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Thermotolerance of the cells, measured as survival at 52\u00b0C, increased in parallel to trehalose accumulation and decreased in parallel to the trehalose levels when cells were shifted back to 27\u00b0C. Trehalose levels, activities of enzymes of trehalose metabolism and thermotolerance strongly increased upon heat shock even in the presence of cycloheximide, indicating that none of these effects requires protein synthesis. 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