{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T20:24:07Z","timestamp":1774556647641,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Foundation for Science and Technology"},{"name":"Univ Coimbra"},{"name":"Unidade Local de Sa\u00fade de Coimbra"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Photochem Photobiol Sci"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s43630-025-00781-0","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T16:03:18Z","timestamp":1759507398000},"page":"1597-1616","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ring-fused chlorin-enhanced photodynamic therapy for effective cell death induction in endometrial cancer"],"prefix":"10.1007","volume":"24","author":[{"given":"Beatriz","family":"Serambeque","sequence":"first","affiliation":[]},{"given":"Gabriela","family":"Correia-Barros","sequence":"additional","affiliation":[]},{"given":"Sofia Pinto","family":"Lopes","sequence":"additional","affiliation":[]},{"given":"Nelson A. M.","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Raquel","family":"Alves","sequence":"additional","affiliation":[]},{"given":"Ana Cristina","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o Martins","family":"Gama","sequence":"additional","affiliation":[]},{"given":"Francisco","family":"Caramelo","sequence":"additional","affiliation":[]},{"given":"Ricardo","family":"Teixo","sequence":"additional","affiliation":[]},{"given":"Catarina","family":"Cerdeira","sequence":"additional","affiliation":[]},{"given":"F\u00e1tima","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Augusta","family":"Cipriano","sequence":"additional","affiliation":[]},{"given":"Marta","family":"Pineiro","sequence":"additional","affiliation":[]},{"given":"Maria Filomena","family":"Botelho","sequence":"additional","affiliation":[]},{"given":"Teresa M. V. D. Pinho e","family":"Melo","sequence":"additional","affiliation":[]},{"given":"Maria Jo\u00e3o","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Mafalda","family":"Laranjo","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"781_CR1","unstructured":"Ferlay, J., Ervik, M., Lam, F., Laversanne, M., Colombet, M., Mery, L., Pi\u00f1eros, M., Znaor, A., Soerjomataram, I., Bray, F. (2024). Global Cancer Observatory: Cancer Tomorrow. Lyon, France: International Agency for Research on Cancer. Retrieved December, 8, 2024, from https:\/\/gco.iarc.who.int\/tomorrow"},{"key":"781_CR2","unstructured":"Ferlay, J., Ervik, M., Lam, F., Laversanne, M., Colombet, M., Mery, L., Pi\u00f1eros, M., Znaor, A., Soerjomataram, I., Bray, F. (2024). Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer. Retrieved December, 8, 2024, from https:\/\/gco.iarc.who.int\/today"},{"issue":"5","key":"781_CR3","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1136\/ijgc-2019-001105","volume":"30","author":"J Son","year":"2020","unstructured":"Son, J., Carr, C., Yao, M., Radeva, M., Priyadarshini, A., Marquard, J., Michener, C. M., & AlHilli, M. (2020). Endometrial cancer in young women: Prognostic factors and treatment outcomes in women aged \u226440 years. International Journal of Gynecological Cancer: Official Journal of the International Gynecological Cancer Society, 30(5), 631\u2013639. https:\/\/doi.org\/10.1136\/ijgc-2019-001105","journal-title":"International Journal of Gynecological Cancer: Official Journal of the International Gynecological Cancer Society"},{"issue":"1","key":"781_CR4","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.ygyno.2021.01.001","volume":"161","author":"OV Novikova","year":"2021","unstructured":"Novikova, O. V., Nosov, V. B., Panov, V. A., Novikova, E. G., Krasnopolskaya, K. V., Andreeva, Y. Y., & Shevchuk, A. S. (2021). Live births and maintenance with levonorgestrel IUD improve disease-free survival after fertility-sparing treatment of atypical hyperplasia and early endometrial cancer. Gynecologic Oncology, 161(1), 152\u2013159. https:\/\/doi.org\/10.1016\/j.ygyno.2021.01.001","journal-title":"Gynecologic Oncology"},{"issue":"8","key":"781_CR5","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1111\/aogs.14815","volume":"103","author":"S Zhao","year":"2024","unstructured":"Zhao, S., Zhang, J., Yan, Y., Tian, L., Chen, L., Zheng, X., Sun, Y., Tian, W., Xue, F., & Wang, Y. (2024). Oncological and reproductive outcomes of endometrial atypical hyperplasia and endometrial cancer patients undergoing conservative therapy with hysteroscopic resection: A systematic review and meta-analysis. Acta Obstetricia Et Gynecologica Scandinavica, 103(8), 1498\u20131512. https:\/\/doi.org\/10.1111\/aogs.14815","journal-title":"Acta Obstetricia Et Gynecologica Scandinavica"},{"issue":"1","key":"781_CR6","doi-asserted-by":"publisher","first-page":"183","DOI":"10.3390\/jcm11010183","volume":"11","author":"A Gallo","year":"2022","unstructured":"Gallo, A., Catena, U., Saccone, G., & Di Spiezio Sardo, A. (2022). Conservative surgery in endometrial cancer. Journal of Clinical Medicine, 11(1), 183. https:\/\/doi.org\/10.3390\/jcm11010183","journal-title":"Journal of Clinical Medicine"},{"issue":"8","key":"781_CR7","doi-asserted-by":"publisher","first-page":"3626","DOI":"10.3390\/app11083626","volume":"11","author":"A-G Niculescu","year":"2021","unstructured":"Niculescu, A.-G., & Grumezescu, A. M. (2021). Photodynamic therapy\u2014An up-to-date review. Applied Sciences, 11(8), 3626. https:\/\/doi.org\/10.3390\/app11083626","journal-title":"Applied Sciences"},{"issue":"2","key":"781_CR8","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3390\/cancers9020019","volume":"9","author":"D Van Straten","year":"2017","unstructured":"Van Straten, D., Mashayekhi, V., De Bruijn, H. S., Oliveira, S., & Robinson, D. J. (2017). Oncologic photodynamic therapy: Basic principles, current clinical status and future directions. Cancers, 9(2), 19. https:\/\/doi.org\/10.3390\/cancers9020019","journal-title":"Cancers"},{"issue":"4","key":"781_CR9","doi-asserted-by":"publisher","first-page":"250","DOI":"10.3322\/caac.20114","volume":"61","author":"P Agostinis","year":"2011","unstructured":"Agostinis, P., Berg, K., Cengel, K. A., Foster, T. H., Girotti, A. W., Gollnick, S. O., Hahn, S. M., Hamblin, M. R., Juzeniene, A., Kessel, D., Korbelik, M., Moan, J., Mroz, P., Nowis, D., Piette, J., Wilson, B. C., & Golab, J. (2011). Photodynamic therapy of cancer: An update. CA: A Cancer Journal for Clinicians, 61(4), 250\u2013281. https:\/\/doi.org\/10.3322\/caac.20114","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"781_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.rechem.2024.101715","volume":"10","author":"AM Oluwajembola","year":"2024","unstructured":"Oluwajembola, A. M., Cleanclay, W. D., Onyia, A. F., Chikere, B. N., Zakari, S., Ndifreke, E., & De Campos, O. C. (2024). Photosensitizers in photodynamic therapy: An advancement in cancer treatment. Results in Chemistry, 10, 1\u201310. https:\/\/doi.org\/10.1016\/j.rechem.2024.101715","journal-title":"Results in Chemistry"},{"key":"781_CR11","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.ejmech.2015.08.059","volume":"103","author":"NA Pereira","year":"2015","unstructured":"Pereira, N. A., Laranjo, M., Pineiro, M., Serra, A. C., Santos, K., Teixo, R., Abrantes, A. M., Gon\u00e7alves, A. C., Sarmento Ribeiro, A. B., Casalta-Lopes, J., Botelho, M. F., & Pinho e Melo, T. M. (2015). Novel 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine fused chlorins as active photodynamic agents for melanoma cells. European Journal of Medicinal Chemistry, 103, 374\u2013380. https:\/\/doi.org\/10.1016\/j.ejmech.2015.08.059","journal-title":"European Journal of Medicinal Chemistry"},{"issue":"3","key":"781_CR12","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1021\/acsmedchemlett.6b00476","volume":"8","author":"NA Pereira","year":"2017","unstructured":"Pereira, N. A., Laranjo, M., Casalta-Lopes, J., Serra, A. C., Pi\u00f1eiro, M., Pina, J., Seixas de Melo, J. S., Senge, M. O., Botelho, M. F., Martelo, L., Burrows, H. D., & Pinho e Melo, T. M. (2017). Platinum(II) ring-fused chlorins as near-infrared emitting oxygen sensors and photodynamic agents. ACS medicinal Chemistry Letters, 8(3), 310\u2013315. https:\/\/doi.org\/10.1021\/acsmedchemlett.6b00476","journal-title":"ACS medicinal Chemistry Letters"},{"key":"781_CR13","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.ejmech.2017.12.093","volume":"146","author":"NAM Pereira","year":"2018","unstructured":"Pereira, N. A. M., Laranjo, M., Pina, J., Oliveira, A. S. R., Ferreira, J. D., S\u00e1nchez-S\u00e1nchez, C., Casalta-Lopes, J., Gon\u00e7alves, A. C., Sarmento-Ribeiro, A. B., Pi\u00f1eiro, M., Seixas de Melo, J. S., Botelho, M. F., & Pinho e Melo, T. M. V. D. (2018). Advances on photodynamic therapy of melanoma through novel ring-fused 5,15-diphenylchlorins. European Journal of Medicinal Chemistry, 146, 395\u2013408. https:\/\/doi.org\/10.1016\/j.ejmech.2017.12.093","journal-title":"European Journal of Medicinal Chemistry"},{"issue":"17","key":"781_CR14","doi-asserted-by":"publisher","first-page":"17244","DOI":"10.1021\/acsomega.9b01865","volume":"4","author":"BFO Nascimento","year":"2019","unstructured":"Nascimento, B. F. O., Laranjo, M., Pereira, N. A. M., Dias-Ferreira, J., Pi\u00f1eiro, M., Botelho, M. F., & Pinho E Melo, T. M. V. D. (2019). Ring-fused diphenylchlorins as potent photosensitizers for photodynamic therapy applications. In vitro tumor cell biology and in vivo chick embryo chorioallantoic membrane studies. ACS Omega, 4(17), 17244\u201317250. https:\/\/doi.org\/10.1021\/acsomega.9b01865","journal-title":"ACS Omega"},{"key":"781_CR15","doi-asserted-by":"publisher","first-page":"112468","DOI":"10.1016\/j.ejmech.2020.112468","volume":"200","author":"M Laranjo","year":"2020","unstructured":"Laranjo, M., Aguiar, M. C., Pereira, N. A. M., Brites, G., Nascimento, B. F. O., Brito, A. F., Casalta-Lopes, J., Gon\u00e7alves, A. C., Sarmento-Ribeiro, A. B., Pineiro, M., Botelho, M. F., & Pinho E Melo, T. M. V. D. (2020). Platinum(II) ring-fused chlorins as efficient theranostic agents: Dyes for tumor-imaging and photodynamic therapy of cancer. European Journal of Medicinal Chemistry, 200, 112468. https:\/\/doi.org\/10.1016\/j.ejmech.2020.112468","journal-title":"European Journal of Medicinal Chemistry"},{"issue":"4","key":"781_CR16","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1039\/d0md00433b","volume":"12","author":"NAM Pereira","year":"2021","unstructured":"Pereira, N. A. M., Laranjo, M., Nascimento, B. F. O., Sim\u00f5es, J. C. S., Pina, J., Costa, B. D. P., Brites, G., Braz, J., Seixas de Melo, J. S., Pineiro, M., Botelho, M. F., & Pinho e Melo, T. M. V. D. (2021). Novel fluorinated ring-fused chlorins as promising PDT agents against melanoma and oesophagal cancer. RSC Medicinal Chemistry, 12(4), 615\u2013627. https:\/\/doi.org\/10.1039\/d0md00433b","journal-title":"RSC Medicinal Chemistry"},{"key":"781_CR17","doi-asserted-by":"publisher","first-page":"873245","DOI":"10.3389\/fchem.2022.873245","volume":"10","author":"M Laranjo","year":"2022","unstructured":"Laranjo, M., Pereira, N. A. M., Oliveira, A. S. R., Campos Aguiar, M., Brites, G., Nascimento, B. F. O., Serambeque, B., Costa, B. D. P., Pina, J., Seixas de Melo, J. S., Pineiro, M., Botelho, M. F., & Pinho E Melo, T. M. V. D. (2022). Ring-fused meso-tetraarylchlorins as auspicious PDT sensitizers: synthesis, structural characterization, photophysics, and biological evaluation. Frontiers in Chemistry, 10, 873245. https:\/\/doi.org\/10.3389\/fchem.2022.873245","journal-title":"Frontiers in Chemistry"},{"key":"781_CR18","doi-asserted-by":"publisher","first-page":"104020","DOI":"10.1016\/j.pdpdt.2024.104020","volume":"46","author":"M Zhou","year":"2024","unstructured":"Zhou, M., Zhang, T., Huang, Z., Zhang, C., Yuan, S., Zhang, M., Dai, K., Wang, Y., Su, Y., & Zhang, M. (2024). Surgery combined with photodynamic therapy for early-stage endometrial carcinoma, a report of two cases. Photodiagnosis and Photodynamic Therapy, 46, 104020. https:\/\/doi.org\/10.1016\/j.pdpdt.2024.104020","journal-title":"Photodiagnosis and Photodynamic Therapy"},{"issue":"11","key":"781_CR19","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.3390\/cancers16112031","volume":"16","author":"B Serambeque","year":"2024","unstructured":"Serambeque, B., Mestre, C., Correia-Barros, G., Teixo, R., Marto, C. M., Gon\u00e7alves, A. C., Caramelo, F., Silva, I., Paiva, A., Beck, H. C., Carvalho, A. S., Botelho, M. F., Carvalho, M. J., Matthiesen, R., & Laranjo, M. (2024). Influence of aldehyde dehydrogenase inhibition on stemness of endometrial cancer stem cells. Cancers, 16(11), 2031. https:\/\/doi.org\/10.3390\/cancers16112031","journal-title":"Cancers"},{"issue":"8","key":"781_CR20","doi-asserted-by":"publisher","first-page":"3680","DOI":"10.1111\/jcmm.16397","volume":"25","author":"K Skok","year":"2021","unstructured":"Skok, K., Gradi\u0161nik, L., Maver, U., Kozar, N., Sobo\u010dan, M., Taka\u010d, I., Arko, D., & Kavalar, R. (2021). Gynaecological cancers and their cell lines. Journal of Cellular and Molecular Medicine, 25(8), 3680\u20133698. https:\/\/doi.org\/10.1111\/jcmm.16397","journal-title":"Journal of Cellular and Molecular Medicine"},{"issue":"6","key":"781_CR21","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.3892\/ijo.2020.5139","volume":"57","author":"EJ Devor","year":"2020","unstructured":"Devor, E. J., Gonzalez-Bosquet, J., Thiel, K. W., & Leslie, K. K. (2020). Genomic characterization of five commonly used endometrial cancer cell lines. International Journal of Oncology, 57(6), 1348\u20131357. https:\/\/doi.org\/10.3892\/ijo.2020.5139","journal-title":"International Journal of Oncology"},{"issue":"2","key":"781_CR22","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1007\/s11033-019-05226-3","volume":"47","author":"K Skok","year":"2020","unstructured":"Skok, K., Maver, U., Gradi\u0161nik, L., Kozar, N., Taka\u010d, I., & Arko, D. (2020). Endometrial cancer and its cell lines. Molecular Biology Reports, 47(2), 1399\u20131411. https:\/\/doi.org\/10.1007\/s11033-019-05226-3","journal-title":"Molecular Biology Reports"},{"issue":"8","key":"781_CR23","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.3390\/ijms19082380","volume":"19","author":"M Remmerie","year":"2018","unstructured":"Remmerie, M., & Janssens, V. (2018). Targeted therapies in type II endometrial cancers: Too little, but not too late. International Journal of Molecular Sciences, 19(8), 2380. https:\/\/doi.org\/10.3390\/ijms19082380","journal-title":"International Journal of Molecular Sciences"},{"issue":"13","key":"781_CR24","doi-asserted-by":"publisher","first-page":"5486","DOI":"10.1158\/0008-5472.CAN-10-0713","volume":"70","author":"T Jiang","year":"2010","unstructured":"Jiang, T., Chen, N., Zhao, F., Wang, X. J., Kong, B., Zheng, W., & Zhang, D. D. (2010). High levels of Nrf2 determine chemoresistance in type II endometrial cancer. Cancer Research, 70(13), 5486\u20135496. https:\/\/doi.org\/10.1158\/0008-5472.CAN-10-0713","journal-title":"Cancer Research"},{"issue":"3","key":"781_CR25","doi-asserted-by":"publisher","first-page":"e20240010","DOI":"10.1002\/smo.20240010","volume":"2","author":"R Wang","year":"2024","unstructured":"Wang, R., He, M., Zhang, Z., Qiu, T., Xi, Y., Zeng, X., Fan, J., Sun, W., & Peng, X. (2024). Photodynamic therapy promotes hypoxia-activated nitrogen mustard drug release. Smart Molecules: Open Access, 2(3), e20240010. https:\/\/doi.org\/10.1002\/smo.20240010","journal-title":"Smart Molecules: Open Access"},{"issue":"1","key":"781_CR26","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1186\/s12885-019-6438-y","volume":"19","author":"T Zaidieh","year":"2019","unstructured":"Zaidieh, T., Smith, J. R., Ball, K. E., & An, Q. (2019). ROS as a novel indicator to predict anticancer drug efficacy. BMC Cancer, 19(1), 1224. https:\/\/doi.org\/10.1186\/s12885-019-6438-y","journal-title":"BMC Cancer"},{"issue":"1","key":"781_CR27","doi-asserted-by":"publisher","first-page":"e20230024","DOI":"10.1002\/smo.20230024","volume":"2","author":"SY Wang","year":"2024","unstructured":"Wang, S. Y., Pan, Y. H., Qu, Y. C., Chen, X. X., Shao, N., Niu, L. Y., & Yang, Q. Z. (2024). Activatable theranostic prodrug scaffold with tunable drug release rate for sequential photodynamic and chemotherapy. Smart Molecules: Open Access, 2(1), e20230024. https:\/\/doi.org\/10.1002\/smo.20230024","journal-title":"Smart Molecules: Open Access"},{"issue":"6","key":"781_CR28","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/s42255-022-00591-z","volume":"4","author":"MP Murphy","year":"2022","unstructured":"Murphy, M. P., Bayir, H., Belousov, V., Chang, C. J., Davies, K. J. A., Davies, M. J., Dick, T. P., Finkel, T., Forman, H. J., Janssen-Heininger, Y., Gems, D., Kagan, V. E., Kalyanaraman, B., Larsson, N. G., Milne, G. L., Nystr\u00f6m, T., Poulsen, H. E., Radi, R., Van Remmen, H., \u2026 Halliwell, B. (2022). Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo. Nature Metabolism, 4(6), 651\u2013662. https:\/\/doi.org\/10.1038\/s42255-022-00591-z","journal-title":"Nature Metabolism"},{"key":"781_CR29","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/978-1-0716-4574-1_12","volume":"2933","author":"TA Kato","year":"2025","unstructured":"Kato, T. A. (2025). DCFDA assay for oxidative stress measurement in fluorometer. Methods in Molecular Biology (Clifton N.J.), 2933, 87\u201391. https:\/\/doi.org\/10.1007\/978-1-0716-4574-1_12","journal-title":"Methods in Molecular Biology (Clifton N.J.)"},{"issue":"4","key":"781_CR30","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/s12276-021-00599-7","volume":"53","author":"DL Sai","year":"2021","unstructured":"Sai, D. L., Lee, J., Nguyen, D. L., & Kim, Y. P. (2021). Tailoring photosensitive ROS for advanced photodynamic therapy. Experimental & molecular medicine, 53(4), 495\u2013504. https:\/\/doi.org\/10.1038\/s12276-021-00599-7","journal-title":"Experimental & molecular medicine"},{"issue":"1","key":"781_CR31","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13000-023-01433-6","volume":"19","author":"H Dou","year":"2024","unstructured":"Dou, H., Li, F., Wang, Y., Chen, X., Yu, P., Jia, S., Ba, Y., Luo, D., Gao, T., Li, Z., & Xiao, M. (2024). Estrogen receptor-negative\/progesterone receptor-positive breast cancer has distinct characteristics and pathologic complete response rate after neoadjuvant chemotherapy. Diagnostic Pathology, 19(1), 5. https:\/\/doi.org\/10.1186\/s13000-023-01433-6","journal-title":"Diagnostic Pathology"},{"key":"781_CR32","doi-asserted-by":"publisher","first-page":"1225694","DOI":"10.3389\/fonc.2023.1225694","volume":"13","author":"K Moloudi","year":"2023","unstructured":"Moloudi, K., Abrahamse, H., & George, B. P. (2023). Photodynamic therapy induced cell cycle arrest and cancer cell synchronization: Review. Frontiers in Oncology, 13, 1225694. https:\/\/doi.org\/10.3389\/fonc.2023.1225694","journal-title":"Frontiers in Oncology"},{"key":"781_CR33","doi-asserted-by":"publisher","first-page":"112208","DOI":"10.1016\/j.jphotobiol.2021.112208","volume":"219","author":"NN Peskova","year":"2021","unstructured":"Peskova, N. N., Brilkina, A. A., Gorokhova, A. A., Shilyagina, N. Y., Kutova, O. M., Nerush, A. S., Orlova, A. G., Klapshina, L. G., Vodeneev, V. V., & Balalaeva, I. V. (2021). The localization of the photosensitizer determines the dynamics of the secondary production of hydrogen peroxide in cell cytoplasm and mitochondria. Journal of Photochemistry and Photobiology, B: Biology, 219, 112208. https:\/\/doi.org\/10.1016\/j.jphotobiol.2021.112208","journal-title":"Journal of Photochemistry and Photobiology, B: Biology"},{"key":"781_CR34","doi-asserted-by":"publisher","first-page":"45633","DOI":"10.1038\/srep45633","volume":"7","author":"Y Chang","year":"2017","unstructured":"Chang, Y., Li, X., Zhang, L., Xia, L., Liu, X., Li, C., Zhang, Y., Tu, L., Xue, B., Zhao, H., Zhang, H., & Kong, X. (2017). Precise photodynamic therapy of cancer via subcellular dynamic tracing of dual-loaded upconversion nanophotosensitizers. Scientific Reports, 7, 45633. https:\/\/doi.org\/10.1038\/srep45633","journal-title":"Scientific Reports"},{"issue":"82","key":"781_CR35","doi-asserted-by":"publisher","first-page":"11610","DOI":"10.1039\/d4cc02702g","volume":"60","author":"GS Attar","year":"2024","unstructured":"Attar, G. S., Kumar, M., & Bhalla, V. (2024). Targeting sub-cellular organelles for boosting precision photodynamic therapy. Chemical Communications (Cambridge), 60(82), 11610\u201311624. https:\/\/doi.org\/10.1039\/d4cc02702g","journal-title":"Chemical Communications (Cambridge)"},{"key":"781_CR36","doi-asserted-by":"publisher","first-page":"113045","DOI":"10.1016\/j.jphotobiol.2024.113045","volume":"261","author":"J Li","year":"2024","unstructured":"Li, J., Wang, G., Mai, Y., Zhang, W., Zhao, H., Zhou, Y., Chen, L., Lin, Y., Jiang, L., Xu, P., Zhou, X., Yuan, C., & Huang, M. (2024). Lysosome-localization and tumor-targeting of novel photosensitisers enhance the ablation of cancer. Journal of Photochemistry and Photobiology, B: Biology, 261, 113045. https:\/\/doi.org\/10.1016\/j.jphotobiol.2024.113045","journal-title":"Journal of Photochemistry and Photobiology, B: Biology"},{"issue":"1","key":"781_CR37","doi-asserted-by":"publisher","first-page":"383027","DOI":"10.1155\/2014\/383027","volume":"2014","author":"PR Sekhejane","year":"2014","unstructured":"Sekhejane, P. R., Houreld, N. N., & Abrahamse, H. (2014). Multiorganelle localization of metallated phthalocyanine photosensitizer in colorectal cancer cells (DLD-1 and CaCo-2) enhances efficacy of photodynamic therapy. International Journal of Photoenergy, 2014(1), 383027. https:\/\/doi.org\/10.1155\/2014\/383027","journal-title":"International Journal of Photoenergy"},{"issue":"Suppl 1","key":"781_CR38","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1159\/000362416","volume":"24","author":"L Benov","year":"2015","unstructured":"Benov, L. (2015). Photodynamic therapy: Current status and future directions. Medical Principles and Practice, 24(Suppl 1), 14\u201328. https:\/\/doi.org\/10.1159\/000362416","journal-title":"Medical Principles and Practice"},{"issue":"3","key":"781_CR39","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1007\/s12253-018-0535-0","volume":"25","author":"MJ Carvalho","year":"2019","unstructured":"Carvalho, M. J., Laranjo, M., Abrantes, A. M., Casalta-Lopes, J., Sarmento-Santos, D., Costa, T., Serambeque, B., Almeida, N., Gon\u00e7alves, T., Mamede, C., Encarna\u00e7\u00e3o, J., Oliveira, R., Paiva, A., de Carvalho, R., Botelho, F., & Oliveira, C. (2019). Endometrial cancer spheres show cancer stem cells phenotype and preference for oxidative metabolism. Pathology and Oncology Research, 25(3), 1163\u20131174. https:\/\/doi.org\/10.1007\/s12253-018-0535-0","journal-title":"Pathology and Oncology Research"},{"issue":"10","key":"781_CR40","first-page":"2355","volume":"56","author":"CJ Gomer","year":"1996","unstructured":"Gomer, C. J., Ryter, S. W., Ferrario, A., Rucker, N., Wong, S., & Fisher, A. M. (1996). Photodynamic therapy-mediated oxidative stress can induce expression of heat shock proteins. Cancer Research, 56(10), 2355\u20132360.","journal-title":"Cancer Research"},{"issue":"9","key":"781_CR41","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1039\/c6pp00097e","volume":"15","author":"ME Rodr\u00edguez","year":"2016","unstructured":"Rodr\u00edguez, M. E., Cogno, I. S., Milla Sanabria, L. S., Mor\u00e1n, Y. S., & Rivarola, V. A. (2016). Heat shock proteins in the context of photodynamic therapy: Autophagy, apoptosis and immunogenic cell death. Photochemical and Photobiological Sciences, 15(9), 1090\u20131102. https:\/\/doi.org\/10.1039\/c6pp00097e","journal-title":"Photochemical and Photobiological Sciences"},{"key":"781_CR42","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.freeradbiomed.2012.11.010","volume":"56","author":"S Singh","year":"2013","unstructured":"Singh, S., Brocker, C., Koppaka, V., Chen, Y., Jackson, B. C., Matsumoto, A., Thompson, D. C., & Vasiliou, V. (2013). Aldehyde dehydrogenases in cellular responses to oxidative\/electrophilic stress. Free Radical Biology & Medicine, 56, 89\u2013101. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2012.11.010","journal-title":"Free Radical Biology & Medicine"}],"updated-by":[{"DOI":"10.1007\/s43630-025-00827-3","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000}}],"container-title":["Photochemical &amp; Photobiological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43630-025-00781-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43630-025-00781-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43630-025-00781-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T06:34:14Z","timestamp":1765262054000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43630-025-00781-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["781"],"URL":"https:\/\/doi.org\/10.1007\/s43630-025-00781-0","relation":{},"ISSN":["1474-905X","1474-9092"],"issn-type":[{"value":"1474-905X","type":"print"},{"value":"1474-9092","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"5 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2025","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s43630-025-00827-3","URL":"https:\/\/doi.org\/10.1007\/s43630-025-00827-3","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare they have no financial and non-financial interests.\n                      Ethical declaration\n                      Animal experiments were conducted in compliance with the guidelines of the Animal Welfare Authority of the Animal Science Faculty at the Institute of Clinical and Biomedical Research of the Faculty of Medicine of the University of Coimbra (Approval Reference: 01\u20132022) and European Union regulations. The project also received approval from the\n                      Dire\u00e7\u00e3o Geral de Alimenta\u00e7\u00e3o e Veterin\u00e1ria\n                      (Portugal), with the Approval Reference 0421\/000\/000\/2022, dated June 15\n                      th\n                      , 2022.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}