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The acylation profiles of the two cell lines as examined by SDS\u2010PAGE differed. TPA induced the myristylation of an \u223c 82 kDa protein in the sensitive cells, but not in the resistant cells. Myristic acid was shown to be covalently linked to these proteins. Analysis of the cell lipids labelled with [<jats:sup>3<\/jats:sup>H]myristate showed that in contrast to observations with the proteins, the changes induced by TPA were observed in both TPA\u2010sensitive and TPA\u2010resistant cells. We conclude that the induction of myristylation may be an important step in the mechanism of differentiation.<\/jats:p>","DOI":"10.1016\/0014-5793(87)80136-9","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T10:22:16Z","timestamp":1027592536000},"page":"175-178","source":"Crossref","is-referenced-by-count":9,"title":["12\u2010<i>O<\/i>\u2010Tetradecanoyl phorbol 13\u2010acetate stimulates the myristylation of an \u223c 82 kDa protein in HL\u201060 cells"],"prefix":"10.1002","volume":"215","author":[{"given":"Etienne","family":"Malvoisin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Wild","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges","family":"Zwingelstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,2,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1985.tb03751.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1985.tb03752.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)83692-X"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3917576"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(82)90139-8"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.53.1.7-12.1985"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(84)90409-4"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.4.12.2697"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.3.1293"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.9.2865"},{"key":"e_1_2_1_12_1","first-page":"3674","volume":"40","author":"Cabot M.C.","year":"1980","journal-title":"Cancer Res."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/308693a0"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.5.2458"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(81)90018-7"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2140665"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)85102-X"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_2_1_19_1","first-page":"4955","volume":"45","author":"Anderson N.L.","year":"1985","journal-title":"Cancer Res."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)88925-6"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)44526-1"},{"key":"e_1_2_1_22_1","first-page":"5159","volume":"45","author":"Zylber-Katz E.","year":"1985","journal-title":"Cancer Res."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)38707-0"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(84)90173-3"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2F0014-5793%2887%2980136-9","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2F0014-5793(87)80136-9","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/0014-5793%2887%2980136-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T04:35:29Z","timestamp":1694925329000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/0014-5793%2887%2980136-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,5,4]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,5,4]]}},"alternative-id":["10.1016\/0014-5793(87)80136-9"],"URL":"https:\/\/doi.org\/10.1016\/0014-5793(87)80136-9","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,5,4]]}}}