{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T07:17:30Z","timestamp":1717744650009},"reference-count":31,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2001,10,19]],"date-time":"2001-10-19T00:00:00Z","timestamp":1003449600000},"content-version":"vor","delay-in-days":4449,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[1989,8,14]]},"abstract":"<jats:p>Tetanus toxin, a potent neurotoxin which blocks neurotransmitter release in the CNS, also inhibits Ca<jats:sup>2+<\/jats:sup>\u2010induced catecholamine release from digitonin\u2010permeabilized, but not from intact bovine chromaffin cells. In searching for intracellular targets for the toxin we studied the binding of affinity\u2010purified tetanus toxin to bovine adrenal chromaffin granules. Tetanus toxin bound in a neuraminidase\u2010sensitive fashion to intact granules and to isolated granule membranes, as assayed biochemically and visualized by electron microscopic techniques. The binding characteristics of the toxin to chromaffin granule membranes are very similar to the binding of tetanus toxin to brain synaptosomal membranes. We suggest that the toxin\u2010binding site is a glycoconjugate of the G1b type (a polysialoganglioside or a glycoprotein\u2010proteoglycan) which is localized on the cytoplasmic face of the granule membrane and might directly be involved in exocytotic membrane fusion.<\/jats:p>","DOI":"10.1016\/0014-5793(89)80943-3","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:45:01Z","timestamp":1027583101000},"page":"121-128","source":"Crossref","is-referenced-by-count":15,"title":["Affinity purified tetanus toxin binds to isolated chromaffin granules and inhibits catecholamine release in digitonin\u2010permeabilized chromaffin cells"],"prefix":"10.1002","volume":"253","author":[{"given":"Philip","family":"Lazarovici","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ko","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita L.","family":"Contreras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James P.","family":"DiOrio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter I.","family":"Lelkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,10,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.46.1.86-94.1982"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0032668"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/249415a0"},{"key":"e_1_2_1_5_1","first-page":"100","volume-title":"Neurotoxins as Tools in Neurochemistry","author":"Lazarovici P.","year":"1988"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(81)90123-8"},{"key":"e_1_2_1_7_1","volume-title":"Stimulus-Secretion Coupling in Chromaffin Cells","author":"Rosenheck K.","year":"1987"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/317719a0"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/324076a0"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1988.tb01059.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(89)80478-8"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)61555-8"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)47754-X"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(86)81049-3"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(85)90128-7"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)33236-2"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00370a044"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)69794-2"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(87)90024-1"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1983.tb13559.x"},{"key":"e_1_2_1_21_1","author":"Fujita K.","year":"1989","journal-title":"J. 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