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The expressed rat heart 1 Na<jats:sup>+<\/jats:sup> currents show kinetic properties and resistance to tetrodotoxin and saxitoxin which are characteristic of native cardiac Na<jats:sup>+<\/jats:sup> currents. The primary amino acid sequence of the rat heart 1 \u03b1\u2010subunit is therefore sufficient for expression of of tetrodotoxin resistance, and the rat heart 1 clone is likely to account for the tetrodotoxin\u2010resistant phenotype of cardiac and denervated skeletal muscle.<\/jats:p>","DOI":"10.1016\/0014-5793(90)81470-9","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:44:17Z","timestamp":1027583057000},"page":"195-200","source":"Crossref","is-referenced-by-count":45,"title":["Functional expression of the rat heart I Na<sup>+<\/sup> channel isoform Demonstration of properties characteristic of native cardiac Na<sup>+<\/sup> channels"],"prefix":"10.1002","volume":"275","author":[{"given":"Leanne L.","family":"Cribbs","sequence":"first","affiliation":[]},{"given":"Jonathan","family":"Satin","sequence":"additional","affiliation":[]},{"given":"Harry A.","family":"Fozzard","sequence":"additional","affiliation":[]},{"given":"Richard B.","family":"Rogart","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2001,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/320188a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(89)90113-X"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.20.8170"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.54.6.813"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(88)90065-4"},{"key":"e_1_2_1_7_1","first-page":"300a","volume":"57","author":"Krafte D.","year":"1990","journal-title":"Biophys. 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