{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T02:54:14Z","timestamp":1761706454292,"version":"3.40.5"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["CEECINST\/00077\/2018","PTDC\/BTM-ORG\/28070\/2017","PTDC\/BTM-ORG\/28070\/2017","PTDC\/BTM-ORG\/28168\/2017","PTDC\/NAN-MAT\/28468\/2017","PTDC\/NAN-MAT\/28468\/2017"],"award-info":[{"award-number":["CEECINST\/00077\/2018","PTDC\/BTM-ORG\/28070\/2017","PTDC\/BTM-ORG\/28070\/2017","PTDC\/BTM-ORG\/28168\/2017","PTDC\/NAN-MAT\/28468\/2017","PTDC\/NAN-MAT\/28468\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["CEECIND\/00352\/2017","PTDC\/BTM-ORG\/28070\/2017"],"award-info":[{"award-number":["CEECIND\/00352\/2017","PTDC\/BTM-ORG\/28070\/2017"]}]},{"DOI":"10.13039\/100010684","name":"H2020 Spreading Excellence and Widening Participation","doi-asserted-by":"publisher","award":["668983"],"award-info":[{"award-number":["668983"]}],"id":[{"id":"10.13039\/100010684","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In vitro models"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s44164-022-00014-z","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T14:03:55Z","timestamp":1648476235000},"page":"119-123","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Forecast cancer: the importance of biomimetic 3D in vitro models in cancer drug testing\/discovery and therapy"],"prefix":"10.1007","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7930-2535","authenticated-orcid":false,"given":"D.","family":"Caballero","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1251-700X","authenticated-orcid":false,"given":"B.","family":"Kundu","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9116-2395","authenticated-orcid":false,"given":"C. M.","family":"Abreu","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6150-9412","authenticated-orcid":false,"given":"S.","family":"Amorim","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9531-6259","authenticated-orcid":false,"given":"D. C.","family":"Fernandes","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9197-0138","authenticated-orcid":false,"given":"R. A.","family":"Pires","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7052-8837","authenticated-orcid":false,"given":"J. M.","family":"Oliveira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5516-7583","authenticated-orcid":false,"given":"V. M.","family":"Correlo","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4295-6129","authenticated-orcid":false,"given":"R. L.","family":"Reis","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7170-2291","authenticated-orcid":false,"given":"S. C.","family":"Kundu","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"issue":"1","key":"14_CR1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s41231-019-0050-7","volume":"4","author":"AA Seyhan","year":"2019","unstructured":"Seyhan AA. Lost in translation: the valley of death across preclinical and clinical divide \u2013 identification of problems and overcoming obstacles. Transl Med Commun. 2019;4(1):18.","journal-title":"Transl Med Commun"},{"issue":"119744","key":"14_CR2","first-page":"26","volume":"232","author":"V Brancato","year":"2020","unstructured":"Brancato V, et al. Could 3D models of cancer enhance drug screening? Biomaterials. 2020;232(119744):26.","journal-title":"Biomaterials"},{"key":"14_CR3","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.biomaterials.2017.10.005","volume":"149","author":"D Caballero","year":"2017","unstructured":"Caballero D, et al. Organ-on-chip models of cancer metastasis for future personalized medicine: from chip to the patient. Biomaterials. 2017;149:98\u2013115.","journal-title":"Biomaterials"},{"key":"14_CR4","doi-asserted-by":"crossref","unstructured":"Caballero D, et al. Chapter 15 - Microfluidic systems in cancer research. In: Kundu SC, Reis RL, editors. Biomaterials for 3D tumor modeling. Amsterdam: Elsevier; 2020. p. 331\u201377.","DOI":"10.1016\/B978-0-12-818128-7.00015-0"},{"key":"14_CR5","doi-asserted-by":"crossref","unstructured":"Guimar\u00e3es CF, et al. Engineering polysaccharide-based hydrogel photonic constructs: from multiscale detection to the biofabrication of living optical fibers. Adv Mater. 2021;33:2105361.","DOI":"10.1002\/adma.202105361"},{"key":"14_CR6","doi-asserted-by":"publisher","first-page":"121299","DOI":"10.1016\/j.biomaterials.2021.121299","volume":"280","author":"D Caballero","year":"2022","unstructured":"Caballero D, et al. Precision biomaterials in cancer theranostics and modelling. Biomaterials. 2022;280:121299.","journal-title":"Biomaterials"},{"issue":"9","key":"14_CR7","doi-asserted-by":"publisher","first-page":"e2101019","DOI":"10.1002\/adbi.202101019","volume":"5","author":"D Caballero","year":"2021","unstructured":"Caballero D, et al. Tumor-associated protrusion fluctuations as a signature of cancer invasiveness. Adv Biol. 2021;(9):e2101019.","journal-title":"Adv Biol"},{"issue":"16","key":"14_CR8","doi-asserted-by":"publisher","first-page":"14548","DOI":"10.1021\/acsami.8b22724","volume":"11","author":"B Kundu","year":"2019","unstructured":"Kundu B, et al. Mechanical property of hydrogels and the presence of adipose stem cells in tumor stroma affect spheroid formation in the 3D osteosarcoma model. ACS Appl Mater Interf. 2019;11(16):14548\u201359.","journal-title":"ACS Appl Mater Interf"},{"key":"14_CR9","doi-asserted-by":"crossref","unstructured":"Kundu B, et al. adipoSIGHT in therapeutic response: consequences in osteosarcoma treatment. Bioengineering. 2021;8(6):83.","DOI":"10.3390\/bioengineering8060083"},{"key":"14_CR10","doi-asserted-by":"crossref","unstructured":"Brancato V, et al. Tumor-stroma interactions alter the sensitivity of drug in breast cancer. Front Mater. 2020;7(116):1\u201315.","DOI":"10.3389\/fmats.2020.00116"},{"issue":"7","key":"14_CR11","doi-asserted-by":"publisher","first-page":"2000045","DOI":"10.1002\/adbi.202000045","volume":"4","author":"MA Luque-Gonz\u00e1lez","year":"2020","unstructured":"Luque-Gonz\u00e1lez MA, et al. Human microcirculation-on-chip models in cancer research: key integration of lymphatic and blood vasculatures. Adv Biosyst. 2020;4(7):2000045.","journal-title":"Adv Biosyst"},{"issue":"5","key":"14_CR12","doi-asserted-by":"publisher","first-page":"eaaw1317","DOI":"10.1126\/sciadv.aaw1317","volume":"5","author":"MR Carvalho","year":"2019","unstructured":"Carvalho MR, et al. Colorectal tumor-on-a-chip system: a 3D tool for precision onco-nanomedicine. Sci Adv. 2019;5(5):eaaw1317.","journal-title":"Sci Adv"},{"issue":"6","key":"14_CR13","doi-asserted-by":"publisher","first-page":"581","DOI":"10.2217\/nnm-2016-0344","volume":"12","author":"MR Carvalho","year":"2017","unstructured":"Carvalho MR, et al. A semiautomated microfluidic platform for real-time investigation of nanoparticles\u2019 cellular uptake and cancer cells\u2019 tracking. Nanomedicine. 2017;12(6):581\u201396.","journal-title":"Nanomedicine"},{"key":"14_CR14","doi-asserted-by":"crossref","unstructured":"Caballero D, Reis RL, Kundu SC. Engineering patient-on-a-chip models for personalized cancer medicine. In: Oliveira JM, Reis RL, editors. Biomaterials- and microfluidics-based tissue engineered 3D models. Cham: Springer International Publishing;\u00a02020. p. 43\u201364.","DOI":"10.1007\/978-3-030-36588-2_4"},{"issue":"5\u20136","key":"14_CR15","first-page":"26","volume":"2","author":"MR Carvalho","year":"2018","unstructured":"Carvalho MR, et al. Tuning enzymatically crosslinked silk fibroin hydrogel properties for the development of a colorectal cancer extravasation 3D model on a chip. Glob Chall. 2018;2(5\u20136):26.","journal-title":"Glob Chall"},{"issue":"1","key":"14_CR16","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.tibtech.2020.06.003","volume":"39","author":"S Amorim","year":"2021","unstructured":"Amorim S, et al. Extracellular matrix mimics using hyaluronan-based biomaterials. Trends Biotechnol. 2021;39(1):90\u2013104.","journal-title":"Trends Biotechnol"},{"issue":"1","key":"14_CR17","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1039\/D0BM00843E","volume":"9","author":"S Amorim","year":"2021","unstructured":"Amorim S, et al. 3D hydrogel mimics of the tumor microenvironment: the interplay among hyaluronic acid, stem cells and cancer cells. Biomater Sci. 2021;9(1):252\u201360.","journal-title":"Biomater Sci"},{"issue":"3","key":"14_CR18","doi-asserted-by":"publisher","first-page":"032001","DOI":"10.1088\/1758-5090\/abec2c","volume":"13","author":"G Decante","year":"2021","unstructured":"Decante G, et al. Engineering bioinks for 3D bioprinting. Biofabrication. 2021;13(3):032001.","journal-title":"Biofabrication"},{"key":"14_CR19","doi-asserted-by":"crossref","unstructured":"Pierantoni L, et al. Chapter 7 - Biomaterials as ECM-like matrices for 3D in vitro tumor models. In: Kundu SC, Reis RL, editors. Biomaterials for 3D tumor modeling. Amsterdam: Elsevier; 2020. p. 157\u201373.","DOI":"10.1016\/B978-0-12-818128-7.00007-1"},{"issue":"46","key":"14_CR20","doi-asserted-by":"publisher","first-page":"2104245","DOI":"10.1002\/adfm.202104245","volume":"31","author":"SM Bakht","year":"2021","unstructured":"Bakht SM, et al. 3D bioprinting of miniaturized tissues embedded in self-assembled nanoparticle-based fibrillar platforms. Adv Funct Mater. 2021;31(46):2104245.","journal-title":"Adv Funct Mater"},{"key":"14_CR21","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.bios.2018.12.057","volume":"130","author":"R Rebelo","year":"2019","unstructured":"Rebelo R, et al. 3D biosensors in advanced medical diagnostics of high mortality diseases. Biosens Bioelectron. 2019;130:20\u201339.","journal-title":"Biosens Bioelectron"}],"container-title":["In vitro models"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s44164-022-00014-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s44164-022-00014-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s44164-022-00014-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T09:10:08Z","timestamp":1651828208000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s44164-022-00014-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,28]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["14"],"URL":"https:\/\/doi.org\/10.1007\/s44164-022-00014-z","relation":{},"ISSN":["2731-3441"],"issn-type":[{"type":"electronic","value":"2731-3441"}],"subject":[],"published":{"date-parts":[[2022,3,28]]},"assertion":[{"value":"31 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}