{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:45:16Z","timestamp":1770702316083,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"vor","delay-in-days":5435,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[1986,12,15]]},"abstract":"<jats:p>The human T\u2010cell leukemia virus type\u20101 (HTLV\u20101) contains a unique pX region, which encodes the gene products p40<jats:sup>\n<jats:italic>x<\/jats:italic>\n<\/jats:sup>, p27<jats:sup>\n<jats:italic>x\u2010III<\/jats:italic>\n<\/jats:sup> and p21<jats:sup>\n<jats:italic>x\u2010III<\/jats:italic>\n<\/jats:sup>. p40<jats:sup>\n<jats:italic>x<\/jats:italic>\n<\/jats:sup> is required for transcriptional trans\u2010activation, whereas p27<jats:sup>\n<jats:italic>x\u2010III<\/jats:italic>\n<\/jats:sup> and p21<jats:sup>\n<jats:italic>x\u2010III<\/jats:italic>\n<\/jats:sup> have no such function. Transfection of pX expression plasmids containing different combinations for the three gene products into cells integrated with HTLV\u20101 proviruses defective in pX expression revealed that both p40<jats:sup>\n<jats:italic>x<\/jats:italic>\n<\/jats:sup> and p27<jats:sup>\n<jats:italic>x\u2010III<\/jats:italic>\n<\/jats:sup> are required for expression of the gag protein and accumulation of gag mRNA. These observations suggest that the pX product p40<jats:sup>\n<jats:italic>x<\/jats:italic>\n<\/jats:sup> activates transcription and p27<jats:sup>\n<jats:italic>x\u2010III<\/jats:italic>\n<\/jats:sup> controls the level of gag mRNA by post\u2010transcriptional modulation.<\/jats:p>","DOI":"10.1016\/0014-5793(86)81108-5","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:57:40Z","timestamp":1027583860000},"page":"187-190","source":"Crossref","is-referenced-by-count":65,"title":["The second pX product p27<sup><i>x\u2010III<\/i><\/sup> of HTLV\u20101 is required for gag gene expression"],"prefix":"10.1002","volume":"209","author":[{"given":"Jun-ichiro","family":"Inoue","sequence":"first","affiliation":[]},{"given":"Motoharu","family":"Seiki","sequence":"additional","affiliation":[]},{"given":"Mitsuaki","family":"Yoshida","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2001,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.6.2031"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.10.6476"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/302626a0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.8.2534"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.12.3618"},{"key":"e_1_2_1_8_1","first-page":"747","volume":"75","author":"Kiyokawa T.","year":"1984","journal-title":"Gann"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6089350"},{"key":"e_1_2_1_10_1","first-page":"752","volume":"75","author":"Miwa M.","year":"1984","journal-title":"Gann"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6089351"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.24.8359"},{"key":"e_1_2_1_13_1","first-page":"375","volume":"225","author":"Sodroski J.G.","year":"1984","journal-title":"Science"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.8.2277"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/318571a0"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2992082"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2990028"},{"key":"e_1_2_1_18_1","first-page":"1127","volume":"76","author":"Seiki M.","year":"1985","journal-title":"Jap. 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