{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T05:40:55Z","timestamp":1773898855141,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T00:00:00Z","timestamp":1590192000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T00:00:00Z","timestamp":1590192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aging Clin Exp Res"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s40520-020-01587-z","type":"journal-article","created":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T10:02:52Z","timestamp":1590228172000},"page":"1071-1078","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Responsiveness to muscle mass gain following 12 and 24\u00a0weeks of resistance training in older women"],"prefix":"10.1007","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8144-5906","authenticated-orcid":false,"given":"Jo\u00e3o Pedro","family":"Nunes","sequence":"first","affiliation":[]},{"given":"F\u00e1bio L. C.","family":"Pina","sequence":"additional","affiliation":[]},{"given":"Alex S.","family":"Ribeiro","sequence":"additional","affiliation":[]},{"given":"Paolo M.","family":"Cunha","sequence":"additional","affiliation":[]},{"given":"Witalo","family":"Kassiano","sequence":"additional","affiliation":[]},{"given":"Bruna D. V.","family":"Costa","sequence":"additional","affiliation":[]},{"given":"Gabriel","family":"Kunevaliki","sequence":"additional","affiliation":[]},{"given":"Matheus A.","family":"Nascimento","sequence":"additional","affiliation":[]},{"given":"Nelson H.","family":"Carneiro","sequence":"additional","affiliation":[]},{"given":"Danielle","family":"Venturini","sequence":"additional","affiliation":[]},{"given":"D\u00e9cio S.","family":"Barbosa","sequence":"additional","affiliation":[]},{"given":"Analiza M.","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Jerry L.","family":"Mayhew","sequence":"additional","affiliation":[]},{"given":"Lu\u00eds B.","family":"Sardinha","sequence":"additional","affiliation":[]},{"given":"Edilson S.","family":"Cyrino","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,5,23]]},"reference":[{"key":"1587_CR1","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1519\/JSC.0000000000003230","volume":"33","author":"MS Fragala","year":"2019","unstructured":"Fragala MS, Cadore EL, Dorgo S et al (2019) Resistance training for older adults: position statement from the National Strength and Conditioning Association. J Strength Cond Res 33:2019\u20132052","journal-title":"J Strength Cond Res"},{"key":"1587_CR2","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.mayocp.2015.10.017","volume":"91","author":"SJ Dankel","year":"2016","unstructured":"Dankel SJ, Loenneke JP, Loprinzi PD (2016) Determining the importance of meeting muscle-strengthening activity guidelines: Is the behavior or the outcome of the behavior (strength) a more important determinant of all-cause mortality? Mayo Clin Proc 91:166\u2013174","journal-title":"Mayo Clin Proc"},{"key":"1587_CR3","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1111\/jgs.13322","volume":"63","author":"EA Chmelo","year":"2015","unstructured":"Chmelo EA, Crotts CI, Newman JC et al (2015) Heterogeneity of physical function responses to exercise training in older adults. J Am Geriatr Soc 63:462\u2013469","journal-title":"J Am Geriatr Soc"},{"key":"1587_CR4","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.exger.2017.09.003","volume":"99","author":"MSM Barbalho","year":"2017","unstructured":"Barbalho MSM, Gentil P, Izquierdo M et al (2017) There are no no-responders to low or high resistance training volumes among older women. Exp Gerontol 99:18\u201326","journal-title":"Exp Gerontol"},{"key":"1587_CR5","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.jamda.2015.01.071","volume":"16","author":"TA Churchward-Venne","year":"2015","unstructured":"Churchward-Venne TA, Tieland M, Verdijk LB et al (2015) There are no nonresponders to resistance-type exercise training in older men and women. J Am Med Dir Assoc 16:400\u2013411","journal-title":"J Am Med Dir Assoc"},{"key":"1587_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s40279-018-01041-1","volume":"49","author":"C Pickering","year":"2019","unstructured":"Pickering C, Kiely J (2019) Do non-responders to exercise exist\u2014and if so, what should we do about them? Sport Med 49:1\u20137","journal-title":"Sport Med"},{"key":"1587_CR7","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1152\/japplphysiol.00934.2010","volume":"110","author":"JA Timmons","year":"2011","unstructured":"Timmons JA (2011) Variability in training-induced skeletal muscle adaptation. J Appl Physiol 110:846\u2013853","journal-title":"J Appl Physiol"},{"key":"1587_CR8","doi-asserted-by":"publisher","first-page":"834","DOI":"10.3389\/fphys.2018.00834","volume":"9","author":"MD Roberts","year":"2018","unstructured":"Roberts MD, Haun CT, Mobley CB et al (2018) Physiological differences between low versus high skeletal muscle hypertrophic responders to resistance exercise training: current perspectives and future research directions. Front Physiol 9:834","journal-title":"Front Physiol"},{"key":"1587_CR9","doi-asserted-by":"publisher","first-page":"191","DOI":"10.2174\/1875399X01710010191","volume":"10","author":"C Pickering","year":"2017","unstructured":"Pickering C, Kiely J (2017) Understanding personalized training responses: can genetic assessment help? Open Sports Sci J 10:191\u2013213","journal-title":"Open Sports Sci J"},{"key":"1587_CR10","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.1519\/JSC.0b013e3181e840f3","volume":"24","author":"BJ Schoenfeld","year":"2010","unstructured":"Schoenfeld BJ (2010) The mechanisms of muscle hypertrophy and their application to resistance training. J Strength Cond Res 24:2857\u20132872","journal-title":"J Strength Cond Res"},{"key":"1587_CR11","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s40279-017-0793-0","volume":"48","author":"VC Figueiredo","year":"2018","unstructured":"Figueiredo VC, de Salles BF, Trajano GS (2018) Volume for muscle hypertrophy and health outcomes: the most effective variable in resistance training. Sport Med 48:499\u2013505","journal-title":"Sport Med"},{"key":"1587_CR12","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1136\/bjsports-2017-097608","volume":"52","author":"RW Morton","year":"2018","unstructured":"Morton RW, Murphy KT, McKellar SR et al (2018) A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults. Br J Sports Med 52:376\u2013384","journal-title":"Br J Sports Med"},{"key":"1587_CR13","doi-asserted-by":"publisher","first-page":"29","DOI":"10.4103\/ijpvm.IJPVM_310_17","volume":"10","author":"R Negaresh","year":"2019","unstructured":"Negaresh R, Ranjbar R, Baker J et al (2019) Skeletal muscle hypertrophy, insulin-like growth factor 1, myostatin and follistatin in healthy and sarcopenic elderly men: the effect of whole-body resistance training. Int J Prev Med 10:29","journal-title":"Int J Prev Med"},{"key":"1587_CR14","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1519\/JSC.0000000000001491","volume":"31","author":"GT Mangine","year":"2017","unstructured":"Mangine GT, Hoffman JR, Gonzalez AM et al (2017) Exercise-induced hormone elevations are related to muscle growth. J Strength Cond Res 31:45\u201353","journal-title":"J Strength Cond Res"},{"key":"1587_CR15","doi-asserted-by":"publisher","first-page":"3377","DOI":"10.1113\/JP273480","volume":"595","author":"D Montero","year":"2017","unstructured":"Montero D, Lundby C (2017) Refuting the myth of non-response to exercise training: \u2018non-responders\u2019 do respond to higher dose of training. J Physiol 595:3377\u20133387","journal-title":"J Physiol"},{"key":"1587_CR16","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1080\/02640414.2016.1210197","volume":"35","author":"BJ Schoenfeld","year":"2017","unstructured":"Schoenfeld BJ, Ogborn D, Krieger JW (2017) Dose-response relationship between weekly resistance training volume and increases in muscle mass: a systematic review and meta-analysis. J Sports Sci 35:1073\u20131082","journal-title":"J Sports Sci"},{"key":"1587_CR17","first-page":"623","volume":"12","author":"FLC Pina","year":"2019","unstructured":"Pina FLC, Nunes JP, Nascimento MA et al (2019) Similar effects of 24 weeks of resistance training performed with different frequencies on muscle strength, muscle mass, and muscle quality in older women. Int J Exerc Sci 12:623\u2013635","journal-title":"Int J Exerc Sci"},{"key":"1587_CR18","doi-asserted-by":"publisher","DOI":"10.23736\/S0022-4707.20.10315-3","author":"FLC Pina","year":"2020","unstructured":"Pina FLC, Nunes JP, Ribeiro AS et al (2020) Comparison of the effects of different weekly frequencies of resistance training on metabolic health markers and body fat in older women. J Sports Med Phys Fit. https:\/\/doi.org\/10.23736\/S0022-4707.20.10315-3 (ahead of print)","journal-title":"J Sports Med Phys Fit"},{"key":"1587_CR19","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1152\/japplphysiol.00260.2004","volume":"97","author":"J Kim","year":"2004","unstructured":"Kim J, Heshka S, Gallagher D et al (2004) Intermuscular adipose tissue-free skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in adults. J Appl Physiol 97:655\u2013660","journal-title":"J Appl Physiol"},{"key":"1587_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2165\/00007256-200030010-00001","volume":"30","author":"WG Hopkins","year":"2000","unstructured":"Hopkins WG (2000) Measures of reliability in sports medicine and science. Sport Med 30:1\u201315","journal-title":"Sport Med"},{"key":"1587_CR21","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","volume":"112","author":"J Cohen","year":"1992","unstructured":"Cohen J (1992) A power primer. Psychol Bull 112:155\u2013159","journal-title":"Psychol Bull"},{"key":"1587_CR22","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3389\/fphys.2019.00297","volume":"10","author":"CT Haun","year":"2019","unstructured":"Haun CT, Vann CG, Mobley CB et al (2019) Pre-training skeletal muscle fiber size and predominant fiber type best predict hypertrophic responses to 6 weeks of resistance training in previously trained young men. Front Physiol 10:297","journal-title":"Front Physiol"},{"key":"1587_CR23","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1096\/fasebj.9.11.7649409","volume":"9","author":"JA Simoneau","year":"1995","unstructured":"Simoneau JA, Bouchard C (1995) Genetic determinism of fiber type proportion in human skeletal muscle. FASEB J 9:1091\u20131095","journal-title":"FASEB J"},{"key":"1587_CR24","doi-asserted-by":"publisher","first-page":"155","DOI":"10.5535\/arm.2015.39.2.155","volume":"39","author":"N Miljkovic","year":"2015","unstructured":"Miljkovic N, Kim J-Y, Miljkovic I et al (2015) Aging of skeletal muscle fibers. Ann Rehabil Med 39:155\u2013162","journal-title":"Ann Rehabil Med"},{"key":"1587_CR25","doi-asserted-by":"publisher","first-page":"E652","DOI":"10.1152\/ajpendo.00486.2015","volume":"310","author":"MJ Stec","year":"2016","unstructured":"Stec MJ, Kelly NA, Many GM et al (2016) Ribosome biogenesis may augment resistance training-induced myofiber hypertrophy and is required for myotube growth in vitro. Am J Physiol Endocrinol Metab 310:E652\u2013E661","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"1587_CR26","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1152\/ajpregu.00162.2019","volume":"317","author":"VC Figueiredo","year":"2019","unstructured":"Figueiredo VC (2019) Revisiting the roles of protein synthesis during skeletal muscle hypertrophy induced by exercise. Am J Physiol Regul Integr Comp Physiol 317:709\u2013718","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"1587_CR27","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1113\/JP278455","volume":"598","author":"D Hammarstr\u00f6m","year":"2020","unstructured":"Hammarstr\u00f6m D, Ofsteng S, Koll L et al (2020) Benefits of higher resistance-training volume depends on ribosome biogenesis. J Physiol 598:543\u2013565","journal-title":"J Physiol"},{"key":"1587_CR28","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s40279-019-01147-0","volume":"50","author":"SJ Dankel","year":"2020","unstructured":"Dankel SJ, Loenneke JP (2020) A method to stop analyzing random error and start analyzing differential responders to exercise. Sport Med 50:231\u2013238","journal-title":"Sport Med"},{"key":"1587_CR29","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1093\/advances\/nmy003","volume":"9","author":"DA Taylor","year":"2018","unstructured":"Taylor DA, Gorissen SHM, Phillips SM (2018) Protein requirements and optimal intakes in aging: are we ready to recommend more than the recommended daily allowance? Adv Nutr 9:171\u2013182","journal-title":"Adv Nutr"},{"key":"1587_CR30","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.1007\/s40279-017-0747-6","volume":"47","author":"A Lacroix","year":"2017","unstructured":"Lacroix A, Hortob\u00e1gyi T, Beurskens R et al (2017) Effects of supervised vs. unsupervised training programs on balance and muscle strength in older adults: a systematic review and meta-analysis. Sport Med 47:2341\u20132361","journal-title":"Sport Med"}],"container-title":["Aging Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-020-01587-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40520-020-01587-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-020-01587-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T23:42:07Z","timestamp":1621726927000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40520-020-01587-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,23]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["1587"],"URL":"https:\/\/doi.org\/10.1007\/s40520-020-01587-z","relation":{},"ISSN":["1720-8319"],"issn-type":[{"value":"1720-8319","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,23]]},"assertion":[{"value":"26 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Our institutional ethics review board approved the study protocol, and it was in accordance with the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All enrolled patients provided their written, informed consent before participating in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}