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Oleic acid activation of protein kinase C is as effective as phosphatidylserine and Ca<jats:sup>2+<\/jats:sup>. <jats:italic>K<\/jats:italic>\n<jats:sub>a<\/jats:sub>, values for oleic acid and arachidonic acid are 50 and 53 \u03bcM, respectively. In contrast to the <jats:italic>cis<\/jats:italic> fatty acids, a <jats:italic>trans<\/jats:italic> form (elaidic acid) or a saturated fatty acid (stearic acid) has little or no effect on protein kinase C activation. If <jats:italic>cis<\/jats:italic> fatty acid liberation is physiologically important, this suggests that another mechanism may exist for protein kinase C activation, in addition to phospholipase C\/phosphatidylinositol turnover signaling, possibly via the liberation of <jats:italic>cis<\/jats:italic> fatty acids by the Ca<jats:sup>2+<\/jats:sup>\u2010dependent phospholipase A<jats:sub>2<\/jats:sub> system.<\/jats:p>","DOI":"10.1016\/0014-5793(85)80105-8","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:57:58Z","timestamp":1027583878000},"page":"189-193","source":"Crossref","is-referenced-by-count":227,"title":["Direct activation of purified protein kinase C by unsaturated fatty acids (oleate and arachidonate) in the absence of phospholipids and Ca<sup>2+<\/sup>"],"prefix":"10.1002","volume":"192","author":[{"given":"Kentaro","family":"Murakami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aryeh","family":"Routtenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)41009-X"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)41010-6"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)50638-4"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)85886-6"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/308693a0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)34459-4"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)68938-6"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)42620-2"},{"key":"e_1_2_1_10_1","unstructured":"Murakami K. 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