{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:47:24Z","timestamp":1770720444448,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2001,11,12]],"date-time":"2001-11-12T00:00:00Z","timestamp":1005523200000},"content-version":"vor","delay-in-days":3990,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[1990,12,10]]},"abstract":"<jats:p>The human placental receptor (\u03b1<jats:sub>2<\/jats:sub>MR) for \u03b1<jats:sub>2<\/jats:sub>\u2010macroglobulin\u2010proteinase complexes contains 3 polypeptides of approx. 500 kDa, 85 kDa, and 40 kDa. N\u2010terminal sequence analysis of the 500 kDa and 85 kDa polypeptides, analysis of a random selection of peptides covering 536 residues from these polypeptides, and analysis of a 1772 bp cDNA encoding part of the 500 kDa polypeptide provide evidence that the 500 kDa and 85 kDa chains are the \u03b1\u2010 and \u03b2\u2010subunits, respectively, of a recently cloned hepatic membrane protein, termed the low density lipoprotein receptor related protein (LRP) (Herz, J., Hamann, U., Rogne, S., Myklebost, O., Gausepohl, H. and Stanley, K.K. (1988) EMBO J. 7, 4119\u20104127; Herz, J., Kowal, R.C., Goldstein, J.L. and Brown, M.S. (1990) EMBO J. 9, 1769\u20101776). N\u2010terminal sequence analysis of the 40 kDa polypeptide shows that it is of distinct genetic origin. It is suggested that LRP is the functional receptor for \u03b1<jats:sub>2<\/jats:sub>\u2010macroglobulin\u2010proteinase complexes (\u03b1<jats:sub>2<\/jats:sub>MR) and in addition may have as yet unsettled functions in lipoprotein metabolism.<\/jats:p>","DOI":"10.1016\/0014-5793(90)80530-v","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:44:17Z","timestamp":1027583057000},"page":"151-155","source":"Crossref","is-referenced-by-count":261,"title":["Evidence that the newly cloned low\u2010density\u2010lipoprotein receptor related protein (LRP) is the \u03b1<sub>2<\/sub>\u2010macroglobulin receptor"],"prefix":"10.1002","volume":"276","author":[{"given":"Torsten","family":"Kristensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren K.","family":"Moestrup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen","family":"Gliemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lone","family":"Bendtsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole","family":"Sand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Sottrup-Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,11,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1988.tb03306.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1990.tb08301.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)80094-1"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(83)90096-X"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(86)90037-6"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(89)90320-9"},{"key":"e_1_2_1_8_1","first-page":"373","volume":"846","author":"Davidsen O.","year":"1985","journal-title":"Biochim. 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