{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:11:01Z","timestamp":1760368261822},"reference-count":36,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[1991,4,1]],"date-time":"1991-04-01T00:00:00Z","timestamp":670464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[1991,4]]},"DOI":"10.1016\/0006-3223(91)90199-v","type":"journal-article","created":{"date-parts":[[2003,4,24]],"date-time":"2003-04-24T13:39:05Z","timestamp":1051191545000},"page":"799-810","source":"Crossref","is-referenced-by-count":35,"title":["Magnetic resonance findings in patients with early-onset Alzheimer's disease"],"prefix":"10.1016","volume":"29","author":[{"given":"William M.","family":"McDonald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ranga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.Murali","family":"Doraiswamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary S.","family":"Figiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa M.","family":"Husain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orest B.","family":"Boyko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Heyman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/0006-3223(91)90199-V_BIB1","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1161\/01.STR.17.6.1084","article-title":"Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. I. Correlation with age and cerebrovascular risk factors","volume":"17","author":"Awad","year":"1986","journal-title":"Stroke"},{"key":"10.1016\/0006-3223(91)90199-V_BIB2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1001\/archpsyc.1990.01810130049007","article-title":"Magnetic resonance imaging and the severity of dementia in older adults","volume":"47","author":"Bondareff","year":"1990","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/0006-3223(91)90199-V_BIB3","first-page":"283","article-title":"MR signal abnormalities in memory disorder and dementia","volume":"11","author":"Bowen","year":"1990","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/0006-3223(91)90199-V_BIB4","first-page":"35","article-title":"Patchy, periventricular white matter lesions in the elderly: A common observation during NMR imaging","volume":"1","author":"Bradley","year":"1984","journal-title":"Noninvas Med Imag"},{"key":"10.1016\/0006-3223(91)90199-V_BIB5","first-page":"675","article-title":"MR imaging of the aging brain: Patchy white-matter lesions and dementia","volume":"6","author":"Brant-Zawadzki","year":"1985","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/0006-3223(91)90199-V_BIB6","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0006-3223(90)90582-M","article-title":"Cerebral white matter in late-onset paranoid psychosis","volume":"28","author":"Breitner","year":"1990","journal-title":"Biol Psychiatry"},{"key":"10.1016\/0006-3223(91)90199-V_BIB7","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/00004728-198008000-00016","article-title":"Explanation of cerebral white\u2014gray contrast in computed tomography","volume":"4","author":"Brooks","year":"1980","journal-title":"J. Comput Assist Tomogr"},{"key":"10.1016\/0006-3223(91)90199-V_BIB8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/ana.410190306","article-title":"A white matter disorder in dementia of the Alzheimer type: A pathoanatomical study","volume":"19","author":"Brun","year":"1986","journal-title":"Ann Neurol"},{"key":"10.1016\/0006-3223(91)90199-V_BIB9","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1212\/WNL.28.12.1206","article-title":"Clinical features of subcortical arteriosclerosis encephalopathy (Binswanger disease)","volume":"18","author":"Caplan","year":"1978","journal-title":"Neurology"},{"key":"10.1016\/0006-3223(91)90199-V_BIB10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0006-3223(88)90270-3","article-title":"Leukoencephalopathy in elderly depressed patients referred for ECT","volume":"24","author":"Coffey","year":"1988","journal-title":"Biol Psychiatry"},{"key":"10.1016\/0006-3223(91)90199-V_BIB11","first-page":"A19","article-title":"Aging of the human brain: Subcortical hyper-intensities on MR images in normals","volume":"38","author":"Doraiswamy","year":"1990","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/0006-3223(91)90199-V_BIB12","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/ana.410170420","article-title":"Early-onset Alzheimer's disease: An analysis of CT findings","volume":"17","author":"Drayer","year":"1985","journal-title":"Ann Neurol"},{"key":"10.1016\/0006-3223(91)90199-V_BIB13","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1148\/radiology.166.3.3277247","article-title":"Imaging of the aging brain. Part I. Normal findings","volume":"166","author":"Drayer","year":"1988","journal-title":"Radiology"},{"key":"10.1016\/0006-3223(91)90199-V_BIB14","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1148\/radiology.166.3.3277248","article-title":"Imaging of the aging brain. Part II. Pathologic conditions","volume":"166","author":"Drayer","year":"1988","journal-title":"Radiology"},{"key":"10.1016\/0006-3223(91)90199-V_BIB15","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1097\/00004728-198408000-00006","article-title":"Cerebral NMR and CT imaging in dementia","volume":"8","author":"Erkinjuntti","year":"1984","journal-title":"Comput Assist Tomogr"},{"key":"10.1016\/0006-3223(91)90199-V_BIB16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1136\/jnnp.50.1.37","article-title":"Do white matter changes on MRI and CT differentiate vascular dementia from Alzheimer's disease?","volume":"50","author":"Erkinjuntti","year":"1987","journal-title":"J Neuro Neurosurgery Psychiatry"},{"key":"10.1016\/0006-3223(91)90199-V_BIB17","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1159\/000116401","article-title":"Magnetic resonance signal abnormalities in asymptomatic individuals: Their incidence and functional correlates","volume":"29","author":"Fazekas","year":"1989","journal-title":"Eur Neurol"},{"key":"10.1016\/0006-3223(91)90199-V_BIB18","first-page":"421","article-title":"MR signal abnormalities at 1.5T in Alzheimer's dementia and normal aging","volume":"8","author":"Fazekas","year":"1987","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/0006-3223(91)90199-V_BIB19","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1212\/WNL.38.12.1822","article-title":"Criteria for increased specificity of MRI interpretation in elderly subjects with suspected multiple sclerosis","volume":"38","author":"Fazekas","year":"1988","journal-title":"Neurology"},{"key":"10.1016\/0006-3223(91)90199-V_BIB20","first-page":"1607","article-title":"Comparison of CT, MR and PET in Alzheimer's dementia and normal aging","volume":"30","author":"Fazekas","year":"1989","journal-title":"J Nucl Med"},{"key":"10.1016\/0006-3223(91)90199-V_BIB21","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1176\/jnp.1.2.188","article-title":"Radiologic correlates of antidepressant-induced delirium: The possible significance of basal-ganglia lesions","volume":"1","author":"Figiel","year":"1989","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"10.1016\/0006-3223(91)90199-V_BIB22","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"Mini-mental state","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.1016\/0006-3223(91)90199-V_BIB23","first-page":"567","article-title":"Leukoencephalopathy in normal and pathologic aging: 2. MRI of brain lucencies","volume":"7","author":"George","year":"1986","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/0006-3223(91)90199-V_BIB24","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1212\/WNL.36.7.998","article-title":"MRI periventricular lesions in adults","volume":"36","author":"Gerard","year":"1986","journal-title":"Neurology"},{"key":"10.1016\/0006-3223(91)90199-V_BIB25","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1148\/radiology.141.3.7302224","article-title":"Diffuse white-matter disease in the geriatric population","volume":"141","author":"Goto","year":"1981","journal-title":"Radiology"},{"key":"10.1016\/0006-3223(91)90199-V_BIB26","first-page":"703","article-title":"Foci of increased T2 signal intensity on brain MR scans of healthy elderly subjects","volume":"10","author":"Hendrie","year":"1989","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/0006-3223(91)90199-V_BIB27","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1212\/WNL.39.11.1470","article-title":"Clinical significance of MRI white matter lesions in the elderly","volume":"39","author":"Hunt","year":"1989","journal-title":"Neurology"},{"key":"10.1016\/0006-3223(91)90199-V_BIB28","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1176\/ajp.140.6.734","article-title":"Validation of a short orientation memory-concentration test of cognitive impairment","volume":"140","author":"Katzman","year":"1983","journal-title":"Am J Psychiatry"},{"key":"10.1016\/0006-3223(91)90199-V_BIB29","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0006-3223(88)90025-X","article-title":"Leukoencephalopathy in patients diagnosed as major depressive","volume":"23","author":"Krishnan","year":"1988","journal-title":"Biol Psychiatry"},{"key":"10.1016\/0006-3223(91)90199-V_BIB30","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: Report of NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"article-title":"Magnetic Resonance Imaging: Atlas of the Head, Neck and Spine","year":"1988","author":"Mills","key":"10.1016\/0006-3223(91)90199-V_BIB31"},{"key":"10.1016\/0006-3223(91)90199-V_BIB32","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1212\/WNL.37.8.1365","article-title":"Periventricular white matter lucencies in senile dementia of the Alzheimer type and in normal aging","volume":"37","author":"Rezek","year":"1987","journal-title":"Neurology"},{"key":"10.1016\/0006-3223(91)90199-V_BIB33","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1001\/archneur.1987.00520190035014","article-title":"Magnetic resonance imaging of periventricular hyperintensity in a Veterans Administration Hospital population","volume":"44","author":"Sarpel","year":"1987","journal-title":"Arch Neurol"},{"key":"10.1016\/0006-3223(91)90199-V_BIB34","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1001\/archneur.1987.00520130028013","article-title":"Cognitive and neurologic findings in demented patients with diffuse white matter lucencies on computed tomographic scan (leuko-araiosis)","volume":"44","author":"Steingart","year":"1987","journal-title":"Arch Neurol"},{"key":"10.1016\/0006-3223(91)90199-V_BIB35","first-page":"331","article-title":"Foci of MRI signal (pseudo lesions) anterior to the frontal horns","volume":"147","author":"Sze","year":"1986","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/0006-3223(91)90199-V_BIB36","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2214\/ajr.146.3.443","article-title":"Periventricular hyperintensity as seen by magnetic resonance imaging: Prevalence and significance","volume":"146","author":"Zimmerman","year":"1986","journal-title":"Am J Roentgenol"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:000632239190199V?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:000632239190199V?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T16:00:06Z","timestamp":1553356806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/000632239190199V"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,4]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1991,4]]}},"alternative-id":["000632239190199V"],"URL":"https:\/\/doi.org\/10.1016\/0006-3223(91)90199-v","relation":{},"ISSN":["0006-3223"],"issn-type":[{"type":"print","value":"0006-3223"}],"subject":[],"published":{"date-parts":[[1991,4]]}}}