{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:50:22Z","timestamp":1789195822479,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[1995,10,1]],"date-time":"1995-10-01T00:00:00Z","timestamp":812505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[1995,10]]},"DOI":"10.1016\/0006-8993(95)00835-e","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T15:52:45Z","timestamp":1027612365000},"page":"223-232","source":"Crossref","is-referenced-by-count":71,"title":["Time-course of the effects of anandamide, the putative endogenous cannabinoid receptor ligand, on extrapyramidal function"],"prefix":"10.1016","volume":"694","author":[{"given":"J.","family":"Romero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"de Miguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Garc\u00eda-Palomero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.","family":"Fern\u00e1ndez-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/0006-8993(95)00835-E_BIB1","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1021\/jm00038a020","article-title":"(R)-Methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability","volume":"37","author":"Abadji","year":"1994","journal-title":"J. Med. Chem."},{"key":"10.1016\/0006-8993(95)00835-E_BIB2","first-page":"27","article-title":"Catecholamines and behavior","volume":"vol. 90\/II","author":"Bloom","year":"1988"},{"key":"10.1016\/0006-8993(95)00835-E_BIB3","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/0006-2952(94)90561-4","article-title":"Possible role of the cytochrome P450-linked mono-oxygenase system in preventing \u03949-tetrahydrocannabinol-induced stimulation of tuberoinfundibular dopaminergic activity in female rats","volume":"48","author":"Bonnin","year":"1994","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/0006-8993(95)00835-E_BIB4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0165-3806(94)90079-5","article-title":"Changes in tyrosine hydroxylase gene expression in mesencephalic catecholaminergic neurons of immature and adult male rats perinatally exposed to cannabinoids","volume":"81","author":"Bonnin","year":"1994","journal-title":"Dev. Brain Res."},{"key":"10.1016\/0006-8993(95)00835-E_BIB5","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0091-3057(93)90230-Q","article-title":"Anandamide, an endogenous ligand of the cannabinoid receptor, induces hypomotility and hypothermia in vivo in rodents","volume":"46","author":"Crawley","year":"1993","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/0006-8993(95)00835-E_BIB6","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/0006-2952(93)90486-G","article-title":"Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist","volume":"46","author":"Deutsch","year":"1993","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/0006-8993(95)00835-E_BIB7","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1126\/science.1470919","article-title":"Isolation and structure of a brain constituent that binds to the cannabinoid receptor","volume":"258","author":"Devane","year":"1992","journal-title":"Science"},{"key":"10.1016\/0006-8993(95)00835-E_BIB8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0006-8993(87)91275-3","article-title":"Presence of tyrosine-hydroxylase activity in anterior pituitary adenomas and ectopic anterior pituitaries in male rats","volume":"421","author":"Fern\u00e1ndez-Ruiz","year":"1987","journal-title":"Brain Res."},{"key":"10.1016\/0006-8993(95)00835-E_BIB9","first-page":"119","article-title":"Maternal cannabinoid exposure and brain development: changes in the ontogeny of dopaminergic neurons","volume":"vol. IV","author":"Fern\u00e1ndez-Ruiz","year":"1992"},{"key":"10.1016\/0006-8993(95)00835-E_BIB10","first-page":"357","article-title":"Ontogenic and adult changes in the activity of hypothalamic and extrahypothalamic dopaminergic neurons after perinatal cannabinoid exposure","volume":"vol. 1","author":"Fern\u00e1ndez-Ruiz","year":"1994"},{"key":"10.1016\/0006-8993(95)00835-E_BIB11","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0014-2999(93)90468-W","article-title":"Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent","volume":"231","author":"Fride","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/0006-8993(95)00835-E_BIB12","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/1044-5765(92)90009-Q","article-title":"D1 and D2 dopamine receptor regulation in striatonigral and striatopallidal neurons","volume":"4","author":"Gerfen","year":"1992","journal-title":"Semin. Neurosci."},{"key":"10.1016\/0006-8993(95)00835-E_BIB13","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1471-4159.1966.tb09873.x","article-title":"Catecholamine regional metabolism in rat brain","volume":"13","author":"Glowinski","year":"1966","journal-title":"J. Neurochem."},{"key":"10.1016\/0006-8993(95)00835-E_BIB14","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1021\/jm00072a026","article-title":"Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor","volume":"36","author":"Hanus","year":"1993","journal-title":"J. Med. Chem."},{"key":"10.1016\/0006-8993(95)00835-E_BIB15","first-page":"1932","article-title":"Cannabinoid receptor localization in brain","volume":"87","author":"Herkenham","year":"1990"},{"key":"10.1016\/0006-8993(95)00835-E_BIB16","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1523\/JNEUROSCI.11-02-00563.1991","article-title":"Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study","volume":"11","author":"Herkenham","year":"1991","journal-title":"J. Neurosci."},{"key":"10.1016\/0006-8993(95)00835-E_BIB17","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0006-8993(91)90970-7","article-title":"Neuronal localization of cannabinoid receptors in the basal ganglia of the rat","volume":"547","author":"Herkenham","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/0006-8993(95)00835-E_BIB18","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/0166-2236(90)90124-S","article-title":"The cannabinoid receptor: biochemical, anatomical and behavioral characterization","volume":"13","author":"Howlett","year":"1990","journal-title":"Trends Neurol. Sci."},{"key":"10.1016\/0006-8993(95)00835-E_BIB19","first-page":"498","article-title":"Anandamide, an endogenous cannabinoid, inhibits calcium current as a partial agonist in N18 neuroblastoma cells","volume":"44","author":"MacKie","year":"1993","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/0006-8993(95)00835-E_BIB20","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/0091-3057(81)90022-8","article-title":"Tetrahydrocannabinol potentiates reserpine-induced hypokinesia","volume":"15","author":"Moss","year":"1981","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/0006-8993(95)00835-E_BIB21","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0378-4347(00)81411-5","article-title":"Highly sensitive assay for tyrosine hydroxylase activity by high performance liquid chromatography","volume":"163","author":"Nagatsu","year":"1979","journal-title":"J. Chromatogr."},{"key":"10.1016\/0006-8993(95)00835-E_BIB22","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0091-3057(93)90241-K","article-title":"Motor disturbances induced by an acute dose of \u03949-tetrahydrocannabinol: possible involvement of nigrostriatal dopaminergic alterations","volume":"45","author":"Navarro","year":"1993","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/0006-8993(95)00835-E_BIB23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0091-3057(94)90110-4","article-title":"Motor behavior and nigrostriatal dopaminergic activity in adult rats perinatally exposed to cannabinoids","volume":"47","author":"Navarro","year":"1994","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/0006-8993(95)00835-E_BIB24","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/0028-3908(88)90029-9","article-title":"Drugs which stimulate or facilitate central GABAergic transmission interact synergistically with \u03949-tetrahydrocannabinol to produce marked catalepsy in mice","volume":"27","author":"Pertwee","year":"1988","journal-title":"Neuropharmacology"},{"key":"10.1016\/0006-8993(95)00835-E_BIB25","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0165-3806(90)90280-C","article-title":"Changes in brain dopaminergic indices induced by perinatal exposure to cannabinoids in rats","volume":"51","author":"Rodr\u00edguez de Fonseca","year":"1990","journal-title":"Dev. Brain Res."},{"key":"10.1016\/0006-8993(95)00835-E_BIB26","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/0306-4522(91)90329-M","article-title":"Effects of pre- and perinatal exposure to hashish extracts on the ontogeny of brain dopaminergic neurons","volume":"43","author":"Rodr\u00edguez de Fonseca","year":"1991","journal-title":"Neuroscience"},{"key":"10.1016\/0006-8993(95)00835-E_BIB27","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0091-3057(92)90526-L","article-title":"Acute effects of \u03949-tetrahydrocannabinol on dopaminergic activity in several rat brain areas","volume":"42","author":"Rodr\u00edguez de Fonseca","year":"1992","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/0006-8993(95)00835-E_BIB28","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0091-3057(94)90108-2","article-title":"Down-regulation of rat brain cannabinnoid binding sites after chronic \u03949-tetrahydrocannabinol","volume":"47","author":"Rodr\u00edguez de Fonseca","year":"1994","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/0006-8993(95)00835-E_BIB29","first-page":"159","article-title":"The putative cannabinoid receptor ligand, anandamide, stimulates hypothalamic tyrosine hydroxylase activity and inhibits prolactin release","volume":"16","author":"Romero","year":"1994","journal-title":"Neuroendocrinol. Lett."},{"key":"10.1016\/0006-8993(95)00835-E_BIB30","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/0024-3205(95)00186-A","article-title":"The endogenous cannabinoid receptor ligand, anandamide, inhibits the motor behavior: role of nigrostriatal dopaminergic neurons, activity and related behaviors","volume":"56","author":"Romero","year":"1995","journal-title":"Life Sci."},{"key":"10.1016\/0006-8993(95)00835-E_BIB31","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/0091-3057(95)00023-P","article-title":"Changes in rat brain cannabinoid binding sites after acute or chronic exposure to their endogenous agonist, anandamide, or to \u03949-tetrahydrocannabinol","volume":"51","author":"Romero","year":"1995","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/0006-8993(95)00835-E_BIB32","first-page":"219","article-title":"The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice","volume":"270","author":"Smith","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/0006-8993(95)00835-E_BIB33","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1471-4159.1993.tb03576.x","article-title":"Anandamide, a brain endogenous compound, interacts specifically with cannabinoid receptors and inhibits adenylate cyclase","volume":"61","author":"Vogel","year":"1993","journal-title":"J. Neurochem."},{"key":"10.1016\/0006-8993(95)00835-E_BIB34","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1159\/000126646","article-title":"The effect of the brain constituent anandamide, a cannabinoid receptor agonist, on the hypothalamic-pituitary-adrenalaxis in the rat","volume":"59","author":"Weidenfeld","year":"1994","journal-title":"Neuroendocrinology"},{"key":"10.1016\/0006-8993(95)00835-E_BIB35","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0014-2999(93)90646-Y","article-title":"\u03949-Tetrahydrocannabinol and anandamide enhance the ability of muscimol to induce catalepsy in the globus pallidus of rats","volume":"250","author":"Wickens","year":"1993","journal-title":"Eur. J. Pharmacol."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:000689939500835E?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:000689939500835E?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T20:08:19Z","timestamp":1578686899000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/000689939500835E"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,10]]},"references-count":35,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[1995,10]]}},"alternative-id":["000689939500835E"],"URL":"https:\/\/doi.org\/10.1016\/0006-8993(95)00835-e","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[1995,10]]}}}