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A second HPLC run of peak X HPLC fractions revealed the presence of PAF itself with concomitant disappearance of peak X. Beside PAF, immunoreactive apolipoproteins A\u2010I and E were found in peak X. Also lipoproteins (Ls) purified using either ultracentrifugation or immunoaffinity chromatography yielded peak X and, in a second HPLC run, authentic PAF. L\u2010free plasma was devoid of peak X. Finally, after preincubation with plasma, labeled PAF was found associated with Ls. Thus in human blood preformed PAF is bound in high amounts to Ls, a result of interest given the role of Ls and platelets in vascular diseases and the present knowledge on PAF biosynthesis.<\/jats:p>","DOI":"10.1016\/0014-5793(88)81456-x","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:45:58Z","timestamp":1027583158000},"page":"371-376","source":"Crossref","is-referenced-by-count":50,"title":["Preformed PAF\u2010acether and lyso PAF\u2010acether are bound to blood lipoproteins"],"prefix":"10.1002","volume":"226","author":[{"given":"Jacques","family":"Benveniste","sequence":"first","affiliation":[]},{"given":"Daniele","family":"Nunez","sequence":"additional","affiliation":[]},{"given":"Patrick","family":"Duriez","sequence":"additional","affiliation":[]},{"given":"Ruth","family":"Korth","sequence":"additional","affiliation":[]},{"given":"Jocelyne","family":"Bidault","sequence":"additional","affiliation":[]},{"given":"Jean-Charles","family":"Fruchart","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2001,10,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.136.6.1356"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.2610050105"},{"key":"e_1_2_1_4_1","unstructured":"1983 Academic Press New York R. 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