{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T23:39:56Z","timestamp":1774309196111,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,10,19]],"date-time":"2001-10-19T00:00:00Z","timestamp":1003449600000},"content-version":"vor","delay-in-days":4673,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[1989,1,2]]},"abstract":"<jats:p>The muscular content of the mRNAs encoding the five subunits of the nicotinic acetylcholine receptor was measured during postnatal development in the rat. Subunit specific mRNAs show differential regulation. The levels of the \u03b1\u2010, \u03b3\u2010 and \u03b4\u2010subunit specific mRNAs decrease steadily after birth, while the \u03b2 and \u03b5\u2010subunit mRNAs increase transiently and then decrease. The adult pattern of subunit specific mRNA levels is reached at 4\u20136 weeks postnatally. The content of \u03b3\u2010 and \u03b5\u2010subunit mRNA changes in a reciprocal fashion during the first 2 postnatal weeks, supporting the view that differential regulation of \u03b3\u2010 and \u03b5\u2010subunit mRNA during development is one mechanism mediating the appearance of the adult, \u03b5\u2010subunit containing, subtype of end\u2010plate channel. Denervation of neonatal muscle increases the levels of all subunit\u2010specific mRNAs during further development. It prevents the postnatal decrease in \u03b3\u2010subunit mRNA and enhances the initial increase in \u03b5\u2010subunit mRNA. This makes it appear that the \u03b5\u2010subunit gene is less sensitive to regulation by the nerve in the postnatal period than the \u03b3\u2010subunit gene.<\/jats:p>","DOI":"10.1016\/0014-5793(89)80514-9","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:45:33Z","timestamp":1027583133000},"page":"419-424","source":"Crossref","is-referenced-by-count":110,"title":["Developmental regulation of five subunit specific mRNAs encoding acetylcholine receptor subtypes in rat muscle"],"prefix":"10.1002","volume":"242","author":[{"given":"Veit","family":"Witzemann","sequence":"first","affiliation":[]},{"given":"Brigitte","family":"Barg","sequence":"additional","affiliation":[]},{"given":"Manuel","family":"Criado","sequence":"additional","affiliation":[]},{"given":"Elke","family":"Stein","sequence":"additional","affiliation":[]},{"given":"Bert","family":"Sakmann","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2001,10,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.10.030187.002155"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/321406a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(87)80518-5"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90195-X"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/276401a0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1980.sp013275"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(80)90494-7"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.05-08-02212.1985"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00582635"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.11.4835"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.9.5201"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(83)90418-9"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(80)90238-X"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)61283-9"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90081-5"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.7.3547"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/271366a0"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1984.tb08348.x"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2F0014-5793%2889%2980514-9","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2F0014-5793(89)80514-9","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/0014-5793%2889%2980514-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T06:51:59Z","timestamp":1694933519000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/0014-5793%2889%2980514-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,1,2]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,1,2]]}},"alternative-id":["10.1016\/0014-5793(89)80514-9"],"URL":"https:\/\/doi.org\/10.1016\/0014-5793(89)80514-9","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,1,2]]}}}