{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T10:45:17Z","timestamp":1761216317078},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,11,14]],"date-time":"2001-11-14T00:00:00Z","timestamp":1005696000000},"content-version":"vor","delay-in-days":4755,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[1988,11,7]]},"abstract":"<jats:p>It was previously demonstrated that C3bi\u2010 but not IgG\u2010mediated phagocytosis in human neutrophils is a Ca<jats:sup>2+<\/jats:sup>\u2010independent process [(1985) Nature 315, 509\u2013511]. The objective of this study was to elucidate the nature of an additional messenger signal(s) that may be involved in receptor\u2010mediated phagocytosis in these cells. The C3bi\u2010 and IgG\u2010mediated phagocytic ability of neutrophils was inhibited by forskolin, a potent activator of adenylate cyclase. It was found that forskolin induced a 3\u2010fold increase in cAMP levels and simultaneously reduced the uptake of both C3bi\u2010 and IgG\u2010opsonized particles by 65%. This inhibition was reversed by exposure to either phorbol myristate acetate (PMA) or diacylglycerol (OAG), which are both activators of protein kinase C, but not by the inactive analog 4\u03b1\u2010PMA. PMA could also restore the phagocytic ability of neutrophils with an experimentally impaired calcium response. These results suggest that activation of protein kinase C might be an important transducing signal controlling receptor\u2010mediated phagocytosis in human neutrophils.<\/jats:p>","DOI":"10.1016\/0014-5793(88)80954-2","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:45:33Z","timestamp":1027583133000},"page":"371-375","source":"Crossref","is-referenced-by-count":28,"title":["Does protein kinase C control receptor\u2010mediated phagocytosis in human neutrophils?"],"prefix":"10.1002","volume":"239","author":[{"given":"Tommy","family":"Andersson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"F\u00e4llman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel P.","family":"Lew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olle","family":"Stendahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,11,14]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"343","volume-title":"Inflammation","author":"Unkeless J.C.","year":"1988"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/312315a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3024320"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(83)90074-9"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112109"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2400333"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.17.5430"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/315509a0"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.106.3.657"},{"key":"e_1_2_1_11_1","first-page":"325","volume-title":"Inflammation","author":"Stossel T.P.","year":"1988"},{"key":"e_1_2_1_12_1","first-page":"287","volume-title":"Phosphoinositides and Receptor Mechanisms","author":"Cockcroft S.","year":"1986"},{"key":"e_1_2_1_13_1","first-page":"77","volume":"97","author":"B\u00f6yum A.","year":"1968","journal-title":"Scand. 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