations of static stretch-mediated adaptations as a potential passive alternative with a focus on therapy and prevention.<\/jats:p>","DOI":"10.1007\/s40279-025-02237-y","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T14:24:30Z","timestamp":1749219870000},"page":"1815-1825","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Implications and Applications of Stretch-Mediated Hypertrophy in Therapy, Rehabilitation and Athletic Training\u2014An Outlook to Future Potential Applications"],"prefix":"10.1007","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4964-2867","authenticated-orcid":false,"given":"Konstantin","family":"Warneke","sequence":"first","affiliation":[]},{"given":"Jos\u00e9","family":"Afonso","sequence":"additional","affiliation":[]},{"given":"Ewan","family":"Thomas","sequence":"additional","affiliation":[]},{"given":"J\u00f6rn","family":"Rittweger","sequence":"additional","affiliation":[]},{"given":"Andreas","family":"Konrad","sequence":"additional","affiliation":[]},{"given":"Othmar","family":"Moser","sequence":"additional","affiliation":[]},{"given":"Lars H.","family":"Lohmann","sequence":"additional","affiliation":[]},{"given":"Astrid","family":"Zech","sequence":"additional","affiliation":[]},{"given":"Brad J.","family":"Schoenfeld","sequence":"additional","affiliation":[]},{"given":"David G.","family":"Behm","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"key":"2237_CR1","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1007\/s40279-024-02002-7","volume":"54","author":"J Afonso","year":"2024","unstructured":"Afonso J, Andrade R, Rocha-Rodrigues S, Nakamura FY, Sarmento H, Freitas SR, et al. 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K.W. developed the idea for the review, provided the first structure, drafted the introduction and worked with J.A. on the section about counteracting immobilization-induced atrophy and the one about athletes with D.G.B. and B.J.S. J.A. worked on the section about counteracting immobilization-induced atrophy, the introduction and conclusion. E.T. provided the graphical illustration and co-authored the section about diabetes with O.M. L.H.L. and A.Z. were responsible for the section about fall prevention and declining motor function, while L.H.L. contributed to the revisions and reworking of the individual sections. J.R. wrote the section about space flight, and D.G.B. was responsible for the conclusion. All authors revised the whole manuscript and agreed to the final version.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contribution"}},{"value":"No funding was received for the preparation or publication of this article.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"N\/A.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"N\/A.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"N\/A.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code Availability"}},{"value":"N\/A.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}}]}}