{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T14:36:49Z","timestamp":1770215809690,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,11,12]],"date-time":"2001-11-12T00:00:00Z","timestamp":1005523200000},"content-version":"vor","delay-in-days":6132,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[1985,1,28]]},"abstract":"<jats:p>Arachidonate metabolites are potent mediators generated in endotoxin shock. Following endotoxin administration (15 <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/feb20014579385810929-math-si1.gif\" xlink:title=\"urn:x-wiley:00145793:media:feb20014579385810929:feb20014579385810929-math-si1\"\/>) into unanesthetized rats, we found a rapid biliary secretion of peptide leukotrienes. Analysis of bile for peptide leukotrienes included organic solvent extractions, reversed phase\u2010HPLC, radioimmunoassay (RIA), and spectrophotometry. The major immunoreactive endogenous leukotriene (LT) from bile was eluted between LTC<jats:sub>4<\/jats:sub> and LTD<jats:sub>4<\/jats:sub> in three chromatographic systems. It corresponded thereby to a biliary metabolite of injected LTC<jats:sub>4<\/jats:sub> and LTD<jats:sub>4<\/jats:sub> which in turn showed the ultraviolet spectrum of a peptide leukotriene. This demonstration of endotoxin\u2010induced generation of peptide LTs in vivo was possible by sequential HPLC and RIA analyses in bile into which peptide LTs are eliminated from blood.<\/jats:p>","DOI":"10.1016\/0014-5793(85)81092-9","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:58:50Z","timestamp":1027583930000},"page":"309-313","source":"Crossref","is-referenced-by-count":103,"title":["Production of peptide leukotrienes in endotoxin shock"],"prefix":"10.1002","volume":"180","author":[{"given":"Wolfgang","family":"Hagmann","sequence":"first","affiliation":[]},{"given":"Claudio","family":"Denzlinger","sequence":"additional","affiliation":[]},{"given":"Dietrich","family":"Keppler","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2001,11,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6301011"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111312"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1963.204.4.641"},{"key":"e_1_2_1_5_1","first-page":"209","volume-title":"Microbial Toxins","author":"Hinshaw L.B.","year":"1971"},{"key":"e_1_2_1_6_1","first-page":"261","volume-title":"Microbial Toxins","author":"Urbaschek B.","year":"1971"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.45.2.292"},{"key":"e_1_2_1_8_1","first-page":"235","volume":"221","author":"Burke J.A.","year":"1982","journal-title":"J. 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