{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T14:15:55Z","timestamp":1770473755373,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2001,10,29]],"date-time":"2001-10-29T00:00:00Z","timestamp":1004313600000},"content-version":"vor","delay-in-days":5719,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[1986,3,3]]},"abstract":"<jats:p>The observed homology between G\u2010proteins which regulate adenylate cyclase and <jats:italic>ras<\/jats:italic> proteins and the suggested role of <jats:italic>ras<\/jats:italic> in the regulation of adenylate cyclase in yeast prompted us to examine the regulation of adenylate cyclase in three cell lines: (i) NIH 3T3 cells, (ii) NIH 3T3 cells transformed by high levels of the normal <jats:italic>ras<\/jats:italic>\n<jats:sup>H<\/jats:sup> gene product and (iii) NIH 3T3 cells transformed by a mutated <jats:italic>ras<\/jats:italic>\n<jats:sup>H<\/jats:sup> gene product. We found that the regulation of adenylate cyclase by G\u2010proteins is identical in the three cell lines, although the response of the transformed NIH 3T3 cells to agonists is strongly attenuated. Our data suggest that mammalian <jats:italic>ras<\/jats:italic> products do not interact directly with adenylate cyclase, although their increased expression may indirectly inhibit the interaction of adenylate cyclase stimulatory receptors with G\u2010proteins.<\/jats:p>","DOI":"10.1016\/0014-5793(86)80313-1","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:57:58Z","timestamp":1027583878000},"page":"134-138","source":"Crossref","is-referenced-by-count":22,"title":["Adenylate cyclase activity of NIH 3T3 cells morphologically transformed by <i>ras<\/i> genes"],"prefix":"10.1002","volume":"197","author":[{"given":"Alexander","family":"Levitzki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce","family":"Rudick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira","family":"Pastan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William C.","family":"Vass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas R.","family":"Lowy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,10,29]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/12.8.3611"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90340-4"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/07357908409020294"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(85)90110-0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(74)90156-1"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)42073-5"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90304-6"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3883495"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/313700a0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.22.6924"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.18.5704"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/310644a0"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/311273a0"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3856323"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/315242a0"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90305-8"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(85)80057-X"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.35.1.76-92.1980"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.36.2.408-420.1980"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.6.3328"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.49.070180.002533"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)32863-1"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02354931"},{"key":"e_1_2_1_25_1","first-page":"145","volume":"17","author":"Ui M.","year":"1984","journal-title":"Adv. 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