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The calcium\u2010binding loops contain all necessary liganding oxygens and most likely form the structural basis for the calcium sensitivity of strictly calcium\u2010regulated non\u2010muscle \u03b1\u2010actinins. Furthermore, the sequence exhibits at the N\u2010terminal site of the molecule a high degree of homology to chicken fibroblast \u03b1\u2010actinin. This stretch of amino acids appears to have remained essentially constant during evolution and might represent the actin\u2010binding site. The findings have led us to propose a model for the inhibitory action of Ca<jats:sup>2+<\/jats:sup> on non\u2010muscle \u03b1\u2010actinins.<\/jats:p>","DOI":"10.1016\/0014-5793(87)80962-6","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:57:06Z","timestamp":1027583826000},"page":"391-396","source":"Crossref","is-referenced-by-count":149,"title":["Calcium\u2010sensitive non\u2010muscle \u03b1\u2010actinin contains EF\u2010hand structures and highly conserved regions"],"prefix":"10.1002","volume":"221","author":[{"given":"Angelika","family":"Noegel","sequence":"first","affiliation":[]},{"given":"Walter","family":"Witke","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Schleicher","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2001,10,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.01.110185.002033"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.55.070186.005011"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.103.3.969"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(86)81395-3"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)61541-8"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1984.tb02096.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(82)90016-6"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.12.5463"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(79)85259-5"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/11.2.541"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/10409238009105467"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00308a007"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.78.3.477"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.75.3.788"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)67439-3"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)61254-2"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.17.5671"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/323455a0"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1986.tb04178.x"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1980.tb29594.x"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.12.3998"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1978.tb20956.x"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1974.tb03489.x"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(85)90086-4"},{"key":"e_1_2_1_26_1","first-page":"473","volume":"1","author":"Maeda N.","year":"1984","journal-title":"Mol. 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