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Fish includes a large variety of foods, in terms of species and food processing, with marked distinction in local diets around the globe. Fish-allergic patients present with phenotypic diversity and major differences in levels of clinical cross-reactivity, features that pose an important challenge for the clinical diagnosis and management.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Recent findings<\/jats:title>\n<jats:p>Parvalbumin is the major fish allergen. However, a single molecule is not sufficient but several homologs, allergens different from parvalbumin and allergen extracts, are needed for IgE-based diagnosis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Summary<\/jats:title>\n<jats:p>Parvalbumin-specific IgE are markers for clinical cross-reactions. Added value is provided by IgE typing to parvalbumin homologs from distantly related fish. IgE co-sensitization profiles (parvalbumin, enolase, aldolase) are referred as severity markers. The allergen panel seems to be not yet complete why fish extracts still play a crucial role in serum IgE analysis. Further clinical validation of a multiplex approach in molecular fish allergy diagnosis is needed for striving to avoid unnecessary food restrictions and in a further sense, improved patient care.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s40521-019-00235-w","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T17:08:18Z","timestamp":1576516098000},"page":"322-337","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Fish Allergy Management: From Component-Resolved Diagnosis to Unmet Diagnostic Needs"],"prefix":"10.1007","volume":"6","author":[{"given":"Julia","family":"Klueber","sequence":"first","affiliation":[]},{"given":"Denise","family":"Schrama","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Rodrigues","sequence":"additional","affiliation":[]},{"given":"Heinrich","family":"Dickel","sequence":"additional","affiliation":[]},{"given":"Annette","family":"Kuehn","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,10,28]]},"reference":[{"issue":"3","key":"235_CR1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s12016-012-8339-6","volume":"46","author":"MH Ho","year":"2014","unstructured":"Ho MH, Wong WH, Chang C. 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