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Membranes prepared from hindquarter muscles of rats perfused with insulin showed a 23% decrease in 5\u2032\u2010nucleotidase activity. Isolated membranes from muscle exposed to insulin in vitro also showed a small but reproducible decrease (9%) in 5\u2032\u2010nucleotidase activity relative to unexposed controls. Phospholipase C from <jats:italic>Staphylococcus aureus<\/jats:italic> released 60% of the membrane\u2010bound 5\u2032\u2010nucleotidase. We propose that insulin may activate an endogenous phospholipase C that cleaves phospholipid\u2010glycan\u2010anchored proteins.<\/jats:p>","DOI":"10.1016\/0014-5793(88)80524-6","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:45:33Z","timestamp":1027583133000},"page":"419-423","source":"Crossref","is-referenced-by-count":37,"title":["Insulin\u2010induced decrease in 5\u2032\u2010nucleotidase activity in skeletal muscle membranes"],"prefix":"10.1002","volume":"238","author":[{"given":"Amira","family":"Klip","sequence":"first","affiliation":[]},{"given":"Toolsie","family":"Ramlal","sequence":"additional","affiliation":[]},{"given":"Andre G.","family":"Douen","sequence":"additional","affiliation":[]},{"given":"Elena","family":"Burdett","sequence":"additional","affiliation":[]},{"given":"Douglas","family":"Young","sequence":"additional","affiliation":[]},{"given":"Gregory D.","family":"Cartee","sequence":"additional","affiliation":[]},{"given":"John O.","family":"Holloszy","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2001,10,25]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3016898"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.16.5793"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)61627-8"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(87)90996-X"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(88)90116-6"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(88)90045-6"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3276003"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2440001"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.37.3.262"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(84)90091-1"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1240639"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(87)80452-0"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.41.1.124"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)96260-5"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)44007-5"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)43072-4"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(74)90222-X"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-119-4-1786"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)61253-0"},{"key":"e_1_2_1_22_1","author":"Brandan E.","year":"1988","journal-title":"J. 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