{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:04:32Z","timestamp":1769213072021,"version":"3.49.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/BBB-BQB\/1368\/2014"],"award-info":[{"award-number":["PTDC\/BBB-BQB\/1368\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/MEC-AND\/28691\/2017"],"award-info":[{"award-number":["PTDC\/MEC-AND\/28691\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["IFCT2015"],"award-info":[{"award-number":["IFCT2015"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020616","name":"Institute of Biomedical Sciences Abel Salazar","doi-asserted-by":"crossref","award":["ICBAS\/BIT\/SPERMBOOST"],"award-info":[{"award-number":["ICBAS\/BIT\/SPERMBOOST"]}],"id":[{"id":"10.13039\/501100020616","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1007\/s43032-020-00328-x","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T13:04:20Z","timestamp":1601471060000},"page":"920-931","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of Leptin in Human Sertoli Cells Mitochondrial Physiology"],"prefix":"10.1007","volume":"28","author":[{"given":"Bruno P.","family":"Moreira","sequence":"first","affiliation":[]},{"given":"Ana M.","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Ana D.","family":"Martins","sequence":"additional","affiliation":[]},{"given":"Mariana P.","family":"Monteiro","sequence":"additional","affiliation":[]},{"given":"M\u00e1rio","family":"Sousa","sequence":"additional","affiliation":[]},{"given":"Pedro F.","family":"Oliveira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7635-783X","authenticated-orcid":false,"given":"Marco G.","family":"Alves","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"issue":"6","key":"328_CR1","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/nrendo.2016.222","volume":"13","author":"H Cui","year":"2017","unstructured":"Cui H, L\u00f3pez M, Rahmouni K. The cellular and molecular bases of leptin and ghrelin resistance in obesity. Nat Rev Endocrinol. 2017;13(6):338\u201351. https:\/\/doi.org\/10.1038\/nrendo.2016.222.","journal-title":"Nat Rev Endocrinol"},{"issue":"7","key":"328_CR2","doi-asserted-by":"publisher","first-page":"3144","DOI":"10.1210\/endo.137.7.8770941","volume":"137","author":"IA Barash","year":"1996","unstructured":"Barash IA, Cheung CC, Weigle DS, Ren H, Kabigting EB, Kuijper JL, et al. Leptin is a metabolic signal to the reproductive system. Endocrinology. 1996;137(7):3144\u20137. https:\/\/doi.org\/10.1210\/endo.137.7.8770941.","journal-title":"Endocrinology."},{"issue":"22","key":"328_CR3","doi-asserted-by":"publisher","first-page":"3535","DOI":"10.1042\/bcj20180631","volume":"475","author":"BP Moreira","year":"2018","unstructured":"Moreira BP, Monteiro MP, Sousa M, Oliveira PF, Alves MG. Insights into leptin signaling and male reproductive health: the missing link between overweight and subfertility? Biochem J. 2018;475(22):3535\u201360. https:\/\/doi.org\/10.1042\/bcj20180631.","journal-title":"Biochem J"},{"issue":"1","key":"328_CR4","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/sj.ijo.0801525","volume":"25","author":"MP Cleary","year":"2001","unstructured":"Cleary MP, Bergstrom HM, Dodge TL, Getzin SC, Jacobson MK, Phillips FC. Restoration of fertility in young obese (Lep(Ob) Lep(Ob)) male mice with low dose recombinant mouse leptin treatment. Int J Obes Relat Metab Disord. 2001;25(1):95\u20137.","journal-title":"Int J Obes Relat Metab Disord"},{"issue":"6 Pt 1","key":"328_CR5","first-page":"E1099","volume":"276","author":"WA Banks","year":"1999","unstructured":"Banks WA, McLay RN, Kastin AJ, Sarmiento U, Scully S. Passage of leptin across the blood-testis barrier. Am J Phys. 1999;276(6 Pt 1):E1099\u2013104.","journal-title":"Am J Phys"},{"issue":"1","key":"328_CR6","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1002\/med.21325","volume":"35","author":"PF Oliveira","year":"2015","unstructured":"Oliveira PF, Martins AD, Moreira AC, Cheng CY, Alves MG. The Warburg effect revisited-lesson from the Sertoli cell. Med Res Rev. 2015;35(1):126\u201351. https:\/\/doi.org\/10.1002\/med.21325.","journal-title":"Med Res Rev"},{"issue":"9","key":"328_CR7","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1016\/j.bbadis.2015.06.005","volume":"1852","author":"AD Martins","year":"2015","unstructured":"Martins AD, Moreira AC, Sa R, Monteiro MP, Sousa M, Carvalho RA, et al. Leptin modulates human Sertoli cells acetate production and glycolytic profile: a novel mechanism of obesity-induced male infertility? Biochim Biophys Acta. 2015;1852(9):1824\u201332. https:\/\/doi.org\/10.1016\/j.bbadis.2015.06.005.","journal-title":"Biochim Biophys Acta"},{"issue":"9","key":"328_CR8","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1002\/jcb.25158","volume":"116","author":"MM Blanquer-Rossell\u00f3","year":"2015","unstructured":"Blanquer-Rossell\u00f3 MM, Santandreu FM, Oliver J, Roca P, Valle A. Leptin modulates mitochondrial function, dynamics and biogenesis in MCF-7 cells. J Cell Biochem. 2015;116(9):2039\u201348. https:\/\/doi.org\/10.1002\/jcb.25158.","journal-title":"J Cell Biochem"},{"issue":"31","key":"328_CR9","doi-asserted-by":"publisher","first-page":"13100","DOI":"10.1073\/pnas.0903723106","volume":"106","author":"A Singh","year":"2009","unstructured":"Singh A, Wirtz M, Parker N, Hogan M, Strahler J, Michailidis G, et al. Leptin-mediated changes in hepatic mitochondrial metabolism, structure, and protein levels. Proc Natl Acad Sci U S A. 2009;106(31):13100\u20135. https:\/\/doi.org\/10.1073\/pnas.0903723106.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"328_CR10","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.mito.2010.05.015","volume":"10","author":"S Rajender","year":"2010","unstructured":"Rajender S, Rahul P, Mahdi AA. Mitochondria, spermatogenesis and male infertility. Mitochondrion. 2010;10(5):419\u201328. https:\/\/doi.org\/10.1016\/j.mito.2010.05.015.","journal-title":"Mitochondrion."},{"issue":"2","key":"328_CR11","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/j.1365-2605.2011.01218.x","volume":"35","author":"P Piomboni","year":"2012","unstructured":"Piomboni P, Focarelli R, Stendardi A, Ferramosca A, Zara V. The role of mitochondria in energy production for human sperm motility. Int J Androl. 2012;35(2):109\u201324. https:\/\/doi.org\/10.1111\/j.1365-2605.2011.01218.x.","journal-title":"Int J Androl"},{"issue":"11","key":"328_CR12","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1161\/01.atv.18.11.1686","volume":"18","author":"F Krempler","year":"1998","unstructured":"Krempler F, Hell E, Winkler C, Breban D, Patsch W. Plasma leptin levels: interaction of obesity with a common variant of insulin receptor substrate-1. Arterioscler Thromb Vasc Biol. 1998;18(11):1686\u201390. https:\/\/doi.org\/10.1161\/01.atv.18.11.1686.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"5","key":"328_CR13","doi-asserted-by":"publisher","first-page":"886","DOI":"10.5114\/aoms.2014.46209","volume":"10","author":"SM Fathy","year":"2014","unstructured":"Fathy SM, Morshed G. Peripheral blood lymphocyte subsets (CD4+, CD8+ T cells), leptin level and weight loss after laparoscopic greater curvature plication in morbidly obese patients. Arch Med Sci. 2014;10(5):886\u201390. https:\/\/doi.org\/10.5114\/aoms.2014.46209.","journal-title":"Arch Med Sci"},{"issue":"2","key":"328_CR14","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1530\/rep-08-0363","volume":"137","author":"PF Oliveira","year":"2009","unstructured":"Oliveira PF, Sousa M, Barros A, Moura T, Rebelo da Costa A. Intracellular pH regulation in human Sertoli cells: role of membrane transporters. Reproduction. 2009;137(2):353\u20139. https:\/\/doi.org\/10.1530\/rep-08-0363.","journal-title":"Reproduction"},{"issue":"6 Pt 2","key":"328_CR15","doi-asserted-by":"publisher","first-page":"e612","DOI":"10.1111\/j.1365-2605.2011.01205.x","volume":"34","author":"PF Oliveira","year":"2011","unstructured":"Oliveira PF, Alves MG, Rato L, Silva J, Sa R, Barros A, et al. Influence of 5alpha-dihydrotestosterone and 17beta-estradiol on human Sertoli cells metabolism. Int J Androl. 2011;34(6 Pt 2):e612\u201320. https:\/\/doi.org\/10.1111\/j.1365-2605.2011.01205.x.","journal-title":"Int J Androl"},{"key":"328_CR16","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/978-1-4939-7831-1_2","volume":"1782","author":"AM Silva","year":"2018","unstructured":"Silva AM, Oliveira PJ. Evaluation of respiration with clark-type electrode in isolated mitochondria and permeabilized animal cells. Methods Mol Biol. 2018;1782:7\u201329. https:\/\/doi.org\/10.1007\/978-1-4939-7831-1_2.","journal-title":"Methods Mol Biol"},{"issue":"1","key":"328_CR17","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s10863-013-9531-y","volume":"46","author":"VF Monteiro-Cardoso","year":"2014","unstructured":"Monteiro-Cardoso VF, Silva AM, Oliveira MM, Peixoto F, Videira RA. Membrane lipid profile alterations are associated with the metabolic adaptation of the Caco-2 cells to aglycemic nutritional condition. J Bioenerg Biomembr. 2014;46(1):45\u201357. https:\/\/doi.org\/10.1007\/s10863-013-9531-y.","journal-title":"J Bioenerg Biomembr"},{"key":"328_CR18","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.mce.2016.07.008","volume":"434","author":"AD Martins","year":"2016","unstructured":"Martins AD, Sa R, Monteiro MP, Barros A, Sousa M, Carvalho RA, et al. Ghrelin acts as energy status sensor of male reproduction by modulating Sertoli cells glycolytic metabolism and mitochondrial bioenergetics. Mol Cell Endocrinol. 2016;434:199\u2013209. https:\/\/doi.org\/10.1016\/j.mce.2016.07.008.","journal-title":"Mol Cell Endocrinol"},{"issue":"9","key":"328_CR19","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","volume":"29","author":"MW Pfaffl","year":"2001","unstructured":"Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001;29(9):e45.","journal-title":"Nucleic Acids Res"},{"issue":"1\u20132","key":"328_CR20","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s11010-014-2076-5","volume":"394","author":"RX Santos","year":"2014","unstructured":"Santos RX, Correia SC, Alves MG, Oliveira PF, Cardoso S, Carvalho C, et al. Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes. Mol Cell Biochem. 2014;394(1\u20132):13\u201322. https:\/\/doi.org\/10.1007\/s11010-014-2076-5.","journal-title":"Mol Cell Biochem"},{"issue":"7","key":"328_CR21","doi-asserted-by":"publisher","first-page":"2624","DOI":"10.1210\/endo.141.7.7542","volume":"141","author":"T El-Hefnawy","year":"2000","unstructured":"El-Hefnawy T, Ioffe S, Dym M. Expression of the leptin receptor during germ cell development in the mouse testis. Endocrinology. 2000;141(7):2624\u201330. https:\/\/doi.org\/10.1210\/endo.141.7.7542.","journal-title":"Endocrinology."},{"issue":"1","key":"328_CR22","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/j.1439-0272.2006.00754.x","volume":"39","author":"T Ishikawa","year":"2007","unstructured":"Ishikawa T, Fujioka H, Ishimura T, Takenaka A, Fujisawa M. Expression of leptin and leptin receptor in the testis of fertile and infertile patients. Andrologia. 2007;39(1):22\u20137. https:\/\/doi.org\/10.1111\/j.1439-0272.2006.00754.x.","journal-title":"Andrologia."},{"issue":"2","key":"328_CR23","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1677\/joe.0.1700413","volume":"170","author":"M Tena-Sempere","year":"2001","unstructured":"Tena-Sempere M, Manna PR, Zhang FP, Pinilla L, Gonz\u00e1lez LC, Di\u00e9guez C, et al. Molecular mechanisms of leptin action in adult rat testis: potential targets for leptin-induced inhibition of steroidogenesis and pattern of leptin receptor messenger ribonucleic acid expression. J Endocrinol. 2001;170(2):413\u201323. https:\/\/doi.org\/10.1677\/joe.0.1700413.","journal-title":"J Endocrinol"},{"key":"328_CR24","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.lfs.2015.02.008","volume":"140","author":"G Fern\u00e1ndez-Formoso","year":"2015","unstructured":"Fern\u00e1ndez-Formoso G, P\u00e9rez-Sieira S, Gonz\u00e1lez-Touceda D, Dieguez C, Tovar S. Leptin, 20 years of searching for glucose homeostasis. Life Sci. 2015;140:4\u20139. https:\/\/doi.org\/10.1016\/j.lfs.2015.02.008.","journal-title":"Life Sci"},{"issue":"1","key":"328_CR25","doi-asserted-by":"publisher","first-page":"T83","DOI":"10.1530\/joe-14-0358","volume":"223","author":"M Rosenbaum","year":"2014","unstructured":"Rosenbaum M, Leibel RL. 20 years of leptin: role of leptin in energy homeostasis in humans. J Endocrinol. 2014;223(1):T83\u201396. https:\/\/doi.org\/10.1530\/joe-14-0358.","journal-title":"J Endocrinol"},{"issue":"3","key":"328_CR26","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/ng0396-318","volume":"12","author":"FF Chehab","year":"1996","unstructured":"Chehab FF, Lim ME, Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet. 1996;12(3):318\u201320. https:\/\/doi.org\/10.1038\/ng0396-318.","journal-title":"Nat Genet"},{"issue":"3","key":"328_CR27","doi-asserted-by":"publisher","first-page":"296","DOI":"10.4103\/aja.aja_98_18","volume":"21","author":"IA Malik","year":"2019","unstructured":"Malik IA, Durairajanayagam D, Singh HJ. Leptin and its actions on reproduction in males. Asian J Androl. 2019;21(3):296\u20139. https:\/\/doi.org\/10.4103\/aja.aja_98_18.","journal-title":"Asian J Androl"},{"issue":"1","key":"328_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.repbio.2012.12.001","volume":"13","author":"D Landry","year":"2013","unstructured":"Landry D, Cloutier F, Martin LJ. Implications of leptin in neuroendocrine regulation of male reproduction. Reprod Biol. 2013;13(1):1\u201314. https:\/\/doi.org\/10.1016\/j.repbio.2012.12.001.","journal-title":"Reprod Biol"},{"issue":"1\u20132","key":"328_CR29","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s11010-014-2142-z","volume":"396","author":"A Bruno","year":"2014","unstructured":"Bruno A, Gerbino S, Ferraro M, Siena L, Bonura A, Colombo P, et al. Fluticasone furoate maintains epithelial homeostasis via leptin\/leptin receptor pathway in nasal cells. Mol Cell Biochem. 2014;396(1\u20132):55\u201365. https:\/\/doi.org\/10.1007\/s11010-014-2142-z.","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"328_CR30","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.fertnstert.2013.03.019","volume":"100","author":"YS Choi","year":"2013","unstructured":"Choi YS, Oh HK, Choi JH. Expression of adiponectin, leptin, and their receptors in ovarian endometrioma. Fertil Steril. 2013;100(1):135\u201341.e1\u20132. https:\/\/doi.org\/10.1016\/j.fertnstert.2013.03.019.","journal-title":"Fertil Steril"},{"issue":"3","key":"328_CR31","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s00395-013-0329-1","volume":"108","author":"W Yan","year":"2013","unstructured":"Yan W, Zhang H, Liu P, Wang H, Liu J, Gao C, et al. Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1\u03b1 signaling contributing to increased vulnerability in diabetic heart. Basic Res Cardiol. 2013;108(3):329. https:\/\/doi.org\/10.1007\/s00395-013-0329-1.","journal-title":"Basic Res Cardiol"},{"issue":"27","key":"328_CR32","doi-asserted-by":"publisher","first-page":"25096","DOI":"10.1074\/jbc.M007383200","volume":"276","author":"SI Yamagishi","year":"2001","unstructured":"Yamagishi SI, Edelstein D, Du XL, Kaneda Y, Guzm\u00e1n M, Brownlee M. Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase a. J Biol Chem. 2001;276(27):25096\u2013100. https:\/\/doi.org\/10.1074\/jbc.M007383200.","journal-title":"J Biol Chem"},{"issue":"6869","key":"328_CR33","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/415339a","volume":"415","author":"Y Minokoshi","year":"2002","unstructured":"Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Muller C, Carling D, et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature. 2002;415(6869):339\u201343. https:\/\/doi.org\/10.1038\/415339a.","journal-title":"Nature."},{"issue":"1\u20132","key":"328_CR34","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s11010-007-9587-2","volume":"307","author":"GF Luo","year":"2008","unstructured":"Luo GF, Yu TY, Wen XH, Li Y, Yang GS. Alteration of mitochondrial oxidative capacity during porcine preadipocyte differentiation and in response to leptin. Mol Cell Biochem. 2008;307(1\u20132):83\u201391. https:\/\/doi.org\/10.1007\/s11010-007-9587-2.","journal-title":"Mol Cell Biochem"},{"issue":"19","key":"328_CR35","doi-asserted-by":"publisher","first-page":"7933","DOI":"10.1073\/pnas.0702683104","volume":"104","author":"LM Rohas","year":"2007","unstructured":"Rohas LM, St-Pierre J, Uldry M, J\u00e4ger S, Handschin C, Spiegelman BM. A fundamental system of cellular energy homeostasis regulated by PGC-1alpha. Proc Natl Acad Sci U S A. 2007;104(19):7933\u20138. https:\/\/doi.org\/10.1073\/pnas.0702683104.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"328_CR36","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1042\/bse0470069","volume":"47","author":"FR Jornayvaz","year":"2010","unstructured":"Jornayvaz FR, Shulman GI. Regulation of mitochondrial biogenesis. Essays Biochem. 2010;47:69\u201384. https:\/\/doi.org\/10.1042\/bse0470069.","journal-title":"Essays Biochem"},{"issue":"2","key":"328_CR37","doi-asserted-by":"publisher","first-page":"87","DOI":"10.14348\/molcells.2016.2318","volume":"39","author":"BL Tang","year":"2016","unstructured":"Tang BL. Sirt1 and the Mitochondria. Mol Cell. 2016;39(2):87\u201395. https:\/\/doi.org\/10.14348\/molcells.2016.2318.","journal-title":"Mol Cell"},{"issue":"6","key":"328_CR38","doi-asserted-by":"publisher","first-page":"3938","DOI":"10.1074\/jbc.M112.385682","volume":"288","author":"C Li","year":"2013","unstructured":"Li C, Liu C, Nissim I, Chen J, Chen P, Doliba N, et al. Regulation of glucagon secretion in normal and diabetic human islets by gamma-hydroxybutyrate and glycine. J Biol Chem. 2013;288(6):3938\u201351. https:\/\/doi.org\/10.1074\/jbc.M112.385682.","journal-title":"J Biol Chem"},{"issue":"1","key":"328_CR39","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.18632\/oncotarget.12157","volume":"8","author":"X Ye","year":"2017","unstructured":"Ye X, Li M, Hou T, Gao T, Zhu WG, Yang Y. Sirtuins in glucose and lipid metabolism. Oncotarget. 2017;8(1):1845\u201359. https:\/\/doi.org\/10.18632\/oncotarget.12157.","journal-title":"Oncotarget"},{"issue":"2","key":"328_CR40","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1111\/andr.12462","volume":"6","author":"T Mostafa","year":"2018","unstructured":"Mostafa T, Nabil N, Rashed L, Makeen K, El-Kasas MA, Mohamaed HA. Seminal SIRT1 expression in infertile oligoasthenoteratozoospermic men with varicocoele. Andrology. 2018;6(2):301\u20135. https:\/\/doi.org\/10.1111\/andr.12462.","journal-title":"Andrology."},{"issue":"8","key":"328_CR41","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1042\/cs20180179","volume":"132","author":"Y Mu","year":"2018","unstructured":"Mu Y, Yin TL, Yin L, Hu X, Yang J. CTRP3 attenuates high-fat diet-induced male reproductive dysfunction in mice. Clin Sci (Lond). 2018;132(8):883\u201399. https:\/\/doi.org\/10.1042\/cs20180179.","journal-title":"Clin Sci (Lond)"},{"issue":"3","key":"328_CR42","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1093\/humupd\/dmy003","volume":"24","author":"C Tatone","year":"2018","unstructured":"Tatone C, Di Emidio G, Barbonetti A, Carta G, Luciano AM, Falone S, et al. Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility. Hum Reprod Update. 2018;24(3):267\u201389. https:\/\/doi.org\/10.1093\/humupd\/dmy003.","journal-title":"Hum Reprod Update"},{"issue":"7029","key":"328_CR43","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/nature03354","volume":"434","author":"JT Rodgers","year":"2005","unstructured":"Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature. 2005;434(7029):113\u20138. https:\/\/doi.org\/10.1038\/nature03354.","journal-title":"Nature."},{"issue":"9","key":"328_CR44","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.1021\/acs.jproteome.8b00260","volume":"17","author":"H Liu","year":"2018","unstructured":"Liu H, Li S, Liu X, Chen Y, Deng H. SIRT3 overexpression inhibits growth of kidney tumor cells and enhances mitochondrial biogenesis. J Proteome Res. 2018;17(9):3143\u201352. https:\/\/doi.org\/10.1021\/acs.jproteome.8b00260.","journal-title":"J Proteome Res"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-020-00328-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-020-00328-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-020-00328-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T23:39:43Z","timestamp":1632958783000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-020-00328-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,30]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["328"],"URL":"https:\/\/doi.org\/10.1007\/s43032-020-00328-x","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,30]]},"assertion":[{"value":"5 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The work presented in this paper resulted from the use of Clonetics\u2122 human Sertoli cells (hSCs) (MM-HSE-2305) purchased from Lonza (Walkersville, MD, USA). Thus, ethics approval is not required according to current law and the national ethical guidelines of our country or European Directives. Nevertheless, our laboratory is authorized to work with human material, particularly human Sertoli cells and sperm samples, according to the authorization from the Joint Ethics Committee CHUP\/ICBAS with the approval number 2019\/CE\/P017(266\/CETI\/ICBAS).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}