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SAP\u20102 originates from a gene which generates a mRNA that codes for four homologous proteins. In a patient with an immunologically proven SAP\u20102 deficiency a G<jats:sup>1154<\/jats:sup> \u2192 T transversion (counted from A of the initiation codon ATG) was found in the mRNA of the SAP\u20102 precursor which results in the substitution of Phe for Cys<jats:sup>385<\/jats:sup> in the mature SAP\u20102. 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