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We studied the synthesis and release of NO from human neutrophils stimulated with the chemotactic peptide <jats:italic>N<\/jats:italic>\u2010formyl\u2010L\u2010methionyl\u2010L\u2010leucyl\u2010L\u2010phenylalanine, platelet activating factor or leukotriene B<jats:sub>4<\/jats:sub>. The formation and release of NO was enhanced several\u2010fold in the presence of superoxide dismutase, probably by inhibiting superoxide\u2010induced breakdown of NO. The formation and release of NO but not the formation of superoxide anions was decreased in neutrophils pretreated with L\u2010canavanine, an inhibitor of arginine\u2010utilizing enzymes. Our data suggest that at least one NDRF is identical with NO or another labile NO containing compound derived from arginine.<\/jats:p>","DOI":"10.1016\/0014-5793(89)80562-9","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:45:33Z","timestamp":1027583133000},"page":"357-360","source":"Crossref","is-referenced-by-count":166,"title":["Formation and release of nitric oxide from human neutrophils and HL\u201060 cells induced by a chemotactic peptide, platelet activating factor and leukotriene B<sub>4<\/sub>"],"prefix":"10.1002","volume":"244","author":[{"given":"Harald H.H.W.","family":"Schmidt","sequence":"first","affiliation":[]},{"given":"Roland","family":"Seifert","sequence":"additional","affiliation":[]},{"given":"Eycke","family":"B\u00f6hme","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2001,11,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/288373a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.58.4.531"},{"key":"e_1_2_1_4_1","first-page":"893","volume":"237","author":"Ignarro L.J.","year":"1986","journal-title":"J. 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