{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:46:55Z","timestamp":1775695615712,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Associa\u00e7\u00e3o de Endocrinologia Oncol\u00f3gica"},{"name":"iNOVA4Health","award":["UIDB\/04462\/2020"],"award-info":[{"award-number":["UIDB\/04462\/2020"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s40618-020-01456-6","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T18:05:44Z","timestamp":1613066744000},"page":"1837-1846","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Correlation of molecular data with histopathological and clinical features in a series of 66 patients with medullary thyroid carcinoma"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2390-5473","authenticated-orcid":false,"given":"M. M.","family":"Moura","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5903-3016","authenticated-orcid":false,"given":"R. A.","family":"Cabrera","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8779-8665","authenticated-orcid":false,"given":"S.","family":"Esteves","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8946-8635","authenticated-orcid":false,"given":"B. M.","family":"Cavaco","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9607-6998","authenticated-orcid":false,"given":"P.","family":"Soares","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5479-7332","authenticated-orcid":false,"given":"V.","family":"Leite","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,2,11]]},"reference":[{"key":"1456_CR1","doi-asserted-by":"publisher","first-page":"3519","DOI":"10.1242\/dev.126581","volume":"142","author":"E Johansson","year":"2015","unstructured":"Johansson E, Andersson L, \u00d6rnros J, Carlsson T, Ingeson-Carlsson C, Liang S, Dahlberg J, Jansson S, Parrillo L, Zoppoli P, Barila GO, Altschuler DL, Padula D, Lickert H, Fagman H, Nilsson M (2015) Revising the embryonic origin of thyroid C cells in mice and humans. Development 142:3519\u20133528. https:\/\/doi.org\/10.1242\/dev.126581","journal-title":"Development"},{"key":"1456_CR2","first-page":"130","volume":"18","author":"E Prokopakis","year":"2014","unstructured":"Prokopakis E, Doulaptsi M, Kaprana A, Velegrakis S, Vlastos Y, Velegrakis G (2014) Treating medullary thyroid carcinoma in a tertiary center. Current trends and review of the literature. Hippokratia 18:130\u2013134","journal-title":"Hippokratia"},{"key":"1456_CR3","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.ecl.2014.02.004","volume":"43","author":"MI Hu","year":"2014","unstructured":"Hu MI, Ying AK, Jimenez C (2014) Update on medullary thyroid cancer. Endocrinol Metab Clin North Am 43:423\u2013442. https:\/\/doi.org\/10.1016\/j.ecl.2014.02.004","journal-title":"Endocrinol Metab Clin North Am"},{"key":"1456_CR4","doi-asserted-by":"publisher","first-page":"2134","DOI":"10.1002\/cncr.22244","volume":"107","author":"S Roman","year":"2006","unstructured":"Roman S, Lin R, Sosa JA (2006) Prognosis of medullary thyroid carcinoma: demographic, clinical, and pathologic predictors of survival in 1252 cases. Cancer 107:2134\u20132142. https:\/\/doi.org\/10.1002\/cncr.22244","journal-title":"Cancer"},{"key":"1456_CR5","unstructured":"Matias-Guiu X, DeLellis R, Moley JF, Gagel RF, Albores-Saavedra J, Bussolati G, Kaserer K, Williams ED, Baloch Z (2004) Medullary thyroid carcinoma. In: DeLellis RA, Lloyd RV, Heitz PU, Eng C (eds) World Health Organization classification of tumours. Pathology and genetics of tumours of endocrine organs, 3rd edn., vol 8. IARC Press, Lyon, pp 86\u201391"},{"key":"1456_CR6","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/363458a0","volume":"363","author":"LM Mulligan","year":"1993","unstructured":"Mulligan LM, Kwok JB, Healey CS, Elsdon MJ, Eng C, Gardner E, Love DR, Mole SE, Moore JK, Papi L, Ponder MA, Telenius H, Tunnacliffe A, Ponder BA (1993) Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. Nature 363:458\u2013460. https:\/\/doi.org\/10.1038\/363458a0","journal-title":"Nature"},{"key":"1456_CR7","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1038\/sj.bjc.6605056","volume":"100","author":"MM Moura","year":"2009","unstructured":"Moura MM, Cavaco BM, Pinto AE, Domingues R, Santos JR, Cid MO, Bugalho MJ, Leite V (2009) Correlation of RET somatic mutations with clinicopathological features in sporadic medullary thyroid carcinomas. Br J Cancer 100:1777\u20131783. https:\/\/doi.org\/10.1038\/sj.bjc.6605056","journal-title":"Br J Cancer"},{"key":"1456_CR8","doi-asserted-by":"publisher","first-page":"E863","DOI":"10.1210\/jc.2010-1921","volume":"96","author":"MM Moura","year":"2011","unstructured":"Moura MM, Cavaco BM, Pinto AE, Leite V (2011) High prevalence of RAS mutations in RET-negative sporadic medullary thyroid carcinomas. J Clin Endocrinol Metab 96:E863\u2013E868. https:\/\/doi.org\/10.1210\/jc.2010-1921","journal-title":"J Clin Endocrinol Metab"},{"key":"1456_CR9","doi-asserted-by":"publisher","first-page":"R235","DOI":"10.1530\/ERC-15-0070","volume":"22","author":"MM Moura","year":"2015","unstructured":"Moura MM, Cavaco BM, Leite V (2015) RAS proto-oncogene in medullary thyroid carcinoma. Endocr Relat Cancer 22:R235\u2013R252. https:\/\/doi.org\/10.1530\/ERC-15-0070","journal-title":"Endocr Relat Cancer"},{"key":"1456_CR10","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1007\/s12022-018-9543-6","volume":"29","author":"YS Chang","year":"2018","unstructured":"Chang YS, Chang CC, Huang HY, Lin CY, Yeh KT, Chang JG (2018) Detection of molecular alterations in taiwanese patients with medullary thyroid cancer using whole-exome sequencing. Endocr Pathol 29:324\u2013331. https:\/\/doi.org\/10.1007\/s12022-018-9543-6","journal-title":"Endocr Pathol"},{"key":"1456_CR11","doi-asserted-by":"publisher","unstructured":"Ciampi R, Romei C, Ramone T, Prete A, Tacito A, Cappagli V, Bottici V, Viola D, Torregrossa L, Ugolini C, Basolo F, Elisei R (2019) Genetic landscape of somatic mutations in a large cohort of sporadic medullary thyroid carcinomas studied by next-generation targeted sequencing. iScience 20:324\u2013336. https:\/\/doi.org\/10.1016\/j.isci.2019.09.030","DOI":"10.1016\/j.isci.2019.09.030"},{"key":"1456_CR12","doi-asserted-by":"publisher","unstructured":"Asa SL, Mete O (2016) Cytology and Pathology: Pitfalls and Challenges. In: Wang TS, Evans DB (eds) Medullary Thyroid Cancer. Chapter 4. Springer International Publishing Switzerland, pp 33\u201345. https:\/\/doi.org\/10.1007\/978-3-319-39412-1_4","DOI":"10.1007\/978-3-319-39412-1_4"},{"key":"1456_CR13","doi-asserted-by":"crossref","unstructured":"DeLellis RA, Al Ghuzlan A, Albores Saavedra J, Baloch ZW, Basolo F, Elisei R, Kaserer K, LiVolsi V, Matias-Guiu X, Mete O, Moley JF, Nikiforov YE, Nos\u00e9 V, Pinto AE (2017) Medullary thyroid carcinoma. In: Lloyd RV, Osamura RY, Kl\u00f6ppel G, Rosai J (eds) World Health Organization classification of tumours. WHO Classification of Tumours of Endocrine Organs, 4th edn., vol 10. IARC, Lyon, pp 108\u2013113","DOI":"10.1097\/PCR.0000000000000205"},{"key":"1456_CR14","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s12022-013-9287-2","volume":"25","author":"X Matias-Guiu","year":"2014","unstructured":"Matias-Guiu X, De Lellis R (2014) Medullary thyroid carcinoma: a 25-year perspective. Endocr Pathol 25:21\u201329. https:\/\/doi.org\/10.1007\/s12022-013-9287-2","journal-title":"Endocr Pathol"},{"key":"1456_CR15","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1097\/PAP.0000000000000004","volume":"21","author":"MP Pusztaszeri","year":"2014","unstructured":"Pusztaszeri MP, Bongiovanni M, Faquin WC (2014) Update on the cytologic and molecular features of medullary thyroid carcinoma. Adv Anat Pathol 21:26\u201335. https:\/\/doi.org\/10.1097\/PAP.0000000000000004","journal-title":"Adv Anat Pathol"},{"issue":"Suppl 1","key":"1456_CR16","doi-asserted-by":"publisher","first-page":"60","DOI":"10.5146\/tjpath.2015.01315","volume":"31","author":"ZW Baloch","year":"2015","unstructured":"Baloch ZW, LiVolsi VA (2015) C-cells and their associated lesions and conditions: a pathologists perspective. Turk Patoloji Derg 31(Suppl 1):60\u201379. https:\/\/doi.org\/10.5146\/tjpath.2015.01315","journal-title":"Turk Patoloji Derg"},{"key":"1456_CR17","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1309\/AJCPHWACTTUYJ7DD","volume":"143","author":"RD Chernock","year":"2015","unstructured":"Chernock RD, Hagemann IS (2015) Molecular pathology of hereditary and sporadic medullary thyroid carcinomas. Am J Clin Pathol 143:768\u2013777. https:\/\/doi.org\/10.1309\/AJCPHWACTTUYJ7DD","journal-title":"Am J Clin Pathol"},{"key":"1456_CR18","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/978-3-319-22542-5_2","volume":"204","author":"KW Schmid","year":"2015","unstructured":"Schmid KW (2015) Histopathology of C cells and medullary thyroid carcinoma. Recent Results Cancer Res 204:41\u201360. https:\/\/doi.org\/10.1007\/978-3-319-22542-5_2","journal-title":"Recent Results Cancer Res"},{"key":"1456_CR19","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1097\/PCR.0000000000000205","volume":"22","author":"RA DeLellis","year":"2017","unstructured":"DeLellis RA, Mangray S (2017) Medullary thyroid carcinoma: a contemporary perspective. AJSP Rev Rep 22:196\u2013208. https:\/\/doi.org\/10.1097\/PCR.0000000000000205","journal-title":"AJSP Rev Rep"},{"key":"1456_CR20","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1007\/s12022-016-9449-0","volume":"27","author":"YH Chu","year":"2016","unstructured":"Chu YH, Lloyd RV (2016) Medullary thyroid carcinoma: recent advances including MicroRNA expression. Endocr Pathol 27:312\u2013324. https:\/\/doi.org\/10.1007\/s12022-016-9449-0","journal-title":"Endocr Pathol"},{"key":"1456_CR21","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1177\/014556131008900712","volume":"89","author":"LD Thompson","year":"2010","unstructured":"Thompson LD (2010) Medullary thyroid carcinoma. Ear Nose Throat J 89:301\u2013302","journal-title":"Ear Nose Throat J"},{"key":"1456_CR22","doi-asserted-by":"publisher","unstructured":"Rosen JE, Lloyd RV, Brierley JD, Grogan RH, Haddad R, Hunt JL, Ridge JA, Seethala RR, Sosa JA, Subramaniam RM, Wang TS, Wirth LJ, Perrier ND (2017) Thyroid\u2013Medullary. In: Amin MB, Edge SB, Greene FL, Byrd D, Brookland RK, Washington MK, Gershenwald JE, Compton CC, Hess KR, Sullivan DC, Jessup JM, Brierley J, Gaspar LE, Schilsky RL, Balch CM, Winchester DP, Asare EA, Madera M, Gress DM, Meyer LR (eds) AJCC Cancer Staging Manual. Chapter 74, 8th edn. Springer, Chicago, pp 891\u2013901. https:\/\/doi.org\/10.1007\/978-3-319-40618-3_74","DOI":"10.1007\/978-3-319-40618-3_74"},{"key":"1456_CR23","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1007\/s12020-015-0559-0","volume":"49","author":"AL Silva","year":"2015","unstructured":"Silva AL, Carmo F, Moura MM, Domingues R, Espadinha C, Leite V, Cavaco B, Bugalho MJ (2015) Identification and characterization of two novel germline RET variants associated with medullary thyroid carcinoma. Endocrine 49:366\u2013372. https:\/\/doi.org\/10.1007\/s12020-015-0559-0","journal-title":"Endocrine"},{"key":"1456_CR24","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3892\/ijo.31.1.59","volume":"31","author":"O Koperek","year":"2007","unstructured":"Koperek O, Scheuba C, Puri C, Birner P, Haslinger C, Rettig W, Niederle B, Kaserer K, Garin Chesa P (2007) Molecular characterization of the desmoplastic tumor stroma in medullary thyroid carcinoma. Int J Oncol 31:59\u201367. https:\/\/doi.org\/10.3892\/ijo.31.1.59","journal-title":"Int J Oncol"},{"key":"1456_CR25","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1136\/ard.61.1.42","volume":"61","author":"TM El Mansoury","year":"2002","unstructured":"El Mansoury TM, Hazenberg BP, El Badawy SA, Ahmed AH, Bijzet J, Limburg PC, van Rijswijk MH (2002) Screening for amyloid in subcutaneous fat tissue of Egyptian patients with rheumatoid arthritis: clinical and laboratory characteristics. Ann Rheum Dis 61:42\u201347. https:\/\/doi.org\/10.1136\/ard.61.1.42","journal-title":"Ann Rheum Dis"},{"key":"1456_CR26","unstructured":"R Core Team (2014) R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. https:\/\/www.R-project.org\/"},{"key":"1456_CR27","unstructured":"Heinze G, Ploner M, Dunkler D, Southworth H (2013) logistf: Firth's bias-reduced logistic regression. R package version 1.21. https:\/\/CRAN.R-project.org\/package=logistf"},{"key":"1456_CR28","unstructured":"Liaw A, Wiener M (2002) Classification and regression by randomForest. R News 2:18\u201322. https:\/\/CRAN.R-project.org\/doc\/Rnews\/"},{"key":"1456_CR29","doi-asserted-by":"publisher","first-page":"25","DOI":"10.4103\/0019-509X.15096","volume":"42","author":"SS Desai","year":"2005","unstructured":"Desai SS, Sarkar S, Borges AM (2005) A study of histopathological features of medullary carcinoma of the thyroid: cases from a single institute in India. Indian J Cancer 42:25\u201329. https:\/\/doi.org\/10.4103\/0019-509X.15096","journal-title":"Indian J Cancer"},{"key":"1456_CR30","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1111\/j.1365-2559.2008.03002.x","volume":"52","author":"O Koperek","year":"2008","unstructured":"Koperek O, Scheuba C, Cherenko M, Neuhold N, De Micco C, Schmid KW, Niederle B, Kaserer K (2008) Desmoplasia in medullary thyroid carcinoma: a reliable indicator of metastatic potential. Histopathology 52:623\u2013630. https:\/\/doi.org\/10.1111\/j.1365-2559.2008.03002.x","journal-title":"Histopathology"},{"key":"1456_CR31","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/j.1365-2303.2010.00747.x","volume":"22","author":"S Kaushal","year":"2011","unstructured":"Kaushal S, Iyer VK, Mathur SR, Ray R (2011) Fine needle aspiration cytology of medullary carcinoma of the thyroid with a focus on rare variants: a review of 78 cases. Cytopathology 22:95\u2013105. https:\/\/doi.org\/10.1111\/j.1365-2303.2010.00747.x","journal-title":"Cytopathology"},{"key":"1456_CR32","first-page":"C130","volume":"3","author":"N Nargotra","year":"2016","unstructured":"Nargotra N, Das A, Singh S, Deepak RK, Tyagi I (2016) Rare presentation of medullary carcinoma of thyroid with predominant spindle cell pattern & abundant calcification. APALM 3:C130\u2013C134","journal-title":"APALM"},{"key":"1456_CR33","doi-asserted-by":"publisher","unstructured":"Arrangoiz R, Cordera F, Caba D, Moreno E, Luque-de-Leon E, Mu\u00f1oz M (2018) Medullary thyroid carcinoma literature review and current management. J Clin Endocrinol Diabetes 2018:JCED-118. https:\/\/doi.org\/10.29011\/JCED-118\/100018","DOI":"10.29011\/JCED-118\/100018"},{"key":"1456_CR34","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1055\/s-0033-1351299","volume":"121","author":"S Barollo","year":"2013","unstructured":"Barollo S, Pezzani R, Cristiani A, Bertazza L, Rubin B, Bulfone A, Pelizzo MR, Torresan F, Mantero F, Pennelli G, Moro S, Mian C (2013) Functional significance of the novel H-RAS gene mutation M72I in a patient with medullary thyroid cancer. Exp Clin Endocrinol Diabetes 121:546\u2013550. https:\/\/doi.org\/10.1055\/s-0033-1351299","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"1456_CR35","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1089\/thy.2012.0207","volume":"23","author":"R Ciampi","year":"2013","unstructured":"Ciampi R, Mian C, Fugazzola L, Cosci B, Romei C, Barollo S, Cirello V, Bottici V, Marconcini G, Rosa PM, Borrello MG, Basolo F, Ugolini C, Materazzi G, Pinchera A, Elisei R (2013) Evidence of a low prevalence of RAS mutations in a large medullary thyroid cancer series. Thyroid 23:50\u201357. https:\/\/doi.org\/10.1089\/thy.2012.0207","journal-title":"Thyroid"},{"key":"1456_CR36","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s00428-014-1589-3","volume":"465","author":"M Simbolo","year":"2014","unstructured":"Simbolo M, Mian C, Barollo S, Fassan M, Mafficini A, Neves D, Scardoni M, Pennelli G, Rugge M, Pelizzo MR, Cavedon E, Fugazzola L, Scarpa A (2014) High-throughput mutation profiling improves diagnostic stratification of sporadic medullary thyroid carcinomas. Virchows Arch 465:73\u201378. https:\/\/doi.org\/10.1007\/s00428-014-1589-3","journal-title":"Virchows Arch"},{"key":"1456_CR37","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1002\/(SICI)1097-0142(19961115)78:10<2173::AID-CNCR20>3.0.CO;2-V","volume":"78","author":"L Scopsi","year":"1996","unstructured":"Scopsi L, Sampietro G, Boracchi P, Del Bo R, Gullo M, Placucci M, Pilotti S (1996) Multivariate analysis of prognostic factors in sporadic medullary carcinoma of the thyroid. A retrospective study of 109 consecutive patients. Cancer 78:2173\u20132183. https:\/\/doi.org\/10.1002\/(SICI)1097-0142(19961115)78:10%3c2173::AID-CNCR20%3e3.0.CO;2-V","journal-title":"Cancer"},{"key":"1456_CR38","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s00428-018-2303-7","volume":"472","author":"S Aubert","year":"2018","unstructured":"Aubert S, Berdelou A, Gnemmi V, Behal H, Caiazzo R, D\u2019herbomez M, Pigny P, Wemeau JL, Carnaille B, Renaud F, Bouchindhomme B, Leteurtre E, Perrais M, Pattou F, Do Cao C (2018) Large sporadic thyroid medullary carcinomas: predictive factors for lymph node involvement. Virchows Arch 472:461\u2013468. https:\/\/doi.org\/10.1007\/s00428-018-2303-7","journal-title":"Virchows Arch"},{"key":"1456_CR39","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.3390\/ijms19082299","volume":"19","author":"MM Kasembeli","year":"2018","unstructured":"Kasembeli MM, Bharadwaj U, Robinson P, Tweardy DJ (2018) Contribution of STAT3 to inflammatory and fibrotic diseases and prospects for its targeting for treatment. Int J Mol Sci 19:2299. https:\/\/doi.org\/10.3390\/ijms19082299","journal-title":"Int J Mol Sci"},{"key":"1456_CR40","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1158\/1078-0432.CCR-16-0947","volume":"23","author":"V Mancikova","year":"2017","unstructured":"Mancikova V, Montero-Conde C, Perales-Paton J, Fernandez A, Santacana M, Jodkowska K, Inglada-P\u00e9rez L, Castelblanco E, Borrego S, Encinas M, Matias-Guiu X, Fraga M, Robledo M (2017) Multilayer OMIC data in medullary thyroid carcinoma identifies the STAT3 pathway as a potential therapeutic target in RETM918T tumors. Clin Cancer Res 23:1334\u20131345. https:\/\/doi.org\/10.1158\/1078-0432.CCR-16-0947","journal-title":"Clin Cancer Res"},{"key":"1456_CR41","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1677\/ERC-07-0128","volume":"14","author":"P Miccoli","year":"2007","unstructured":"Miccoli P, Minuto MN, Ugolini C, Molinaro E, Basolo F, Berti P, Pinchera A, Elisei R (2007) Clinically unpredictable prognostic factors in the outcome of medullary thyroid cancer. Endocr Relat Cancer 14:1099\u20131105. https:\/\/doi.org\/10.1677\/ERC-07-0128","journal-title":"Endocr Relat Cancer"},{"key":"1456_CR42","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1530\/ERC-18-0056","volume":"25","author":"HG Vuong","year":"2018","unstructured":"Vuong HG, Odate T, Ngo HTT, Pham TQ, Tran TTK, Mochizuki K, Nakazawa T, Katoh R, Kondo T (2018) Clinical significance of RET and RAS mutations in sporadic medullary thyroid carcinoma: a meta-analysis. Endocr Relat Cancer 25:633\u2013641. https:\/\/doi.org\/10.1530\/ERC-18-0056","journal-title":"Endocr Relat Cancer"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-020-01456-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-020-01456-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-020-01456-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T19:40:16Z","timestamp":1671219616000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-020-01456-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,11]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["1456"],"URL":"https:\/\/doi.org\/10.1007\/s40618-020-01456-6","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,11]]},"assertion":[{"value":"25 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was conducted with approval from the Institutional Ethics Committee of IPOLFG.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from the patients but was waived by the Ethics Committee for those who had died.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}