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PGC is supported in part by the UK NIHR Leeds Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. CC: lecture fees and honoraria from Amgen, Danone, Eli Lilly, GSK, Medtronic, Merck, Nestl\u00e9, Novartis, Pfizer, Roche, Servier, Shire, Takeda and UCB outside of the submitted work. TT: honorarium for lectures or advisory board from Abbvie, Amgen, Arrow, BMS, Chugai, Expanscience, Gilead, HAC-Pharma, LCA, Lilly, Medac, MSD, Pfizer, Thuasne, TEVA and UCB; research support from Amgen, Bone Therapeutics, Chugai, HAC-Pharma, MSD, Novartis, Pfizer, and UCB. JYR: consulting fees or paid advisory boards from IBSA-Genevrier, Mylan, Radius Health, Pierre Fabre, Teva; lecture fees when speaking at the invitation of sponsor: IBSA-Genevrier, Mylan, CNIEL, Dairy Research Council, Teva; Grant support from industry (all through institution) from IBSA-Genevrier, Mylan, CNIEL, Radius Health. OB research supports from Biophytis, IBSA, MEDA, Servier, SMB. NAD, CB, JB, CC, MH, GHB, FJ, DP, WL, and RR have no conflict of interest relevant to the content of this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}