{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:37:56Z","timestamp":1767706676312},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,12,7]],"date-time":"2001-12-07T00:00:00Z","timestamp":1007683200000},"content-version":"vor","delay-in-days":3952,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[1991,2,11]]},"abstract":"<jats:p>We examined the myocardial form of the Na<jats:sup>+<\/jats:sup> \/H<jats:sup>+<\/jats:sup> exchanger. A partial length cDNA clone was isolated from a rabbit cardiac library and it encoded for a Na<jats:sup>+<\/jats:sup> \/H<jats:sup>+<\/jats:sup> exchange protein. In comparison with the human Na<jats:sup>+<\/jats:sup> \/H<jats:sup>+<\/jats:sup> exchanger, the sequence of the 5\u2032 end of the cDNA was highly conserved, much more than the 3\/t' region, while the deduced amino acid sequence was also highly conserved. To further characterize the myocardial Na<jats:sup>+<\/jats:sup> \/H<jats:sup>+<\/jats:sup> exchange protein, we examined Western blots of isolated sarcolemma with antibody produced against a fusion protein of the Na<jats:sup>+<\/jats:sup> \/H<jats:sup>+<\/jats:sup> exchanger. The antibodies reacted with a sarcolemma protein of 50 kDa and with a protein of 70 kDa. The results show that the rabbit myocardium does possess a Na<jats:sup>+<\/jats:sup> \/H<jats:sup>+<\/jats:sup> exchanger protein homologous to the known human Na<jats:sup>+<\/jats:sup> \/H<jats:sup>+<\/jats:sup> exchanger.<\/jats:p>","DOI":"10.1016\/0014-5793(91)80241-t","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:43:20Z","timestamp":1027583000000},"page":"25-29","source":"Crossref","is-referenced-by-count":49,"title":["Identification of the protein and cDNA of the cardiac Na<sup>+<\/sup> \/H<sup>+<\/sup> exchanger"],"prefix":"10.1002","volume":"279","author":[{"given":"Larry","family":"Fliegel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Sardet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Pouyssegur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Barr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.56.6.773"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1976.sp011619"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1980.sp013337"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1979.sp012957"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1983.244.5.C422"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.85.1.43"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)89152-9"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(85)90553-X"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.64.4.676"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)39287-7"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)75866-9"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01869721"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.18.6797"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)40005-7"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(89)80041-5"},{"key":"e_1_2_1_17_1","first-page":"A941","volume":"2","author":"Knickelbein R.C.","year":"1988","journal-title":"FASEB J."},{"key":"e_1_2_1_18_1","first-page":"H608","volume":"255","author":"Karnazyn M.","year":"1988","journal-title":"Am. J. Physiol."},{"key":"e_1_2_1_19_1","first-page":"H1499","volume":"253","author":"Jeffrey F.M.H.","year":"1987","journal-title":"Am. J. Physiol."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)84996-7"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00433a036"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2154036"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)39360-3"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90901-X"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(20)88216-7"},{"key":"e_1_2_1_26_1","first-page":"1194","volume":"80","author":"Sanger F.","year":"1977","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(88)57070-2"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)39443-8"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.9.4350"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(89)80488-0"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2F0014-5793%2891%2980241-T","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2F0014-5793(91)80241-T","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/0014-5793%2891%2980241-T","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T02:16:40Z","timestamp":1694830600000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/0014-5793%2891%2980241-T"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,2,11]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,2,11]]}},"alternative-id":["10.1016\/0014-5793(91)80241-T"],"URL":"https:\/\/doi.org\/10.1016\/0014-5793(91)80241-t","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,2,11]]}}}