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A selectivity of interaction has been established for different lipid species, and in certain cases evidence is obtained for a partial penetration of the peripheral proteins into the membrane. The latter may be relevant to the import mechanism of apocytochrome <jats:italic>c<\/jats:italic> into mitochondria. Integral proteins induce a more direct motional restriction of the spin\u2010labelled lipid chains, allowing the stoichiometry and specificity of the interaction, and the lipid exchange rate at the protein interface to be determined from the ESR spectra. In this way, a population of very slowly exchanging cardiolipin associated with the mitochondrial ADP\u2010ATP carrier has been identified. The residues involved in the specificity for charged lipids of the myelin proteolipid protein have been localized to the deletion in the DM\u201020 mutant, and the difference in lipid\u2010protein interactions with the \u03b2\u2010sheet and \u03b1\u2010helical conformations of the M\u201013 coat protein, has been characterized.<\/jats:p>","DOI":"10.1016\/0014-5793(90)81288-y","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:44:17Z","timestamp":1027583057000},"page":"371-375","source":"Crossref","is-referenced-by-count":64,"title":["Lipid\u2010protein interactions in membranes"],"prefix":"10.1002","volume":"268","author":[{"given":"Derek","family":"Marsh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,11,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00521a026"},{"key":"e_1_2_1_3_1","first-page":"143","volume-title":"Progress in Protein-Lipid Interactions","author":"Marsh D.","year":"1985"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00300a011"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00452a018"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00762302"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00523a036"},{"key":"e_1_2_1_8_1","author":"Abramovitch D.A.","year":"1990","journal-title":"Biochim. 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