{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T19:49:40Z","timestamp":1780688980413,"version":"3.54.1"},"reference-count":181,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[1985,5,1]],"date-time":"1985-05-01T00:00:00Z","timestamp":483753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1985,5,1]],"date-time":"1985-05-01T00:00:00Z","timestamp":483753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[1985,5]]},"DOI":"10.1016\/0002-8703(85)90712-4","type":"journal-article","created":{"date-parts":[[2004,4,17]],"date-time":"2004-04-17T02:15:37Z","timestamp":1082168137000},"page":"1211-1223","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"P2","title":["Acebutolol: Ten years of experience"],"prefix":"10.1016","volume":"109","author":[{"given":"George","family":"De Bono","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive M.","family":"Kaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmond","family":"Roland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.H.","family":"Summers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/0002-8703(85)90712-4_BIB1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.2042-7158.1981.tb13743.x","article-title":"An investigation of the comparative liposolubilities of beta-adrenoceptor blocking agents","volume":"33","author":"Woods","year":"1981","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.2042-7158.1978.tb10763.x","article-title":"Lung accumulation of some beta-adrenoceptor antagonists","volume":"30","author":"Street","year":"1978","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.2042-7158.1977.tb11520.x","article-title":"The central uptake of beta-adrenoceptor antagonists","volume":"29","author":"Day","year":"1977","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1365-2125.1980.tb01067.x","article-title":"Blood plasma binding of acebutolol and diacetolol in man","volume":"9","author":"Coombs","year":"1980","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB5","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1365-2125.1981.tb01239.x","article-title":"The penetration of acebutolol and its major metabolite, diacetolol, into human cerebrospinal fluid and saliva","volume":"12","author":"Zaman","year":"1981","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB6","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0021-9673(76)80023-4","article-title":"A thin-layer chromatographic method for the determination of acebutolol and its major metabolite in serum","volume":"120","author":"Steyn","year":"1976","journal-title":"J Chromatogr"},{"key":"10.1016\/0002-8703(85)90712-4_BIB7","first-page":"31","article-title":"Quantitation in plasma and urine of acebutolol and a major metabolite with preliminary observations on their disposition","volume":"15","author":"Meffin","year":"1976","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB8","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0009-8981(80)90009-1","article-title":"A simple radioimmunoassay of acebutolol in plasma","volume":"108","author":"Gourmel","year":"1980","journal-title":"Clin Chim Acta"},{"key":"10.1016\/0002-8703(85)90712-4_BIB9","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0009-8981(81)90079-6","article-title":"Plasma diacetolol assessment by radioimmunoassay","volume":"115","author":"Gourmel","year":"1981","journal-title":"Clin Chim Acta"},{"key":"10.1016\/0002-8703(85)90712-4_BIB10","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0021-9673(00)92284-2","article-title":"M\u00e9thode sensible de dosage de l'ac\u00e9butolol et de son metabolite N-ac\u00e9tyl\u00e9 dans les milieux biologiques par chromatographie liquide haute performance avec d\u00e9tection de fluorescence","volume":"166","author":"Roux","year":"1978","journal-title":"J Chromatogr"},{"key":"10.1016\/0002-8703(85)90712-4_BIB11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0021-9673(00)98009-9","article-title":"High pressure liquid chromatographic analysis of drugs in biological fluids. V. Analysis of acebutolol and its major metabolite","volume":"138","author":"Meffin","year":"1977","journal-title":"J Chromatogr"},{"key":"10.1016\/0002-8703(85)90712-4_BIB12","first-page":"44","article-title":"High-performance liquid chromatographic analysis of acebutolol and its major metabolites","volume":"56","author":"Ferry","year":"1968"},{"key":"10.1016\/0002-8703(85)90712-4_BIB13","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0378-4347(00)81640-0","article-title":"Evaluation of a modified high-performance liquid chromatographic assay for acebutolol and its major metabolite","volume":"163","author":"Guentert","year":"1979","journal-title":"J Chromatogr"},{"key":"10.1016\/0002-8703(85)90712-4_BIB14","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.2042-7158.1981.tb13811.x","article-title":"Preliminary observations on the excretion of acebutolol and its acetyl metabolite in the urine and faeces of man","volume":"33","author":"Gabriel","year":"1981","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB15","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0378-4347(00)80496-X","article-title":"High-performance liquid chromatography assay of acebutolol and two of its metabolites in plasma and urine","volume":"230","author":"Buskin","year":"1982","journal-title":"J Chromatogr"},{"key":"10.1016\/0002-8703(85)90712-4_BIB16","first-page":"282","article-title":"Use of reversed-phase high-pressure liquid chromatography for the assay of acebutolol, practolol and propranolol in plasma","volume":"12","author":"Holt","year":"1981","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB17","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1080\/01483918108059948","article-title":"Beta-blocking agents: Determinations of biological levels using high-performance liquid chromatography","volume":"4","author":"Lefebvre","year":"1981","journal-title":"J Liquid Chromatogr"},{"key":"10.1016\/0002-8703(85)90712-4_BIB18","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0021-9673(00)87901-7","article-title":"Detection of some antihypertensive drugs and their metabolites in urine by thin-layer chromatography: Five commonly used beta blockers and hydralazine","volume":"187","author":"Jack","year":"1980","journal-title":"J Chromatogr"},{"key":"10.1016\/0002-8703(85)90712-4_BIB19","first-page":"89","article-title":"Chromatographic resolution and stereoselective disposition of acebutolol and diacetolol in dog and man","volume":"81","author":"Boobis","year":"1984","journal-title":"Br J Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB20","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.2042-7158.1984.tb04370.x","article-title":"Preliminary study of the disposition in man of acebutolol and its metabolite, diacetolol, using a new stereoselective HPLC method","volume":"36","author":"Sankey","year":"1984","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB21","first-page":"347","article-title":"Les esp\u00e8ces animales et le m\u00e9tabolisme","volume":"96","author":"Heusse","year":"1980","journal-title":"Inserm"},{"issue":"suppl 3","key":"10.1016\/0002-8703(85)90712-4_BIB22","first-page":"9","article-title":"Acebutolol (\u201cSectral\u201d). I. Review of the pharmacology and pharmacokinetics","volume":"11","author":"Maxwell","year":"1974","journal-title":"Clin Trials J"},{"key":"10.1016\/0002-8703(85)90712-4_BIB23","first-page":"360","article-title":"Metabolism of acebutolol-d6 in the rat correlates with the identification of a new metabolite in human urine","volume":"79","author":"Andresen","year":"1979","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/0002-8703(85)90712-4_BIB24","first-page":"200","article-title":"Acebutolol metabolism in the isolated perfused rat liver","volume":"31","author":"Alexander","year":"1982","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/0002-8703(85)90712-4_BIB25","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1365-2125.1978.tb01634.x","article-title":"Lack of correlation between acetylator status and the production of the acetyl metabolite of acebutolol in man","volume":"5","author":"Gulaid","year":"1978","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB26","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/cpt1977225part1557","article-title":"Acebutolol disposition after intravenous administration","volume":"22","author":"Meffin","year":"1977","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/0002-8703(85)90712-4_BIB27","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/cpt1978245542","article-title":"Dose-dependent acebutolol disposition following oral administration","volume":"24","author":"Meffin","year":"1978","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/0002-8703(85)90712-4_BIB28","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1365-2125.1977.tb00779.x","article-title":"Acebutolol metabolite plasma concentrations during chronic oral therapy","volume":"4","author":"Winkle","year":"1977","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB29","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1365-2125.1980.tb05837.x","article-title":"Pharmacokinetics of acebutolol after intravenous bolus administration","volume":"9","author":"Roux","year":"1980","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB30","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/bdd.2510040309","article-title":"Systemic bioavailability of acebutolol in man","volume":"4","author":"Roux","year":"1983","journal-title":"Biopharm Drug Dispos"},{"key":"10.1016\/0002-8703(85)90712-4_BIB31","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/bdd.2510020202","article-title":"The pharmacokinetics of acebutolol in man, following the oral administration of acebutolol HCl as a single dose (400 mg), and during and after repeated oral dosing (400 mg b.d.)","volume":"2","author":"Gulaid","year":"1981","journal-title":"Biopharm Drug Dispos"},{"key":"10.1016\/0002-8703(85)90712-4_BIB32","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.2042-7158.1976.tb04653.x","article-title":"The biliary excretion of acebutolol in man","volume":"28","author":"Kaye","year":"1976","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB33","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/cpt1976194416","article-title":"Observations on the pharmacokinetics of acebutolol","volume":"19","author":"Kaye","year":"1976","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/0002-8703(85)90712-4_BIB34","first-page":"180","article-title":"Tissue levels of several radiolabeled beta-adrenoceptor antagonists after intravenous administration in rats","volume":"237","author":"Street","year":"1979","journal-title":"Arch Int Pharmacodyn"},{"key":"10.1016\/0002-8703(85)90712-4_BIB35","first-page":"123","article-title":"Metabolic fate of acebutolol","volume":"9","author":"Sakurai","year":"1978","journal-title":"Iyakuhin Kenkyu"},{"key":"10.1016\/0002-8703(85)90712-4_BIB36","first-page":"233","article-title":"Placental transfer and pharmacokinetics of acebutolol in newborn infants","volume":"29","author":"Bianchetti","year":"1981","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/0002-8703(85)90712-4_BIB37","first-page":"2154","article-title":"Passage transplancentaire de l'ac\u00e9butolol et du diacetolol","volume":"11","author":"Daffos","year":"1982","journal-title":"Nouv Presse Med"},{"key":"10.1016\/0002-8703(85)90712-4_BIB38","first-page":"357","article-title":"Le lait, compartiment de diffusion d'un m\u00e9dicament","volume":"37","author":"Tillement","year":"1982","journal-title":"Therapie"},{"key":"10.1016\/0002-8703(85)90712-4_BIB39","first-page":"724","article-title":"Plasma-salivary ratios of acebutolol and propranolol","volume":"4","author":"Kaye","year":"1977","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB40","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1365-2125.1979.tb04724.x","article-title":"Acebutolol saliva excretion","volume":"8","author":"Giudicelli","year":"1979","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB41","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/BF00558446","article-title":"Pharmacokinetics of acebutolol in patients with all grades of renal failure","volume":"17","author":"Roux","year":"1980","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB42","first-page":"346","article-title":"Studies on the disposition and fate of [14C]-acebutolol in man and dog","volume":"3","author":"Collins","year":"1976","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB43","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.2042-7158.1979.tb13613.x","article-title":"Elimination of drugs by active intestinal transport","volume":"31","author":"George","year":"1979","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB44","first-page":"225","article-title":"Acebutolol kinetics following oral and intravenous administration in man","volume":"35","author":"Alexander","year":"1984","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/0002-8703(85)90712-4_BIB45","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1365-2125.1979.tb04644.x","article-title":"Pharmacokinetics, pharmacology of atenolol and effect of renal disease","volume":"7","author":"Wan","year":"1979","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB46","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/clpt.1980.166","article-title":"Atenolol kinetics in renal failure","volume":"28","author":"McAinsh","year":"1980","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/0002-8703(85)90712-4_BIB47","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1056\/NEJM198108273050907","article-title":"Beta-adrenoceptor antagonists: New drugs and new indications","volume":"305","author":"Frishman","year":"1981","journal-title":"N Engl J Med"},{"key":"10.1016\/0002-8703(85)90712-4_BIB48","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1365-2125.1976.tb00601.x","article-title":"The effect of end-stage renal failure and haemodialysis on the elimination kinetics of sotalol","volume":"3","author":"Tjandramaga","year":"1976","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB49","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0014-2999(82)90176-5","article-title":"Pharmacological properties of diacetolol (M&B 16,942), a major metabolite of acebutolol","volume":"80","author":"Basil","year":"1982","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB50","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/bdd.2510050112","article-title":"The effect of food and alcohol on the pharmacokinetics of acebutolol and its metabolite, diacetolol","volume":"5","author":"Zaman","year":"1984","journal-title":"Biopharm Drug Dispos"},{"key":"10.1016\/0002-8703(85)90712-4_BIB51","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF00562806","article-title":"Pharmacokinetics and bioavailability of diacetolol, the main metabolite of acebutolol","volume":"19","author":"Flouvat","year":"1981","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB52","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1365-2125.1979.tb04642.x","article-title":"Onset and duration of beta-adrenergic receptor blockade following single oral dose acebutolol hydrochloride (\u201cSectral\u201d)","volume":"7","author":"Watson","year":"1979","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB53","first-page":"835","article-title":"Dose-response relationship and duration of action of acebutolol","volume":"32","author":"Kober","year":"1982","journal-title":"Arzneimittel Forsch"},{"key":"10.1016\/0002-8703(85)90712-4_BIB54","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF01061375","article-title":"Variability of beta-blocker pharmacokinetics in young volunteers","volume":"23","author":"Jack","year":"1982","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB55","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1365-2125.1976.tb00590.x","article-title":"The influence of pH on the buccal absorption and plasma and renal elimination of acebutolol","volume":"3","author":"Kaye","year":"1976","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB56","first-page":"282","article-title":"Resorption, verteilung und elimination von acebutolol und seinem hauptmetaboliten noch intravenoeser und chronisch oraler gabe","volume":"70","author":"Kirch","year":"1981","journal-title":"Z Kardiol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB57","first-page":"746","article-title":"Compilation of pharmacokinetic parameters of beta-adrenergic blocking agents","volume":"14","author":"Ritschel","year":"1980","journal-title":"Drug Intell Clin Pharm"},{"key":"10.1016\/0002-8703(85)90712-4_BIB58","first-page":"123","article-title":"Influence of age on the pharmacokinetics of acebutolol","volume":"15","author":"Vincon","year":"1984","journal-title":"J Pharmacol (Paris)"},{"key":"10.1016\/0002-8703(85)90712-4_BIB59","first-page":"799","article-title":"Pharmacokinetics of acebutolol in renal insufficiency","volume":"82","author":"Aubert","year":"1976","journal-title":"J Urol Nephrol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB60","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1365-2125.1976.tb00591.x","article-title":"Preliminary observations on the elimination of acebutolol in severe chronic renal failure","volume":"3","author":"Kaye","year":"1976","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB61","first-page":"289","article-title":"Plasma and urine concentrations of acebutolol and its acetyl metabolite in patients with renal functional impairment","volume":"i","author":"Munn","year":"1980","journal-title":"NZ Med J"},{"key":"10.1016\/0002-8703(85)90712-4_BIB62","first-page":"286","article-title":"Pharmacokinetics of acebutolol and its acetyl metabolite, in hypertensive patients and in renal use","volume":"77","author":"De Villiers","year":"1981","journal-title":"S Afr J Sci"},{"key":"10.1016\/0002-8703(85)90712-4_BIB63","first-page":"635","article-title":"Influence de la fixation proteique sur la clairance de dialyse de plusiers b\u00eata-bloquants, chex l'h\u00e9modialys\u00e9 chronique","volume":"37","author":"Decourt","year":"1982","journal-title":"Therapie"},{"key":"10.1016\/0002-8703(85)90712-4_BIB64","first-page":"88","article-title":"The influence of renal function on plasma levels and urinary excretion of acebutolol and its main N-acetyl metabolite","volume":"18","author":"Kirch","year":"1982","journal-title":"Clin Nephrol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB65","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1365-2125.1983.tb02158.x","article-title":"Acebutolol pharmacokinetics in renal disease","volume":"16","author":"Smith","year":"1983","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB66","first-page":"608","article-title":"Plasma protein binding of beta blockers and its influence on dialysis in patients with chronic renal insufficiency","volume":"37","author":"Decourt","year":"1982","journal-title":"Therapie"},{"key":"10.1016\/0002-8703(85)90712-4_BIB67","unstructured":"Zaman R, Jack DB, Wilkins, MR, Kendall MJ. Lack of effect of liver disease on the pharmacokinetics of acebutolol and diacetolol: A single-dose study. Biopharm Drug Dispos (in press)."},{"key":"10.1016\/0002-8703(85)90712-4_BIB68","first-page":"15","article-title":"Pharmacokinetics of acebutolol in hypertensive children: Plasma levels compared with those in adults","volume":"10","author":"Guillot","year":"1980","journal-title":"Sci Med (France)"},{"key":"10.1016\/0002-8703(85)90712-4_BIB69","first-page":"144","article-title":"Pharmacokinetics of acebutolol in elderly as compared to young volunteers","volume":"3","author":"Roux","year":"1981"},{"key":"10.1016\/0002-8703(85)90712-4_BIB70","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000213115","article-title":"A pharmacokinetic study of acebutolol in aged subjects as compared to young subjects","volume":"29","author":"Roux","year":"1983","journal-title":"Gerontology"},{"key":"10.1016\/0002-8703(85)90712-4_BIB71","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/BF00607091","article-title":"Pharmacokinetics in man of acebutolol and hydrochlorothiazide as single agents and in combination","volume":"24","author":"Roux","year":"1983","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB72","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1365-2125.1982.tb01412.x","article-title":"The effect of acebutolol and propranolol on the hypoglycaemic action of glibenclamide","volume":"13","author":"Zaman","year":"1982","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB73","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/00005344-198103000-00017","article-title":"Sulfinpyrazone does not alter the pharmacokinetics of acebutolol","volume":"3","author":"Patard","year":"1981","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB74","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2165\/00003088-198207010-00003","article-title":"Clinical pharmacokinetics and potentially important drug interactions of sulfinpyrazone","volume":"7","author":"Pedersen","year":"1982","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/0002-8703(85)90712-4_BIB75","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/bdd.2510030107","article-title":"The effect of hydralazine on the pharmacokinetics of three different beta-adrenoceptor antagonists: Metoprolol, nadolol and acebutolol","volume":"3","author":"Jack","year":"1982","journal-title":"Biopharm Drug Dispos"},{"issue":"suppl 2","key":"10.1016\/0002-8703(85)90712-4_BIB76","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2165\/00003495-198300252-00036","article-title":"Inhibition of drug metabolism by beta-adrenoceptor antagonists","volume":"25","author":"Bax","year":"1983","journal-title":"Drug"},{"key":"10.1016\/0002-8703(85)90712-4_BIB77","doi-asserted-by":"crossref","first-page":"21S","DOI":"10.1111\/j.1365-2125.1984.tb02424.x","article-title":"Effects of beta-adrenoceptor antagonists on the pharmacokinetics of lignocaine","volume":"17","author":"Tucker","year":"1984","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB78","doi-asserted-by":"crossref","first-page":"87S","DOI":"10.1111\/j.1365-2125.1984.tb02435.x","article-title":"Beta-adrenoceptor blocker pharmacokinetics and the oral contraceptive pill","volume":"17","author":"Kendall","year":"1984","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB79","series-title":"Pharmacology of antihypertensive drugs","first-page":"283","article-title":"Acebutolol","author":"Basil","year":"1980"},{"key":"10.1016\/0002-8703(85)90712-4_BIB80","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0140-6736(75)90001-X","article-title":"Cardiac and pulmonary effects of acebutolol","volume":"2","author":"Kumana","year":"1975","journal-title":"Lancet"},{"key":"10.1016\/0002-8703(85)90712-4_BIB81","first-page":"473","article-title":"Comparative beta-blocking potencies of acebutolol and propranolol relative to plasma drug levels","volume":"19","author":"Collett","year":"1981","journal-title":"Int J Clin Pharmacol Ther Toxicol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB82","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1365-2125.1975.tb00471.x","article-title":"Plasma levels and beta-adrenoceptor blockade with acebutolol, practolol and propranolol in man","volume":"2","author":"Cuthbert","year":"1975","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB83","first-page":"725","article-title":"Heart rate response to glyceryl trinitrate as a test of beta-adrenergic blockade: A reappraisal","volume":"43","author":"Stallard","year":"1980","journal-title":"Br Heart J"},{"key":"10.1016\/0002-8703(85)90712-4_BIB84","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1365-2125.1981.tb01265.x","article-title":"Observations on the clinical pharmacology and plasma concentrations of diacetolol, the major human metabolite of acebutolol","volume":"12","author":"Ohashi","year":"1981","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB85","first-page":"358","article-title":"The beta-blocking effect of diacetolol in humans and its relationship to plasma levels","volume":"20","author":"Flouvat","year":"1982","journal-title":"Int J Clin Pharmacol Ther Toxicol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB86","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/BF00716378","article-title":"Acebutolol in hypertension: Relationship between drug concentration and effects","volume":"14","author":"Martin","year":"1978","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB87","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1365-2125.1979.tb00974.x","article-title":"The effects of time on the activity of beta-adrenoceptor blocking drugs","volume":"7","author":"Harry","year":"1979","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB88","series-title":"Atenolol and renal function","first-page":"93","article-title":"The chemistry of beta-adrenergic blocking agents relative to cardioselectivity","volume":"19","author":"Smith","year":"1979"},{"key":"10.1016\/0002-8703(85)90712-4_BIB89","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0022-3565(25)30687-7","article-title":"Isoproterenol antagonism of cardioselective beta-adrenergic receptor blocking agents: A comparative study of human and guinea-pig cardiac and bronchial beta adrenergic receptors","volume":"199","author":"Harms","year":"1976","journal-title":"J Pharmacol Exp Ther"},{"issue":"suppl 2","key":"10.1016\/0002-8703(85)90712-4_BIB90","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2165\/00003495-198300252-00066","article-title":"Effect of beta-blocker therapy on airway function","volume":"25","author":"Tattersfield","year":"1983","journal-title":"Drugs"},{"key":"10.1016\/0002-8703(85)90712-4_BIB91","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1136\/hrt.40.2.184","article-title":"Beta blockers and asthma","volume":"40","author":"Decalmer","year":"1978","journal-title":"Br Heart J"},{"key":"10.1016\/0002-8703(85)90712-4_BIB92","first-page":"1","article-title":"Pulmonary effects of acebutolol, a \u201ccardioselective\u201d beta-adrenergic blocking agent","volume":"20","author":"DiBianco","year":"1982","journal-title":"Int J Clin Pharmacol Ther Toxicol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB93","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/BF00542093","article-title":"Comparative study of the ventilatory effects of three beta1-selective blocking agents in asthmatic patients","volume":"20","author":"Greefhorst","year":"1981","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB94","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1097\/00005344-198300051-00007","article-title":"Beta-adrenoceptor blockade and pulmonary function in patients suffering from chronic obstructive lung disease","volume":"5","author":"Van Heerwaarden","year":"1983","journal-title":"J Cardiovasc Pharmacol"},{"issue":"suppl 3","key":"10.1016\/0002-8703(85)90712-4_BIB95","first-page":"143","article-title":"Cardioselective and non-cardioselective beta-blockers in reversible obstructive airways disease","volume":"53","author":"Benson","year":"1977","journal-title":"Postgrad Med J"},{"key":"10.1016\/0002-8703(85)90712-4_BIB96","first-page":"67","article-title":"Influence of acebutolol on the haemodynamic and respiratory function of asthmatic patients","volume":"2","author":"Mue","year":"1979","journal-title":"J Pharmacother"},{"key":"10.1016\/0002-8703(85)90712-4_BIB97","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1161\/01.CIR.62.6.1179","article-title":"Effects of acebutolol on chronic stable angina pectoris: A placebo-controlled, double-blind, randomized crossover study","volume":"62","author":"DiBianco","year":"1980","journal-title":"Circulation"},{"key":"10.1016\/0002-8703(85)90712-4_BIB98","first-page":"519","article-title":"The effect of acebutolol, a beta adrenergic blocking agent, and placebo on pulmonary function in asthmatics","volume":"19","author":"Nair","year":"1981","journal-title":"Int J Clin Pharmacol Ther Toxicol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB99","first-page":"116","article-title":"Influence of propranolol and acebutolol on isoprenaline-induced changes in heart rate and peripheral blood flow in man","volume":"251","author":"Mougeot","year":"1981","journal-title":"Arch Int Pharmacodyn"},{"key":"10.1016\/0002-8703(85)90712-4_BIB100","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1365-2125.1981.tb01227.x","article-title":"The effect of oral acebutolol and propranolol on forearm blood flow in hypertensive patients","volume":"12","author":"Ireland","year":"1981","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB101","first-page":"781","article-title":"A comparison and two beta-blocking drugs in patients with Raynaud's phenomenon","volume":"226","author":"Holti","year":"1982","journal-title":"Practitioner"},{"key":"10.1016\/0002-8703(85)90712-4_BIB102","series-title":"Clinical hypertension","article-title":"Beta-adrenoceptor blocking drugs in hypertension","author":"Roland","year":"1985"},{"key":"10.1016\/0002-8703(85)90712-4_BIB103","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1002\/cpt1979256813","article-title":"Acute hemodynamic effects and cardioselectivity of acebutolol, practolol and propranolol","volume":"25","author":"Wollam","year":"1979","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/0002-8703(85)90712-4_BIB104","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1136\/bmj.2.6033.447","article-title":"Comparison of propranolol, metoprolol and acebutolol on insulin-induced hypoglycaemia","volume":"2","author":"Newman","year":"1976","journal-title":"Br Med J"},{"key":"10.1016\/0002-8703(85)90712-4_BIB105","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1136\/bmj.2.6097.1255","article-title":"Acebutolol, atenolol and propranolol and metabolic responses to acute hypoglycaemia in diabetics","volume":"2","author":"Deacon","year":"1977","journal-title":"Br Med J"},{"key":"10.1016\/0002-8703(85)90712-4_BIB106","first-page":"55","article-title":"Beta-adrenoceptor blockade and physical activity: Cardiovascular and metabolic aspects","volume":"672","author":"Koch","year":"1982","journal-title":"Acta Med Scand (suppl)"},{"key":"10.1016\/0002-8703(85)90712-4_BIB107","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1136\/bmj.2.6087.601","article-title":"Comparison of the antilipolytic effect of metoprolol, acebutolol, and propranolol in man","volume":"2","author":"Newman","year":"1977","journal-title":"Br Med J"},{"key":"10.1016\/0002-8703(85)90712-4_BIB108","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1136\/hrt.40.1.29","article-title":"Haemodynamic effects of acebutolol","volume":"40","author":"Mason","year":"1978","journal-title":"Br Heart J"},{"key":"10.1016\/0002-8703(85)90712-4_BIB109","first-page":"11","article-title":"After-load advantage of cardioselective blockade by acebutolol versus propranolol: Hemodynamic assessment by cardiac catheterization in coronary patients","volume":"58","author":"Joye","year":"1978","journal-title":"Circulation"},{"key":"10.1016\/0002-8703(85)90712-4_BIB110","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00005344-198300051-00004","article-title":"Central hemodynamics of beta-adrenoceptor blocking drugs: Beta1 selectivity versus intrinsic sympathomimetic activity","volume":"5","author":"Svendsen","year":"1983","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB111","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2125.1981.tb00532.x","article-title":"Acute effects of acebutolol on cardiovascular function in man","volume":"11","author":"Dalal","year":"1981","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB112","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/clpt.1981.24","article-title":"Acebutolol and left ventricular function: Assessment by radionuclide angiography","volume":"29","author":"Katz","year":"1981","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/0002-8703(85)90712-4_BIB113","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/clpt.1980.64","article-title":"Effects of acebutolol and propranolol on left ventricular performance assessed by echocardiography","volume":"27","author":"Chandraratna","year":"1980","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/0002-8703(85)90712-4_BIB114","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1136\/hrt.40.1.22","article-title":"Haemodynamic effects of atenolol in patients with coronary artery disease","volume":"40","author":"Robinson","year":"1978","journal-title":"Br Heart J"},{"key":"10.1016\/0002-8703(85)90712-4_BIB115","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/0002-8703(80)90201-X","article-title":"Hemodynamic effects of newer antiarrhythmic drugs","volume":"100","author":"Jewitt","year":"1980","journal-title":"Am Heart J"},{"key":"10.1016\/0002-8703(85)90712-4_BIB116","first-page":"245","article-title":"How intrinsic sympathomimetic activity modulates the haemodynamic responses to beta-adrenoceptor antagonists: A clue to the nature of their antihypertensive mechanism","volume":"13","author":"Man in 't Veld","year":"1982","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB117","first-page":"429","article-title":"The beta-blocker dilemma: Is intrinsic sympathomimetic activity an advantage or not?","volume":"13","author":"James","year":"1983","journal-title":"Geriatric Med"},{"key":"10.1016\/0002-8703(85)90712-4_BIB118","first-page":"81","article-title":"Antihypertensive drugs","volume":"24","author":"Turner","year":"1983","journal-title":"Curr Ther"},{"key":"10.1016\/0002-8703(85)90712-4_BIB119","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1177\/106002808401800701","article-title":"Intrinsic sympathomimetic activity: Physiological reality or marketing phenomenon","volume":"18","author":"Black","year":"1984","journal-title":"Drug Intell Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB120","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1136\/bmj.1.6156.77","article-title":"Metabolic consequences of atenolol and propranolol in treatment of essential hypertension","volume":"1","author":"Day","year":"1979","journal-title":"Br Med J"},{"key":"10.1016\/0002-8703(85)90712-4_BIB121","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1161\/01.HYP.5.5_Pt_2.III120","article-title":"Effects of antihypertensive therapy on serum lipoproteins","volume":"5","author":"Weidmann","year":"1983","journal-title":"Hypertension"},{"key":"10.1016\/0002-8703(85)90712-4_BIB122","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.0954-6820.1984.tb03771.x","article-title":"The effect of acebutolol on plasma lipids, blood glucose and serum insulin levels","volume":"216","author":"Lehtonen","year":"1984","journal-title":"Acta Med Scand"},{"key":"10.1016\/0002-8703(85)90712-4_BIB123","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/S0140-6736(83)91239-4","article-title":"Which beta-blocker in pregnancy-induced hypertension?","volume":"2","author":"Lardoux","year":"1983","journal-title":"Lancet"},{"key":"10.1016\/0002-8703(85)90712-4_BIB124","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1365-2125.1982.tb01944.x","article-title":"Treatment of hypertension in pregnancy with beta-adrenoceptor antagonists","volume":"13","author":"Dubois","year":"1982","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB125","first-page":"431","article-title":"Placebo-controlled trial of atenolol in treatment of pregnancy-associated hypertension","volume":"1","author":"Rubin","year":"1983","journal-title":"Lancet"},{"key":"10.1016\/0002-8703(85)90712-4_BIB126","first-page":"487","article-title":"A comparison of acebutolol with methyldopa in hypertensive pregnancy","volume":"3","author":"Williams","year":"1983","journal-title":"Pharmatherapeutics"},{"key":"10.1016\/0002-8703(85)90712-4_BIB127","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/med.2610010405","article-title":"Central actions of beta-adrenoceptor blocking drugs in man","volume":"1","author":"Patel","year":"1981","journal-title":"Med Res Rev"},{"key":"10.1016\/0002-8703(85)90712-4_BIB128","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/BF00562446","article-title":"Central effects of the beta-adrenergic blocking agent acebutolol: A quantitative EEG study using normalised slope descriptors","volume":"12","author":"Kayed","year":"1977","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB129","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/BF00562445","article-title":"Effects of the beta-adrenoceptor antagonists acebutolol and metoprolol on sleep pattern in normal subjects","volume":"12","author":"Kayed","year":"1977","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB130","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1185\/03007998009116512","article-title":"Comparison of effect on psychomotor performance of single doses of propranolol and acebutolol","volume":"7","author":"Broadhurst","year":"1980","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/0002-8703(85)90712-4_BIB131","first-page":"693","article-title":"The use of a beta-blocker (acebutolol, \u201cSectral\u201d) and a benzodiazepine (diazepam) in the treatment of anxiety","volume":"29","author":"Emerson","year":"1981","journal-title":"Curr Ther Res"},{"key":"10.1016\/0002-8703(85)90712-4_BIB132","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1185\/03007997809110206","article-title":"A randomised crossover comparison of acebutolol and methyldopa in the treatment of mild to moderate essential hypertension","volume":"5","author":"Chatterji","year":"1978","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/0002-8703(85)90712-4_BIB133","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1185\/03007997909109398","article-title":"A multicentre study of twice-daily acebutolol (\u201cSectral\u201d) in the treatment of hypertension in general practice","volume":"6","author":"Baker","year":"1979","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/0002-8703(85)90712-4_BIB134","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1177\/030006057900700307","article-title":"A multicentre study of a once-daily dosage of acebutolol in the treatment of hypertension in a general practice","volume":"7","author":"Baker","year":"1979","journal-title":"J Int Med Res"},{"key":"10.1016\/0002-8703(85)90712-4_BIB135","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1365-2125.1984.tb02356.x","article-title":"The psychological side-effects of acebutolol and atenolol","volume":"17","author":"Lewis","year":"1984","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB136","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1185\/03007997609112001","article-title":"An open, multicentre study of acebutolol in hypertension","volume":"4","author":"Ashton","year":"1976","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/0002-8703(85)90712-4_BIB137","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/0002-9343(76)90909-8","article-title":"Rapid identification of patients with essential hypertension sensitive to acebutolol (a new cardioselective beta-blocker)","volume":"60","author":"Menard","year":"1976","journal-title":"Am J Med"},{"key":"10.1016\/0002-8703(85)90712-4_BIB138","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/0002-9343(78)90456-4","article-title":"Comparison of the antihypertensive and hormonal effects of a cardioselective beta-blocker, acebutolol, and diuretics in essential hypertension","volume":"64","author":"Alhenc-Gelas","year":"1978","journal-title":"Am J Med"},{"key":"10.1016\/0002-8703(85)90712-4_BIB139","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/clpt.1980.165","article-title":"Acebutolol and hydrochlorothiazide in essential hypertension","volume":"28","author":"Nadeau","year":"1980","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/0002-8703(85)90712-4_BIB140","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1161\/01.HYP.4.2.320","article-title":"Cardioselective effects of acebutolol and hydrochlorothiazide in essential hypertension","volume":"4","author":"Ogilvie","year":"1982","journal-title":"Hypertension"},{"key":"10.1016\/0002-8703(85)90712-4_BIB141","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/clpt.1981.232","article-title":"Addition of acebutolol to diuretics in hypertension","volume":"30","author":"Gorkin","year":"1981","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/0002-8703(85)90712-4_BIB142","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/j.1552-4604.1982.tb05703.x","article-title":"Merits of adding a beta-blocker (acebutolol) to a diuretic (hydrochlorothiazide) in the treatment of hypertension","volume":"22","author":"Belleau","year":"1982","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB143","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1365-2125.1982.tb01358.x","article-title":"Antihypertensive action of acebutolol (Sectral) when used concomitantly with hydrochlorothiazide","volume":"13","author":"Mitenko","year":"1982","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB144","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0002-9149(80)90075-2","article-title":"Differential antihypertensive effect of acebutolol and hydrochlorothiazide\/amiloride combination on elevated blood pressure in hypertensive patients","volume":"46","author":"Franz","year":"1980","journal-title":"Am J Cardiol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB145","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0002-8703(85)90600-3","article-title":"Comparison of acebutolol and propranolol in essential hypertension","volume":"109","author":"Wahl","year":"1985","journal-title":"Am Heart J"},{"key":"10.1016\/0002-8703(85)90712-4_BIB146","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.0954-6820.1982.tb08532.x","article-title":"Comparison of two cardioselective beta blockers with different ancillary properties in the treatment of hypertension","volume":"668","author":"Manttari","year":"1982","journal-title":"Acta Med Scand (Suppl)"},{"key":"10.1016\/0002-8703(85)90712-4_BIB147","first-page":"964","article-title":"Double-blind cross-over study of two beta-blocking agents acebutolol and propranolol in essential hypertension","volume":"28","author":"Singh","year":"1980","journal-title":"Curr Res"},{"key":"10.1016\/0002-8703(85)90712-4_BIB148","series-title":"Beta-blockade in clinical practice: Current trends","first-page":"40","article-title":"Trial of acebutolol and atenolol in the treatment of mild to moderate hypertension","author":"Smith","year":"1979"},{"key":"10.1016\/0002-8703(85)90712-4_BIB149","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1185\/03007998309109800","article-title":"Comparison of efficacy of a single daily dose of 400 mg acebutolol and 100 mg atenolol in the treatment of arterial hypertension","volume":"8","author":"Turner","year":"1983","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/0002-8703(85)90712-4_BIB150","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF00645127","article-title":"Controlled trial of acebutolol in hypertension","volume":"12","author":"Hansson","year":"1977","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB151","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1365-2125.1978.tb00863.x","article-title":"Acebutolol in hypertension: A double-blind trial against placebo","volume":"6","author":"Martin","year":"1978","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB152","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1185\/03007997709110180","article-title":"An open multicentre study of acebutolol, given as a single daily dose, in the management of hypertension","volume":"5","author":"Ashton","year":"1977","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/0002-8703(85)90712-4_BIB153","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1365-2125.1980.tb05835.x","article-title":"Comparison of once- and twice-daily administration of acebutolol in hypertension","volume":"9","author":"Watson","year":"1980","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB154","series-title":"Beta-blockade in clinical practice: Current trends","first-page":"3","article-title":"Multifactorial analysis of the antihypertensive effect of acebutolol","author":"Cody","year":"1979"},{"key":"10.1016\/0002-8703(85)90712-4_BIB155","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1365-2125.1982.tb01924.x","article-title":"Effects of adrenoceptor antagonists on central haemodynamics in essential hypertension","volume":"13","author":"Tsukiyama","year":"1982","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB156","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/0002-9343(81)90530-1","article-title":"Diuretic-induced ventricular ectopic activity","volume":"70","author":"Holland","year":"1981","journal-title":"Am J Med"},{"key":"10.1016\/0002-8703(85)90712-4_BIB157","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/0002-9149(83)90229-1","article-title":"New choices for the initial drug therapy of hypertension","volume":"51","author":"Kaplan","year":"1983","journal-title":"Am J Cardiol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB158","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1136\/hrt.41.6.654","article-title":"Reduction of early ventricular arrhythmia by acebutolol in patients with acute myocardial infarction","volume":"41","author":"Ahumada","year":"1979","journal-title":"Br Heart J"},{"key":"10.1016\/0002-8703(85)90712-4_BIB159","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0140-6736(80)92839-1","article-title":"Drugs and the heart","volume":"1","author":"Opie","year":"1980","journal-title":"Lancet"},{"key":"10.1016\/0002-8703(85)90712-4_BIB160","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0002-9343(83)91127-0","article-title":"Role of beta-adrenergic blockade in the therapy of patients with myocardial infarction","volume":"74","author":"Braunwald","year":"1983","journal-title":"Am J Med"},{"key":"10.1016\/0002-8703(85)90712-4_BIB161","first-page":"296","article-title":"Effects of selective and nonselective beta-blockade on reperfusion-induced ventricular fibrillation","volume":"49","author":"Manning","year":"1983","journal-title":"Br Heart J"},{"issue":"suppl D","key":"10.1016\/0002-8703(85)90712-4_BIB162","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/eurheartj\/4.suppl_D.79","article-title":"Adrenergic factors in arrhythmogenesis in the ischemic and reperfused myocardium","volume":"4","author":"Sharma","year":"1983","journal-title":"Eur Heart J"},{"key":"10.1016\/0002-8703(85)90712-4_BIB163","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1161\/01.CIR.55.5.785","article-title":"Suppression of premature ventricular contractions by acebutolol","volume":"55","author":"Gradman","year":"1977","journal-title":"Circulation"},{"key":"10.1016\/0002-8703(85)90712-4_BIB164","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1161\/01.CIR.65.6.1129","article-title":"Acebutolol therapy for ventricular arrhythmias","volume":"65","author":"De Soyza","year":"1982","journal-title":"Circulation"},{"key":"10.1016\/0002-8703(85)90712-4_BIB165","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/0002-8703(83)90231-4","article-title":"Reduction of ventricular ectopic beats with oral acebutolol: A double-blind, randomized crossover study","volume":"105","author":"Lui","year":"1983","journal-title":"Am Heart J"},{"key":"10.1016\/0002-8703(85)90712-4_BIB166","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/0002-9149(81)90358-1","article-title":"Antiarrhythmic significance of dosing intervals in beta receptor blocking therapy of hypertension with acebutolol","volume":"48","author":"Frick","year":"1981","journal-title":"Am J Cardiol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB167","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/0002-9149(84)90406-5","article-title":"Effect of acebutolol on left ventricular hemodynamics and anatomy in systemic hypertension","volume":"53","author":"Trimarco","year":"1984","journal-title":"Am J Cardiol"},{"issue":"suppl 2","key":"10.1016\/0002-8703(85)90712-4_BIB168","first-page":"50","article-title":"Beta-blockers and calcium antagonists: Cornerstones of antihypertensive therapy in the 1980s","volume":"25","author":"Buehler","year":"1983","journal-title":"Drugs"},{"key":"10.1016\/0002-8703(85)90712-4_BIB169","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1185\/03007997709109339","article-title":"Anti-arrhythmic properties of acebutolol (Bay c 7705), a new cardioselective beta-adrenergic blocking agent: A preliminary report","volume":"4","author":"Burckhardt","year":"1977","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/0002-8703(85)90712-4_BIB170","first-page":"557","article-title":"Evaluation of the clinical effectiveness of acebutolol, a cardiospecific beta-adrenergic blocking agent in the suppression of premature ventricular contractions","volume":"26","author":"Peretz","year":"1979","journal-title":"Curr Ther Res"},{"key":"10.1016\/0002-8703(85)90712-4_BIB171","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0002-8703(80)90378-6","article-title":"The effect of acebutolol on cardiac arrhythmias in patients with chronic coronary artery disease","volume":"99","author":"Burckhardt","year":"1980","journal-title":"Am Heart J"},{"key":"10.1016\/0002-8703(85)90712-4_BIB172","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/0002-8703(85)90709-4","article-title":"Comparison of acebutolol with propranolol, quinidine, and placebo: Results of three multicenter arrhythmia trials","volume":"109","author":"Chandraratna","year":"1985","journal-title":"Am Heart J"},{"key":"10.1016\/0002-8703(85)90712-4_BIB173","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/0002-8703(85)90710-0","article-title":"Acebutolol for premature ventricular contractions: Short- and long-term effects","volume":"109","author":"de Soyza","year":"1985","journal-title":"Am Heart J"},{"key":"10.1016\/0002-8703(85)90712-4_BIB174","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1161\/01.CIR.65.7.1356","article-title":"Comparison of acebutolol and propranolol for treatment of chronic ventricular arrhythmia: A placebo-controlled, double-blind, randomized crossover trial","volume":"65","author":"Singh","year":"1982","journal-title":"Circulation"},{"key":"10.1016\/0002-8703(85)90712-4_BIB175","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/0002-9149(83)90518-0","article-title":"Comparison of the antiarrhythmic effects of acebutolol and propranolol in the treatment of ventricular arrhythmias","volume":"52","author":"Glasser","year":"1983","journal-title":"Am J Cardiol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB176","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0002-9149(82)90523-9","article-title":"Variability of spontaneous and exercise-induced ventricular arrhythmia in the absence or presence of treatment with acebutolol or quinidine","volume":"49","author":"Shapiro","year":"1982","journal-title":"Am J Cardiol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB177","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/0002-8703(84)90268-0","article-title":"Role of beta-adrenoceptor antagonism in the prevention of reperfusion ventricular arrhythmias: Effects of acebutolol, atenolol, and d-propranolol on isolated working rat hearts subject to myocardial ischemia and reperfusion","volume":"107","author":"Rochette","year":"1984","journal-title":"Am Heart J"},{"key":"10.1016\/0002-8703(85)90712-4_BIB178","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2165\/00003495-197815040-00003","article-title":"Antiarrhythmic drugs: Clinical pharmacology and therapeutic uses","volume":"15","author":"Anderson","year":"1978","journal-title":"Drugs"},{"key":"10.1016\/0002-8703(85)90712-4_BIB179","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/j.1365-2044.1982.tb01751.x","article-title":"Acebutolol and coronary artery surgery","volume":"37","author":"Thoms","year":"1982","journal-title":"Anaesthesia"},{"key":"10.1016\/0002-8703(85)90712-4_BIB180","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/j.1365-2125.1983.tb02221.x","article-title":"Ophthalmological monitoring of patients receiving long-term acebutolol","volume":"16","author":"Lyall","year":"1983","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/0002-8703(85)90712-4_BIB181","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1136\/hrt.40.1.35","article-title":"Electrophysiological effects of acebutolol","volume":"40","author":"Mason","year":"1978","journal-title":"Br Heart J"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0002870385907124?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0002870385907124?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T05:31:57Z","timestamp":1756877517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/0002870385907124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,5]]},"references-count":181,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1985,5]]}},"alternative-id":["0002870385907124"],"URL":"https:\/\/doi.org\/10.1016\/0002-8703(85)90712-4","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[1985,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acebutolol: Ten years of experience","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/0002-8703(85)90712-4","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1985 Published by Mosby, Inc.","name":"copyright","label":"Copyright"}]}}