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Whereas GTP and GTP\u03b3S stimulated C3\u2010catalyzed ADP\u2010ribosylation in the absence of Mg<jats:sup>2+<\/jats:sup>, in the presence of added Mg<jats:sup>2+<\/jats:sup> ADP\u2010ribosylation was impaired by GTP\u03b3S. C3 was about 1000\u2010fold more potent than botulinum C1 neurotoxin in ADP\u2010ribosylation of the 21\u201324 kDa protein(s) in human platelet membranes. Antibodies raised against C3 blocked ADP\u2010ribosylation of the 21\u201324 kDa protein by C3 and neurotoxin C1 but neither cross reacted with neurotoxin C1 immunoblots nor neutralized the toxicity of neurotoxin C1 in mice. The data indicate that the ADP\u2010ribosylation of low molecular mass GTP\u2010binding proteins in various eukaryotic cells is not caused by botulinum neurotoxins but is due to the action of botulinum ADP\u2010ribosyltransferase C3. The weak enzymatic activities described for botulinum neurotoxins appear to be due to the contamination of C1 and D preparations with ADP\u2010ribosyltransferase C3.<\/jats:p>","DOI":"10.1016\/0014-5793(87)80418-0","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:45:58Z","timestamp":1027583158000},"page":"38-42","source":"Crossref","is-referenced-by-count":50,"title":["Botulinum ADP\u2010ribosyltransferase C3 but not botulinum neurotoxins C1 and D ADP\u2010ribosylates low molecular mass GTP\u2010binding proteins"],"prefix":"10.1002","volume":"224","author":[{"given":"S.","family":"R\u00f6sener","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.S.","family":"Chhatwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Aktories","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,10,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-71399-6_2"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/322390a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)75651-8"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(87)91518-X"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(87)80709-3"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(87)81566-1"},{"key":"e_1_2_1_8_1","author":"Aktories K.","year":"1987","journal-title":"Biochem. 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