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This finding is based on the remarkable similarity of both these proteins in physicochemical, biochemical and immunochemical properties, as well as on detection for the 14\u20103\u20103 protein of an activator activity towards tryptophan 5\u2010monooxygenase. The result suggests that the 14\u20103\u20103 protein plays a role in the regulation of serotonin and noradrenaline biosynthesis in brain.<\/jats:p>","DOI":"10.1016\/0014-5793(87)81194-8","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:57:40Z","timestamp":1027583860000},"page":"79-82","source":"Crossref","is-referenced-by-count":232,"title":["Brain 14\u20103\u20103 protein is an activator protein that activates tryptophan 5\u2010monooxygenase and tyrosine 3\u2010monooxygenase in the presence of Ca<sup>2+<\/sup>,calmodulin\u2010dependent protein kinase II"],"prefix":"10.1002","volume":"219","author":[{"given":"Tohru","family":"Ichimura","sequence":"first","affiliation":[]},{"given":"Toshiaki","family":"Isobe","sequence":"additional","affiliation":[]},{"given":"Tsueno","family":"Okuyama","sequence":"additional","affiliation":[]},{"given":"Takashi","family":"Yamauchi","sequence":"additional","affiliation":[]},{"given":"Hitoshi","family":"Fujisawa","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2001,10,19]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"1967 Prentice-Hall Englewood Cliff NJ B.W. 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